Caregiving in Alzheimer’s Disease: Research Designs &Considerations

Alzheimer’s disease and related dementias have made a considerable impact on society, and can take a significant toll on familial caregivers. Recent successful caregiving interventions suggest a promising future, though informed research design, a priori, is paramount in ensuring quality results that the Government and public may use to make informed policy and personal healthcare decisions. Research designs including basic science, randomized controlled trials (RCTs), qualitative, and quasi-experimental designs serve as the primary basis for discussion with literary examples and caveats.

Research and Design of Reconfigurable Matrix Multiplication over Finite Field in VLIW Processor

Matrix multiplication plays a pivotal role in the symmetric cipher algorithms, but it is one of the most complex and time consuming units, its performance directly affects the efficiency of cipher algorithms. Combined with the characteristics of VLIW processor and matrix multiplication of symmetric cipher algorithms, this paper extracted the reconfigurable elements and analyzed the principle of matrix multiplication, then designed the reconfigurable architecture of matrix multiplication of VLIW processor further, at last we put forward single instructions for matrix multiplication between 4×1 and 4×4 matrix or two 4×4 matrix over GF(2~8), through the instructions extension, the instructions could support larger dimension operations. The experiment shows that the instructions we designed supports different dimensions matrix multiplication and improves the processing speed of multiplication greatly.

Research and Design of IPv6 Network Management and Operations Support System

IPv6 is the foundation of the development of Next Generation Internet (NGI). An IPv6 network management and operations support system is necessary for real operable NGI. Presently there are no approved standards yet and relevant equipment interfaces are not perfect. A Network Management System (NMS) at the network layer helps implement the integrated management of a network with equipment from multiple vendors, including the network resources and topology, end-to-end network performance, network failures and customer Service Level Agreement (SLA) management. Though the NMS will finally realize pure IPv6 network management, it must be accommodated to the management of relevant IPv4 equipment. Therefore, modularized and layered structure is adopted for the NMS in order to implement its smooth transition.

Research on and Design of Mechanical System with Optimal Cutting Movement Trajectory of Energy-Saving Stone-Sawing Machine

The technique of cutting slabstone with stone-sawi ng machine is analyzed completely. A new kind of cutting movement trajectory is gi ven whose actual cutting efficiency is near to 100%. It can reduce the energy w earing greatly, and the surface quality of the product is improved to the utmost extent. The design mechanism of the optimal cutting movement trajectory system structure is analyzed incisively. At the same time, the principle of the complex movement of horizontal movement and swing is researched. The optimal design scheme of th e cutting movement trajectory system structure is set up. The choice method to g et the superior value of the movement system structure is found. The mathematics function formula is established which exhibits the relationship between the par ameter of the complex movement structure and that of the system movement structu re. By the formula, the precision value of the offset can be figured out. The r ule is adapted to different types of energy-saving stone-sawing machines. The complex movement structure of horizontal movement and swing is designed to f ulfill the cutting movement. It can make the saw frame move up with the hanging pod deviating from the vertical direction. At the same time, the saw frame have a down-movement. Then the sum of the two movements is near to zero, and the saw blade and the stone can keep in touch during the whole horizontal cutting. The result is that the actual cutting efficiency is 100%. Also, when the hanging pod moves to the limited position, the saw frame can keep the original inertia, and continue to swing up. It makes the back-cutting have high energy-storing. The optimal design of the eccentricity balance wheel is done. The mathematics fo rmula for expressing the movement system structure is deduced. The calculation m ethod and formula is set up which is used to get the value of important componen ts such as offset. The choice method and formula of elasticity distortion coeffi cient is set up when the saw frame moves smoothly. It is concluded that the offs et is the key dimension to actualize the optimal cutting movement trajectory. The resolving of the technical problems discussed above offers a theoretic and technical basis for optimal design of energy-saving stone-sawing machines.

