目的探讨慢性阻塞性肺疾病急性加重期(acute exacerhation of chronic obstructive pulmonary disease,AECOPD)患者治疗前后Th17/Treg免疫平衡、呼出气一氧化氮(fraction of exhaled nitric oxide,FeNO)水平变化及对预后的影响。方法选...目的探讨慢性阻塞性肺疾病急性加重期(acute exacerhation of chronic obstructive pulmonary disease,AECOPD)患者治疗前后Th17/Treg免疫平衡、呼出气一氧化氮(fraction of exhaled nitric oxide,FeNO)水平变化及对预后的影响。方法选取AECOPD患者126例,采用肺功能检测仪测定第1秒用力呼气量(forced expiratory volume in one second,FEV1)、第1秒用力呼气量占预计值百分比(FEV1%)、用力肺活量(forced vital capacity,FVC)、用力肺活量占预计值百分比(FVC%)、第1秒用力呼气量占用力肺活量的百分比(FEV1/FVC)。并使用一氧化氮测定仪检测FeNO水平,采用全身炎性反应综合征(systemic inflammaton response syndrome,SIRS)评分进行评分,采用流式细胞仪检测血清辅助性T细胞17(T help 17cells,Th17)、调节性T细胞(T Regulatory cells,Treg)水平,比较治疗前后患者肺功能指标、FeNO水平、SIRS评分、Th17/Treg水平等指标变化情况。结果治疗3个月后,AECOPD患者FEV1%、FEV1/FVC、Th17、Th17/Treg水平显著高于治疗前,FeNO、血清Treg水平、SIRS评分显著低于治疗前(P<0.05)。126例AECOPD患者治疗3个月后存活94例(74.60%);死亡32例(25.40%)。存活组FEV1%、FEV1/FVC、Treg水平显著高于死亡组,FeNO、Th17、Th17/Treg及SIRS评分显著低于死亡组(P<0.05)。多因素Logistic回归分析结果显示,治疗前FEV1%、FEV1/FVC、Treg是AECOPD患者预后的危险因素(P<0.05);FeNO、Th17、Th17/Treg、SIRS评分是AECOPD患者预后的保护因素(P<0.05)。结论AECOPD患者治疗后肺功能提高,Th17/Treg、FeNO降低,肺功能、Th17/Treg免疫平衡、FeNO水平对AECOPD患者疗效评估及预后判断具有重要意义。展开更多
The safety and reliability of weapon systems would be significantly affected by changes in the performance of energetic materials due to ambient temperature and humidity.Nanothermites have promising applications due t...The safety and reliability of weapon systems would be significantly affected by changes in the performance of energetic materials due to ambient temperature and humidity.Nanothermites have promising applications due to their excellent reactivity.Therefore it becomes extremely important to understand their aging and failure process in the environment before using them.Here,the aging and failure process of Al/CuO in 71°C/60%RH were investigated,and showed that CuO nanoparticles negatively catalyze Al nanopowders,resulting in rapid hydration.The anti-aging effect of FAS-17-coated Al nanopowder was also examined.The aging process of Al,Al/CuO,and Al@FAS-17/CuO in high humidity and heat environment were revealed by quasi-in situ SEM and TEM methods.Compared with the aging of pure Al,the Al nanopowder in the nanothermites strongly agglomerated with the CuO nanopowder and hydrated earlier.This may be caused by CuO catalyzed hydration of Al nanopowder.The energy release experiments showed that the performance of Al/CuO decreased rapidly and failed to ignite after 4 h of aging.In contrast,the Al@FAS-17/CuO thermite can achieve long-term stability of up to 60 h in the same environment by simple cladding of FAS-17.It is found that FAS-17 coated Al nanopowder can prevent both particle agglomeration and water erosion,which is an effective means to make nanothermites application in high humidity and heat environment.展开更多
Phosphorus(P)is essential for living plants,and P deficiency is one of the key factors limiting the yield in rapeseed production worldwide.As the most important organ for plants,root morphology traits(RMTs)play a key ...Phosphorus(P)is essential for living plants,and P deficiency is one of the key factors limiting the yield in rapeseed production worldwide.As the most important organ for plants,root morphology traits(RMTs)play a key role in P absorption.To investigate the genetic variability of RMT under low P availability,we dissected the genetic structure of RMTs by genome-wide association studies(GWAS),linkage mapping and candidate gene association studies(CGAS).A total of 52 suggestive loci were associated with RMTs under P stress conditions in 405 oilseed rape accessions.The purple acid phosphatase gene BnPAP17 