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Sandwich structures with tapered tubes as core:A quasi-static investigation
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作者 Xinmei Xiang Dehua Shao +5 位作者 Xin Zhang Umer Sharif Ngoc San Ha Li Xiang Jing Zhang Jiang Yi 《Defence Technology(防务技术)》 SCIE EI CAS CSCD 2024年第3期447-462,共16页
In this article,the experimental and finite element analysis is utilized to investigate the quasi-static compression features of sandwich constructions built with tapered tubes.3D printing technology was utilized to c... In this article,the experimental and finite element analysis is utilized to investigate the quasi-static compression features of sandwich constructions built with tapered tubes.3D printing technology was utilized to create the hollow centers of the tapering tubes,with and without corrugations.The results demonstrate that the energy absorption(EA)and specific energy absorption(SEA)of the single corrugated tapered tube sandwich are 51.6% and 19.8% higher,respectively,than those of the conical tube sandwich.Furthermore,the results demonstrate that energy absorbers can benefit from corrugation in order to increase their efficiency.Additionally,the tapered corrugated tubes'resistance to oblique impacts was studied.Compared to a straight tube,the tapered tube is more resistant to oblique loads and has a lower initial peak crushing force(PCF),according to numerical simulations.After conducting a parametric study,it was discovered that the energy absorption performance of the sandwich construction is significantly affected by the amplitude,number of corrugations,and wall thickness.EA and SEA of DTS with corrugation number of 8 increased by 17.4%and 29.6%,respectively,while PCF decreased by 9.2% compared to DTS with corrugation number of 10. 展开更多
关键词 Sandwich structure Corrugated tube Tapered tube quasi-static Energy absorption
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Quasi-static and dynamic compressive behaviour of additively manufactured Menger fractal cube structures
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作者 Damith Mohotti Dakshitha Weerasinghe +3 位作者 Madhusha Bogahawaththa Hongxu Wang Kasun Wijesooriya Paul JHazell 《Defence Technology(防务技术)》 SCIE EI CAS CSCD 2024年第7期39-49,共11页
This paper presents the first-ever investigation of Menger fractal cubes'quasi-static compression and impact behaviour.Menger cubes with different void ratios were 3D printed using polylactic acid(PLA)with dimensi... This paper presents the first-ever investigation of Menger fractal cubes'quasi-static compression and impact behaviour.Menger cubes with different void ratios were 3D printed using polylactic acid(PLA)with dimensions of 40 mm×40 mm×40 mm.Three different orders of Menger cubes with different void ratios were considered,namely M1 with a void ratio of 0.26,M2 with a void ratio of 0.45,and M3with a void ratio of 0.60.Quasi-static Compression tests were conducted using a universal testing machine,while the drop hammer was used to observe the behaviour under impact loading.The fracture mechanism,energy efficiency and force-time histories were studied.With the structured nature of the void formation and predictability of the failure modes,the Menger geometry showed some promise compared to other alternatives,such as foams and honeycombs.With the increasing void ratio,the Menger geometries show force-displacement behaviour similar to hyper-elastic materials such as rubber and polymers.The third-order Menger cubes showed the highest energy absorption efficiency compared to the other two geometries in this study.The findings of the present work reveal the possibility of using additively manufactured Menger geometries as an energy-efficient system capable of reducing the transmitting force in applications such as crash barriers. 展开更多
关键词 Additive manufacturing Fractal geometries Menger cube Energy absorption quasi-static
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Experimental crushing behavior and energy absorption of angular gradient honeycomb structures under quasi-static and dynamic compression
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作者 Jiachen Li Yuchen Wei +2 位作者 Hao Wu Xingyu Shen Mengqi Yuan 《Defence Technology(防务技术)》 SCIE EI CAS CSCD 2024年第6期47-63,共17页
The high variability of shock in terrorist attacks poses a threat to people's lives and properties,necessitating the development of more effective protective structures.This study focuses on the angle gradient and... The high variability of shock in terrorist attacks poses a threat to people's lives and properties,necessitating the development of more effective protective structures.This study focuses on the angle gradient and proposes four different configurations of concave hexagonal honeycomb structures.The structures'macroscopic deformation behavior,stress-strain relationship,and energy dissipation characteristics are evaluated through quasi-static compression and Hopkinson pressure bar impact experiments.The study reveals that,under varying strain rates,the structures deform starting from the weak layer and exhibit significant interlayer separation.Additionally,interlayer shear slip becomes more pronounced with increasing strain rate.In terms of