Engineering Intelligent Racing Concepts Using Design Research Methods

The automotive seat market is positioned to significantly grow over the next five years. Research into how sensor implementation in every day driver cars can enhance driver wellness is becoming increasingly popular and visible in the automotive seat industry. However, in the competitive race car industry,?drivers prioritize driving ability over wellness. To further examine this phenomenon, the Human-Machine Interaction?Lab at the Georgia Institute of Technology took a unique approach to developing strong use cases for implementing sensor technology to improve driving ability for race car drivers by combining qualitative and quantitative research data obtained through modern design research and planning methodology. Following a process relying heavily on user-centered design methods, the authors developed a business case concept?for?a sensor-based seat accessory that acts as a competitive racer’s?driving coach?that is able to identify the mechanics of braking, turning, and accelerating through pressure sensors in the driver’s seat pan surface. This technology allows drivers to precisely understand when and how hard to brake, turn, or accelerate out of turns, thus reducing heat times and financial burden for drivers.

Neutronic design investigation of a liquid injection-based second shutdown system for a typical research reactor using MCNPX

Safety systems, built on state-of-the-art technology, are essential for achieving acceptable levels of plant safety to minimize hazards to the reactor and the general public. The second shutdown system(SSS) as an engineered safety feature and a part of the reactor protection system(RPS) is a means for rapidly shutting down a nuclear reactor, keeping it in a subcritical state and serving as a backup to the first shutdown system(FSS). In this research, one SSS with two types of optimum chamber designs is proposed that take into account the main current characteristic features of the Tehran research reactor with improvements over earlier designs. They are based on a liquid neutron absorber injection that is preferably different, diverse, and independent from the FSS based on the rod drop mechanism. The major design characteristics of this SSS with two different chambers were investigated using MCNPX 2.6.0 code. The performed calculations showed that the designed SSS is a reliable shutdown system, assuring an appropriate shutdown margin and injection time, with no significant effects on the effective delayed neutron fraction while causing minimal variations to the core structure. Further, the reasonable financial cost and the prolongation of the operation cycle are additional advantages of this design.

创新设计与实践课程研究性教学改革设计与实践

研究性教学是一种以培养学生研究意识、研究能力和创新能力为目标的教学模式。根据研究性教学的内涵,针对创新设计与实践课程特征,通过项目驱动、跨学科合作、实验与模拟教学等策略实施研究性教学。实践结果表明,该教学模式显著提高学生的知识应用能力和创新能力,为应用型高校培养高素质创新人才提供有效路径。

Research on Key Techniques of Collaborative Design System

The development of product is a complex process. Collaboration is necessary to this process to support multi-function teams’ participation in this process at the same time. Effective task decomposition is the prerequisite of collaborative design and constraint network was used to express the relationship among design participants. In order to make the coupling collaborative design go smoothly, a constraint satisfaction model based on dynamic constraint is put forward. An integrated-based conflict resolution model is advanced to resolve the complex conflict during the process of collaborative design.

冷链物流技术在车辆工程专业教学中融合渗透研究——以A大学为例

文章从农业院校工科人才培养出发,开展冷链物流技术与车辆工程专业教学融合渗透研究,拟提高科学研究对本科教学的支持,在兼顾专业培养目标的前提下培养乡村振兴相关人才。以《汽车构造》中汽车空调相关教学内容为例,分析了当前汽车空调课程教学现状,提出传热学、计算流体动力学方法等内容的融合思路。最后,通过“三位一体”教学设计,提升教学内容与科学研究的结合度,促进学生对课程内容的理解。研究结果将对农业院校人才培养及车辆工程教学改革起到一定作用。

面向创新能力培养的数字图像处理教学改革

数字图像处理课程具有理论难度大、实践性强、碎片化程度高、考核不充分的特点。为适应新工科建设要求,深化培养学生的创新能力,该文设计了理论与实践一体化教学改革方案,重构了教学内容,构建了理论融入式探索性作业和综合项目设计,通过全过程、多维度的方式来考核学生的综合能力。实践表明,该教学改革能显著激发学生兴趣,有效地培养了学生的综合创新能力,为学生从事数字图像处理领域的高阶研究和研发奠定了基础。

