Analysis of the Self-Protection Characteristics of a 1.5T Bitter-Like HTS Magnet Operated at 65K

We present a conceptual configuration of a high-temperature superconducting（HTS）magnet made from REBCO（Re=Rare Earth,B=Barium,C=Copper,O=Oxide）annular plates,called a Bitter-like HTS magnet,which can operate in persistent current mode without joint resistance and can be excited by a flux pump and without current leads and a persistent power supply.An REBCO annular magnet which can generate 1.5 T corresponding to the operating current density 80%of critical current density of the magnet at an operating temperature of65 K is conceptually designed.Then the thermal stability of the magnet is numerically simulated by Comsol software.Whein a piece of RBCO annular plate quenches,the maximum released energy is its stored energy because each REBCO annular plate in the Bitter-like magnet is in parallel.To calculate the stored energy in the REBCO annular plate,the inductance of every annular plate,including self-inductance and mutual inductance,is calculated.Compared with the minimum quench energy（MQE）and stored energy in one REBCO annular plate,the stored energy in one REBCO annular plate is always smaller than the MQE,and the REBCO annular plate will not be damaged even though the stored energy in the REBCO annular plate is fully released,which indicates that this 1.5 T Bitter-like magnet has the property of self-protection.

被困空腔对T-bar循环贯入软黏土流动特性影响的试验研究

为观测和分析T-bar循环贯入过程中被困空腔对软黏土流动特性的影响,利用Laponite RD、焦磷酸钠和去离子水配制透明黏土,自制由加载设备、CCD相机、激光器和控制系统组成的T-bar循环贯入试验装置,开展T-bar在透明黏土中的循环贯入试验。结果表明:T-bar初次贯入过程中,被困空腔影响土体绕探头的流动,土体不能进入全流动状态;T-bar初次上拔过程中,被困空腔与探头发生脱离,悬浮于探头上方,对土体流动的影响逐渐减弱,T-bar上拔2倍探头直径深度时土体流动不再受被困空腔影响,进入到全流动状态;第2—第10次循环贯入过程中,被困空腔稳定悬浮于土中,不影响土体流动,T-bar贯入1倍探头直径深度时土体流动表现为全流动状态;被困空腔对于T-bar循环贯入测试结果无显著影响,在T-bar初次贯入被困空腔阶段下通过T-bar循环贯入测试软黏土重塑强度是合理的。

Clinical characteristics and current management of hepatitis B and C in China

AIM: To describe a population of outpatients in Chinainfected by hepatitis B virus(HBV) and/or hepatitis C virus(HCV), and assess their current management status.METHODS: A multicenter, cross-sectional study of HBV- and/or HCV-infected patients was conducted from August to November, 2011 in western China. Patients ≥ 18 years of age with HBV and/or HCV infections who visited outpatient departments at 10 hospitals were evaluated, whether treated or not. Data were collected on the day of visit from medical records and patient interviews.RESULTS: A total 4010 outpatients were analyzed, including 2562 HBV-infected and 1406 HCV-infected and 42 HBV/HCV co-infected patients. The median duration of documented infection was 7.5 years in HBV-infected and 1.8 years in HCV-infected patients. Cirrhosis was the most frequent hepatic complication(12.2%), appearing in one-third of patients within 3 years prior to or at diagnosis. The HCV genotype was determined in only 10% of HCV-infected patients. Biopsy data were only available for 54 patients(1.3%). Antiviral medications had been received by 58.2% of patients with HBV infection and 66.6% with HCV infection. Nucleos(t)ide analogs were the major antiviral medications prescribed for HBV-infected patients(most commonly adefovir dipivoxil and lamivudine). Ribavirin + pegylated interferon was prescribed for two-thirds of HCV-infected patients. In the previous 12 mo, around one-fifth patients had been hospitalized due to HBV or HCV infection.CONCLUSION: This observational, real-life study has identified some gaps between clinical practice and guideline recommendations in China. To achieve better health outcomes, several improvements, such as disease monitoring and optimizing antiviral regimens, should be made to improve disease management.

