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Detecting XSS with Random Forest and Multi-Channel Feature Extraction
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作者 Qiurong Qin Yueqin Li +3 位作者 Yajie Mi Jinhui Shen Kexin Wu Zhenzhao Wang 《Computers, Materials & Continua》 SCIE EI 2024年第7期843-874,共32页
In the era of the Internet,widely used web applications have become the target of hacker attacks because they contain a large amount of personal information.Among these vulnerabilities,stealing private data through cr... In the era of the Internet,widely used web applications have become the target of hacker attacks because they contain a large amount of personal information.Among these vulnerabilities,stealing private data through crosssite scripting(XSS)attacks is one of the most commonly used attacks by hackers.Currently,deep learning-based XSS attack detection methods have good application prospects;however,they suffer from problems such as being prone to overfitting,a high false alarm rate,and low accuracy.To address these issues,we propose a multi-stage feature extraction and fusion model for XSS detection based on Random Forest feature enhancement.The model utilizes RandomForests to capture the intrinsic structure and patterns of the data by extracting leaf node indices as features,which are subsequentlymergedwith the original data features to forma feature setwith richer information content.Further feature extraction is conducted through three parallel channels.Channel I utilizes parallel onedimensional convolutional layers(1Dconvolutional layers)with different convolutional kernel sizes to extract local features at different scales and performmulti-scale feature fusion;Channel II employsmaximum one-dimensional pooling layers(max 1D pooling layers)of various sizes to extract key features from the data;and Channel III extracts global information bi-directionally using a Bi-Directional Long-Short TermMemory Network(Bi-LSTM)and incorporates a multi-head attention mechanism to enhance global features.Finally,effective classification and prediction of XSS are performed by fusing the features of the three channels.To test the effectiveness of the model,we conduct experiments on six datasets.We achieve an accuracy of 100%on the UNSW-NB15 dataset and 99.99%on the CICIDS2017 dataset,which is higher than that of the existing models. 展开更多
关键词 random forest feature enhancement three-channel parallelism XSS detection
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Piezo1 channel exaggerates ferroptosis of nucleus pulposus cells by mediating mechanical stress-induced iron influx 被引量:1
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作者 Ziqian Xiang Pengfei Zhang +15 位作者 Chunwang Jia Rongkun Xu Dingren Cao Zhaoning Xu Tingting Lu Jingwei Liu Xiaoxiong Wang Cheng Qiu Wenyang Fu Weiwei Li Lei Cheng Qiang Yang Shiqing Feng Lianlei Wang Yunpeng Zhao Xinyu Liu 《Bone Research》 SCIE CAS CSCD 2024年第2期334-348,共15页
To date,several molecules have been found to facilitate iron influx,while the types of iron influx channels remain to be elucidated.Here,Piezo1 channel was identified as a key iron transporter in response to mechanica... To date,several molecules have been found to facilitate iron influx,while the types of iron influx channels remain to be elucidated.Here,Piezo1 channel was identified as a key iron transporter in response to mechanical stress.Piezo1-mediated iron overload disturbed iron metabolism and exaggerated ferroptosis in nucleus pulposus cells(NPCs).Importantly,Piezo1-induced iron influx was independent of the transferrin receptor(TFRC),a well-recognized iron gatekeeper.Furthermore,pharmacological inactivation of Piezo1 profoundly reduced iron accumulation,alleviated mitochondrial ROS,and suppressed ferroptotic alterations in stimulation of mechanical stress.Moreover,conditional knockout of Piezo1(Col2a1-CreERT Piezo1^(flox/flox))attenuated the mechanical injury-induced intervertebral disc degeneration(IVDD).Notably,the protective effect of Piezo1 deficiency in IVDD was dampened in Piezo1/Gpx4 conditional double knockout(cDKO)mice(Col2a1-CreERT Piezo1^(flox/flox)/Gpx4^(flox/flox)).These findings suggest that Piezo1 is a potential determinant of iron influx,indicating that the Piezo1-iron-ferroptosis axis might shed light on the treatment of mechanical stress-induced diseases. 展开更多
关键词 STRESS OVERLOAD channel
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Theoretical and experimental study of a bi-stable piezoelectric energy harvester under hybrid galloping and band-limited random excitations 被引量:1
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作者 Haitao LI Tianyu ZHENG +4 位作者 Weiyang QIN Ruilan TIAN Hu DING J.C.JI Liqun CHEN 《Applied Mathematics and Mechanics(English Edition)》 SCIE EI CSCD 2024年第3期461-478,共18页