quasi-static compression,symmetric gradient structures demonstrate superior energy absorption,particularly the symmetric negative gradient structure(SNG-SMS)with a specific energy absorption of 13.77 J/cm~3.For dynamic impact,unidirectional gradient structures exhibit exceptional energy absorption,particularly the unidirectional positive gradient honeycomb structure(UPG-SML)with outstanding mechanical properties.The angle gradient design plays a crucial role in determining the structure's stability and deformation mode during impact.Fewer interlayer separations result in a more pronounced negative Poisson's ratio effect and enhance the structure's energy absorption capacity.These findings provide a foundation for the rational design and selection of seismic protection structures in different strain rate impact environments. 展开更多
关键词 Negative Poisson's ratio Gradient honeycomb structure quasi-static compression Dynamic impact Titanium alloy
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Seismic performance of precast bridge columns connected with grouted corrugated-metal duct through biaxial quasi-static experiment and modeling 被引量:5
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作者 Xia Zhanghua Lin Shangshun +2 位作者 He Yongbo Ge Jiping Sun Jinlei 《Earthquake Engineering and Engineering Vibration》 SCIE EI CSCD 2021年第3期747-770,共24页
In this paper,the seismic behaviors of precast bridge columns connected with grouted corrugated-metal duct(GCMD)were investigated through the biaxial quasi-static experiment and numerical simulation.With a geometric s... In this paper,the seismic behaviors of precast bridge columns connected with grouted corrugated-metal duct(GCMD)were investigated through the biaxial quasi-static experiment and numerical simulation.With a geometric scale ratio of 1:5,five specimens were fabricated,including four precast bridge columns connected with GCMD and one cast-in-place(CIP)bridge column.A finite element analysis model was also established by using OpenSees and was then calibrated by using the experimental results for parameter analysis.The results show the biaxial seismic performance of the precast bridge columns connected with GCMD was similar to the CIP bridge columns regarding ultimate bearing capacity and hysteresis energy,and further,that it could meet the design goal of equivalent performance.The seismic performance of the precast bridge columns connected with GCMD deteriorated more significantly under bi-directional load than under uni-directional load.A proper slenderness ratio(e.g.,7.0-10.0)and longitudinal reinforcement ratio could significantly improve the energy dissipation capacity and deformation capacity of the precast bridge columns,while the axial load ratio and concrete strength had little influence on the above properties.The research results could bring insights to the development of the seismic design of precast bridge columns connected with GCMD. 展开更多
关键词 precast bridge column cast-in-place column grouted corrugated-metal duct connection biaxial quasi-static test seismic performance hysteresis energy
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Design,Development and Testing of the JTech Bolt for Use in Static,Quasi-Static and Dynamic Domains
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作者 Trent Roberts 《Journal of Civil Engineering and Architecture》 2024年第6期282-295,共14页
Designing a rock reinforcement element requires knowledge of:geomechanical behaviour,interaction of the reinforcement element with rock mass and the element’s mechanistic response in static and dynamic environments.U... Designing a rock reinforcement element requires knowledge of:geomechanical behaviour,interaction of the reinforcement element with rock mass and the element’s mechanistic response in static and dynamic environments.Using this knowledge the JTech bolt was developed and subjected to a thorough program to test,gather data and validate the bolt performance in varying domains.By conducting FE(finite element)modeling,the simulation reviews the JTech bolt design evaluating the effects of threadbar geometric variation,threadbar and nut engagement results under high stress,coating friction response and effects of thread tolerance extremes on the failure mode.These results determine safety factors,tolerances and quality management criteria.Once manufactured,in-situ system testing,laboratory and underground short encapsulation testing,resin mixing testing,double shear testing and dynamic testing at varying velocity and mass,determine the system’s capacity and effectiveness in static,quasi-static and dynamic mining environments.In this paper,the process and results are described. 展开更多
关键词 Rock reinforcement geomechanical behavior STATIC quasi-static dynamic domains
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IDENTIFICATION OF QUASI-STATIC DISPLACEMENT FOR CONSTITUTIVE MODELS OF VISCOELASTICITY
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作者 杨海天 邬瑞锋 张群 《Applied Mathematics and Mechanics(English Edition)》 SCIE EI 1998年第3期237-242,共6页
