On the basis of continuous improvement in recent years,radiofrequency therapy technology has been widely developed,and has become an effective method for the treatment of various intractable pain.Radiofrequency therap...On the basis of continuous improvement in recent years,radiofrequency therapy technology has been widely developed,and has become an effective method for the treatment of various intractable pain.Radiofrequency therapy is a technique that uses special equipment and puncture needles to output ultra-high frequency radio waves and accurately act on local tissues.In order to standardize the application of radiofrequency technology in the treatment of painful diseases,Chinese Association for the Study of Pain(CASP)has developed a consensus proposed by many domestic experts and scholars.展开更多
BACKGROUND According to the World Health Organization analgesic ladder,cancer-related pain generally begins with pharmacotherapy in a stepwise approach.Nevertheless,some patients continue to experience poorly controll...BACKGROUND According to the World Health Organization analgesic ladder,cancer-related pain generally begins with pharmacotherapy in a stepwise approach.Nevertheless,some patients continue to experience poorly controlled pain despite medications,particularly when considering adverse effects and self-care quality.Percutaneous cervical cordotomy is an alternative interventional procedure for unremitting unilateral intractable cancer-related pain.CASE SUMMARY The patient was diagnosed with lung cancer with destruction of the brachial plexus and ribs.For 2 mo,the patient experienced progressive severe weakness and pain in the right upper extremity.Notably,the pain intensity reached an extreme level,particularly when lying supine,even under heavy sedation.This heightened pain response posed a significant challenge;as a result,the patient was unable to undergo further evaluation through magnetic resonance imaging.Ultimately,he underwent percutaneous cervical cordotomy for symptom relief,resulting in complete resolution of right arm pain.After a 3-mo follow-up,the pain did not recur,and only a flurbiprofen local patch was required for mild scapular tightness.CONCLUSION Cordotomy,under careful patient selection,appears to enhance the quality of life of patients with unilateral cancerrelated pain.展开更多
Background and aims:Hepatocellular carcinoma(HCC)is one of the most prevalent and lethal forms of cancer,posing challenges to standard treatment methods.Radiofrequency ablation(RFA)has emerged as a valuable technique ...Background and aims:Hepatocellular carcinoma(HCC)is one of the most prevalent and lethal forms of cancer,posing challenges to standard treatment methods.Radiofrequency ablation(RFA)has emerged as a valuable technique for the local control of advanced HCC,especially in cases unsuitable for surgical resection.Paratoluenesulfonamide(PTS)has demonstrated antitumor properties in various cancers,yet its efficacy against HCC remains underexplored.The present study aims to investigate the therapeutic potential of PTS in HCC and examine potential synergistic effects with RFA.Methods:PTS was injected directly into subcutaneous tumor tissues and its effects on cell survival,gene expression,and metabolic activity in HCC cells were evaluated.The effect of PTS and RFA in combination on HCC growth was examined using a nude mouse model of subcutaneous HCC.Data were visualized using heat maps.Results:PTS inhibited the survival of HCC cells in a dose-dependent manner,modulating the expression of key genes related to cell survival,apoptosis,epithelial–mesenchymal transition,and proliferation.The combination of PTS and RFA markedly enhanced the inhibition of HCC tumor growth and induced alterations in cellular metabolism.Conclusion:Combining PTS and RFA may be a promising approach to improve the efficacy of HCC treatment.展开更多
文摘On the basis of continuous improvement in recent years,radiofrequency therapy technology has been widely developed,and has become an effective method for the treatment of various intractable pain.Radiofrequency therapy is a technique that uses special equipment and puncture needles to output ultra-high frequency radio waves and accurately act on local tissues.In order to standardize the application of radiofrequency technology in the treatment of painful diseases,Chinese Association for the Study of Pain(CASP)has developed a consensus proposed by many domestic experts and scholars.
文摘BACKGROUND According to the World Health Organization analgesic ladder,cancer-related pain generally begins with pharmacotherapy in a stepwise approach.Nevertheless,some patients continue to experience poorly controlled pain despite medications,particularly when considering adverse effects and self-care quality.Percutaneous cervical cordotomy is an alternative interventional procedure for unremitting unilateral intractable cancer-related pain.CASE SUMMARY The patient was diagnosed with lung cancer with destruction of the brachial plexus and ribs.For 2 mo,the patient experienced progressive severe weakness and pain in the right upper extremity.Notably,the pain intensity reached an extreme level,particularly when lying supine,even under heavy sedation.This heightened pain response posed a significant challenge;as a result,the patient was unable to undergo further evaluation through magnetic resonance imaging.Ultimately,he underwent percutaneous cervical cordotomy for symptom relief,resulting in complete resolution of right arm pain.After a 3-mo follow-up,the pain did not recur,and only a flurbiprofen local patch was required for mild scapular tightness.CONCLUSION Cordotomy,under careful patient selection,appears to enhance the quality of life of patients with unilateral cancerrelated pain.
基金supported by the National Natural Science Foundation of China[No.81572461].
文摘Background and aims:Hepatocellular carcinoma(HCC)is one of the most prevalent and lethal forms of cancer,posing challenges to standard treatment methods.Radiofrequency ablation(RFA)has emerged as a valuable technique for the local control of advanced HCC,especially in cases unsuitable for surgical resection.Paratoluenesulfonamide(PTS)has demonstrated antitumor properties in various cancers,yet its efficacy against HCC remains underexplored.The present study aims to investigate the therapeutic potential of PTS in HCC and examine potential synergistic effects with RFA.Methods:PTS was injected directly into subcutaneous tumor tissues and its effects on cell survival,gene expression,and metabolic activity in HCC cells were evaluated.The effect of PTS and RFA in combination on HCC growth was examined using a nude mouse model of subcutaneous HCC.Data were visualized using heat maps.Results:PTS inhibited the survival of HCC cells in a dose-dependent manner,modulating the expression of key genes related to cell survival,apoptosis,epithelial–mesenchymal transition,and proliferation.The combination of PTS and RFA markedly enhanced the inhibition of HCC tumor growth and induced alterations in cellular metabolism.Conclusion:Combining PTS and RFA may be a promising approach to improve the efficacy of HCC treatment.