THE GEOCHEMISTRY CHARACTERISTICS OF BLUESCHIST IN THE GANGMAR AREA, QIANGTANG BLOCK, TIBET

The Qinghai—Xizang (Tibet) Plateau was assembled by the successive accretion of continental and arc terranes to Asia during the Palaeozoic, Mesozoic and early Tertiary. From north to south, the Plateau was divided into four terranes (from north to south): Songpan\|Garze, Qingtang, Lhasa and India terranes. The Qiangtang terrane was divided into two parts by Chabu\|Shuanghu suture: Northern Qiangtang and Southern Qiangtang blocks. It was believed that there is a suture as Palaeotethyan suture between the two blocks from Lungmu lake to Chabu, to Shuanghu, to Langcangjiang, but some geologists opposited this opinion, such as Wang Chengshan et al.(1987) and Deng Wanming et al.(1996). The blueschists that bear the typical glaucophane were found in the Gangmar Area in summer of 1997. The blueschists consist of glaucophane, crossite, phengite, actinolite, epidote, sphene ,rutile, and so on. Blueschists show nappe structures in enclosing rocks, and thrust over Tertiary from north to south.The age of blueschist is 275～285Ma which stand for the metamorphic age of blueschist. The geochemical contents of blueschists are the following: SiO\-2 is 45 37%～53 82%, Na 2O>K 2O, K 2O+Na 2O are 3 72%～7 61%, Na 2O/K 2O is 1 70～19 67, MnO is 0 16%～0 22%, FeO+Fe 2O 3 are 11 12%～14 27%, TiO 2 is 2 34%～4 28%, P 2O 5 is 0 34%～1 03%. From the contents, SiO 2 is inverse relation with K 2O+Na 2O, K 2O and FeO+Fe 2O 3. In the SiO 2\|K 2O+Na 2O diagram, the blueschists fall in the field of Alkali basalt; in the TiO 2\|MnO(10\|P 2O 5×10 triangular diagram, these plot within the Ocean Island Basalts(OIB) field. The whole REE content is (117 03～390 97)×10 -6 , LREE/HREE is 5 05～9 80, the REE diagram shows the feature that LREE is rich and HREE is depleted, this is similar to the OIB. In the spidergram of trace elements show the same characterristics as the OIB. Meanwhile, the trace elements ratios, such as Ba/Nb, La/Nb, Nb/Th, Nb/Y, Zr/Y, Zr/Nb, Hf/Sm, Ta/Hf, Nb/Ta, Nb/U, suggest the tectonic setting is OIB. On the basis of these materials, the blueschists are akin to within\|plate ocean island basalts. This shows that there is a ocean or oceanic basin in the Chabu\|Shuanghu belts and the formation of blueschists is the quicky subduction of the Ocean Island Basalts in Early Permian between the Gondwana and Eurasia continents. It demonstrated, therefore, that the Chabu\|Suanghu suture exists and may extend to the east to Lnagchangjiang, and may extend into Thailand\|Malaysia Peninsula.

