We investigated the relationship of apoB/apoA1 ratio and coronary heart disease （CHD） in persons who were overweight or obese. The subjects were divided by the body mass indexes （BMI） into the normal weight group ...We investigated the relationship of apoB/apoA1 ratio and coronary heart disease （CHD） in persons who were overweight or obese. The subjects were divided by the body mass indexes （BMI） into the normal weight group （n=397, BMI〈24 kg/m2） and the overweight group （n=400, BMI〉24 kg/m2）. Our results showed that the overweight group had higher blood pressure [（130.15±19.01） mmHg vs （123.66±18.70） mmHg] and higher levels of blood sugar [（7.09±2.89） mmol/L vs （6.21±2.59） mmol/L], triglyceride [（1.93±1.19） mmol/L vs （1.44 ±0.85） mmol/L], total cholesterol [（4.26±1.06） mmol/L vs （4.09±0.99） mmol/L], low-density lipoprotein cholesterol （LDL-C） [（2.56±0.75） mmol/L vs （2.39±0.72） mmol/L], and apoB [（0.83±0.27） mg/L vs （0.78±0.23） mg/L], and a higher apoB/apoA1 ratio （0.83 ±0.27 vs 0.75±0.25） and lower levels high-density lipoprotein cholesterol [（1.10±0.26） mmol/L vs （1.21±0.31） mmol/L] and apoA1 [（1.04±0.20） mg/L vs （1.08±0.22） mg/L] than those of the normal weight group （all P 〈 0.05）. The prevalence of CHD in the over-weight group in the lowest LDL quartile was almost twice greater than that of the highest apoB/apoA1 quartile, compared with the subjects in the lowest apoB/apoA1 quartile. The higher apoB/apoA1 quartile was in agreement with the higher prevalence of CHD. In the overweight and obesity group, the area under ROC curve （AUC） was the highest for apoB/apoA1 （0.655）. The cut-off point of apoB/apoA1 for optimal sensitivity and specificity was at 0.80, with a sensitivity of 57.19% and a specificity of 71.72%. In conclusion, apoB and apoA1 were simple clinical indicators, and the apoB/apoA1 ratio was closely related with CHD in overweight and obese patients. The apoB/apoA1 ratio may provide some useful information in the differential diagnosis.展开更多
Background Less studies were done to compare the lipid ratios including ApoB100/ApoA1, LDL-C/HDL- C,TC/HDL-Cin elderly. So the study was to investigate the relationship between Apolipoprotein B100/ApoA1 ratio and coro...Background Less studies were done to compare the lipid ratios including ApoB100/ApoA1, LDL-C/HDL- C,TC/HDL-Cin elderly. So the study was to investigate the relationship between Apolipoprotein B100/ApoA1 ratio and coronary artery disease （CAD） in elderly. Methods 498 participants aged over 65 years with chest pain had been subsumed from Sep. 2009 to April 2011 of Guangdong General Hospital. Clinic informations of gender, age, history of hypertension, diabetes mellitus, smoking was collected. Simultaneously, serum lipids should be phlebotomized in 24 hours after be inpatient. ApoB100/ApoA1 ratio, LDL-C/HDL-C ratio. TC/HDL-C ratio, non-HDL-C were calculated using the above data. Accroding to the mean of ApoB100/ApoA1 ratio, ApoB100, non-HDL-C, all individuals were divided into two groups： high level group and low level group, while all individuals were divided into two groups whether the level of LDL-C was achieve 2.06 mmol/L. We classified the participants into CAD group and non-CAD group on the basis of CAG. The incidence of CAD was compared between the two groups of four different lipid indicators. The ability of estimating CAD was described by Reciever Operating Characteristic curve （ROC curve）. Result There were significantly statistical differences in the incidence of CAD between the high level group and low level group of ApoB100/ApoA1 ratio （75.0% vs. 55.9%, %2 = 19.681, P 〈 0.001）. By logistic regression analysis, odds ratio of ApoB100/ApoA1 ratio was 2.142, 95% CI （1.437, 3.195）（P 〈 0.001）. The AUC （area under curve） of ApoB100/ApoA1 ratio were 0.66. There were significant for diagnosis of CAD （P 〈 0.001）. Conclusion The ApoB100/ApoA1 ratio was an independent risk factor of CAD in elderly population, and it is better than traditional lipid indicators, and can be used for the ability of estimating CAD.展开更多
