TCM-HIN2Vec:A strategy for uncovering biological basis of heart qi deficiency pattern based on network embedding and transcriptomic experiment

Objective:To elucidate the biological basis of the heart qi deficiency(HQD)pattern,an in-depth understanding of which is essential for improving clinical herbal therapy.Methods: We predicted and characterized HQD pattern genes using the new strategy,TCM-HIN2Vec,which involves heterogeneous network embedding and transcriptomic experiments.First,a heterogeneous network of traditional Chinese medicine(TCM)patterns was constructed using public databases.Next,we predicted HQD pattern genes using a heterogeneous network-embedding algorithm.We then analyzed the functional characteristics of HQD pattern genes using gene enrichment analysis and examined gene expression levels using RNA-seq.Finally,we identified TCM herbs that demonstrated enriched interactions with HQD pattern genes via herbal enrichment analysis.Results: Our TCM-HIN2Vec strategy revealed that candidate genes associated with HQD pattern were significantly enriched in energy metabolism,signal transduction pathways,and immune processes.Moreover,we found that these candidate genes were significantly differentially expressed in the transcriptional profile of mice model with heart failure with a qi deficiency pattern.Furthermore,herbal enrichment analysis identified TCM herbs that demonstrated enriched interactions with the top 10 candidate genes and could potentially serve as drug candidates for treating HQD.Conclusion: Our results suggested that TCM-HIN2Vec is capable of not only accurately identifying HQD pattern genes,but also deciphering the basis of HQD pattern.Furthermore our finding indicated that TCM-HIN2Vec may be further expanded to develop other patterns,leading to a new approach aimed at elucidating general TCM patterns and developing precision medicine.

Network pharmacology-based exploration of molecular mechanisms underlying therapeutic effects of Jianpi Huatan Quyu recipe on chronic heart failure with spleen Qi deficiency syndrome

BACKGROUND Chronic heart failure is a complex clinical syndrome.The Chinese herbal compound preparation Jianpi Huatan Quyu recipe has been used to treat chronic heart failure;however,the underlying molecular mechanism is still not clear.AIM To identify the effective active ingredients of Jianpi Huatan Quyu recipe and explore its molecular mechanism in the treatment of chronic heart failure.METHODS The effective active ingredients of eight herbs composing Jianpi Huatan Quyu recipe were identified using the Traditional Chinese Medicine Systems Pharmacology Database and Analysis Platform.The target genes of chronic heart failure were searched in the Genecards database.The target proteins of active ingredients were mapped to chronic heart failure target genes to obtain the common drugdisease targets,which were then used to construct a key chemical componenttarget network using Cytoscape 3.7.2 software.The protein-protein interaction network was constructed using the String database.Gene Ontology and Kyoto Encyclopedia of Genes and Genomes enrichment analyses were performed through the Metascape database.Finally,our previously published relevant articles were searched to verify the results obtained via network pharmacology.RESULTS A total of 227 effective active ingredients for Jianpi Huatan Quyu recipe were identified,of which quercetin,kaempferol,7-methoxy-2-methyl isoflavone,formononetin,and isorhamnetin may be key active ingredients and involved in the therapeutic effects of TCM by acting on STAT3,MAPK3,AKT1,JUN,MAPK1,TP53,TNF,HSP90AA1,p65,MAPK8,MAPK14,IL6,EGFR,EDN1,FOS,and other proteins.The pathways identified by KEGG enrichment analysis include pathways in cancer,IL-17 signaling pathway,PI3K-Akt signaling pathway,HIF-1 signaling pathway,calcium signaling pathway,cAMP signaling pathway,NF-kappaB signaling pathway,AMPK signaling pathway,etc.Previous studies on Jianpi Huatan Quyu recipe suggested that this Chinese compound preparation can regulate the TNF-α,IL-6,MAPK,cAMP,and AMPK pathways to affect the mitochondrial structure of myocardial cells,oxidative stress,and energy metabolism,thus achieving the therapeutic effects on chronic heart failure.CONCLUSION The Chinese medicine compound preparation Jianpi Huatan Quyu recipe exerts therapeutic effects on chronic heart failure possibly by influencing the mitochondrial structure of cardiomyocytes,oxidative stress,energy metabolism,and other processes.Future studies are warranted to investigate the role of the IL-17 signaling pathway,PI3K-Akt signaling pathway,HIF-1 signaling pathway,and other pathways in mediating the therapeutic effects of Jianpi Huatan Quyu recipe on chronic heart failure.