In the practical environment,it is very common for the simultaneous occurrence of base excitation and crosswind.Scavenging the combined energy of vibration and wind with a single energy harvesting structure is fascina... In the practical environment,it is very common for the simultaneous occurrence of base excitation and crosswind.Scavenging the combined energy of vibration and wind with a single energy harvesting structure is fascinating.For this purpose,the effects of the wind speed and random excitation level are investigated with the stochastic averaging method(SAM)based on the energy envelope.The results of the analytical prediction are verified with the Monte-Carlo method(MCM).The numerical simulation shows that the introduction of wind can reduce the critical excitation level for triggering an inter-well jump and make a bi-stable energy harvester(BEH)realize the performance enhancement for a weak base excitation.However,as the strength of the wind increases to a particular level,the influence of the random base excitation on the dynamic responses is weakened,and the system exhibits a periodic galloping response.A comparison between a BEH and a linear energy harvester(LEH)indicates that the BEH demonstrates inferior performance for high-speed wind.Relevant experiments are conducted to investigate the validity of the theoretical prediction and numerical simulation.The experimental findings also show that strong random excitation is favorable for the BEH in the range of low wind speeds.However,as the speed of the incoming wind is up to a particular level,the disadvantage of the BEH becomes clear and evident. 展开更多
关键词 bi-stability inter-well response GALLOPING band-limited random
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Lithium-Ion Charged Polymer Channels Flattening Lithium Metal Anode 被引量:2
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作者 Haofan Duan Yu You +11 位作者 Gang Wang Xiangze Ou Jin Wen Qiao Huang Pengbo Lyu Yaru Liang Qingyu Li Jianyu Huang Yun‑Xiao Wang Hua‑Kun Liu Shi Xue Dou Wei‑Hong Lai 《Nano-Micro Letters》 SCIE EI CAS CSCD 2024年第4期379-393,共15页
The concentration difference in the near-surface region of lithium metal is the main cause of lithium dendrite growth.Resolving this issue will be key to achieving high-performance lithium metal batteries(LMBs).Herein... The concentration difference in the near-surface region of lithium metal is the main cause of lithium dendrite growth.Resolving this issue will be key to achieving high-performance lithium metal batteries(LMBs).Herein,we construct a lithium nitrate(LiNO_(3))-implanted electroactiveβphase polyvinylidene fluoride-co-hexafluoropropylene(PVDF-HFP)crystalline polymorph layer(PHL).The electronegatively charged polymer chains attain lithium ions on the surface to form lithium-ion charged channels.These channels act as reservoirs to sustainably release Li ions to recompense the ionic flux of electrolytes,decreasing the growth of lithium dendrites.The stretched molecular channels can also accelerate the transport of Li ions.The combined effects enable a high Coulombic efficiency of 97.0%for 250 cycles in lithium(Li)||copper(Cu)cell and a stable symmetric plating/stripping behavior over 2000 h at 3 mA cm^(-2)with ultrahigh Li utilization of 50%.Furthermore,the full cell coupled with PHL-Cu@Li anode and Li Fe PO_(4) cathode exhibits long-term cycle stability with high-capacity retention of 95.9%after 900 cycles.Impressively,the full cell paired with LiNi_(0.87)Co_(0.1)Mn_(0.03)O_(2)maintains a discharge capacity of 170.0 mAh g^(-1)with a capacity retention of 84.3%after 100 cycles even under harsh condition of ultralow N/P ratio of 0.83.This facile strategy will widen the potential application of LiNO_(3)in ester-based electrolyte for practical high-voltage LMBs. 展开更多
关键词 Polymer ionic channel Li metal batteries Artificial protective layer Uniform Li deposition Electrochemical performances
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Deep learning for joint channel estimation and feedback in massive MIMO systems 被引量:1
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作者 Jiajia Guo Tong Chen +3 位作者 Shi Jin Geoffrey Ye Li Xin Wang Xiaolin Hou 《Digital Communications and Networks》 SCIE CSCD 2024年第1期83-93,共11页
The great potentials of massive Multiple-Input Multiple-Output(MIMO)in Frequency Division Duplex(FDD)mode can be fully exploited when the downlink Channel State Information(CSI)is available at base stations.However,th... The great potentials of massive Multiple-Input Multiple-Output(MIMO)in Frequency Division Duplex(FDD)mode can be fully exploited when the downlink Channel State Information(CSI)is available at base stations.However,the accurate CsI is difficult to obtain due to the large amount of feedback overhead caused by massive antennas.In this paper,we propose a deep learning based joint channel estimation and feedback framework,which comprehensively realizes the estimation,compression,and reconstruction of downlink channels in FDD massive MIMO systems.Two networks are constructed to perform estimation and feedback explicitly and implicitly.The explicit network adopts a multi-Signal-to-Noise-Ratios(SNRs)technique to obtain a single trained channel estimation subnet that works well with different SNRs and employs a deep residual network to reconstruct the channels,while the implicit network directly compresses pilots and sends them back to reduce network parameters.Quantization module is also designed to generate data-bearing bitstreams.Simulation results show that the two proposed networks exhibit excellent performance of reconstruction and are robust to different environments and quantization errors. 展开更多
关键词 channel estimation CSI feedback Deep learning Massive MIMO FDD