胃癌患者血浆hsa_circ_0001588水平与TLR4和T淋巴细胞亚群相关性

目的 探究胃癌患者血浆中hsa_circ_0001588水平,并分析其血浆水平与患者临床特征、Toll样受体4(Toll-like receptors 4,TLR4)、T淋巴细胞亚群的关系。方法 选取2021年3月至2022年5月于我院治疗的胃癌患者124例为研究组,另选取接受胃镜检查确诊为浅表性胃炎的患者130例作为良性组以及健康体检者130例作为对照组。采用实时荧光定量聚合酶链反应、Wmini5146流式细胞仪和双抗体夹心ELISA法检测受试者血浆hsa_circ_0001588水平、TLR4水平和CD3^(+)、CD4^(+)、CD8^(+)、CD4^(+)/CD8^(+)水平。分析血浆hsa_circ_0001588、TLR4、T淋巴细胞对于胃癌的诊断效能以及血浆hsa_circ_0001588水平与TLR4和T淋巴细胞水平的关系。结果 研究组血浆hsa_circ_0001588、TLR4和CD8^(+)表达水平高于良性组和对照组,CD3^(+)、CD4^(+)、CD4^(+)/CD8^(+)水平低于良性组和对照组(P<0.05),且研究组患者术后hsa_circ_0001588水平下降。临床分期越高、浸润深度越深、分化程度越低,发生远端转移的患者血浆hsa_circ_0001588水平越高(P<0.05)。血浆hsa_circ_0001588、TLR4和T淋巴细胞对于胃癌均有较好的诊断效能,其联合诊断的整体效能最高。血浆hsa_circ_0001588高表达患者CD3^(+)、CD4^(+)和CD4^(+)/CD8^(+)表达较低,TLR4和CD8^(+)表达较高(P<0.05),其血浆hsa_circ_0001588水平与CD3^(+)、CD4^(+)和CD4^(+)/CD8^(+)表达呈负相关性,与TLR4和CD8^(+)呈正相关性。结论 胃癌患者血浆hsa_circ_0001588水平偏高,且与CD3^(+)、CD4^(+)、CD4^(+)/CD8^(+)水平呈负相关性,与TLR4、CD8^(+)呈正相关性。

不同HDAC水平的外周T细胞淋巴瘤患者预后复发的影响因素分析

目的:基于潜在类别分析不同组蛋白去乙酰化酶(HDAC)水平的外周T细胞淋巴瘤(PTCL)患者预后复发的影响因素分布特征。方法:选取2012年9月至2019年9月在本院就诊的PTCL患者112例,将患者分为复发组和未复发组,比较两组患者的临床资料。通过多因素Logistic回归分析影响患者预后复发的危险因素。采用潜在类别分析法比较复发高风险组与复发低风险组间预后复发影响因素的分布特征差异。结果:复发组患者87例(77.68%),未复发组患者25例(22.32%)。多因素Logistic回归分析结果显示,ECOG评分≥2分、Ann Arbor分期为III-IV期、IPI评分>2分、骨髓受累、血清β2-微球蛋白(β2-MG)水平升高、近期疗效未达到完全缓解(CR)和部分缓解(PR)、HDAC高表达为患者复发的独立危险因素(P<0.05)。HDAC高水平患者的复发率明显高于HDAC低水平患者(P<0.05)。聚类分析结果显示,预后复发风险呈明显聚集性,可将患者分为预后复发高风险组(HDAC>5分)和低风险组(HDAC≤5分)。潜在类别分析结果显示,与预后复发低风险组相比,预后复发高风险组中“危险因素分布较多型”占比较高(P<0.05)。结论:不同HDAC水平的PTCL患者的预后复发情况以及预后复发高风险与低风险人群中危险因素分布特征均有差异。