Observation on the Nursing Effect of Ginger Moxibustion on Gastrointestinal Symptoms in Patients with Heart Failure Due to Yang Qi Deficiency

Objective:To evaluate the nursing measures and effects of ginger moxibustion in the treatment of heart failure(yang qi deficiency type)with gastrointestinal symptoms.Methods:86 patients with heart failure(yang qi deficiency type)accompanied by gastrointestinal symptoms who were admitted to the hospital between January 2023 and January 2024 were selected and divided into 43 cases in each group by random number table grouping;Group I implemented integrated care,while Group II adopted conventional care.The indicators of care were compared between the two groups.Results:After the nursing care,the digestive symptom scores of Group I were lower than those of Group I,and the psychological scores were lower than those of Group II(P<0.05).Conclusion:Ginger moxibustion can improve gastrointestinal symptoms and enhance the psychological health of patients with heart failure(yang qi deficiency type)with gastrointestinal symptoms.

Clinical Observation of the Therapeutic Effects of Wenzhong Hewei Formula in Treating Spleen and Stomach Qi Deficiency Syndrome in Internal Medicine Diseases

Objective:To observe the clinical efficacy and safety of Wenzhong Hewei Formula in treating spleen and stomach qi deficiency syndrome in internal medicine diseases.Methods:Sixty patients with spleen and stomach qi deficiency syndrome admitted to the hospital from April 2022 to June 2023 were randomly divided into observation and control groups,with 30 patients in each group.The control group received conventional internal medicine treatment,while the observation group was additionally treated with Wenzhong Hewei Formula on the basis of conventional treatment.Both groups were treated for 4 weeks.Results:The total effective rate of treatment in the observation group was higher than that of the control group(P<0.05).After treatment,the traditional Chinese medicine syndrome scores of both groups were significantly lower than before treatment,with the observation group showing a more pronounced reduction(P<0.05).There was no statistically significant difference in the incidence of adverse reactions between the two groups(P>0.05).Conclusion:Wenzhong Hewei Formula can effectively improve clinical symptoms in patients with spleen and stomach qi deficiency syndrome,enhance clinical efficacy,and have a high level of safety,making it worthy of clinical promotion.

Effect of Sijunzi Decoction on the Myonuclear Domain of Rat Soleus in Spleen Qi Deficiency

Objective: To study the mechanism of Sijunzi decoction treating limb weakness in spleen Qi deficiency (SQD) based on the myonuclear domain (MND) theory. Methods: 40 male Sprague-Dawley rats were randomly divided into the normal group, SQD model group (model group), SQD+ still water group (SW group) and SQD+ Sijunzi decoction group (CM group), 10 rats each group;Grip-Strength Meter was used to measure limb grip strength;transmission electron microscope was employed to observe the ultrastructural changes of the myofibers, Image Pro 6.0 was used to measure the myonuclear numbers, cross-section area (CSA) and then their ratios (the MND sizes) were calculated, immunofluorescence assay was chosen to test the expressions of paired box gene 7 (Pax7) and myogenic differentiation antigen (MyoD). Results: Compared with those in the normal group, limb grip strength was decreased, sarcomeres were abnormal, and all the myonuclear numbers, CSA and MND sizes were reduced, but the Pax7+ cell numbers were increased, significantly, in the model and SW groups;Compared with those in the model and SW groups, limb grip strength was increased, sarcomeres were basically normal, the myonuclear number and CSA were both greater, and the Pax7+ and MyoD+ cell numbers were both increased, significantly, in the CM group. Conclusion: Sijunzi decoction might increase the myonuclear number by activating the MSCs to treat limb weakness in SQD.

