The occurrence state of methane is mostly controlled by coalfield geologicalstructures.The coal-bearing strata at Qidong coalmine experienced many tectonic cyclessince their formation.The gas content made by the compl...The occurrence state of methane is mostly controlled by coalfield geologicalstructures.The coal-bearing strata at Qidong coalmine experienced many tectonic cyclessince their formation.The gas content made by the complicated structural geologic systemat the coalfield is very different, which is obviously higher on the north side of the Weimiaofracture belt than that on the south side and near itself.This thesis discussed the gas occurrenceregularity based on the geometric characteristics of the geological structure andits regional tectonic evolution.This study can provide a foundation for coalfield exploitationand deal with coal and gas outburst.展开更多
Background:There have been few reports on long-term survival of gastric cancer patients.This study analyzed the survival data of gastric cancer patients obtained from the population-based Qidong Cancer Registry betwee...Background:There have been few reports on long-term survival of gastric cancer patients.This study analyzed the survival data of gastric cancer patients obtained from the population-based Qidong Cancer Registry between 1972 and 2011,providing a basis for evaluation of gastric cancer treatment and prognosis.Methods:The cumulative observed survival rate and relative survival rate of gastric cancer patients were calculated using Hakulinen's method via the SURV3.01 software,which was developed by the Finnish Cancer Registry.The date of the last follow-up for the survival status of the 15,401 registered cases was April 30,2012.Results:The 1-,5-,10-,20-,and 30-year observed survival rates were 33.82%,14.18%,10.35%,6.63%,and 4.19%,respectively,and the 1-,5-,10-,20-,and 30-year relative survival rates were 35.43%,18.13%,17.50%,21.96%,and32.84%,respectively.For males,the corresponding observed survival rates were 34.50%,14.40%,10.42%,6.46%,and4.05%,and the corresponding relative survival rates were 36.23%,18.67%,18.28%,23.73%,and 38.61%.For females,the corresponding observed survival rates were 32.62%,13.80%,10.22%,6.95%,and 4.46%,and the corresponding relative survival rates were 34.03%,17.21%,16.28%,19.70%,and 26.78%.Significant differences in relative survival rates were observed between sexes(P=0.003).For the 15-34,35-44,45-54,55-64,65-74,and 75+ age groups,the 5-year relative survival rates were 16.13%,21.77%,18.63%,12.61%,7.99%,and 2.94%,respectively,and the 10-year relative survival rates were 16.49%,22.83%,20.50%,15.97%,15.88%,and 15.73%,respectively.Remarkable improvement could be observed for the 5-,10-,and 15-year relative survival rates in Qidong beginning in the 1980 s.Conclusion:The survival outcome of registered gastric cancer cases in Qidong showed gradual progress over the past two decades.展开更多
O6-methylguanine DNA methyltransferase (O6-AT) is an enzyme for the repair of the promutagenic structure, O6-aIkylguanine, from alkylated DNA, therefore low activity of O6-AT is involved in the predisposition of tissu...O6-methylguanine DNA methyltransferase (O6-AT) is an enzyme for the repair of the promutagenic structure, O6-aIkylguanine, from alkylated DNA, therefore low activity of O6-AT is involved in the predisposition of tissues to some nitrosamines and the development of cancer. The levels of O6-AT in livers of ducks from Qidong (Qd), a high incidence area of liver cancer, and from Qingpu(Qp), a relatively low incidence area were determined in this study. The results showed that the activity of O6-AT was higher in Qp than in Qd. It suggested that some nitrosamine in Qd might be one of factors responsible for the higher incidence of ducks liver cancer, because these ducks were more sensitive to nitrosa-mine.展开更多