was found to control the lateral root number(LRN)and root dry weight(RDW)under low P stress.The expression of BnPAP17 was increased in shoot tissue in P-efficient cultivars compared to root tissue and P-inefficient cultivars in response to low P stress.Moreover,the haplotype of BnPAP17^(Hap3)was detected for the selective breeding of P efficiency in oilseed rape.Over-expression of the BnPAP17^(Hap3)could promote the shoot and root growth with enhanced tolerance to low P stress and organic phosphorus(Po)utilization in oilseed rape.Collectively,these findings increase our understanding of the mechanisms underlying BnPAP17-mediated low P stress tolerance in oilseed rape.展开更多
The photocatalytic conversion of CO_(2)into solar‐powered fuels is viewed as a forward‐looking strategy to address energy scarcity and global warming.This work demonstrated the selective photoreduction of CO_(2)to C...The photocatalytic conversion of CO_(2)into solar‐powered fuels is viewed as a forward‐looking strategy to address energy scarcity and global warming.This work demonstrated the selective photoreduction of CO_(2)to CO using ultrathin Bi_(12)O_(17)Cl_(2)nanosheets decorated with hydrothermally synthesized bismuth clusters and oxygen vacancies(OVs).The characterizations revealed that the coexistences of OVs and Bi clusters generated in situ contributed to the high efficiency of CO_(2)–CO conversion(64.3μmol g^(−1)h^(−1))and perfect selectivity.The OVs on the facet(001)of the ultrathin Bi_(12)O_(17)Cl_(2)nanosheets serve as sites for CO_(2)adsorption and activation sites,capturing photoexcited electrons and prolonging light absorption due to defect states.In addition,the Bi‐cluster generated in situ offers the ability to trap holes and the surface plasmonic resonance effect.This study offers great potential for the construction of semiconductor hybrids as multiphotocatalysts,capable of being used for the elimination and conversion of CO_(2)in terms of energy and environment.展开更多
文摘目的探讨慢性阻塞性肺疾病急性加重期(acute exacerhation of chronic obstructive pulmonary disease,AECOPD)患者治疗前后Th17/Treg免疫平衡、呼出气一氧化氮(fraction of exhaled nitric oxide,FeNO)水平变化及对预后的影响。方法选取AECOPD患者126例,采用肺功能检测仪测定第1秒用力呼气量(forced expiratory volume in one second,FEV1)、第1秒用力呼气量占预计值百分比(FEV1%)、用力肺活量(forced vital capacity,FVC)、用力肺活量占预计值百分比(FVC%)、第1秒用力呼气量占用力肺活量的百分比(FEV1/FVC)。并使用一氧化氮测定仪检测FeNO水平,采用全身炎性反应综合征(systemic inflammaton response syndrome,SIRS)评分进行评分,采用流式细胞仪检测血清辅助性T细胞17(T help 17cells,Th17)、调节性T细胞(T Regulatory cells,Treg)水平,比较治疗前后患者肺功能指标、FeNO水平、SIRS评分、Th17/Treg水平等指标变化情况。结果治疗3个月后,AECOPD患者FEV1%、FEV1/FVC、Th17、Th17/Treg水平显著高于治疗前,FeNO、血清Treg水平、SIRS评分显著低于治疗前(P<0.05)。126例AECOPD患者治疗3个月后存活94例(74.60%);死亡32例(25.40%)。存活组FEV1%、FEV1/FVC、Treg水平显著高于死亡组,FeNO、Th17、Th17/Treg及SIRS评分显著低于死亡组(P<0.05)。多因素Logistic回归分析结果显示,治疗前FEV1%、FEV1/FVC、Treg是AECOPD患者预后的危险因素(P<0.05);FeNO、Th17、Th17/Treg、SIRS评分是AECOPD患者预后的保护因素(P<0.05)。结论AECOPD患者治疗后肺功能提高,Th17/Treg、FeNO降低,肺功能、Th17/Treg免疫平衡、FeNO水平对AECOPD患者疗效评估及预后判断具有重要意义。
基金supported by the National Natural Science Foundation of China(Grant No.22275092)。
文摘The safety and reliability of weapon systems would be significantly affected by changes in the performance of energetic materials due to ambient temperature and humidity.Nanothermites have promising applications due to their excellent reactivity.Therefore it becomes extremely important to understand their aging and failure process in the environment before using them.Here,the aging and failure process of Al/CuO in 71°C/60%RH were investigated,and showed that CuO nanoparticles negatively catalyze Al nanopowders,resulting in rapid hydration.The anti-aging effect of