Clinical effects of a traditional Chinese medicine nursing programme to intervene in gastric pain of the spleen and stomach with Qi deficiency

BACKGROUND Gastroparesis is a common digestive disorder characterized by delayed gastric emptying,which can lead to symptoms such as nausea,vomiting,abdominal pain,and poor appetite.Traditional Chinese medicine(TCM)has been used for centuries to treat gastrointestinal disorders,including gastroparesis.TCM theory suggests that spleen and stomach qi deficiency syndrome is one of the main pathogenic factors in gastroparesis.Nursing care plays an important role in the treatment of gastroparesis,and TCM nursing interventions have shown promising results in improving patient outcomes.However,there is limited research on the clinical effectiveness of TCM nursing interventions for gastroparesis with spleen stomach deficiency syndrome.This study aimed to evaluate the clinical effect of TCM nursing intervention in the treatment of gastroparesis with spleen stomach deficiency syndrome and to compare it with routine nursing interventions.AIM To analyze the clinical effect of traditional Chinese medicine nursing intervention in the treatment of gastric paraplegia with spleen stomach deficiency syndrome.METHODS From January 2020 to July 2021,80 patients with gastroparesis of spleen stomach qi deficiency type diagnosed in our hospital were selected for the study.The 80 patients were randomly divided into a control group and an experimental group,with 40 cases in each group.During the treatment period,the control group received routine nursing interventions,while the experimental group received traditional Chinese medicine nursing procedures.Compare the nursing effects of the two groups and observe the changes in traditional Chinese medicine symptom scores,pain levels,and sleep quality before and after treatment.RESULTS After treatment,comparing the treatment effects of the two groups,the total effective rate of the experimental group was significantly higher than that of the control group,with statistical significance(P<0.05).There was no statistically significant difference in the TCM symptom score,visual analogue scale(VAS)score,and Pittsburgh sleep quality index(PSQI)score between the two groups before treatment(P>0.05).However,after treatment,the TCM syndrome scores,VAS scores,and PSQI scores of the experimental group were significantly lower than those of the control group,with a statistically significant difference(P<0.05).CONCLUSION In the clinical nursing intervention of patients with mild gastroparesis due to spleen and stomach qi deficiency,the traditional Chinese medicine nursing plan has good clinical application value and nursing effect,and has a good effect on improving patients’pain and sleep quality.

从“虚气留滞夹火”探讨应激敏化所致抑郁症辨治思路

中医学认为“虚气留滞夹火”是抑郁症的核心病机,具有“虚气”为本,本虚在脾、标虚在脑,“留滞”为标,气滞、痰凝、血瘀留滞脑络,“夹火”灼脑络,郁生火热、火生虚滞的病机特点和演变规律。本文基于现代医学对抑郁症“应激敏化”发病机制的认识,探讨其与中医学“虚气留滞夹火”核心病机的潜在关联,提出补虚、通滞、泻火是抑郁症的基本治法,通过抑制炎症反应,改善神经元及小胶质细胞的应激敏化状态,发挥中药复方多靶点及多维度的治疗特性。