An explicit relation between constitutive parameters and quasi-static displacement of viscoelasticity is derived under a kind of boundary condition, and an iterative form of optimized identification is presented. Visc... An explicit relation between constitutive parameters and quasi-static displacement of viscoelasticity is derived under a kind of boundary condition, and an iterative form of optimized identification is presented. Viscoelastic constitutive models are identified from a two order differential model, and effects of information errors on results of inverse analysis are discussed. 展开更多
关键词 VISCOELASTICITY constitutive model static displacement inverse analysis
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Aquaporin-4-IgG-seropositive neuromyelitis optica spectrum disorders:progress of experimental models based on disease pathogenesis
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作者 Li Xu Huiming Xu Changyong Tang 《Neural Regeneration Research》 SCIE CAS 2025年第2期354-365,共12页
Neuromyelitis optica spectrum disorders are neuroinflammatory demyelinating disorders that lead to permanent visual loss and motor dysfunction.To date,no effective treatment exists as the exact causative mechanism rem... Neuromyelitis optica spectrum disorders are neuroinflammatory demyelinating disorders that lead to permanent visual loss and motor dysfunction.To date,no effective treatment exists as the exact causative mechanism remains unknown.Therefore,experimental models of neuromyelitis optica spectrum disorders are essential for exploring its pathogenesis and in screening for therapeutic targets.Since most patients with neuromyelitis optica spectrum disorders are seropositive for IgG autoantibodies against aquaporin-4,which is highly expressed on the membrane of astrocyte endfeet,most current experimental models are based on aquaporin-4-IgG that initially targets astrocytes.These experimental models have successfully simulated many pathological features of neuromyelitis optica spectrum disorders,such as aquaporin-4 loss,astrocytopathy,granulocyte and macrophage infiltration,complement activation,demyelination,and neuronal loss;however,they do not fully capture the pathological process of human neuromyelitis optica spectrum disorders.In this review,we summarize the currently known pathogenic mechanisms and the development of associated experimental models in vitro,ex vivo,and in vivo for neuromyelitis optica spectrum disorders,suggest potential pathogenic mechanisms for further investigation,and provide guidance on experimental model choices.In addition,this review summarizes the latest information on pathologies and therapies for neuromyelitis optica spectrum disorders based on experimental models of aquaporin-4-IgG-seropositive neuromyelitis optica spectrum disorders,offering further therapeutic targets and a theoretical basis for clinical trials. 展开更多
关键词 AQUAPORIN-4 experimental model neuromyelitis optica spectrum disorder PATHOGENESIS
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Landslide Susceptibility Mapping Using RBFN-Based Ensemble Machine Learning Models
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作者 Landslide Susceptibility Mapping Using RBFN-Based Ensemble Machine Learning Models Duc-Dam Nguyen Nguyen Viet Tiep +5 位作者 Quynh-Anh Thi Bui Hiep Van Le Indra Prakash Romulus Costache Manish Pandey Binh Thai Pham 《Computer Modeling in Engineering & Sciences》 SCIE EI 2025年第1期467-500,共34页
This study was aimed to prepare landslide susceptibility maps for the Pithoragarh district in Uttarakhand,India,using advanced ensemble models that combined Radial Basis Function Networks(RBFN)with three ensemble lear... This study was aimed to prepare landslide susceptibility maps for the Pithoragarh district in Uttarakhand,India,using advanced ensemble models that combined Radial Basis Function Networks(RBFN)with three ensemble learning techniques:DAGGING(DG),MULTIBOOST(MB),and ADABOOST(AB).This combination resulted in three distinct ensemble models:DG-RBFN,MB-RBFN,and AB-RBFN.Additionally,a traditional weighted method,Information Value(IV),and a benchmark machine learning(ML)model,Multilayer Perceptron Neural Network(MLP),were employed for comparison and validation.The models were developed using ten landslide conditioning factors,which included slope,aspect,elevation,curvature,land cover,geomorphology,overburden depth,lithology,distance to rivers and distance to roads.These factors were instrumental in predicting the output variable,which was the probability of landslide occurrence.Statistical analysis of the models’performance indicated that the DG-RBFN model,with an Area Under ROC Curve(AUC)of 0.931,outperformed the other models.The AB-RBFN model achieved an AUC of 0.929,the MB-RBFN model had an AUC of 0.913,and the MLP model recorded an AUC of 0.926.These results suggest that the advanced ensemble ML model DG-RBFN was more accurate than traditional statistical model,single MLP model,and other ensemble models in preparing trustworthy landslide susceptibility maps,thereby enhancing land use planning and decision-making. 展开更多
关键词 Landslide susceptibility map spatial analysis ensemble modelling information values(IV)
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Global Piecewise Analysis of HIV Model with Bi-Infectious Categories under Ordinary Derivative and Non-Singular Operator with Neural Network Approach