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Channel Correlation Based User Grouping Algorithm for Nonlinear Precoding Satellite Communication System 被引量:1
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作者 Ke Wang Baorui Feng +5 位作者 Jingui Zhao Wenliang Lin Zhongliang Deng Dongdong Wang Yi Cen Genan Wu 《China Communications》 SCIE CSCD 2024年第1期200-214,共15页
Low Earth Orbit(LEO)multibeam satellites will be widely used in the next generation of satellite communication systems,whose inter-beam interference will inevitably limit the performance of the whole system.Nonlinear ... Low Earth Orbit(LEO)multibeam satellites will be widely used in the next generation of satellite communication systems,whose inter-beam interference will inevitably limit the performance of the whole system.Nonlinear precoding such as Tomlinson-Harashima precoding(THP)algorithm has been proved to be a promising technology to solve this problem,which has smaller noise amplification effect compared with linear precoding.However,the similarity of different user channels(defined as channel correlation)will degrade the performance of THP algorithm.In this paper,we qualitatively analyze the inter-beam interference in the whole process of LEO satellite over a specific coverage area,and the impact of channel correlation on Signal-to-Noise Ratio(SNR)of receivers when THP is applied.One user grouping algorithm is proposed based on the analysis of channel correlation,which could decrease the number of users with high channel correlation in each precoding group,thus improve the performance of THP.Furthermore,our algorithm is designed under the premise of co-frequency deployment and orthogonal frequency division multiplexing(OFDM),which leads to more users under severe inter-beam interference compared to the existing research on geostationary orbit satellites broadcasting systems.Simulation results show that the proposed user grouping algorithm possesses higher channel capacity and better bit error rate(BER)performance in high SNR conditions relative to existing works. 展开更多
关键词 channel correlation inter-beam interference multibeam satellite Tomlinson-Harashima precoding user grouping
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Two-Staged Method for Ice Channel Identification Based on Image Segmentation and Corner Point Regression 被引量:1
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作者 DONG Wen-bo ZHOU Li +2 位作者 DING Shi-feng WANG Ai-ming CAI Jin-yan 《China Ocean Engineering》 SCIE EI CSCD 2024年第2期313-325,共13页
Identification of the ice channel is the basic technology for developing intelligent ships in ice-covered waters,which is important to ensure the safety and economy of navigation.In the Arctic,merchant ships with low ... Identification of the ice channel is the basic technology for developing intelligent ships in ice-covered waters,which is important to ensure the safety and economy of navigation.In the Arctic,merchant ships with low ice class often navigate in channels opened up by icebreakers.Navigation in the ice channel often depends on good maneuverability skills and abundant experience from the captain to a large extent.The ship may get stuck if steered into ice fields off the channel.Under this circumstance,it is very important to study how to identify the boundary lines of ice channels with a reliable method.In this paper,a two-staged ice channel identification method is developed based on image segmentation and corner point regression.The first stage employs the image segmentation method to extract channel regions.In the second stage,an intelligent corner regression network is proposed to extract the channel boundary lines from the channel region.A non-intelligent angle-based filtering and clustering method is proposed and compared with corner point regression network.The training and evaluation of the segmentation method and corner regression network are carried out on the synthetic and real ice channel dataset.The evaluation results show that the accuracy of the method using the corner point regression network in the second stage is achieved as high as 73.33%on the synthetic ice channel dataset and 70.66%on the real ice channel dataset,and the processing speed can reach up to 14.58frames per second. 展开更多
关键词 ice channel ship navigation IDENTIFICATION image segmentation corner point regression
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Influence of variable viscosity and double diffusion on the convective stability of a nanofluid flow in an inclined porous channel 被引量:1
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作者 N.HUMNEKAR D.SRINIVASACHARYA 《Applied Mathematics and Mechanics(English Edition)》 SCIE EI CSCD 2024年第3期563-580,共18页
The influence of variable viscosity and double diffusion on the convective stability of a nanofluid flow in an inclined porous channel is investigated.The DarcyBrinkman model is used to characterize the fluid flow dyn... The influence of variable viscosity and double diffusion on the convective stability of a nanofluid flow in an inclined porous channel is investigated.The DarcyBrinkman model is used to characterize the fluid flow dynamics in porous materials.The analytical solutions are obtained for the unidirectional and completely developed flow.Based on a normal mode analysis,the generalized eigenvalue problem under a perturbed state is solved.The eigenvalue problem is then solved by the spectral method.Finally,the critical Rayleigh number with the corresponding wavenumber is evaluated at the assigned values of the other flow-governing parameters.The results show that increasing the Darcy number,the Lewis number,the Dufour parameter,or the Soret parameter increases the stability of the system,whereas increasing the inclination angle of the channel destabilizes the flow.Besides,the flow is the most unstable when the channel is vertically oriented. 展开更多