FAS-17-coated Al nanopowder was also examined.The aging process of Al,Al/CuO,and Al@FAS-17/CuO in high humidity and heat environment were revealed by quasi-in situ SEM and TEM methods.Compared with the aging of pure Al,the Al nanopowder in the nanothermites strongly agglomerated with the CuO nanopowder and hydrated earlier.This may be caused by CuO catalyzed hydration of Al nanopowder.The energy release experiments showed that the performance of Al/CuO decreased rapidly and failed to ignite after 4 h of aging.In contrast,the Al@FAS-17/CuO thermite can achieve long-term stability of up to 60 h in the same environment by simple cladding of FAS-17.It is found that FAS-17 coated Al nanopowder can prevent both particle agglomeration and water erosion,which is an effective means to make nanothermites application in high humidity and heat environment.
基金financially supported by the National Natural Science Foundation of China(32201868 and 32001575)。
文摘Phosphorus(P)is essential for living plants,and P deficiency is one of the key factors limiting the yield in rapeseed production worldwide.As the most important organ for plants,root morphology traits(RMTs)play a key role in P absorption.To investigate the genetic variability of RMT under low P availability,we dissected the genetic structure of RMTs by genome-wide association studies(GWAS),linkage mapping and candidate gene association studies(CGAS).A total of 52 suggestive loci were associated with RMTs under P stress conditions in 405 oilseed rape accessions.The purple acid phosphatase gene BnPAP17 was found to control the lateral root number(LRN)and root dry weight(RDW)under low P stress.The expression of BnPAP17 was increased in shoot tissue in P-efficient cultivars compared to root tissue and P-inefficient cultivars in response to low P stress.Moreover,the haplotype of BnPAP17^(Hap3)was detected for the selective breeding of P efficiency in oilseed rape.Over-expression of the BnPAP17^(Hap3)could promote the shoot and root growth with enhanced tolerance to low P stress and organic phosphorus(Po)utilization in oilseed rape.Collectively,these findings increase our understanding of the mechanisms underlying BnPAP17-mediated low P stress tolerance in oilseed rape.
基金Natural Science Foundation of Shandong Province,Grant/Award Number:ZR2022MB106national training program of innovation and entrepreneurship for undergraduates,Grant/Award Number:202210424099National Natural Science Foundation of China,Grant/Award Numbers:21601067,21701057,21905147。
文摘The photocatalytic conversion of CO_(2)into solar‐powered fuels is viewed as a forward‐looking strategy to address energy scarcity and global warming.This work demonstrated the selective photoreduction of CO_(2)to CO using ultrathin Bi_(12)O_(17)Cl_(2)nanosheets decorated with hydrothermally synthesized bismuth clusters and oxygen vacancies(OVs).The characterizations revealed that the coexistences of OVs and Bi clusters generated in situ contributed to the high efficiency of CO_(2)–CO conversion(64.3μmol g^(−1)h^(−1))and perfect selectivity.The OVs on the facet(001)of the ultrathin Bi_(12)O_(17)Cl_(2)nanosheets serve as sites for CO_(2)adsorption and activation sites,capturing photoexcited electrons and prolonging light absorption due to defect states.In addition,the Bi‐cluster generated in situ offers the ability to trap holes and the surface plasmonic resonance effect.This study offers great potential for the construction of semiconductor hybrids as multiphotocatalysts,capable of being used for the elimination and conversion of CO_(2)in terms of energy and environment.