The sedimentation rate is an important environmental parameter to understand the evolution of coastal geomorphology. The tidal flat around Qidong foreland is located in the junction between Yangtze Estuary and Jiangsu...The sedimentation rate is an important environmental parameter to understand the evolution of coastal geomorphology. The tidal flat around Qidong foreland is located in the junction between Yangtze Estuary and Jiangsu coast,where the land-ocean interactions are strong and highly sensitive to environmental changes. The QDZ-1 core sediments collected at Qidong foreland was analyzed for137 Cs dating and grain size.The results showed that silt is the main sedimentary type with a trend of gradually fining from the bottom to the top,conforming to the sedimentation characteristic of the silt muddy tidal flat. The sedimentation rate could be divided into three distinct stages: 1963 to 1986 was 2. 61 cm/yr,1963 to 2011 was 1. 82 cm/yr,and 1986 to 2011 was 1. 10 cm/yr. Based on these,further explanation was made for the significance of environmental changes. According to the estimation of sedimentation rate,the impact of extreme environmental change was reflected by the sudden increase in sand proportion at the depth of 172. 5 cm. Since the introduction of Spartina alterniflora in the 1970 s,it has played an important role in tidal flat development. The tidal flat has a high sedimentary rate during this time. With continuous accretion of the tidal flat,low tidal flat turns to high tidal flat,the sedimentation rate gradually declines,and tidal flat sedimentation appears.展开更多
以祁东煤矿为例,通过研究矿井地下水运移规律及其所在区域的构造控水特征,以期为煤矿水害的超前精准治理和区域防治提供借鉴参考。利用构造控水理论结合祁东煤矿及其所在矿区、煤田的地质构造背景,对构造控水的逐级控制作用和构造控水...以祁东煤矿为例,通过研究矿井地下水运移规律及其所在区域的构造控水特征,以期为煤矿水害的超前精准治理和区域防治提供借鉴参考。利用构造控水理论结合祁东煤矿及其所在矿区、煤田的地质构造背景,对构造控水的逐级控制作用和构造控水作用方式进行研究,结果如下:祁东煤矿基岩地层形态整体受宿南向斜控制,局部受魏庙断层等构造控制,新生界地层形态亦受到构造的间接控制;在宿南向斜控制下,矿井内或矿井外南部风化后的二叠系煤系砂岩裂隙含水层、太灰、奥灰与四含角度不整合接触;在魏庙断层控制下,在矿井南部采区部分二叠系煤系砂岩裂隙含水层含水层再次露头,与四含角度不整合接触,不整合接触使得含水层间可产生水力联系。总结分析结果,认为:(1)地质构造通过对地层形态的控制,对地下含水层水起到控制作用;(2)地质构造通过控制含水层间的接触,对含水层间的水力联系起到控制作用。为进一步验证含水层间的水力联系,利用水位变化的对比分析和皮尔逊(Person)相关系数,对放水试验期间南部采区四含、太灰和正常水位观测期间四含、太灰、奥灰的钻孔水位观测结果进行分析,得出:(1)南部采区放水试验期间,四含(SQ10-14)与太灰(ST4)水位变化基本同步,相关性极强;(2)正常水位观测期间,四含(SQ10)、太灰(ST4)、奥灰(SO_(2))两两之间水位变化具有极强的相关性,同一含水层内不同观测孔间水位变化的相关性差异较大。证实:受构造控制,在矿井局部,四含与基岩含水层角度不整合接触区域,存在水力联系。利用地下水数值模拟软件Groundwater Model System(GMS)结合参数反演Parameter Estimation(PEST),对四含水位分布和径流规律进行研究,得出:四含水位在-7~-57 m,南部水位比北部水位高,在魏庙断层处,水力梯度较大;四含水径流集中在矿井西南部和中部,西南部整体向北径流,中部以东西向径流为主,四含径流有绕过魏庙断层。展开更多
Cellular Automata(CA) is widely used for the simulation of land use changes. This study applied a vector-based CA model to simulate land use change in order to minimize or eliminate the scale sensitivity in traditiona...Cellular Automata(CA) is widely used for the simulation of land use changes. This study applied a vector-based CA model to simulate land use change in order to minimize or eliminate the scale sensitivity in traditional raster-based CA model. The cells of vector-based CA model are presented according to the shapes and attributes of geographic entities, and the transition rules of vector-based CA model are improved by taking spatial variables of the study area into consideration. The vector-based CA model is applied to simulate land use changes in downtown of Qidong City, Jiangsu Province, China and its validation is confirmed by the methods of visual assessment and spatial accuracy. The simulation result of vector-based CA model reveals that nearly 75% of newly increased urban cells are located in the northwest and southwest parts of the study area from 2002 to 2007, which is in consistent with real land use map. In addition, the simulation results of the vector-based and raster-based CA models are compared to real land use data and their spatial accuracies are found to be 84.0% and 81.9%, respectively. In conclusion, results from this study indicate that the vector-based CA model is a practical and applicable method for the simulation of urbanization processes.展开更多