外周血PD-1、CTLA-4、T-reg、pDC与鼻咽癌患者临床特征及疗效的相关性

目的:探讨初治鼻咽癌患者治疗前外周血PD-1/CTL(%)、CTLA-4/CTL(%)、T-reg(%)、pDC与患者临床特征及即刻疗效的关系,以及以上指标在鼻咽癌患者及健康人群中的表达差异。方法:收集112例初治鼻咽癌患者治疗前临床资料及淋巴细胞亚群和树突细胞亚群数据,进行外周血PD-1/CTL(%)、CTLA-4/CTL(%)、T-reg(%)、pDC与鼻咽癌患者临床特征及即刻疗效的相关性分析,从112例鼻咽癌患者中随机选取30例患者作为病例组,年龄、性别匹配的30例同期体检健康者作为对照组,分析两组外周血PD-1/CTL(%)、CTLA-4/CTL(%)、T-reg(%)、pDC表达差异。结果:112例初治鼻咽癌患者中,年龄≥50岁组与年龄<50岁组相比,外周血PD-1/CTL(%)更高。CTLA-4/CTL(%)与T分期、N分期、TNM分期呈负相关,CTLA-4/CT(%)越高,疗效越好。T-reg(%)与N分期呈正相关,T-reg(%)与M分期存在“S”型曲线关系。pDC与N分期、TNM分期呈负相关。病例组与对照组外周血PD-1/CTL(%)、T-reg(%)差异存在统计学意义,病例组与对照组外周血CTLA-4/CTL(%)差异不存在统计学意义。结论:外周血CTLA-4/CT(%)越高,鼻咽癌T分期、N分期、TNM分期越早,外周血CTLA-4/CT(%)越高,疗效越好。外周血T-reg(%)越高,N分期越晚。当外周血T-reg(%)<20%时,鼻咽癌可能未发生远处转移,当外周血T-reg(%)为20%~50%时,外周血T-reg(%)表达越高,发生远处转移的可能越大,当外周血T-reg(%)>50%时,鼻咽癌已经远处转移的可能性大。外周血pDC越高,N分期、TNM分期越早。外周血以上指标可动态观察,有望成为预测鼻咽癌患者疗效及预后的生物标志物。

B7-H6在宫颈上皮内瘤变、宫颈癌组织中表达差异及与肿瘤浸润T淋巴细胞、预后的相关性

目的探究宫颈上皮内瘤变、宫颈癌组织中B7同源体6(B7-H6)表达差异与肿瘤浸润T淋巴细胞、预后相关性。方法选取2019年6月—2021年3月60例经病理检查确诊为宫颈癌的手术患者作为研究组,另选同期同年龄段60例宫颈上皮内瘤变作为对照组。比较2组组织B7-H6表达情况(H-score评分)及血清B7-H6水平,并比较研究组不同肿瘤浸润T淋巴细胞浸润程度患者H-score评分、血清B7-H6水平,分析研究组H-score评分、血清B7-H6水平与肿瘤浸润T淋巴细胞浸润程度的相关性。研究组术后随访1年,比较不同预后患者一般资料、H-score评分、血清B7-H6水平,探讨预后影响因素,并分析H-score评分和血清B7-H6水平预测患者预后的价值。结果研究组H-score评分和血清B7-H6水平高于对照组(P<0.01)。研究组肿瘤浸润T淋巴细胞浸润程度0级患者H-score评分、血清B7-H6水平高于1级、2级患者,且1级患者高于2级患者(P<0.05)。研究组H-score评分、血清B7-H6水平与肿瘤浸润T淋巴细胞浸润程度呈负相关(P<0.01)。多因素Logistic回归分析显示,肿瘤直径、国际妇产科协会(FIGO)分期、淋巴结转移、间质浸润深度、H-score评分、血清B7-H6水平均为宫颈癌手术患者预后不良的独立危险因素(P<0.01)。肿瘤直径、FIGO分期、淋巴结转移、间质浸润深度、H-score评分和血清B7-H6水平预测宫颈癌手术患者预后不良的曲线下面积(AUC)分别为0.736、0.726、0.714、0.712、0.842和0.840,H-score评分和血清B7-H6水平预测的AUC分别大于肿瘤直径、FIGO分期、淋巴结转移、间质浸润深度预测的AUC(P<0.05)。H-score评分和血清B7-H6水平在预测宫颈癌手术患者预后不良方面拥有良好的临床效用。结论宫颈癌组织B7-H6表达高于宫颈上皮内瘤变,且宫颈癌组织B7-H6表达、血清B7-H6水平与肿瘤浸润T淋巴细胞浸润程度呈负相关,也是宫颈癌手术患者预后不良的独立危险因素,在预测预后方面具有一定临床价值。

Resistance Characteristics of Hydraulic Oil through Isodiametric T-type Duct with Sharp Corners