基于糖代谢和胰岛素抵抗评估益气养阴法治疗气阴两虚型2型糖尿病的疗效

目的分析益气养阴法治疗气阴两虚型2型糖尿病对患者糖代谢和胰岛素抵抗评估的影响。方法南京中医药大学附属南京市中西医结合医院2019年6月—2022年3月收治的90例气阴两虚型2型糖尿病患者随机分为胰岛素泵治疗组(45例)和益气养阴治疗组(45例)。益气养阴治疗组采用胰岛素泵强化治疗联合益气养阴法进行治疗,胰岛素泵治疗组单独进行胰岛素泵强化治疗,两组均治疗2周。统计两组治疗2周后的临床疗效及治疗期间不良反应发生情况,比较两组治疗前和治疗2周后中医证候积分、糖代谢情况、胰岛素抵抗情况。结果治疗2周后,益气养阴治疗组总有效率为91.11%(41/45),高于胰岛素泵治疗组[73.33%(33/45),P<0.05]。治疗2周后与治疗前比较,两组口燥咽干、倦怠乏力、失眠、自汗盗汗、五心烦热、气短懒言评分及血清空腹血糖(fasting blood glucose,FPG)、餐后2 h血糖(postprandial 2-hour blood glucose,2 h PG)、糖化血红蛋白(glycated hemoglobin,HbA1c)、空腹胰岛素(fasting insulin,FINS)水平、胰岛素抵抗指数(Homa-IR)降低,益气养阴治疗组低于胰岛素泵治疗组(P<0.05),两组胰岛素敏感指数(insulin sensitivity index,ISI)、胰岛功能指数(Homa-islet)升高,益气养阴治疗组高于胰岛素泵治疗组(P<0.05)。治疗期间,益气养阴治疗组总不良反应发生率与胰岛素泵治疗组比较,差异无统计学意义(P>0.05)。结论气阴两虚型2型糖尿病患者采用益气养阴法进行治疗,可有效改善患者中医证候、糖代谢,降低患者机体胰岛素抵抗程度,具有较好的治疗效果。

体质贴联合八段锦功法治疗气虚血瘀质新型冠状病毒感染恢复期患者的临床研究

[目的]观察气虚血瘀体质贴(简称体质贴)联合八段锦功法对气虚血瘀体质的新型冠状病毒感染恢复期患者的临床疗效。[方法]符合入选标准的43例新型冠状病毒感染恢复期患者分为试验组(21例)和对照组(22例)两组均在八段锦功法的基础上予体质贴辅助治疗,治疗12周后,观察两组患者治疗前后在中医症状积分量表、改良英国医学研究委员会呼吸困难量表(mMRC)、Borg自觉疲劳量表和匹兹堡睡眠问卷(PSQI)的评分改善情况。[结果]治疗12周后,与治疗前相比,试验组中医症状总积分明显降低(P<0.05);组间比较显示试验组总积分明显低于对照组(P<0.05)。在改善单项症状积分方面,两组与各自治疗前相比,试验组在改善肌肉疲劳、气短、胸闷、干咳的方面积分明显降低(P<0.05),对照组在改善肌肉疲劳、自汗盗汗方面的积分明显降低(P<0.05)。组间比较显示,试验组在改善肌肉疲劳、气短、心悸、胸闷、干咳上的积分较对照组积分明显降低(P<0.05)。mMRC量表评分结果显示,两组患者与治疗前相比,呼吸症状评分无明显变化(P>0.05)。Borg量表和PSQI量表结果显示,与治疗前相比,两组患者症状积分均明显下降(P<0.05),但组间比较差异无统计学意义(P>0.05)。[结论]体质贴联合八段锦康复治疗对气虚血瘀质新型冠状病毒感染恢复期患者的中医症状有改善作用,尤对肌肉疲劳、气短、心悸、胸闷、干咳改善明显,同时可以减轻患者疲劳,改善患者睡眠质量。