改进基本医疗(初级保健)研究报告内容的CRISP共识声明

基本医疗(初级保健)是一门独特的临床专业和研究学科,具有其自身的视角和方法。该领域的研究使用多种研究方法和研究设计来调查各种主题。基本医疗(初级保健)的多样性对其研究内容的报告提出了挑战,尽管已有大量报告指南问世,但没有一项指南专门针对基本医疗(初级保健)学科的需求而设。基本医疗(初级保健)研究报告内容的条目共识(CRISP)清单,旨在指导基本医疗(初级保健)研究的报告,包括提供基本医疗(初级保健)相关人群(从业者、患者和社区)所需的信息。CRISP清单完善了现有指南,有利于基本医疗(初级保健)研究结果的报告、传播和应用。先前的CRISP研究,探索了在该领域改善研究内容报告的可能性。工作组通过对国际化、跨学科和跨专业的基本医疗(初级保健)社区的调查,确定了基本医疗(初级保健)研究报告中需要包含的基本条目。工作组开展了一项包含两轮德尔菲的研究,对必要的条目达成了共识,并汇总成清单。CRISP清单包含24个条目,涵盖了基本医疗(初级保健)研究报告中的研究团队、患者、研究参与者、健康状况、临床接触、护理团队、干预、研究测量、照护环境,以及研究结果的实施等方面。并非全部条目都适用于每种研究设计或主题。CRISP指南为设计和报告以下三类研究提供了参考信息:(1)基本医疗(初级保健)研究人员开展的研究,(2)其他研究人员在基本医疗(初级保健)人群和环境中开展的研究,(3)旨在应用于基本医疗(初级保健)实践中的研究,从而改进对临床服务和研究过程背景的报告。这对于解释研究结果并将其应用于基本医疗(初级保健)的不同人群和环境至关重要。

Application of evidence-based medicine methods in integrative oncology research

To present the advances of evidence-based medicine and clinical research methodology in integrative oncology,we conducted a literature review of real-world studies of traditional Chinese medicine(TCM)in cancer care and summarized the available evidence.Pragmatic randomized controlled trials(pRCTs)and clinical registry studies are becoming more popular as they could compensate for the limitations of RCTs.Many RCTs of TCM for cancer treatment as well as systematic reviews have been published.The most investigated therapies are based on acupuncture,Chinese herbal compounds,and Chinese patent medicines.Acupuncture has a significant advantage in relieving cancer-related symptoms.Published studies focus more on improving clinical symptoms and laboratory indicators.However,the patient's quality of life deserves more attention.

Research on Distributed System Course Under the Background of New Engineering

Distributed System Course is a professional computer course of Harbin Institute of Technology.With the guidance of the education strategy under the background of New Engineering,we adhere to the concept of cultivating diverse and innovative outstanding engineering and technology talents.This course conducts research on the teaching content,teaching mode,and evaluation system.It combines the traditional teaching mode with the online teaching mode,as well as problem-driven theories with practice,and adopts a diversified evaluation system.The research of the course has fully mobilized students’learning enthusiasm,improved teaching quality,and achieved significant teaching results.

手持式电动绿篱修剪机的研究

针对绿篱修剪机目前的使用情况,设计了一种手持式电动绿篱修剪机。本文所设计的手持式电动绿篱修剪机是由220V电源驱动小型电动机、刀片高速旋转切割的新型电动绿篱修剪机,它可以代替小型汽油机驱动的绿篱修剪机。与其他修剪机相比轻便、效率高、无污染、振动轻、噪音低且价格便宜,可以实现连续、全方位的绿篱快速成形修剪,并且工作可靠、故障少,使用和维修方便。

Synoptic review on existing and potential sources for bias in dental research methodology with methods on their prevention and remedies

The results of years of dental study serve as the foundation for the practise of medicine and,for that matter,dentistry.Doctors may have their own preferences for techniques and materials,but whether directly or indirectly,their decisions are influenced by systematic reviews and meta-analyses.However,due to poorly conducted or presented research,this very basic foundation may not be reliable.Bias in research is one of several factors that might make study results or research itself unreliable.Bias can be introduced into research at many stages,deliberately or unknowingly.Bias can appear at any point during the research process,even before the study itself begins.There are many biases in research,but some of them are more relevant to dentistry research than others.Because it is said that“eyes see what the mind knows”,it is essential to have a complete understanding of the different types of bias,how and when they get entrenched,and what steps may be taken to prevent or lessen them if they do occur.This comprehensive summary of bias in dentistry research is provided by this synoptic review.The goal is to identify gaps and measures that have been taken-or that should have been taken-by providing both descriptive and evaluative summaries,as well as examples from the literature,when needed.