Rational determination and reduction of local energy loss of oil flow at pipe junctions are of important significance to improve hydraulic pipeline＇s work efficiency, especially for complex hydraulic pipeline connected by isodiametric T-type ducts with sharp comers to get combined and divided flow. From this point of view, the formulae of resistance loss for combined flow and divided flow through isodiametric T-type duct with sharp comers as well as the correlations of resistance loss coefficients in the branches of the duct are derived using energy method. On this basis, resistance characteristics of hydraulic oil in the duct are obtained by numerical simulation of different flow modes, which are commonly applied in hydraulic pipelines, using computational fluid dynamics （CFD） method, and the reasons for the resistance loss are analyzed based on the pressure change mechanism in the flow field. A part of simulation results was validated with the reference data. The research shows that for combined flows the resistance loss of symmetrical is lower than that of unsymmetrical to obtain low speed in common branch, but to gain high speed is quite the contrary, for divided flows, the symmetrical is always a reasonable choice to reduce resistance loss. These conclusions can be applied to optimize the design of hydraulic pipeline.

ST-T段改变患者心电瀑布图形态特征及其对心血管疾病的预测价值

目的探讨究ST-T段改变患者心电瀑布图形态特征及其对心血管疾病的预测价值。方法选择2020年6月1日至2022年6月1日在该院进行心电瀑布图及传统心电图检查的疑似心脏病患者970例作为研究对象,根据24 h动态心电图分为ST-T段改变216例及正常心电图754例。分析心电图ST段下降、ST段抬高、T波低平、T波负向、T波正向、T波双向波长中心电瀑布图形态特征;采用一致性检验法检测心电瀑布图、常规心电图与24 h动态心电图诊断ST-T段改变的一致性;采用四格表法检测心电瀑布图、常规心电图诊断ST-T段改变的灵敏度、特异度。结果正常心电图受检者心电图波及波群TP带、P峰带、PR峰、QPS带、ST带、T峰带、TP带心电瀑布图特征主要表现浅蓝色、亮蓝色、蓝色、红色/黄色/橙色、蓝色、蓝色/亮蓝色、浅蓝色。216例ST-T段改变患者中,156例患者心电图显示为ST段下降,其中68例患者为T波负向,心电瀑布图表现为深蓝色62例(91.18%)、蓝黑色6例(8.82%);73例患者为T波正向,心电瀑布图表现为蓝黑色66例(90.41%)、深蓝色7例(9.59%)。60例患者心电图显示为ST段抬高,其中51例患者为T波正向,心电瀑布图表现为亮蓝色43例(84.31%)、深蓝色6例(11.76%)、淡黄色2例(3.92%)。74例患者存在T波负向,心电瀑布图表现为蓝黑色;124例患者存在T波正向,心电瀑布图随T波幅度呈浅蓝-亮蓝-黄-红改变;12例存在T波低平,心电瀑布图上方随T波幅度呈浅蓝-亮蓝-黄-红改变,下方主要表现为蓝黑色。心电瀑布图诊断ST-T段改变的灵敏度、特异度、准确度分别为96.30%、88.73%、90.41%,常规心电图诊断ST-T段改变的灵敏度、特异度、准确度分别为83.33%、72.68%、75.05%。一致性检验结果显示,心电瀑布图与24 h动态心电图诊断ST-T段改变的一致性极强,常规心电图与24 h动态心电图诊断ST-T段改变的一致性较好。结论ST-T改变患者心电瀑布图具有明显特征性改变,其在诊断心血管疾病方面的价值优于常规心电图,可推广应用。

A simulating investigation into the characteristics of the mass transfer between molten steel and particles in the 150 t RH-IJ refining