关键词 NANOFLUID inclined channel variable viscosity linear stability double dif-fusion porous medium
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Research progress on the water vapor channel within the Yarlung Zsangbo Grand Canyon, China 被引量:1
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作者 Xuelong Chen Yajing Liu +9 位作者 Yaoming Ma Xiangde Xu Xin Xu Luhan Li Dianbin Cao Qiang Zhang Gaili Wang Maoshan Li Siqiong Luo Xin Wang 《Atmospheric and Oceanic Science Letters》 CSCD 2024年第5期10-15,共6页
The Second Tibetan Plateau Scientific Expedition and Research Program tasked a research team with the“Investigation of the water vapor channel of the Yarlung Zsangbo Grand Canyon(INVC)”in the southeastern Tibetan Pl... The Second Tibetan Plateau Scientific Expedition and Research Program tasked a research team with the“Investigation of the water vapor channel of the Yarlung Zsangbo Grand Canyon(INVC)”in the southeastern Tibetan Plateau(TP).This paper summarizes the scientific achievements obtained from the data collected by the INVC observation network and highlights the progress in investigating the development of heavy rainfall events associated with water vapor changes.The rain gauge network of the INVC can represent the impacts of the Yarlung Zsangbo Grand Canyon(YGC)topography on precipitation at the hourly scale.The microphysical characteristics of the precipitation in the YGC are different than those in the lowland area.The GPM-IMERG(Integrated MultisatellitE Retrievals for Global Precipitation Measurement)satellite precipitation data for the YGC region should be calibrated before they are used.The meridional water vapor flux through the YGC is more important than the zonal flux for the precipitation over the southeastern TP.The decreased precipitation around the YGC region is partly due to the decreased meridional water vapor flux passing through the YGC.High-resolution numerical models can benefit precipitation forecasting in this region by using a combination of specific schemes that capture the valley wind and water vapor flux along the valley floor. 展开更多
关键词 Water vapor channel Land-air interaction Mountian meteorology Extreme rainfall Observation network
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Cascaded ELM-Based Joint Frame Synchronization and Channel Estimation over Rician Fading Channel with Hardware Imperfections 被引量:1
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作者 Qing Chaojin Rao Chuangui +2 位作者 Yang Na Tang Shuhai Wang Jiafan 《China Communications》 SCIE CSCD 2024年第6期87-102,共16页
Due to the interdependency of frame synchronization(FS)and channel estimation(CE),joint FS and CE(JFSCE)schemes are proposed to enhance their functionalities and therefore boost the overall performance of wireless com... Due to the interdependency of frame synchronization(FS)and channel estimation(CE),joint FS and CE(JFSCE)schemes are proposed to enhance their functionalities and therefore boost the overall performance of wireless communication systems.Although traditional JFSCE schemes alleviate the influence between FS and CE,they show deficiencies in dealing with hardware imperfection(HI)and deterministic line-of-sight(LOS)path.To tackle this challenge,we proposed a cascaded ELM-based JFSCE to alleviate the influence of HI in the scenario of the Rician fading channel.Specifically,the conventional JFSCE method is first employed to extract the initial features,and thus forms the non-Neural Network(NN)solutions for FS and CE,respectively.Then,the ELMbased networks,named FS-NET and CE-NET,are cascaded to capture the NN solutions of FS and CE.Simulation and analysis results show that,compared with the conventional JFSCE methods,the proposed cascaded ELM-based JFSCE significantly reduces the error probability of FS and the normalized mean square error(NMSE)of CE,even against the impacts of parameter variations. 展开更多
关键词 channel estimation extreme learning machine frame synchronization hardware imperfection nonlinear distortion synchronization metric
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Transient receptor potential channels as predictive marker and potential indicator of chemoresistance in colon cancer 被引量:1
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作者 WEI HU THOMAS WARTMANN +5 位作者 MARCO STRECKER ARISTOTELIS PERRAKIS ROLAND CRONER ARPAD SZALLASI WENJIE SHI ULF D.KAHLERT 《Oncology Research》 SCIE 2024年第1期227-239,共13页