基金supported by National High-Tech Research and Development Program of China (No.2006AA02A406)Natural Science Foundation of China (No.30871042)
文摘We investigated the relationship of apoB/apoA1 ratio and coronary heart disease （CHD） in persons who were overweight or obese. The subjects were divided by the body mass indexes （BMI） into the normal weight group （n=397, BMI〈24 kg/m2） and the overweight group （n=400, BMI〉24 kg/m2）. Our results showed that the overweight group had higher blood pressure [（130.15±19.01） mmHg vs （123.66±18.70） mmHg] and higher levels of blood sugar [（7.09±2.89） mmol/L vs （6.21±2.59） mmol/L], triglyceride [（1.93±1.19） mmol/L vs （1.44 ±0.85） mmol/L], total cholesterol [（4.26±1.06） mmol/L vs （4.09±0.99） mmol/L], low-density lipoprotein cholesterol （LDL-C） [（2.56±0.75） mmol/L vs （2.39±0.72） mmol/L], and apoB [（0.83±0.27） mg/L vs （0.78±0.23） mg/L], and a higher apoB/apoA1 ratio （0.83 ±0.27 vs 0.75±0.25） and lower levels high-density lipoprotein cholesterol [（1.10±0.26） mmol/L vs （1.21±0.31） mmol/L] and apoA1 [（1.04±0.20） mg/L vs （1.08±0.22） mg/L] than those of the normal weight group （all P 〈 0.05）. The prevalence of CHD in the over-weight group in the lowest LDL quartile was almost twice greater than that of the highest apoB/apoA1 quartile, compared with the subjects in the lowest apoB/apoA1 quartile. The higher apoB/apoA1 quartile was in agreement with the higher prevalence of CHD. In the overweight and obesity group, the area under ROC curve （AUC） was the highest for apoB/apoA1 （0.655）. The cut-off point of apoB/apoA1 for optimal sensitivity and specificity was at 0.80, with a sensitivity of 57.19% and a specificity of 71.72%. In conclusion, apoB and apoA1 were simple clinical indicators, and the apoB/apoA1 ratio was closely related with CHD in overweight and obese patients. The apoB/apoA1 ratio may provide some useful information in the differential diagnosis.
基金supportet by the grants from The Science and Techonlogy Planning Project of Gungdong Prvince (2010B060900105) and (2011B061300034)
文摘Background Less studies were done to compare the lipid ratios including ApoB100/ApoA1, LDL-C/HDL- C,TC/HDL-Cin elderly. So the study was to investigate the relationship between Apolipoprotein B100/ApoA1 ratio and coronary artery disease （CAD） in elderly. Methods 498 participants aged over 65 years with chest pain had been subsumed from Sep. 2009 to April 2011 of Guangdong General Hospital. Clinic informations of gender, age, history of hypertension, diabetes mellitus, smoking was collected. Simultaneously, serum lipids should be phlebotomized in 24 hours after be inpatient. ApoB100/ApoA1 ratio, LDL-C/HDL-C ratio. TC/HDL-C ratio, non-HDL-C were calculated using the above data. Accroding to the mean of ApoB100/ApoA1 ratio, ApoB100, non-HDL-C, all individuals were divided into two groups： high level group and low level group, while all individuals were divided into two groups whether the level of LDL-C was achieve 2.06 mmol/L. We classified the participants into CAD group and non-CAD group on the basis of CAG. The incidence of CAD was compared between the two groups of four different lipid indicators. The ability of estimating CAD was described by Reciever Operating Characteristic curve （ROC curve）. Result There were significantly statistical differences in the incidence of CAD between the high level group and low level group of ApoB100/ApoA1 ratio （75.0% vs. 55.9%, %2 = 19.681, P 〈 0.001）. By logistic regression analysis, odds ratio of ApoB100/ApoA1 ratio was 2.142, 95% CI （1.437, 3.195）（P 〈 0.001）. The AUC （area under curve） of ApoB100/ApoA1 ratio were 0.66. There were significant for diagnosis of CAD （P 〈 0.001）. Conclusion The ApoB100/ApoA1 ratio was an independent risk factor of CAD in elderly population, and it is better than traditional lipid indicators, and can be used for the ability of estimating CAD.