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作者 Ghaliah Alhamzi Badr Saad TAlkahtani +1 位作者 Ravi Shanker Dubey Mati ur Rahman 《Computer Modeling in Engineering & Sciences》 SCIE EI 2025年第1期609-633,共25页
This study directs the discussion of HIV disease with a novel kind of complex dynamical generalized and piecewise operator in the sense of classical and Atangana Baleanu(AB)derivatives having arbitrary order.The HIV i... This study directs the discussion of HIV disease with a novel kind of complex dynamical generalized and piecewise operator in the sense of classical and Atangana Baleanu(AB)derivatives having arbitrary order.The HIV infection model has a susceptible class,a recovered class,along with a case of infection divided into three sub-different levels or categories and the recovered class.The total time interval is converted into two,which are further investigated for ordinary and fractional order operators of the AB derivative,respectively.The proposed model is tested separately for unique solutions and existence on bi intervals.The numerical solution of the proposed model is treated by the piece-wise numerical iterative scheme of Newtons Polynomial.The proposed method is established for piece-wise derivatives under natural order and non-singular Mittag-Leffler Law.The cross-over or bending characteristics in the dynamical system of HIV are easily examined by the aspect of this research having a memory effect for controlling the said disease.This study uses the neural network(NN)technique to obtain a better set of weights with low residual errors,and the epochs number is considered 1000.The obtained figures represent the approximate solution and absolute error which are tested with NN to train the data accurately. 展开更多
关键词 HIV infection model qualitative scheme approximate solution piecewise global operator neural network
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Prognostic model for esophagogastric variceal rebleeding after endoscopic treatment in liver cirrhosis: A Chinese multicenter study
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作者 Jun-Yi Zhan Jie Chen +7 位作者 Jin-Zhong Yu Fei-Peng Xu Fei-Fei Xing De-Xin Wang Ming-Yan Yang Feng Xing Jian Wang Yong-Ping Mu 《World Journal of Gastroenterology》 SCIE CAS 2025年第2期85-101,共17页
BACKGROUND Rebleeding after recovery from esophagogastric variceal bleeding(EGVB)is a severe complication that is associated with high rates of both incidence and mortality.Despite its clinical importance,recognized p... BACKGROUND Rebleeding after recovery from esophagogastric variceal bleeding(EGVB)is a severe complication that is associated with high rates of both incidence and mortality.Despite its clinical importance,recognized prognostic models that can effectively predict esophagogastric variceal rebleeding in patients with liver cirrhosis are lacking.AIM To construct and externally validate a reliable prognostic model for predicting the occurrence of esophagogastric variceal rebleeding.METHODS This study included 477 EGVB patients across 2 cohorts:The derivation cohort(n=322)and the validation cohort(n=155).The primary outcome was rebleeding events within 1 year.The least absolute shrinkage and selection operator was applied for predictor selection,and multivariate Cox regression analysis was used to construct the prognostic model.Internal validation was performed with bootstrap resampling.We assessed the discrimination,calibration and accuracy of the model,and performed patient risk stratification.RESULTS Six predictors,including albumin and aspartate aminotransferase concentrations,white blood cell count,and the presence of ascites,portal vein thrombosis,and bleeding signs,were selected for the rebleeding event prediction following endoscopic treatment(REPET)model.In predicting rebleeding within 1 year,the REPET model ex-hibited a concordance index of 0.775 and a Brier score of 0.143 in the derivation cohort,alongside 0.862 and 0.127 in the validation cohort.Furthermore,the REPET model revealed a significant difference in rebleeding rates(P<0.01)between low-risk patients and intermediate-to high-risk patients in both cohorts.CONCLUSION We constructed and validated a new prognostic model for variceal rebleeding with excellent predictive per-formance,which will improve the clinical management of rebleeding in EGVB patients. 展开更多
关键词 Esophagogastric variceal bleeding Variceal rebleeding Liver cirrhosis Prognostic model Risk stratification Secondary prophylaxis
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Exploiting fly models to investigate rare human neurological disorders
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作者 Tomomi Tanaka Hyung-Lok Chung 《Neural Regeneration Research》 SCIE CAS 2025年第1期21-28,共8页