补中益气汤合增液汤加减治疗功能性便秘气阴两虚证疗效评价

目的探讨补中益气汤合增液汤加减治疗功能性便秘气阴两虚证的临床疗效。方法将该院于2019年1月—2021年12月收治的80例功能性便秘气阴两虚证患者纳入研究,采用随机对照法将所选患者进行分组,分为治疗组及对照组各40例。其中治疗组患者应用补中益气汤合增液汤加减治疗,150 mL/次,每日2次。对照组予以枸橼酸莫沙必利分散片5 mg/次口服,每日3次。2组均以4周为1个疗程,比较治疗前后便秘主要症状评分、便秘患者症状自评量表(PAC-SYM)评分变化情况,并比较两组患者的临床疗效。结果药物干预前,两组患者临床症状包括大便性状、排便间隔、排便困难、排便不尽症状评分及腹部症状、直肠症状、大便症状、PAC-SYM量表总分评分对比,差异无统计学意义,均P>0.05;经药物干预后,两组患者大便性状、排便间隔、排便困难、排便不尽症状评分及腹部症状、直肠症状、大便症状、PAC-SYM量表总分评分均明显低于治疗前,且观察组明显低于对照组,均P<0.05。观察组的总有效率明显高于对照组(P<0.05)。结论补中益气汤合增液汤加减治疗功能性便秘气阴两虚证具有较好临床效果,能够显著缓解大便干燥症状,改善患者生存状态,且具有不良反应小、患者认可度高等优势,是值得广泛应用的方案之一。

益心泰颗粒对慢性心衰(心气虚兼血瘀水停证)大鼠AMPK、PGC-1α的影响

目的观察益心泰颗粒对慢性心力衰竭(CHF)(心气虚兼血瘀水停证)大鼠AMPK、PGC-1α的影响。方法采用丙硫氧嘧啶灌胃及阿霉素腹腔注射复制CHF(心气虚兼血瘀水停证)模型大鼠,将造模成功大鼠分为模型组与益心泰低、中、高剂量组和曲美他嗪组;另设正常对照组。灌胃4周后观察心肌组织病理结构,检测LVEF、血清NT-proBNP及心肌组织FFA、ATP/AMP、LAC、pAMPK、AMPK、PGC-1α水平。结果与模型组比较,益心泰颗粒低、中、高剂量组及曲美他嗪组LVEF、心肌组织ATP/AMP值、心肌组织p-AMPK、AMPK、PGC-1α相对灰度值均明显升高(P<0.05或P<0.01),血清NT-proBNP及心肌组织FFA、LAC明显降低(P<0.05或P<0.01)。结论益心泰颗粒能促进慢性心力衰竭(心气虚兼血瘀水停证)大鼠AMPK、PGC-1α表达,改善心肌能量代谢。

基于气络学说运用芪归通络口服液联合艾灸治疗气虚血瘀型慢性疲劳综合征的临床观察

【目的】观察基于气络学说,运用芪归通络口服液(广东省第二中医院院内制剂,由黄芪、当归、三七、赤芍、牛膝、鸡血藤、丹参、地龙等中药组成)联合艾灸治疗气虚血瘀型慢性疲劳综合征(chronic fatigue syndrome,CFS)的临床疗效。【方法】采用回顾性研究方法,根据治疗方法的不同将60例气虚血瘀型CFS患者分为观察组和对照组,每组各30例。对照组给予艾条温和灸神阙穴治疗,观察组在对照组的基础上联合芪归通络口服液治疗,疗程为4周。观察2组患者治疗前后中医证候积分、疲劳量表-14(FS-14)评分、血清免疫球蛋白IgA、IgM、IgG含量及皮质醇(COR)水平的变化情况,并评价2组患者的临床疗效和安全性。【结果】(1)疗效方面,治疗4周后,观察组的总有效率为96.67%(29/30),对照组为80.00%(24/30),组间比较,观察组的临床疗效明显优于对照组(P<0.05)。(2)量表评分方面,治疗后,2组患者的中医证候积分、FS-14评分均较治疗前明显降低(P<0.01),且观察组对中医证候积分、FS-14评分的降低作用均明显优于对照组(P<0.01)。(3)实验室指标方面,治疗后,2组患者血清IgA、IgG水平以及观察组血清IgM、COR水平均较治疗前明显升高(P<0.01),且观察组对血清IgA、IgM、IgG及COR水平的升高作用均明显优于对照组(P<0.05或P<0.01)。(4)安全性方面,治疗过程中,2组患者均未发生明显不良反应。【结论】基于中医气络学说,以正虚络阻为CFS核心病机,运用补虚通络法,采用芪归通络口服液联合艾灸治疗气虚血瘀型CFS患者疗效确切,能明显缓解患者的临床症状,提高患者的免疫力水平,调节患者的神经-内分泌-免疫(NEI)网络。