The characteristics of the mass transfer between powder particles and liquid steel in the Ruhrstahl Heraeus process injection （RH-IJ） refining were simulatively investigated by the use of a 1/4 scale water model of a 150 t Ruhrstahl Heraeus（RH） degasser. The influences of the lifting gas flow rate, the up-snorkel and down-snorkel inner diameters and the size of powder particles on the characteristics of the mass transfer were examined. The results show that under the condition that the inner diameters of both the up-snorkel and the down-snorkel are the same, the mass transfer coefficient in the liquid,k increases with the increase of the inner diameter of the up-snorkel,the particle size and the lifting gas flow rate （Q1）. However, the increase of Q~ should not result in a saturated circulation rate. Under the current working condition,k ranges from 3. 392 × 10 -5 m/s to 2. 661 × 10-4 m/s. On the other hand,with a given lifting gas flow rate and up-snorkel inner diameters ,the mass transfer weakens with the increase of the down-snorkel inner diameter. An inherently nonlinear relationship between the circulation rate （Q~） of molten steel in the RH degasser and k,which increases with the increase of Q1,was found. Under the condition of other parameters being the same,k increases with the increase of the powder particle size. In order to enhance the mass transfer,it is better not to use extremely fine powder.

F-T固废黏附特性调控及成浆特性研究

F-T固废由含油铁基废催化剂和稳定渣蜡组成,含有55%~65%的蜡质组份,属于危废。文中通过将F-T固废与水煤浆气化装置煤粉进行共混复配,研究了F-T固废黏附特性调控,添加F-T固废的水煤浆表观黏度、静态稳定性等成浆性能,为在气化装置上掺烧F-T固废,实现资源化利用提供了可靠的实验数据。结果表明:添加烷基酚聚氧乙烯醚或十二烷基苯磺酸钠,可以有效改善F-T固废的黏附特性;相同成浆浓度下,含有F-T固废的水煤浆表观黏度随固废含量增加而增大;当添加10%F-T固废,水煤浆最大成浆浓度由62.2%下降到了60.7%。

优良紫花苜蓿品种骑士t在庆阳市的适应性研究

试验旨在探讨紫花苜蓿骑士t在庆阳市的综合生产能力及适应性。试验采用随机区组试验方法,分析引进品种骑士t、当地主栽品种甘农5号和陇东紫花苜蓿的田间生产性状、生长势、鲜草产量、营养成分和饲用价值。结果表明,苜蓿不同品种生长曲线一致,但同一品种不同时期生长速度不同;3个苜蓿品种种植当年(春播)产量低,但品质优、营养价值高,初花期粗蛋白(CP)含量20%以上,酸性洗涤纤维(ADF)含量在28%~30%之间,中性洗涤纤维(NDF)含量在35.0%~38.5%之间,相对饲用价值(RFV)在161~172之间。骑士t播种当年越冬率为100%,抗寒性好,翌年第一茬株高达105.24 cm,显著高于甘农5号和陇东紫花苜蓿(P<0.05);茎粗为3.46 mm,显著低于甘农5号(P<0.05);鲜草产量达1 235.06 kg/667 m2。甘农5号抗旱性好,越夏成活率为73.38%,分枝较多,鲜草产量明显高于陇东紫花苜蓿(P<0.05)。骑士t粗脂肪含量低,但RFV高,鲜干比为2.96,粗蛋白和磷含量可达22.6%和0.3%,ADF和NDF含量为28.8%和35.97%,RFV为172,相对饲草品质(RFQ)为170,总可消化养分(TDN)含量为60%。研究表明,骑士t适宜在庆阳市及气候相似的区域种植。