OBJECTIVE:To evaluate the efficacy of Qidong Huoxue decoction(芪冬活血饮,QDHX)in treating acute lung injury and acute respiratory distress syndrome(ALI/ARDS)when used as an adjunctive treatment.METHODS:ALI/ARDS patien...OBJECTIVE:To evaluate the efficacy of Qidong Huoxue decoction(芪冬活血饮,QDHX)in treating acute lung injury and acute respiratory distress syndrome(ALI/ARDS)when used as an adjunctive treatment.METHODS:ALI/ARDS patients admitted to our medical intensive care unit were randomly allocated to the control group or the QDHX group and received standard therapy.The QDHX group received QDHX(50 mL per day for 14 d)orally or via a gastric tube.The primary outcome was measured according to Traditional Chinese Medicine(TCM)syndrome scores,with partial pressure of oxygen/fraction of inspired oxygen(PaO_(2)/FiO_(2))levels as the secondary outcome.RESULTS:A total of 73 patients completed the study(36 in the TCM and 37 in the conventional group),and their records were analyzed.After 14-d treatment,the TCM group showed a significant decrease in TCM syndrome scores(P<0.05)and increased PaO_(2)/FiO_(2) levels(P<0.05).The therapeutic effect of integrated Chinese and western medicine was more significant than that of Western Medicine alone.No serious side effects were observed.CONCLUSIONS:Our study results show that QDHX in combination with conventional drug therapy can significantly reduce some clinical symptoms in patients with ALI/ARDS.展开更多
基金Supported by the National Natural Science Foundation of China(40872103)
文摘The occurrence state of methane is mostly controlled by coalfield geologicalstructures.The coal-bearing strata at Qidong coalmine experienced many tectonic cyclessince their formation.The gas content made by the complicated structural geologic systemat the coalfield is very different, which is obviously higher on the north side of the Weimiaofracture belt than that on the south side and near itself.This thesis discussed the gas occurrenceregularity based on the geometric characteristics of the geological structure andits regional tectonic evolution.This study can provide a foundation for coalfield exploitationand deal with coal and gas outburst.
基金supported partially by the National Central Cancer Registries of China(the Tumor Follow-up Registration Programs MF2008293,2009-193,and 2010-90)by the National Science and Technology Mega-Projects of China(2012ZX100020009-018 and 2012ZX10002-008)
文摘Background:There have been few reports on long-term survival of gastric cancer patients.This study analyzed the survival data of gastric cancer patients obtained from the population-based Qidong Cancer Registry between 1972 and 2011,providing a basis for evaluation of gastric cancer treatment and prognosis.Methods:The cumulative observed survival rate and relative survival rate of gastric cancer patients were calculated using Hakulinen's method via the SURV3.01 software,which was developed by the Finnish Cancer Registry.The date of the last follow-up for the survival status of the 15,401 registered cases was April 30,2012.Results:The 1-,5-,10-,20-,and 30-year observed survival rates were 33.82%,14.18%,10.35%,6.63%,and 4.19%,respectively,and the 1-,5-,10-,20-,and 30-year relative survival rates were 35.43%,18.13%,17.50%,21.96%,and32.84%,respectively.For males,the corresponding observed survival rates were 34.50%,14.40%,10.42%,6.46%,and4.05%,and the corresponding relative survival rates were 36.23%,18.67%,18.28%,23.73%,and 38.61%.For females,the corresponding observed survival rates were 32.62%,13.80%,10.22%,6.95%,and 4.46%,and the corresponding relative survival rates were 34.03%,17.21%,16.28%,19.70%,and 26.78%.Significant differences in relative survival rates were observed between sexes(P=0.003).For the 15-34,35-44,45-54,55-64,65-74,and 75+ age groups,the 5-year relative survival rates were 16.13%,21.77%,18.63%,12.61%,7.99%,and 2.94%,respectively,and the 10-year relative survival rates were 16.49%,22.83%,20.50%,15.97%,15.88%,and 15.73%,respectively.Remarkable improvement could be observed for the 5-,10-,and 15-year relative survival rates in Qidong beginning in the 1980 s.Conclusion:The survival outcome of registered gastric cancer cases in Qidong showed gradual progress over the past two decades.