What are Different Research Approaches?Comprehensive Review of Qualitative,Quantitative,and Mixed Method Research,Their Applications,Types,and Limitations

There are different ways to examine and explain a study and its findings based on using numbers as a measure,a descriptive style,or a mixture of both.These three research approaches are quantitative,qualitative,and mixed methods that are commonly used by researchers in various research studies.However,with many options regarding the research design,it seems challenging for researchers to select the most appropriate approach based on the study and realize differences.This study provides a comprehensive review of qualitative,quantitative,and mixed-method research methods.Each method is clearly defined and specifically discussed based on applications,types,advantages,and limitations to help researchers identify select the most relevant type based on each study and navigate accordingly.

Incisional Negative Pressure Wound Therapy in the Prevention of Surgical Site Infection after Vascular Surgery with Inguinal Incisions: Rationale and Design of a Randomized Controlled Trial (INVIPS-Trial)

Background/Aims: Inguinal incisions are a common route of access in vascular surgery. Due to anatomical challenges and a diverse bacterial flora in this area, surgical site infections (SSI) represent a common, debilitating and sometimes life-threatening complication. The INVIPS-Trial evaluates the role of Negative Pressure Wound Therapy (NPWT) on closed inguinal incisions in elective vascular surgery to prevent SSI and other wound complications. Methods: This randomized controlled trial (RCT) registered at ClinicalTrials.gov (Identifier: NCT01913132) compares the effects of a NPWT dressing (PICO, Smith & Nephew, UK) and the center’s standard wound dressing (Vitri Pad, ViTri Medical, Sweden) on postoperative wound complications, especially SSI. The study includes two distinct vascular procedures with different SSI risk profiles: endovascular aortic repair (EVAR) and open surgical approaches involving the common femoral artery (OPEN). Results: Four hundred ninety-five groin incisions in both treatment arms are anticipated to be included in the EVAR group and 147 inguinal incisions in both treatment arms in the OPEN group. Since a large percentage of inguinal vascular procedures in both groups but especially in the EVAR group are performed bilaterally, many patients can serve as their own control by randomly receiving NPWT on one and the standard dressing on the contralateral inguinal incision. Conclusions: This ongoing RCT attempts to elucidate the potential benefit of NPWT on closed inguinal incisions after different vascular procedures. Outcome and conclusions of this trial could have implications on postoperative wound care of patients in both vascular surgery and other surgical specialties.

基于海绵城市理念的公路路面排水设计研究

海绵城市理念是通过自然积存、自然渗透的方式,恢复城市的自然水文循环,缓解城市排水压力。公路作为城市基础设施的重要组成部分,其路面排水设计对城市排水系统的有效性至关重要。在海绵城市理念的指导下,公路路面排水设计不仅要注重排水效率,还需兼顾生态环境的保护,以及水资源的循环利用。基于此,文章对海绵城市理念下的公路路面排水设计进行研究,以供参考。

设计研究发展与热点分析——以Design Studies期刊于2007—2021年发表的论文为例

为更好地了解设计研究领域的发展趋势,掌握设计研究过程的前沿热点,以Web of Science数据库收录的核心期刊Design Studies于2007—2021年发表的论文为例,利用文献计量法和VOSviewer可视化工具对发文国家、文献共被引、研究机构、高产作者、高频关键词等方面进行分析。结果表明:设计研究领域发展脉络清晰,英国、美国占据主导地位。近年来的研究热点聚焦于设计实践方法、设计交互理念、设计成果评估与设计解决方案创新等方面;而设计方法开发、设计灵感来源及未来服务设计等主题已成为该领域的研究前沿。结合当前国内设计研究领域发展现状,中国学者需适当兼顾国际期刊发表规律,积极促进与设计过程相关的理论开发与应用,在该领域发出更多“中国声音”。

数字媒体技术与动画设计研究

当前数字化、信息化高速发展的时代背景下,数字媒体技术与动画设计的深度融合已成为艺术与科技交融的典范,正迅速改变着人们的生活方式及审美价值取向。本文旨在深入剖析数字媒体技术在动画设计领域的广泛应用,以揭示其深刻影响。