Rare neurological diseases,while individually are rare,collectively impact millions globally,leading to diverse and often severe neurological symptoms.Often attributed to genetic mutations that disrupt protein functio... Rare neurological diseases,while individually are rare,collectively impact millions globally,leading to diverse and often severe neurological symptoms.Often attributed to genetic mutations that disrupt protein function or structure,understanding their genetic basis is crucial for accurate diagnosis and targeted therapies.To investigate the underlying pathogenesis of these conditions,researchers often use non-mammalian model organisms,such as Drosophila(fruit flies),which is valued for their genetic manipulability,cost-efficiency,and preservation of genes and biological functions across evolutionary time.Genetic tools available in Drosophila,including CRISPR-Cas9,offer a means to manipulate gene expression,allowing for a deep exploration of the genetic underpinnings of rare neurological diseases.Drosophila boasts a versatile genetic toolkit,rapid generation turnover,and ease of large-scale experimentation,making it an invaluable resource for identifying potential drug candidates.Researchers can expose flies carrying disease-associated mutations to various compounds,rapidly pinpointing promising therapeutic agents for further investigation in mammalian models and,ultimately,clinical trials.In this comprehensive review,we explore rare neurological diseases where fly research has significantly contributed to our understanding of their genetic basis,pathophysiology,and potential therapeutic implications.We discuss rare diseases associated with both neuron-expressed and glial-expressed genes.Specific cases include mutations in CDK19 resulting in epilepsy and developmental delay,mutations in TIAM1 leading to a neurodevelopmental disorder with seizures and language delay,and mutations in IRF2BPL causing seizures,a neurodevelopmental disorder with regression,loss of speech,and abnormal movements.And we explore mutations in EMC1 related to cerebellar atrophy,visual impairment,psychomotor retardation,and gain-of-function mutations in ACOX1 causing Mitchell syndrome.Loss-of-function mutations in ACOX1 result in ACOX1 deficiency,characterized by very-long-chain fatty acid accumulation and glial degeneration.Notably,this review highlights how modeling these diseases in Drosophila has provided valuable insights into their pathophysiology,offering a platform for the rapid identification of potential therapeutic interventions.Rare neurological diseases involve a wide range of expression systems,and sometimes common phenotypes can be found among different genes that cause abnormalities in neurons or glia.Furthermore,mutations within the same gene may result in varying functional outcomes,such as complete loss of function,partial loss of function,or gain-of-function mutations.The phenotypes observed in patients can differ significantly,underscoring the complexity of these conditions.In conclusion,Drosophila represents an indispensable and cost-effective tool for investigating rare neurological diseases.By facilitating the modeling of these conditions,Drosophila contributes to a deeper understanding of their genetic basis,pathophysiology,and potential therapies.This approach accelerates the discovery of promising drug candidates,ultimately benefiting patients affected by these complex and understudied diseases. 展开更多
关键词 ACOX1 Drosophila melanogaster GLIA lipid metabolism model organisms NEUROINFLAMMATION neurologic disorders NEURON rare disease VLCFA
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A promising approach for quantifying focal stroke modeling and assessing stroke progression:optical resolution photoacoustic microscopy photothrombosis
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作者 Xiao Liang Xingping Quan +6 位作者 Xiaorui Geng Yujing Huang Yonghua Zhao Lei Xi Zhen Yuan Ping Wang Bin Liu 《Neural Regeneration Research》 SCIE CAS 2025年第7期2029-2037,共9页
To investigate the mechanisms underlying the onset and progression of ischemic stroke,some methods have been proposed that can simultaneously monitor and create embolisms in the animal cerebral cortex.However,these me... To investigate the mechanisms underlying the onset and progression of ischemic stroke,some methods have been proposed that can simultaneously monitor and create embolisms in the animal cerebral cortex.However,these methods often require complex systems and the effect of age on cerebral embolism has not been adequately studied,although ischemic stroke is strongly age-related.In this study,we propose an optical-resolution photoacoustic microscopy-based visualized photothrombosis methodology to create and monitor ischemic stroke in mice simultaneously using a 532 nm pulsed laser.We observed the molding process in mice of different ages and presented age-dependent vascular embolism differentiation.Moreover,we integrated optical coherence tomography angiography to investigate age-associated trends in cerebrovascular variability following a stroke.Our imaging data and quantitative analyses underscore the differential cerebrovascular responses to stroke in mice of different ages,thereby highlighting the technique's potential for evaluating cerebrovascular health and unraveling age-related mechanisms involved in ischemic strokes. 展开更多
关键词 AGE-DEPENDENT cerebral cortex ischemic stroke mouse model optical coherence tomography angiography photoacoustic microscopy PHOTOTHROMBOSIS vascular imaging
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LoRa Sense:Sensing and Optimization of LoRa Link Behavior Using Path-Loss Models in Open-Cast Mines
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作者 Bhanu Pratap Reddy Bhavanam Prashanth Ragam 《Computer Modeling in Engineering & Sciences》 SCIE EI 2025年第1期425-466,共42页