基于子午流注的气交灸法在脑卒中后气虚型尿潴留病人中的应用

目的:探讨基于子午流注的气交灸法治疗脑卒中后气虚型尿潴留病人的临床效果。方法:选取2022年1月—2023年1月在我院住院治疗的60例脑卒中后气虚型尿潴留病人,采用随机数字表法将其分为治疗组和对照组,各30例,对照组给予脑卒中后尿潴留护理常规护理,治疗组在对照组的基础上实施基于子午流注的气交灸法,比较两组治疗前、治疗2周后膀胱残余尿量、治疗后的临床疗效和满意度。结果:治疗2周后,治疗组膀胱残余尿量、临床疗效和满意度均优于对照组,差异有统计学意义(P<0.05)。结论:基于子午流注的气交灸法能有效减少脑卒中后气虚型尿潴留病人的残余尿量,改善临床疗效,提高病人满意度。

基于《黄帝内经》气虚理论对动脉粥样硬化论治探微

动脉粥样硬化是心血管疾病的病理基础。本虚标实为动脉粥样硬化的基本病机。从《黄帝内经》气虚理论出发,以五脏及营卫之气的虚损作为切入点,探讨其影响津液血液运行从而产生“痰瘀毒”等病理产物的作用机制,探讨动脉粥样硬化的病因病机。治疗上应以补益为主,佐以活血化瘀之法。

炙黄芪-水蛭联合阿加曲班注射液治疗气虚血瘀型急性脑梗死的疗效观察

[目的]探究炙黄芪-水蛭联合阿加曲班注射液治疗气虚血瘀型急性脑梗死的疗效观察。[方法]选取2021年2月—2023年2月于本院进行急性脑梗死治疗的患者110例,按照随机数字表法将其分为阿加曲班注射液组(西药组)34例、炙黄芪-水蛭组(中药组)36例,以及联合组40例。西药组给予阿加曲班注射液;中药组给予炙黄芪-水蛭;联合组给予炙黄芪-水蛭联合阿加曲班注射液治疗。评估患者治疗前后中医证候积分水平;采用美国国立卫生研究院卒中量表(NIHSS)、改良Rankin(mRS)评分量表评估患者自身的神经功能缺损情况以及神经功能恢复情况;检测脑血流阻力指数(RI)、舒张期血流速度(Vd)、收缩期峰值流速(Vs)、平均血流速度(Vm)、血管内皮生长因子(VEGF)、一氧化氮(NO)水平。[结果]治疗后,联合组中医证候积分、NIHSS、mRS评分、RI、VEGF水平均低于西药组、中药组(P<0.05);Vd、Vs、Vm、NO水平高于西药组、中药组(P<0.05);联合组总有效率较高(P<0.01)。[结论]经炙黄芪-水蛭、阿加曲班注射液联合治疗,其气虚血瘀型急性脑梗死患者中医证候积分水平降低,相关神经功能、血流情况及血管内皮损伤情况均得到显著改善,临床治疗效果显著。

基于“脾气散精”理论探讨慢性肝病的中医治疗

慢性肝病的发病与脾密切相关,“脾气散精”是《黄帝内经》对脾功能的高度概括,脾气散精功能障碍贯穿慢性肝病始终,脾失运化,生湿生痰,瘀血阻络为慢性肝病进展的关键因素。治疗时应将健脾作为慢性肝病的基本治法之一,并根据脾运的不同状态,配合运脾、醒脾、温脾等不同治法,以复脾气散精之能,病程中尤应抓住瘀血络阻这一关键病机,活血化瘀通络,防止慢性肝病进一步向肝积、鼓胀发展,使脾运得复,瘀阻得除,标本兼治。