Transient receptor potential(TRP)channels are strongly associated with colon cancer development and progression.This study leveraged a multivariate Cox regression model on publicly available datasets to construct a TR... Transient receptor potential(TRP)channels are strongly associated with colon cancer development and progression.This study leveraged a multivariate Cox regression model on publicly available datasets to construct a TRP channels-associated gene signature,with further validation of signature in real world samples from our hospital treated patient samples.Kaplan-Meier(K-M)survival analysis and receiver operating characteristic(ROC)curves were employed to evaluate this gene signature’s predictive accuracy and robustness in both training and testing cohorts,respectively.Additionally,the study utilized the CIBERSORT algorithm and single-sample gene set enrichment analysis to explore the signature’s immune infiltration landscape and underlying functional implications.The support vector machine algorithm was applied to evaluate the signature’s potential in predicting chemotherapy outcomes.The findings unveiled a novel three TRP channels-related gene signature(MCOLN1,TRPM5,and TRPV4)in colon adenocarcinoma(COAD).The ROC and K-M survival curves in the training dataset(AUC=0.761;p=1.58e-05)and testing dataset(AUC=0.699;p=0.004)showed the signature’s robust predictive capability for the overall survival of COAD patients.Analysis of the immune infiltration landscape associated with the signature revealed higher immune infiltration,especially an increased presence of M2 macrophages,in high-risk group patients compared to their low-risk counterparts.High-risk score patients also exhibited potential responsiveness to immune checkpoint inhibitor therapy,evident through increased CD86 and PD-1 expression profiles.Moreover,the TRPM5 gene within the signature was highly expressed in the chemoresistance group(p=0.00095)and associated with poor prognosis(p=0.036)in COAD patients,highlighting its role as a hub gene of chemoresistance.Ultimately,this signature emerged as an independent prognosis factor for COAD patients(p=6.48e-06)and expression of model gene are validated by public data and real-world patients.Overall,this bioinformatics study provides valuable insights into the prognostic implications and potential chemotherapy resistance mechanisms associated with TRPs-related genes in colon cancer. 展开更多
关键词 Colon cancer Transient receptor potential channels Prognostic signature Chemotherapy efficiency TRPM5
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Immune cell signatures and causal association with irritable bowel syndrome:A mendelian randomization study 被引量:1
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作者 Wei-Hao Chai Yan Ma +3 位作者 Jia-Jia Li Fei Guo Yi-Zhan Wu Jiang-Wei Liu 《World Journal of Clinical Cases》 SCIE 2024年第17期3094-3104,共11页
BACKGROUND The mucosal barrier's immune-brain interactions,pivotal for neural development and function,are increasingly recognized for their potential causal and therapeutic relevance to irritable bowel syndrome(I... BACKGROUND The mucosal barrier's immune-brain interactions,pivotal for neural development and function,are increasingly recognized for their potential causal and therapeutic relevance to irritable bowel syndrome(IBS).Prior studies linking immune inflammation with IBS have been inconsistent.To further elucidate this relationship,we conducted a Mendelian randomization(MR)analysis of 731 immune cell markers to dissect the influence of various immune phenotypes on IBS.Our goal was to deepen our understanding of the disrupted brain-gut axis in IBS and to identify novel therapeutic targets.AIM To leverage publicly available data to perform MR analysis on 731 immune cell markers and explore their impact on IBS.We aimed to uncover immunophenotypic associations with IBS that could inform future drug development and therapeutic strategies.METHODS We performed a comprehensive two-sample MR analysis to evaluate the causal relationship between immune cell markers and IBS.By utilizing genetic data from public databases,we examined the causal associations between 731 immune cell markers,encompassing median fluorescence intensity,relative cell abundance,absolute cell count,and morphological parameters,with IBS susceptibility.Sensitivity analyses were conducted to validate our findings and address potential heterogeneity and pleiotropy.RESULTS Bidirectional false discovery rate correction indicated no significant influence of IBS on immunophenotypes.However,our analysis revealed a causal impact of IBS on 30 out of 731 immune phenotypes(P<0.05).Nine immune phenotypes demonstrated a protective effect against IBS[inverse variance weighting(IVW)<0.05,odd ratio(OR)<1],while 21 others were associated with an increased risk of IBS onset(IVW≥0.05,OR≥1).CONCLUSION Our findings underscore a substantial genetic correlation between immune cell phenotypes and IBS,providing valuable insights into the pathophysiology of the condition.These results pave the way for the development of more precise biomarkers and targeted therapies for IBS.Furthermore,this research enriches our comprehension of immune cell roles in IBS pathogenesis,offering a foundation for more effective,personalized treatment approaches.These advancements hold promise for improving IBS patient quality of life and reducing the disease burden on individuals and their families. 展开更多
关键词 Irritable bowel syndrome Immunophenotypes CAUSALITY Brain-gut axis Mendelian randomization Sensitivity analysis