文摘O6-methylguanine DNA methyltransferase (O6-AT) is an enzyme for the repair of the promutagenic structure, O6-aIkylguanine, from alkylated DNA, therefore low activity of O6-AT is involved in the predisposition of tissues to some nitrosamines and the development of cancer. The levels of O6-AT in livers of ducks from Qidong (Qd), a high incidence area of liver cancer, and from Qingpu(Qp), a relatively low incidence area were determined in this study. The results showed that the activity of O6-AT was higher in Qp than in Qd. It suggested that some nitrosamine in Qd might be one of factors responsible for the higher incidence of ducks liver cancer, because these ducks were more sensitive to nitrosa-mine.
基金Supported by National Natural Science Foundation of China(Grant No.:41501003,41701101,41807403)Open Foundation of Research Institute of Jiangsu Coastal Development(Grant No.:RIJCD11008)
文摘The sedimentation rate is an important environmental parameter to understand the evolution of coastal geomorphology. The tidal flat around Qidong foreland is located in the junction between Yangtze Estuary and Jiangsu coast,where the land-ocean interactions are strong and highly sensitive to environmental changes. The QDZ-1 core sediments collected at Qidong foreland was analyzed for137 Cs dating and grain size.The results showed that silt is the main sedimentary type with a trend of gradually fining from the bottom to the top,conforming to the sedimentation characteristic of the silt muddy tidal flat. The sedimentation rate could be divided into three distinct stages: 1963 to 1986 was 2. 61 cm/yr,1963 to 2011 was 1. 82 cm/yr,and 1986 to 2011 was 1. 10 cm/yr. Based on these,further explanation was made for the significance of environmental changes. According to the estimation of sedimentation rate,the impact of extreme environmental change was reflected by the sudden increase in sand proportion at the depth of 172. 5 cm. Since the introduction of Spartina alterniflora in the 1970 s,it has played an important role in tidal flat development. The tidal flat has a high sedimentary rate during this time. With continuous accretion of the tidal flat,low tidal flat turns to high tidal flat,the sedimentation rate gradually declines,and tidal flat sedimentation appears.