The Internet of Things(IoT)has orchestrated various domains in numerous applications,contributing significantly to the growth of the smart world,even in regions with low literacy rates,boosting socio-economic developm... The Internet of Things(IoT)has orchestrated various domains in numerous applications,contributing significantly to the growth of the smart world,even in regions with low literacy rates,boosting socio-economic development.This study provides valuable insights into optimizing wireless communication,paving the way for a more connected and productive future in the mining industry.The IoT revolution is advancing across industries,but harsh geometric environments,including open-pit mines,pose unique challenges for reliable communication.The advent of IoT in the mining industry has significantly improved communication for critical operations through the use of Radio Frequency(RF)protocols such as Bluetooth,Wi-Fi,GSM/GPRS,Narrow Band(NB)-IoT,SigFox,ZigBee,and Long Range Wireless Area Network(LoRaWAN).This study addresses the optimization of network implementations by comparing two leading free-spreading IoT-based RF protocols such as ZigBee and LoRaWAN.Intensive field tests are conducted in various opencast mines to investigate coverage potential and signal attenuation.ZigBee is tested in the Tadicherla open-cast coal mine in India.Similarly,LoRaWAN field tests are conducted at one of the associated cement companies(ACC)in the limestone mine in Bargarh,India,covering both Indoor-toOutdoor(I2O)and Outdoor-to-Outdoor(O2O)environments.A robust framework of path-loss models,referred to as Free space,Egli,Okumura-Hata,Cost231-Hata and Ericsson models,combined with key performance metrics,is employed to evaluate the patterns of signal attenuation.Extensive field testing and careful data analysis revealed that the Egli model is the most consistent path-loss model for the ZigBee protocol in an I2O environment,with a coefficient of determination(R^(2))of 0.907,balanced error metrics such as Normalized Root Mean Square Error(NRMSE)of 0.030,Mean Square Error(MSE)of 4.950,Mean Absolute Percentage Error(MAPE)of 0.249 and Scatter Index(SI)of 2.723.In the O2O scenario,the Ericsson model showed superior performance,with the highest R^(2)value of 0.959,supported by strong correlation metrics:NRMSE of 0.026,MSE of 8.685,MAPE of 0.685,Mean Absolute Deviation(MAD)of 20.839 and SI of 2.194.For the LoRaWAN protocol,the Cost-231 model achieved the highest R^(2)value of 0.921 in the I2O scenario,complemented by the lowest metrics:NRMSE of 0.018,MSE of 1.324,MAPE of 0.217,MAD of 9.218 and SI of 1.238.In the O2O environment,the Okumura-Hata model achieved the highest R^(2)value of 0.978,indicating a strong fit with metrics NRMSE of 0.047,MSE of 27.807,MAPE of 27.494,MAD of 37.287 and SI of 3.927.This advancement in reliable communication networks promises to transform the opencast landscape into networked signal attenuation.These results support decision-making for mining needs and ensure reliable communications even in the face of formidable obstacles. 展开更多
关键词 Internet of things long range wireless area network ZigBee mining environments path-loss models coefficient of determination mean square error
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Reduced mesencephalic astrocyte-derived neurotrophic factor expression by mutant androgen receptor contributes to neurodegeneration in a model of spinal and bulbar muscular atrophy pathology
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作者 Yiyang Qin Wenzhen Zhu +6 位作者 Tingting Guo Yiran Zhang Tingting Xing Peng Yin Shihua Li Xiao-Jiang Li Su Yang 《Neural Regeneration Research》 SCIE CAS 2025年第9期2655-2666,共12页
Spinal and bulbar muscular atrophy is a neurodegenerative disease caused by extended CAG trinucleotide repeats in the androgen receptor gene,which encodes a ligand-dependent transcription facto r.The mutant androgen r... Spinal and bulbar muscular atrophy is a neurodegenerative disease caused by extended CAG trinucleotide repeats in the androgen receptor gene,which encodes a ligand-dependent transcription facto r.The mutant androgen receptor protein,characterized by polyglutamine expansion,is prone to misfolding and forms aggregates in both the nucleus and cytoplasm in the brain in spinal and bulbar muscular atrophy patients.These aggregates alter protein-protein interactions and compromise transcriptional activity.In this study,we reported that in both cultured N2a cells and mouse brain,mutant androgen receptor with polyglutamine expansion causes reduced expression of mesencephalic astrocyte-de rived neurotrophic factor.Overexpressio n of mesencephalic astrocyte-derived neurotrophic factor amelio rated the neurotoxicity of mutant androgen receptor through the inhibition of mutant androgen receptor aggregation.Conversely.knocking down endogenous mesencephalic astrocyte-derived neurotrophic factor in the mouse brain exacerbated neuronal damage and mutant androgen receptor aggregation.Our findings suggest that inhibition of mesencephalic astrocyte-derived neurotrophic factor expression by mutant androgen receptor is a potential mechanism underlying neurodegeneration in spinal and bulbar muscular atrophy. 展开更多