参苓白术散加减治疗肺脾气虚津亏干燥综合征疗效及对Toll样受体4/核因子-κB水平的影响

目的探究参苓白术散加减治疗肺脾气虚津亏干燥综合征的疗效及对血清Toll样受体4(TLR4)和核因子-κB(NF-κB)水平的影响。方法选取2019年3月—2022年3月收治的107例干燥综合征患者为研究对象,采用信封法从密封箱子抽取带有数字的纸团,大于等于54的号码为观察组,小于54的号码为对照组。观察组54例,对照组53例。对照组给予硫酸羟氯喹片、甲泼尼龙片治疗,观察组在此基础上联合使用参苓白术散加减治疗。观察两组患者治疗前后中医证候评分、疾病活动指数(ESSDAI)和自我报告指数(ESSPRI)评分、γ-干扰素(IFN-γ)、白介素-17(IL-17)、免疫功能(CD_(8)^(+)、CD_(4)^(+)和CD^(+)_(4/)CD_(8)^(+))、血清TLR4和NF-κB水平。观察两组患者临床疗效。结果治疗前两组患者两目干涩、关节疼痛、口燥咽干、皮肤干燥、体倦乏力和唾液腺肿评分差异无统计学意义(P>0.05)。治疗后观察组两目干涩、关节疼痛、口燥咽干、皮肤干燥、体倦乏力和唾液腺肿评分显著低于对照组(P<0.05)。治疗前两组患者ESSDAI和ES⁃SPRI评分差异无统计学意义(P>0.05)。治疗后观察组ESSDAI和ESSPRI评分显著低于对照组(P<0.05)。治疗前两组患者IFN-γ、IL-17水平差异无统计学意义(P>0.05)。治疗后观察组IFN-γ、IL-17水平显著低于对照组(P<0.05)。两组患者治疗前CD_(4)^(+)、CD_(8)^(+)、CD_(4)^(+)/CD^(+)8水平差异无统计学意义(P>0.05)。治疗后观察组的CD_(4)^(+)、CD_(4)^(+)/CD_(8)^(+)水平较对照组显著升高,而CD^(+)8水平较对照组显著降低(P<0.05)。两组患者治疗前TLR4/NF-κB水平差异无统计学意义(P>0.05)。治疗后观察组TLR4/NF-κB水平较对照组显著降低(P<0.05)。观察组总有效率为96.30%(52/54),显著高于对照组的84.91%(45/53)(χ^(2)=4.096,P=0.043)。结论参苓白术散加减能有效提高干燥综合征患者临床疗效、降低ESSDAI和ESSPRI评分、改善TLR4/NF-κB的水平,有利于提高患者免疫力。

黄芪竹叶汤配合益气生津丸治疗2型糖尿病气阴两虚证患者的临床观察

目的观察黄芪竹叶汤配合益气生津片治疗2型糖尿病气阴两虚证的临床效果。方法选取2020年1月—2022年1月期间河南省安阳市中医院收治的2型糖尿病(T2DM)患者90例作为研究对象,按随机数字表法分为对照组和治疗组,每组各45例。两组患者均给予常规西药治疗,对照组采用黄芪竹叶汤,治疗组在对照组基础上加用益气生津丸治疗,均连续治疗3个月。观察比较两组患者临床疗效、不良反应发生率,治疗前后中医证候积分、血糖指标[空腹血糖(Fasting plasma glucose,FPG),糖化血红蛋白(Glycosylated hemoglobin,HbA1c),空腹胰岛素(Fasting insulin,FINS)]及血清炎性因子[C-反应蛋白(C-reactive protein,CRP)、白细胞介素-1β(Interleukin-1β,IL-1β)、白细胞介素-6(Interleukin-6,IL-6)]水平。结果治疗后治疗组总有效率91.11%(41/45)明显高于对照组75.55%(34/45),差异有统计学意义(P<0.05)。治疗后两组患者中医证候积分均较治疗前降低,差异有统计学意义(P<0.05);且治疗组各主症及各次症积分均低于对照组,差异有统计学意义(P<0.05)。治疗后两组患者血糖指标FPG、FINS、HbA1c均较治疗前降低,差异有统计学意义(P<0.05);且治疗组FPG、FINS、HbA1c均低于对照组,差异有统计学意义(P<0.05)。治疗后两组患者血清炎性因子水平CRP、IL-6、IL-1β均较治疗前降低,差异有统计学意义(P<0.05);且治疗组CRP、IL-6、IL-1β均低于对照组,差异有统计学意义(P<0.05)。治疗期间,两组患者不良反应发生率比较,差异无统计学意义(P>0.05)。结论黄芪竹叶汤配合益气生津丸是治疗2型糖尿病有效且安全的方案,能明显控制患者血糖,减轻炎症反应。