文摘以祁东煤矿为例,通过研究矿井地下水运移规律及其所在区域的构造控水特征,以期为煤矿水害的超前精准治理和区域防治提供借鉴参考。利用构造控水理论结合祁东煤矿及其所在矿区、煤田的地质构造背景,对构造控水的逐级控制作用和构造控水作用方式进行研究,结果如下:祁东煤矿基岩地层形态整体受宿南向斜控制,局部受魏庙断层等构造控制,新生界地层形态亦受到构造的间接控制;在宿南向斜控制下,矿井内或矿井外南部风化后的二叠系煤系砂岩裂隙含水层、太灰、奥灰与四含角度不整合接触;在魏庙断层控制下,在矿井南部采区部分二叠系煤系砂岩裂隙含水层含水层再次露头,与四含角度不整合接触,不整合接触使得含水层间可产生水力联系。总结分析结果,认为:(1)地质构造通过对地层形态的控制,对地下含水层水起到控制作用;(2)地质构造通过控制含水层间的接触,对含水层间的水力联系起到控制作用。为进一步验证含水层间的水力联系,利用水位变化的对比分析和皮尔逊(Person)相关系数,对放水试验期间南部采区四含、太灰和正常水位观测期间四含、太灰、奥灰的钻孔水位观测结果进行分析,得出:(1)南部采区放水试验期间,四含(SQ10-14)与太灰(ST4)水位变化基本同步,相关性极强;(2)正常水位观测期间,四含(SQ10)、太灰(ST4)、奥灰(SO_(2))两两之间水位变化具有极强的相关性,同一含水层内不同观测孔间水位变化的相关性差异较大。证实:受构造控制,在矿井局部,四含与基岩含水层角度不整合接触区域,存在水力联系。利用地下水数值模拟软件Groundwater Model System(GMS)结合参数反演Parameter Estimation(PEST),对四含水位分布和径流规律进行研究,得出:四含水位在-7~-57 m,南部水位比北部水位高,在魏庙断层处,水力梯度较大;四含水径流集中在矿井西南部和中部,西南部整体向北径流,中部以东西向径流为主,四含径流有绕过魏庙断层。
基金Under the auspices of National Natural Science Foundation of China(No.41101349)Surveying and Mapping Scientific Research Projects of Jiangsu Province(No.JSCHKY201304)+1 种基金Program of Natural Science Research of Jiangsu Higher Education Institutions of China(No.13KJB420003)Priority Academic Program Development of Jiangsu Higher Education Institutions
文摘Cellular Automata(CA) is widely used for the simulation of land use changes. This study applied a vector-based CA model to simulate land use change in order to minimize or eliminate the scale sensitivity in traditional raster-based CA model. The cells of vector-based CA model are presented according to the shapes and attributes of geographic entities, and the transition rules of vector-based CA model are improved by taking spatial variables of the study area into consideration. The vector-based CA model is applied to simulate land use changes in downtown of Qidong City, Jiangsu Province, China and its validation is confirmed by the methods of visual assessment and spatial accuracy. The simulation result of vector-based CA model reveals that nearly 75% of newly increased urban cells are located in the northwest and southwest parts of the study area from 2002 to 2007, which is in consistent with real land use map. In addition, the simulation results of the vector-based and raster-based CA models are compared to real land use data and their spatial accuracies are found to be 84.0% and 81.9%, respectively. In conclusion, results from this study indicate that the vector-based CA model is a practical and applicable method for the simulation of urbanization processes.
基金Zhejiang Province Traditional Chinese Medicine Science and Technology Plan:the Study on Clinical Effects of Qidong Huoxue decoction in the Treatment of Acute Lung Injury(No.2017ZZ008)。
文摘OBJECTIVE:To evaluate the efficacy of Qidong Huoxue decoction(芪冬活血饮,QDHX)in treating acute lung injury and acute respiratory distress syndrome(ALI/ARDS)when used as an adjunctive treatment.METHODS:ALI/ARDS patients admitted to our medical intensive care unit were randomly allocated to the control group or the QDHX group and received standard therapy.The QDHX group received QDHX(50 mL per day for 14 d)orally or via a gastric tube.The primary outcome was measured according to Traditional Chinese Medicine(TCM)syndrome scores,with partial pressure of oxygen/fraction of inspired oxygen(PaO_(2)/FiO_(2))levels as the secondary outcome.RESULTS:A total of 73 patients completed the study(36 in the TCM and 37 in the conventional group),and their records were analyzed.After 14-d treatment,the TCM group showed a significant decrease in TCM syndrome scores(P<0.05)and increased PaO_(2)/FiO_(2) levels(P<0.05).The therapeutic effect of integrated Chinese and western medicine was more significant than that of Western Medicine alone.No serious side effects were observed.CONCLUSIONS:Our study results show that QDHX in combination with conventional drug therapy can significantly reduce some clinical symptoms in patients with ALI/ARDS.
