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Feasibility Study on Recovering Human-Occupied Vehicle with An Offshore Crane
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作者 HAN Ming-yue XIE Peng +4 位作者 XIAN Hao-yi ZHONG Xin-xin CHEN Sheng-lin SUN Tie-rui SUN Feng-lei 《China Ocean Engineering》 SCIE EI CSCD 2024年第4期648-662,共15页
Launching and recovering human-occupied vehicles(HOVs)has always been a challenging problem.The current recovery process requires staff to manually complete the tethering task,which is inefficient and endangers the li... Launching and recovering human-occupied vehicles(HOVs)has always been a challenging problem.The current recovery process requires staff to manually complete the tethering task,which is inefficient and endangers the lives of staff.This paper suggests moving the recovery position from the surface to underwater at approximately half the wavelength of the water depth(30−50 m underwater),where the HOV experiences less environmental disturbance.An ROV equipped with a ultra-short baseline beacon(USBL)and a manipulator was used to complete the tethering operation.Additionally,a shackle customized to the shape of the manipulator’s gripper is fitted to the end of the cable to simplify the tethering process.To investigate the dynamic response of recovering the HOV using this suggested method,a comprehensive numerical model is developed in this research.The effects of wind,surface waves,ocean currents,and nonlinear interaction between the installation vessel and the HOV are quantitatively examined.The results show that the proposed recovery method can reduce the motion amplitude of the HOV and that the wave has the greatest influence on the dynamic response of the HOV during the recovery process.This model provides better insight into the proposed HOV recovery method and confirms the effectiveness of the heave compensation system.The proposed approach aims to enhance safety and operational efficiency by reducing direct human involvement in the recovery process and mitigating potential dangers.This finding holds particular significance,especially in environmentally sensitive areas,where reducing the impact on the surrounding ecosystem is crucial. 展开更多
关键词 human-occupied vehicle recovery dynamic response active heave compensation
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The Impact of Nursing Staff’s Work Attitude on the Fear of Patients Recovering from Benign Tumors:Family Support as a Mediating Variable
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作者 Chengzhe Guo Aihua Cheng +1 位作者 Jian Chen Gaojie Cheng 《Psycho-Oncologie》 SCIE 2024年第4期291-303,共13页
The perception of nursing staff’s attitude influences patient fear.Understanding this dynamic is crucial for fostering a supportive environment conducive to patient well-being and effective healthcare practices.The p... The perception of nursing staff’s attitude influences patient fear.Understanding this dynamic is crucial for fostering a supportive environment conducive to patient well-being and effective healthcare practices.The purpose of this research is to investigate how the attitudes and behaviours of nursing staff influence the fear and anxiety levels of patients recovering from benign tumors,aiming to improve patient care and recovery outcomes.Data was collected from a sample of 100 participants,comprising 20 nursing staff and 80 patients recovering from benign tumors.Surveys were administered to gather quantitative data on attitudes and fear levels.Participants were selected randomly from hospital records and outpatient clinics.Our analysis encompassed nursing staff attitude,patient fear levels,the influence of family support,progression of tumor recovery,patient-reported satisfaction,and the quality of healthcare services provided.The quantitative aspect utilized PLS-SEM software to perform regression analysis,evaluating both direct and indirect effects.Statistical analysis assessed the relationships between nursing staff attitudes,patient fear during benign tumor recovery,and the mediating role of family support.The findings of the study demonstrate that better nurse attitudes(Hypothesis 1,β=0.45,p<0.001)and stronger family support(Hypothesis 2,β=0.32;p<0.001) are linked to lower levels of patient fear.Partially mediating the relationship between nurse attitudes and patient fear,according to Hypothesis 3(β=0.28,p<0.002),is family support.Patients’perceptions of family support are highly influenced by nursing behaviour,as demonstrated by Hypothesis 4(β=0.38;p<0.001).Our research showed a strong relationship between the attitudes of nursing personnel and patient fear levels.Family support demonstrated a strong mediating effect on patient fear.Patient-reported satisfaction is positively correlated with family support.However,no significant relationship was found between healthcare service quality and patient fear. 展开更多