关键词 androgen receptor mesencephalic astrocyte-derived neurotrophic factor mouse model NEURODEGENERATION neuronal loss neurotrophic factor polyglutamine disease protein misfolding spinal and bulbar muscular atrophy transcription factor
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Physiology and health assessment,risk balance,and model for endstage liver disease scores:Postoperative outcome of liver transplantation
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作者 Raquel Hohenreuther Andresa ThoméSilveira +4 位作者 Edison Moraes Rodrigues Filho Anderson Garcez Bruna Goularth Lacerda Sabrina Alves Fernandes Claudio Augusto Marroni 《World Journal of Transplantation》 2025年第1期86-94,共9页
BACKGROUND Liver transplantation aims to increase the survival of patients with end-stage liver diseases and improve their quality of life.The number of organs available for transplantation is lower than the demand.To... BACKGROUND Liver transplantation aims to increase the survival of patients with end-stage liver diseases and improve their quality of life.The number of organs available for transplantation is lower than the demand.To provide fair organ distribution,predictive mortality scores have been developed.AIM To compare the Acute Physiology and Chronic Health Evaluation IV(APACHE IV),balance of risk(BAR),and model for end-stage liver disease(MELD)scores as predictors of mortality.METHODS Retrospective cohort study,which included 283 adult patients in the postoperative period of deceased donor liver transplantation from 2014 to 2018.RESULTS The transplant recipients were mainly male,with a mean age of 58.1 years.Donors were mostly male,with a mean age of 41.6 years.The median cold ischemia time was 3.1 hours,and the median intensive care unit stay was 5 days.For APACHE IV,a mean of 59.6 was found,BAR 10.7,and MELD 24.2.The 28-day mortality rate was 9.5%,and at 90 days,it was 3.5%.The 28-day mortality prediction for APACHE IV was very good[area under the curve(AUC):0.85,P<0.001,95%CI:0.76-0.94],P<0.001,BAR(AUC:0.70,P<0.001,95%CI:0.58–0.81),and MELD(AUC:0.66,P<0.006,95%CI:0.55-0.78),P<0.008.At 90 days,the data for APACHE IV were very good(AUC:0.80,P<0.001,95%CI:0.71–0.90)and moderate for BAR and MELD,respectively,(AUC:0.66,P<0.004,95%CI:0.55–0.77),(AUC:0.62,P<0.026,95%CI:0.51–0.72).All showed good discrimination between deaths and survivors.As for the best value for liver transplantation,it was significant only for APACHE IV(P<0.001).CONCLUSION The APACHE IV assessment score was more accurate than BAR and MELD in predicting mortality in deceased donor liver transplant recipients. 展开更多
关键词 Liver transplantation Acute physiology and chronic health evaluation IV Balance of risk model for end-stage liver disease MORTALITY Intensive care unit
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Modeling and Comprehensive Review of Signaling Storms in 3GPP-Based Mobile Broadband Networks:Causes,Solutions,and Countermeasures
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作者 Muhammad Qasim Khan Fazal Malik +1 位作者 Fahad Alturise Noor Rahman 《Computer Modeling in Engineering & Sciences》 SCIE EI 2025年第1期123-153,共31页
Control signaling is mandatory for the operation and management of all types of communication networks,including the Third Generation Partnership Project(3GPP)mobile broadband networks.However,they consume important a... Control signaling is mandatory for the operation and management of all types of communication networks,including the Third Generation Partnership Project(3GPP)mobile broadband networks.However,they consume important and scarce network resources such as bandwidth and processing power.There have been several reports of these control signaling turning into signaling storms halting network operations and causing the respective Telecom companies big financial losses.This paper draws its motivation from such real network disaster incidents attributed to signaling storms.In this paper,we present a thorough survey of the causes,of the signaling storm problems in 3GPP-based mobile broadband networks and discuss in detail their possible solutions and countermeasures.We provide relevant analytical models to help quantify the effect of the potential causes and benefits of their corresponding solutions.Another important contribution of this paper is the comparison of the possible causes and solutions/countermeasures,concerning their effect on several important network aspects such as architecture,additional signaling,fidelity,etc.,in the form of a table.This paper presents an update and an extension of our earlier conference publication.To our knowledge,no similar survey study exists on the subject. 展开更多
关键词 Signaling storm problems control signaling load analytical modeling 3GPP networks smart devices diameter signaling mobile broadband data access data traffic mobility management signaling network architecture 5G mobile communication
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Seismic performance of double- skin steel- concrete composite box piers: Part Ⅰ——Bidirectional quasi-static testing 被引量:6
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作者 夏坚 宗周红 +1 位作者 徐焯然 李明鸿 《Journal of Southeast University(English Edition)》 EI CAS 2016年第1期58-66,共9页