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Causal associations between gastroesophageal reflux disease and essential hypertension: A bidirectional Mendelian randomization study 被引量:1
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作者 Ning Wei Ming-Hui Liu Yu-Hu Song 《World Journal of Clinical Cases》 SCIE 2024年第5期880-890,共11页
BACKGROUND Clinical studies have reported that patients with gastroesophageal reflux disease(GERD)have a higher prevalence of hypertension.AIM To performed a bidirectional Mendelian randomization(MR)analysis to invest... BACKGROUND Clinical studies have reported that patients with gastroesophageal reflux disease(GERD)have a higher prevalence of hypertension.AIM To performed a bidirectional Mendelian randomization(MR)analysis to investi-gate the causal link between GERD and essential hypertension.METHODS Eligible single nucleotide polymorphisms(SNPs)were selected,and weighted median,inverse variance weighted(IVW)as well as MR egger(MR-Egger)re-gression were used to examine the potential causal association between GERD and hypertension.The MR-Pleiotropy RESidual Sum and Outlier analysis was used to detect and attempt to reduce horizontal pleiotropy by removing outliers SNPs.The MR-Egger intercept test,Cochran’s Q test and“leave-one-out”sen-sitivity analysis were performed to evaluate the horizontal pleiotropy,heterogen-eities,and stability of single instrumental variable.RESULTS IVW analysis exhibited an increased risk of hypertension(OR=1.46,95%CI:1.33-1.59,P=2.14E-16)in GERD patients.And the same result was obtained in replication practice(OR=1.002,95%CI:1.0008-1.003,P=0.000498).Meanwhile,the IVW analysis showed an increased risk of systolic blood pressure(β=0.78,95%CI:0.11-1.44,P=0.021)and hypertensive heart disease(OR=1.68,95%CI:1.36-2.08,P=0.0000016)in GERD patients.Moreover,we found an decreased risk of Barrett's esophagus(OR=0.91,95%CI:0.83-0.99,P=0.043)in essential hypertension patients.CONCLUSION We found that GERD would increase the risk of essential hypertension,which provided a novel prevent and therapeutic perspectives of essential hypertension. 展开更多
关键词 Gastroesophageal reflux disease Essential hypertension Hypertensive heart disease Mendelian randomization study
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Genetically predicted fatty liver disease and risk of psychiatric disorders: A mendelian randomization study 被引量:1
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作者 Wei-Ming Xu Hai-Fu Zhang +2 位作者 Yong-Hang Feng Shuo-Jun Li Bi-Yun Xie 《World Journal of Clinical Cases》 SCIE 2024年第14期2359-2369,共11页
BACKGROUND Non-alcoholic fatty liver disease(NAFLD)and alcohol-related liver disease(Ar-LD)constitute the primary forms of chronic liver disease,and their incidence is progressively increasing with changes in lifestyl... BACKGROUND Non-alcoholic fatty liver disease(NAFLD)and alcohol-related liver disease(Ar-LD)constitute the primary forms of chronic liver disease,and their incidence is progressively increasing with changes in lifestyle habits.Earlier studies have do-cumented a correlation between the occurrence and development of prevalent mental disorders and fatty liver.AIM To investigate the correlation between fatty liver and mental disorders,thus ne-cessitating the implementation of a mendelian randomization(MR)study to elu-cidate this association.METHODS Data on NAFLD and ArLD were retrieved from the genome-wide association studies catalog,while information on mental disorders,including Alzheimer's disease,schizophrenia,anxiety disorder,attention deficit hyperactivity disorder(ADHD),bipolar disorder,major depressive disorder,multiple personality dis-order,obsessive-compulsive disorder(OCD),post-traumatic stress disorder(PTSD),and schizophrenia was acquired from the psychiatric genomics consor-tium.A two-sample MR method was applied to investigate mediators in signifi-cant associations.RESULTS After excluding weak instrumental variables,a causal relationship was identified between fatty liver disease and the occurrence and development of some psychia-tric disorders.Specifically,the findings indicated that ArLD was associated with a significantly elevated risk of developing ADHD(OR:5.81,95%CI:5.59-6.03,P<0.01),bipolar disorder(OR:5.73,95%CI:5.42-6.05,P=0.03),OCD(OR:6.42,95%CI:5.60-7.36,P<0.01),and PTSD(OR:5.66,95%CI:5.33-6.01,P<0.01).Meanwhile,NAFLD significantly increased the risk of developing bipolar disorder(OR:55.08,95%CI:3.59-845.51,P<0.01),OCD(OR:61.50,95%CI:6.69-565.45,P<0.01),and PTSD(OR:52.09,95%CI:4.24-639.32,P<0.01).CONCLUSION Associations were found between genetic predisposition to fatty liver disease and an increased risk of a broad range of psychiatric disorders,namely bipolar disorder,OCD,and PTSD,highlighting the significance of preven-tive measures against psychiatric disorders in patients with fatty liver disease. 展开更多
关键词 Non-alcoholic fatty liver disease Alcohol-related liver disease Psychiatric disorders Mendelian randomization Single nucleotide polymorphisms
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一种基于KMeans与Random Forest的异常温升捕捉方法
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作者 汪海良 《现代建筑电气》 2024年第6期21-26,49,共7页
针对线路老化、线路过载的火灾频发问题,分析了线路老化、线路过载与异常温升之间的关联性,以电流值、线缆温度作为输入,利用KMeans聚类算法划分可能存在异常温升的区间,通过Random Forest算法识别线路过载问题,可以提前通知用户整改线... 针对线路老化、线路过载的火灾频发问题,分析了线路老化、线路过载与异常温升之间的关联性,以电流值、线缆温度作为输入,利用KMeans聚类算法划分可能存在异常温升的区间,通过Random Forest算法识别线路过载问题,可以提前通知用户整改线路,预防火灾的发生。 展开更多