喷油特性对F-T煤制油压力振荡影响规律研究

为了减小燃烧噪声,确定影响柴油机高频压力振荡的关键因素,在某型电控高压共轨柴油发动机上燃用的清洁代用燃料Fischer-Tropsch(F-T)煤制油,选取柴油机典型运行工况,研究不同喷油特性条件下柴油机燃烧压力振荡的时域和频域特性。结果表明:推后主喷提前角和提前预喷提前角会使放热率降低,压力振荡幅值减小,气缸压力级也有明显减小的趋势;减小预喷油量会使压力升高率和放热率降低,气缸声压级减小,压力振荡现象减缓,使燃烧更加柔和;提高喷射压力,会使喷油速率增大,燃油雾化效果增强,混合气放热率提升,放热率曲线也随之上升,气缸声压级增大,发动机缸内燃烧压力振荡幅值增大。喷射压力是影响压力振荡的最显著的参数,喷射压力从85MPa上升至115MPa时,压力振荡幅值增加一倍以上;预喷油量对F-T煤制油发动机的燃烧压力振荡影响不显著;同时压力振荡的产生与放热率的变化呈现出较强的相关性。

倒T型管道的振动特性分析与优化控制

三通管道是管网中最基本的连接单元之一,在管网的布置过程中有不可或缺的作用。通过利用ANSYS Workbench大型软件建立倒T型三通管道模型,从多个影响因素考虑,对倒T型管道的振动特性进行研究,最后对其振动特性提出优化控制。研究结果表明:在其他条件相同的情况下,双进单出的倒T型三通管道的固有频率比单进双出的固有频率稍大,倒T型圆形三通管道的固有频率略大于方形三通管道的固有频率,不同入水口压强和不同管道壁厚对固有频率有一定的影响;通过增加约束可以对管道的振动有较好的控制。

肿瘤特异性CD8^(+)T细胞研究现状

CD8^(+)T细胞是介导抗原特异性免疫应答的主要细胞,其功能状态受到分子机制的精密调控,在肿瘤免疫中发挥关键作用。近年来,基于CD8^(+)T细胞杀伤功能的过继性细胞疗法(例如TCR-T和CAR-T细胞治疗)和阻断PD-1抑制性信号的免疫检测点疗法在肿瘤临床治疗中取得了前所未有的效果。但是这些免疫疗法对患者的治疗效果仍然有限,主要表现为免疫治疗抵抗,其中重要的机制是肿瘤抗原特异性CD8^(+)T细胞功能耗竭。因此,免疫治疗研究的热点和难点是探究肿瘤抗原特异性CD8^(+)T细胞功能耗竭的调控机制,并探索干预策略和靶点以增强CD8^(+)T细胞的效应功能,抵抗功能耗竭。本文分别从耗竭CD8^(+)T细胞的异质性、对PD-1 ICB的响应及表观遗传特征三个方面综述CD8^(+)T细胞抗肿瘤免疫应答的研究进展。

Intermediate-scale Analysis of Landscape Characteristics Affecting Edge Formation in Burned Forests in Samcheok,Korea

Compared to burn interiors, edges exhibit distinct biotic and abiotic conditions that include microclimate, wind speed, sunlight levels, soil composition, moisture content, nutrient availability, population density, and species diversity. This study characterized the landscapes in which burned forest edges formed in Samcheok, Korea. Over the study area, 500-m2 grid cells were generated to capture landscape characteristics. Grid cells intersecting burn boundary lines were designated as edge, while cells without these lines were classified as the interior of burned areas. Topographic variables including slope, elevation, topographic wetness index, solar radiation index, and proportions of fuel and land use types within grid cells were computed in a geographical information system(GIS). Correlation analysis with modified t-test and regression tree analysis were performed to explore the influences of landscape variables on edge formation with avoiding spatial autocorrelation problems. The results indicated that edges formed at low elevations with mild slopes, high topographic wetness, and low solar radiation. Edges were unlikely to form in areas dominated by Japanese red pines at low elevations. Moreover, heterogeneous land use/cover types contributed significantly to edge formation. Different forest management strategies for different landscape conditions can be more effective for enhancing resilience of forests to fire. Reducing susceptible fuel types might be effective at low elevations, while enhancing forest heterogeneity might be more effective at high elevations.