To study the seismic performance of double-skin steelconcrete composite box( DSCB) piers, a total of 11 DSCB pier specimens were tested under bidirectional cyclic loading. The effects of the loading pattern, the ste... To study the seismic performance of double-skin steelconcrete composite box( DSCB) piers, a total of 11 DSCB pier specimens were tested under bidirectional cyclic loading. The effects of the loading pattern, the steel plate thickness, the axial load ratio, the slenderness ratio and the aspect ratio were taken into consideration. The damage evolution process and failure modes of the tested specimens are presented in detail. Test results are also discussed in terms of the hysteretic curve, skeleton curve, ductility and energy dissipation capacity of DSCB pier specimens. It can be concluded that the hysteretic performance of DSCB piers in one direction is affected and weakened by the cyclic loading in the other direction. DSCB piers under bidirectional cyclic loading exhibit good performance in terms of load carrying capacity, ductility, and energy dissipation capacity. Overall, DSCB piers can meet the basic aseismic requirements. The research results can be taken as a reference for using DSCB piers as high piers in bridges in strong earthquakeprone areas. 展开更多
关键词 double-skin steel-concrete composite box(DSCB) pier bidirectional quasi-static testing hysteretic curve skeleton curve ductility energy dissipation capacity
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Quasi-static and dynamic tensile behaviors in electron beam welded Ti-6Al-4V alloy
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作者 张静 谭成文 +2 位作者 任宇 王富耻 才鸿年 《Transactions of Nonferrous Metals Society of China》 SCIE EI CAS CSCD 2011年第1期39-44,共6页
The quasi-static and dynamic tensile behaviors in electron beam welded(EBW) Ti-6Al-4V alloy were investigated at strain rates of 10-3 and 103 s-1,respectively,by materials test system(MTS) and reconstructive Hopki... The quasi-static and dynamic tensile behaviors in electron beam welded(EBW) Ti-6Al-4V alloy were investigated at strain rates of 10-3 and 103 s-1,respectively,by materials test system(MTS) and reconstructive Hopkinson bars apparatus.The microstructures of the base metal(BM) and the welded metal(WM) were observed with optical microscope.The fracture characteristics of the BM and WM were characterized with scanning electronic microscope.In Ti-6Al-4V alloy joint,the flow stress of WM is higher than that of BM,while the fracture strain of WM is less than that of BM at strain rates of 103 and 10-3 s-1,respectively.The fracture strain of WM has apparent improvement when the strain rate rises from 10-3 to 103 s-1,while the fracture strain of BM almost has no change.At the same time,the fracture mode of WM alters from brittle to ductile fracture,which causes improvement of the fracture strain of WM. 展开更多
关键词 Ti-6Al-4V alloy electron beam welding quasi-static tensile behavior dynamic behavior fracture mode
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The asymptotic field of mode Ⅰ quasi-static crack growth on the interface between a rigid and a pressure-sensitive material
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作者 麻文军 唐立强 《Journal of Marine Science and Application》 2009年第3期252-257,共6页
A mechanical model of the quasi-static interface of a mode I crack between a rigid and a pressure-sensitive viscoelastic material was established to investigate the mechanical characteristic of ship-building engineeri... A mechanical model of the quasi-static interface of a mode I crack between a rigid and a pressure-sensitive viscoelastic material was established to investigate the mechanical characteristic of ship-building engineering hi-materials. In the stable growth stage, stress and strain have the same singularity, ie (σ, ε) ∝ r^-1/(n-1). The variable-separable asymptotic solutions of stress and strain at the crack tip were obtained by adopting Airy's stress function and the numerical results of stress and strain in the crack-tip field were obtained by the shooting method. The results showed that the near-tip fields are mainly governed by the power-hardening exponent n and the Poisson ratio v of the pressure-sensitive material. The fracture criterion of mode I quasi-static crack growth in pressure-sensitive materials, according to the asymptotic analyses of the crack-tip field, can be viewed from the perspective of strain. 展开更多
关键词 pressure-sensitive material mode I quasi-static interface crack crack-tip field asymptotic analysis
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采用STAMP-24Model的多组织事故分析
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作者 曾明荣 秦永莹 +2 位作者 刘小航 栗婧 尚长岭 《安全与环境学报》 CAS CSCD 北大核心 2024年第7期2741-2750,共10页
安全生产事故往往由多组织交互、多因素耦合造成,事故原因涉及多个组织。为预防和遏制多组织生产安全事故的发生,基于系统理论事故建模与过程模型(Systems-Theory Accident Modeling and Process,STAMP)、24Model,构建一种用于多组织事... 安全生产事故往往由多组织交互、多因素耦合造成,事故原因涉及多个组织。为预防和遏制多组织生产安全事故的发生,基于系统理论事故建模与过程模型(Systems-Theory Accident Modeling and Process,STAMP)、24Model,构建一种用于多组织事故分析的方法,并以青岛石油爆炸事故为例进行事故原因分析。结果显示:STAMP-24Model可以分组织,分层次且有效、全面、详细地分析涉及多个组织的事故原因,探究多组织之间的交互关系;对事故进行动态演化分析,可得到各组织不安全动作耦合关系与形成的事故失效链及管控失效路径,进而为预防多组织事故提供思路和参考。 展开更多
关键词 安全工程 系统理论事故建模与过程模型(STAMP) 24model 多组织事故 原因分析
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