子午流注择时电温针联合双补增津汤治疗结肠慢传输型便秘气阴两虚证的疗效观察

目的:观察子午流注择时电温针联合双补增津汤治疗结肠慢传输型便秘(STC)气阴两虚证的临床疗效。方法:选择符合纳入标准的152例STC气阴两虚证患者,按随机抽取法分为对照组(枸橼酸莫沙必利治疗)、电针组(枸橼酸莫沙必利+子午流注择时电温针治疗)、中药组(枸橼酸莫沙必利+双补增津汤治疗)和结合组(枸橼酸莫沙必利+子午流注择时电温针+双补增津汤治疗),每组各38例,均治疗4周。观察比较4组患者治疗前后中医症状积分和总积分、结肠传输试验标志物含量、肠道菌群数量、焦虑自评量表评分(SAS)、抑郁自评量表评分(SDS)、慢性便秘严重度评分(CSS)的变化情况,比较临床疗效及随访6个月复发率。结果:4组患者治疗后中医症状积分和总积分、结肠传输试验标志物含量和SAS、SDS、CSS评分均较治疗前比较均明显下降(P<0.05),肠道内大肠埃希数量与治疗前比较明显减少(P<0.05),双歧杆菌、乳酸杆菌数量与治疗前比较明显增多(P<0.05);结合组临床疗效明显优于其他3组(P<0.05),随访期复发率明显低于其他3组(P<0.05)。结论:子午流注择时电温针联合双补增津汤治疗STC气阴两虚证的疗效显著,二者可发挥协同增效作用,能有效缓解便秘症状,调节肠道菌群,恢复肠道运动功能,改善焦虑、抑郁心理状态,降低复发率。

参芪桃花四物汤合复遂汤联合针刺对气虚血瘀证缺血性脑梗死恢复期痉挛性瘫痪患者的临床疗效

目的探讨参芪桃花四物汤合复遂汤联合针刺对气虚血瘀证缺血性脑梗死恢复期痉挛性瘫痪患者的临床疗效。方法92例患者随机分为对照组和观察组,每组46例,2组采用常规治疗,同时对照组给予针刺,观察组在对照组基础上加用参芪桃花四物汤合复遂汤,疗程4周。检测临床疗效、中医证候评分、血清学指标(Glu、GABA、Glu/GABA、Gly、HCY、ASP)、神经功能指标(BDNF、NGF、NT-3)、NIHSS评分、FMA评分、MAS评分、Barthel评分、表面肌电信号(Hmax、Mmax、Hmax/Mmax)、不良反应发生率变化。结果观察组总有效率高于对照组(P<0.05)。治疗后,2组GABA、Gly、神经功能指标、FMA评分、Barthel评分升高(P<0.05),中医证候评分、Glu、Glu/GABA、HCY、ASP、NIHSS评分、MAS评分、表面肌电信号降低(P<0.05),以观察组更明显(P<0.05)。2组不良反应发生率比较,差异无统计学意义(P>0.05)。结论参芪桃花四物汤合复遂汤联合针刺可安全有效地改善气虚血瘀证缺血性脑梗死恢复期痉挛性瘫痪患者神经功能、运动功能、生活质量,降低中医证候评分、痉挛程度。