基于T-S模糊神经网络的光伏发电机组自动控制

光照情况变化会使光伏发电机组功率呈现不稳定性,加大光伏发电机组控制难度,为此,设计了基于T-S模糊神经网络的光伏发电机组自动控制方法。构建光伏阵列数学模型,分析在均匀和不均匀2种光照情况下光伏发电机组特性曲线。以分析结果为依据,采用T-S模糊神经网络构建光伏发电机组自动控制模型。为保证良好的控制效果,引入定比因子优化隶属度函数,输出最佳跟踪结果,结合最佳跟踪结果和自动控制模型实现光伏发电机组自动控制。测试结果显示,该方法能够完成光伏阵列特性分析,控制效果好。

食管鳞癌组织中TIM-3、FOXA2表达与其临床病理特征及预后的关系研究

目的探讨食管鳞癌组织中T细胞免疫球蛋白黏蛋白分子3(TIM-3)、叉头框蛋白A2(FOXA2)表达与其临床病理特征及预后的关系。方法选取87例食管鳞癌患者(食管鳞癌组)、50例慢性食管炎患者(对照组)为研究对象。分别比较食管鳞癌组与对照组、不同临床病理特征食管鳞癌患者及不同预后食管鳞癌患者TIM-3、FOXA2表达;采用Kaplan-Meier生存曲线进行生存分析,应用Cox比例风险回归模型分析TIM-3、FOXA2表达与食管鳞癌预后的关系。结果食管鳞癌组TIM-3阳性表达率高于对照组,FOXA2阳性表达率低于对照组(P<0.05);不同TNM分期、有无淋巴结转移及不同浸润深度的食管鳞癌患者TIM-3、FOXA2表达比较,差异有统计学意义(P<0.05);食管鳞癌组随访期间生存68例,死亡19例,死亡患者TIM-3阳性表达率高于生存患者,FOXA2阳性表达率低于生存患者(P<0.05);Kaplan-Meier生存曲线显示,TIM-3、FOXA2阴性表达患者总生存率较阳性表达患者高(P<0.05);Cox单因素回归分析显示,TNM分期、淋巴结转移、浸润深度、TIM-3、FOXA2是影响食管鳞癌患者预后的危险因素(P<0.05);Cox多因素分析显示,TNM分期、淋巴结转移、TIM-3、FOXA2是影响食管鳞癌患者预后的独立危险因素(P<0.05)。结论食管鳞癌组织中存在TIM-3、FOXA2表达异常,且与TNM分期、淋巴结转移、浸润深度及预后密切相关。

血清sTim-3和Galectin-9对重症急性肾损伤患者连续肾脏替代治疗短期预后的评估价值

目的探讨血清可溶性T淋巴细胞免疫球蛋白黏蛋白分子-3(sTim-3)和半乳糖凝集素-9(Galectin-9)对重症急性肾损伤(AKI)患者连续肾脏替代治疗(CRRT)短期预后的评估价值。方法选取2021年3月—2023年3月收治的重症AKI 136例作为研究对象。根据重症AKI患者CRRT开始90 d内生存情况(短期预后),将病死患者纳入病死组(42例),存活患者纳入生存组(94例)。采用受试者工作特征(ROC)曲线评估血清sTim-3和Galectin-9对重症AKI患者CRRT短期预后预测价值,采用多因素Logistic回归分析探讨重症AKI患者CRRT短期预后影响因素。结果病死组血清sTim-3和Galectin-9均高于生存组(P<0.01);血清sTim-3和Galectin-9预测重症AKI患者CRRT短期预后的曲线下面积分别为0.762和0.847,二者联合预测的曲线下面积为0.914。多因素Logistic回归分析显示,sTim-3≥17.00 ng/L、Galectin-9≥4.00 ng/L、急性生理与慢性健康状况评分系统Ⅱ评分≥20分是重症AKI患者CRRT 90 d病死的危险因素(P<0.05,P<0.01)。结论血清sTim-3和Galectin-9升高与重症AKI患者CRRT短期预后不良密切相关,可作为评估重症AKI患者CRRT短期预后不良的生物学指标,且二者联合预测效能更高。