BACKGROUND Optical coherence tomography angiography(OCTA)is a new and reliable machine used to evaluate retinal structure and macular perfusion in children.The use of OCTA under bad condition such as high altitude,low...BACKGROUND Optical coherence tomography angiography(OCTA)is a new and reliable machine used to evaluate retinal structure and macular perfusion in children.The use of OCTA under bad condition such as high altitude,low atmospheric oxygen,and low humidity,in children is rarely.AIM To quantify the macular micro-vasculature in healthy children of various ages using OCTA in Qamdo.METHODS Design:Prospective cross-sectional,school-based study.Three hundred and fortyseven normal students from 9 schools in 4 different areas in Qamdo were included.OCTA was performed on a 3 mm×3 mm area centered on the macular region and macular cube 512×128 showed details in macular.Early treatment of diabetic retinopathy study Vessel Flow Density(VD)of the macular central vascular plexus density(CVD),inner vascular plexus density(IVD),full vascular plexus density(FVD),and the size of the foveal avascular zone(FAZ)were measured.All these results corrected by t/s=3.382×0.01306×(axial length-1.82).The differences were compared among various ages,sexes and living environments.RESULTS The mean FAZ area in all eyes was 0.27 mm^(2)±0.12 mm^(2).The mean foveal thickness(MFT)in the macular cube was 227.64μm±23.51μm.Compared with girls,boys had a lager FAZ(P=0.0029).Among the different age groups,MFT(P<0.001)and FVD(P<0.0001),IVD(P<0.0001),and CVD(P=0.0050)increased with age.FAZ areas were not correlated with age(P=0.8853)or others(MFT,area).CONCLUSION OCTA can use to evaluate macular perfusion in children.Our data bridge the gap between structural OCT and perfusion density in children in high altitude.Even though these were not a longitudinal study,it may provide us with hints about retina development during puberty and clinical implications of OCTA in children.展开更多
Qamdo block in the east Tibet lay in front of southwestern margin of the Yangtze landmass and was one of many micro\|blocks between the Gondwana and the Eurasia continents .It played an important role in the developme...Qamdo block in the east Tibet lay in front of southwestern margin of the Yangtze landmass and was one of many micro\|blocks between the Gondwana and the Eurasia continents .It played an important role in the development of the multi\|arc\|basin system of the north sector of the Jinsha\|lancang\|nujiang rivers . Space\|time texture of the block reflected the tectonic evolution of the east Tibet and neighbouring areas directly, providing important information for evolutionary history of the east Tethys.1\ Crustal structure of the Qamdo block\;Crustal structure of the Qamdo block is characterized by “double basement and double cover”.By double basement is meant the Middle—Upper Proterozoic crystalline basement and the Lower Paleozoic folded basement. The Middle—Upper Proterozoic crystalline basement is composed of medium\|high\|grade metamorphic biotite\|plagiogneiss, plagioclase\|amphibole schist, nacritid intercalated with (intermediate\|) basic metavolcanite. These rocks are characteristic of strong ductile deformed metamorphic core complex. The zircon of gneiss yields an U\|Pb age of 1680～2200Ma while the basic metavolcanite give a Sm\|Nd age of 1594Ma.The Lower Paleozoic folded basement consists of the Lower Ordovician and Silurian. Basement of the Qamdo block is similar to that of the Yangtze landmass. By double cover we mean two covers consisting of the Upper Paleozoic and Mesozoic, respectively. The Upper Paleozoic is composed of carbonate and clastic rock which were formed from epicontinental to back\|arc basins. The Mesozoic consists of the Upper Triassic—Cretaceous concordant formations which were formed in a back\|arc foreland basin.Sequences of the formations are molasse, neritic carbonate, paralic coal\|bearing rock and terrigenous red clastic rock from the bottom to the top.展开更多
基金Supported by the National Natural Science Foundation of China,No.81870650,No.81570832,and No.81300794Science and Technology Program Chongqing,China,No.2018GDRC008.
文摘BACKGROUND Optical coherence tomography angiography(OCTA)is a new and reliable machine used to evaluate retinal structure and macular perfusion in children.The use of OCTA under bad condition such as high altitude,low atmospheric oxygen,and low humidity,in children is rarely.AIM To quantify the macular micro-vasculature in healthy children of various ages using OCTA in Qamdo.METHODS Design:Prospective cross-sectional,school-based study.Three hundred and fortyseven normal students from 9 schools in 4 different areas in Qamdo were included.OCTA was performed on a 3 mm×3 mm area centered on the macular region and macular cube 512×128 showed details in macular.Early treatment of diabetic retinopathy study Vessel Flow Density(VD)of the macular central vascular plexus density(CVD),inner vascular plexus density(IVD),full vascular plexus density(FVD),and the size of the foveal avascular zone(FAZ)were measured.All these results corrected by t/s=3.382×0.01306×(axial length-1.82).The differences were compared among various ages,sexes and living environments.RESULTS The mean FAZ area in all eyes was 0.27 mm^(2)±0.12 mm^(2).The mean foveal thickness(MFT)in the macular cube was 227.64μm±23.51μm.Compared with girls,boys had a lager FAZ(P=0.0029).Among the different age groups,MFT(P<0.001)and FVD(P<0.0001),IVD(P<0.0001),and CVD(P=0.0050)increased with age.FAZ areas were not correlated with age(P=0.8853)or others(MFT,area).CONCLUSION OCTA can use to evaluate macular perfusion in children.Our data bridge the gap between structural OCT and perfusion density in children in high altitude.Even though these were not a longitudinal study,it may provide us with hints about retina development during puberty and clinical implications of OCTA in children.
文摘Qamdo block in the east Tibet lay in front of southwestern margin of the Yangtze landmass and was one of many micro\|blocks between the Gondwana and the Eurasia continents .It played an important role in the development of the multi\|arc\|basin system of the north sector of the Jinsha\|lancang\|nujiang rivers . Space\|time texture of the block reflected the tectonic evolution of the east Tibet and neighbouring areas directly, providing important information for evolutionary history of the east Tethys.1\ Crustal structure of the Qamdo block\;Crustal structure of the Qamdo block is characterized by “double basement and double cover”.By double basement is meant the Middle—Upper Proterozoic crystalline basement and the Lower Paleozoic folded basement. The Middle—Upper Proterozoic crystalline basement is composed of medium\|high\|grade metamorphic biotite\|plagiogneiss, plagioclase\|amphibole schist, nacritid intercalated with (intermediate\|) basic metavolcanite. These rocks are characteristic of strong ductile deformed metamorphic core complex. The zircon of gneiss yields an U\|Pb age of 1680～2200Ma while the basic metavolcanite give a Sm\|Nd age of 1594Ma.The Lower Paleozoic folded basement consists of the Lower Ordovician and Silurian. Basement of the Qamdo block is similar to that of the Yangtze landmass. By double cover we mean two covers consisting of the Upper Paleozoic and Mesozoic, respectively. The Upper Paleozoic is composed of carbonate and clastic rock which were formed from epicontinental to back\|arc basins. The Mesozoic consists of the Upper Triassic—Cretaceous concordant formations which were formed in a back\|arc foreland basin.Sequences of the formations are molasse, neritic carbonate, paralic coal\|bearing rock and terrigenous red clastic rock from the bottom to the top.