关键词 线路过载 异常温升 random Forest KMeans
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A Correlation-Based Stochastic Model for Massive MIMO Channel
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作者 Yang Liu Gang Li Chengxiang Wang 《China Communications》 SCIE CSCD 2024年第1期175-187,共13页
In this paper,the channel impulse response matrix(CIRM)can be expressed as a sum of couplings between the steering vectors at the base station(BS)and the eigenbases at the mobile station(MS).Nakagami distribution was ... In this paper,the channel impulse response matrix(CIRM)can be expressed as a sum of couplings between the steering vectors at the base station(BS)and the eigenbases at the mobile station(MS).Nakagami distribution was used to describe the fading of the coupling between the steering vectors and the eigenbases.Extensive measurements were carried out to evaluate the performance of this proposed model.Furthermore,the physical implications of this model were illustrated and the capacities are analyzed.In addition,the azimuthal power spectrum(APS)of several models was analyzed.Finally,the channel hardening effect was simulated and discussed.Results showed that the proposed model provides a better fit to the measured results than the other CBSM,i.e.,Weichselberger model.Moreover,the proposed model can provide better tradeoff between accuracy and complexity in channel synthesis.This CIRM model can be used for massive MIMO design in the future communication system design. 展开更多
关键词 CBSM channel capacity channel hardening channel modeling massive MIMO
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Statistical Channel Modeling for Indoor VLC Communications Based on Channel Measurements
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作者 Shuo Liu Pan Tang +5 位作者 Jianhua Zhang Yue Yin Yu Tong Baobao Liu Guangyi Liu Liang Xia 《China Communications》 SCIE CSCD 2024年第1期131-147,共17页
Visible light communication(VLC)has attracted much attention in the research of sixthgeneration(6G)systems.Furthermore,channel modeling is the foundation for designing efficient and robust VLC systems.In this paper,we... Visible light communication(VLC)has attracted much attention in the research of sixthgeneration(6G)systems.Furthermore,channel modeling is the foundation for designing efficient and robust VLC systems.In this paper,we present extensive VLC channel measurement campaigns in indoor environments,i.e.,an office and a corridor.Based on the measured data,the large-scale fading characteristics and multipath-related characteristics,including omnidirectional optical path loss(OPL),K-factor,power angular spectrum(PAS),angle spread(AS),and clustering characteristics,are analyzed and modeled through a statistical method.Based on the extracted statistics of the above-mentioned channel characteristics,we propose a statistical spatial channel model(SSCM)capable of modeling multipath in the spatial domain.Furthermore,the simulated statistics of the proposed model are compared with the measured statistics.For instance,in the office,the simulated path loss exponent(PLE)and the measured PLE are 1.96and 1.97,respectively.And,the simulated medians of AS and measured medians of AS are 25.94°and 24.84°,respectively.Generally,the fact that the simulated results fit well with measured results has demonstrated the accuracy of our SSCM. 展开更多
关键词 channel characteristics channel measurement channel modeling 6G spatial lobe VLC
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Multi-User Semantic Fusion for Semantic Communications over Degraded Broadcast Channels
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作者 Wu Tong Chen Zhiyong +2 位作者 Tao Meixia Xia Bin Zhang Wenjun 《China Communications》 SCIE CSCD 2024年第10期86-100,共15页
Degraded broadcast channels(DBC) are a typical multiuser communication scenario, Semantic communications over DBC still lack in-depth research. In this paper, we design a semantic communications approach based on mult... Degraded broadcast channels(DBC) are a typical multiuser communication scenario, Semantic communications over DBC still lack in-depth research. In this paper, we design a semantic communications approach based on multi-user semantic fusion for wireless image transmission over DBC. The transmitter extracts semantic features for two users separately and then effectively fuses them for broadcasting by leveraging semantic similarity. Unlike traditional allocation of time, power, or bandwidth, the semantic fusion scheme can dynamically control the weight of the semantic features of the two users to balance their performance. Considering the different channel state information(CSI) of both users over DBC,a DBC-Aware method is developed that embeds the CSI of both users into the joint source-channel coding encoder and fusion module to adapt to the channel.Experimental results show that the proposed system outperforms the traditional broadcasting schemes. 展开更多
关键词 channel adaptability degraded broadcasting channels semantic communications semantic fusion
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Potassium and calcium channels in different nerve cells act as therapeutic targets in neurological disorders
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作者 Qing Qiu Mengting Yang +2 位作者 Danfeng Gong Haiying Liang Tingting Chen 《Neural Regeneration Research》 SCIE CAS 2025年第5期1258-1276,共19页
The central nervous system, information integration center of the body, is mainly composed of neurons and glial cells. The neuron is one of the most basic and important structural and functional units of the central n... The central nervous system, information integration center of the body, is mainly composed of neurons and glial cells. The neuron is one of the most basic and important structural and functional units of the central nervous system, with sensory stimulation and excitation conduction functions. Astrocytes and microglia belong to the glial cell family, which is the main source of cytokines and represents the main defense system of the central nervous system. Nerve cells undergo neurotransmission or gliotransmission, which regulates neuronal activity via the ion channels, receptors, or transporters expressed on nerve cell membranes. Ion channels, composed of large transmembrane proteins, play crucial roles in maintaining nerve cell homeostasis. These channels are also important for control of the membrane potential and in the secretion of neurotransmitters. A variety of cellular functions and life activities, including functional regulation of the central nervous system, the generation and conduction of nerve excitation, the occurrence of receptor potential, heart pulsation, smooth muscle peristalsis, skeletal muscle contraction, and hormone secretion, are closely related to ion channels associated with passive transmembrane transport. Two types of ion channels in the central nervous system, potassium channels and calcium channels, are closely related to various neurological disorders, including Alzheimer's disease, Parkinson's disease, and epilepsy. Accordingly, various drugs that can affect these ion channels have been explored deeply to provide new directions for the treatment of these neurological disorders. In this review, we focus on the functions of potassium and calcium ion channels in different nerve cells and their involvement in neurological disorders such as Parkinson's disease, Alzheimer's disease, depression, epilepsy, autism, and rare disorders. We also describe several clinical drugs that target potassium or calcium channels in nerve cells and could be used to treat these disorders. We concluded that there are few clinical drugs that can improve the pathology these diseases by acting on potassium or calcium ions. Although a few novel ion-channelspecific modulators have been discovered, meaningful therapies have largely not yet been realized. The lack of target-specific drugs, their requirement to cross the blood–brain barrier, and their exact underlying mechanisms all need further attention. This review aims to explain the urgent problems that need research progress and provide comprehensive information aiming to arouse the research community's interest in the development of ion channel-targeting drugs and the identification of new therapeutic targets for that can increase the cure rate of nervous system diseases and reduce the occurrence of adverse reactions in other systems. 展开更多
关键词 ASTROCYTES calcium channels central nervous system extracellular ion concentration MICROGLIA neurological disorders NEURONS potassium channels
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Artificial Intelligence Based Multi-Scenario mmWave Channel Modeling for Intelligent High-Speed Train Communications
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作者 Zhang Mengjiao Liu Yu +4 位作者 Huang Jie He Ruisi Zhang Jingfan Yu Chongyang Wang Chengxiang 《China Communications》 SCIE CSCD 2024年第3期260-272,共13页
A large amount of mobile data from growing high-speed train(HST)users makes intelligent HST communications enter the era of big data.The corresponding artificial intelligence(AI)based HST channel modeling becomes a tr... A large amount of mobile data from growing high-speed train(HST)users makes intelligent HST communications enter the era of big data.The corresponding artificial intelligence(AI)based HST channel modeling becomes a trend.This paper provides AI based channel characteristic prediction and scenario classification model for millimeter wave(mmWave)HST communications.Firstly,the ray tracing method verified by measurement data is applied to reconstruct four representative HST scenarios.By setting the positions of transmitter(Tx),receiver(Rx),and other parameters,the multi-scenarios wireless channel big data is acquired.Then,based on the obtained channel database,radial basis function neural network(RBF-NN)and back propagation neural network(BP-NN)are trained for channel characteristic prediction and scenario classification.Finally,the channel characteristic prediction and scenario classification capabilities of the network are evaluated by calculating the root mean square error(RMSE).The results show that RBF-NN can generally achieve better performance than BP-NN,and is more applicable to prediction of HST scenarios. 展开更多
关键词 artificial intelligence channel characteristic prediction HST channel millimeter wave scenario classification
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