关键词 Nursing staff’s work attitude fear of patients benign tumors recovery family support statistical analysis
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First and Second Law Analysis of a LiBr-Water Absorption Cycle with Recovering Condensation Heat for Generation
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作者 J.L.Rodríguez-Muñoz J.S.Pacheco-Cedeño +2 位作者 J.F.Ituna-Yudonago J.J.Ramírez-Minguela I.J.González-Hernández 《Frontiers in Heat and Mass Transfer》 EI 2024年第6期1719-1741,共23页
In conventional absorption refrigeration systems(ARS),the heat from the condenser is usually rejected by the environment in place to be used in the system,so recuperating this is a good alternative to enhance the sys... In conventional absorption refrigeration systems(ARS),the heat from the condenser is usually rejected by the environment in place to be used in the system,so recuperating this is a good alternative to enhance the system’s performance.For instance,in this paper,an alternative ARS in which LiBr/Water is used as a refrigerant mixture,where part of condensing heat is recovered via the solution heat recovery generator absorption cycle(HR-ARS)was energy and exergy evaluated.The influence of generator,condenser and evaporator temperatures,as well as the efficiency of the solution heat exchanger on the coefficient of performance,exergy performance and exergy destroyed of the HR-ARS system,were analyzed and compared with the traditional ARS system at the same working conditions.The results showed an increase between 5.8%–6.3%on the COP and 3.7%–9.5%in the exergy efficiency when condenser/absorber temperature was reduced from 40℃ to 30℃.However,when the evaporation temperature rose from 5℃ to 15℃,the COP(coefficient of performance)increased by around 8%,although this could be increased by 2.3%–6.3%if the generator temperature decreases from 100℃ to 80℃.Moreover,the COP and exergetic performance for the HR-ARS is more significant at the lowest generator,condenser and evaporator temperatures,as well as at high efficiency in the solution heat exchanger,in comparison to ARS system.Furthermore,the COP and exergy performance for the HR-ARS system was improved by 2.57%to 3.11%and 0.22%to 0.7%,respectively,while the recovering condensation heat for generation is around 1.51%–3.76%lower than with the ARS.It also was found that for all ranges of evaporator and condenser temperatures,the COP for the HR-ARS system is around 3%higher than that obtained with the ARS at the three different generator temperatures here analyzed,while when the solution heat exchanger effectiveness was increased from 0.7–1.0,the total exergy destruction for the HR-ARS resulted be 3.24%–5.01%smaller than the ARS system.Finally,it can be concluded that the components with the most exergy destroyed in the systems(80%to 94%)are the generator and absorber. 展开更多
关键词 Absorption refrigeration system recovery condensation heat energy and exergy analysis LiBr-H_(2)O
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“摸鱼”如何带来创新?恢复体验曲线中介效应的情景实验与调查证据
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作者 徐世勇 杨春梦 +1 位作者 李超平 李海蓉 《心理学报》 北大核心 2025年第1期135-151,共17页
基于资源保存理论,文章探索了时间窃取行为的过犹不及效应,分析其如何通过恢复体验对创新行为产生影响,以及正念的调节作用。通过对情景回顾实验的182份样本和三轮问卷调研的503份领导−员工配对数据进行统计检验,结果发现:(1)时间窃取... 基于资源保存理论,文章探索了时间窃取行为的过犹不及效应,分析其如何通过恢复体验对创新行为产生影响,以及正念的调节作用。通过对情景回顾实验的182份样本和三轮问卷调研的503份领导−员工配对数据进行统计检验,结果发现:(1)时间窃取与恢复体验呈倒U型关系,并进一步对创新行为产生影响;(2)正念调节了时间窃取通过恢复体验对创新行为的影响,即员工的正念水平越高,时间窃取对恢复体验的影响以及通过恢复体验对创新行为的间接作用越强。文章发现时间窃取可以作为一种工作内恢复形式影响员工的恢复体验和创新行为,这一观点丰富了时间窃取相关文献,拓展了工作内恢复的效果和机制研究,同时也为管理员工“摸鱼”提供了实践启示。 展开更多
关键词 时间窃取 恢复体验 正念 创新行为
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钻孔联合地质剖面探测施工中若干问题探讨
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作者 贺为民 《地球与行星物理论评(中英文)》 2025年第2期157-166,共10页
基于《活动断层探测》GB/T 36072—2018、《活动断层探查钻探》DB/T 92—2022等现行规范规程,对跨隐伏活动断层的钻孔联合地质剖面探测施工的基本要求和存在的主要问题进行了探讨,认为现行技术标准存在的问题有:(1)对岩芯采取率的要求偏... 基于《活动断层探测》GB/T 36072—2018、《活动断层探查钻探》DB/T 92—2022等现行规范规程,对跨隐伏活动断层的钻孔联合地质剖面探测施工的基本要求和存在的主要问题进行了探讨,认为现行技术标准存在的问题有:(1)对岩芯采取率的要求偏低;(2)对横跨隐伏逆断层的钻孔深度和钻孔之间距离的要求偏低.提出了下列改进措施:(1)各类岩土的岩芯采取率应大于现行技术标准要求的数值;其中,黏土的岩芯采取率应不小于99%;(2)对横跨隐伏逆断层的钻孔深度应大于现行技术标准要求的孔深;在第四系厚度较薄时,在逆断层上断点附近,位于逆断层上盘的钻孔在钻遇上盘的前第四系后,还应继续钻进,钻孔深度应达到能够揭露逆断层下盘的前第四系的深度;(3)当隐伏逆断层在第四系中的断距较小时,逆断层上断点两侧的2个相邻钻孔间距就需要1~3 m甚至更小的数值.补充了钻孔联合地质剖面探测中的钻孔布设方式、隐伏断层产状的求取方法.分析了在钻孔联合地质剖面探测的断层识别中存在的一些不确定性因素,并提出了相应对策.指出钻孔联合地质剖面探测施工是基于动态设计的信息化施工,现场技术负责人及其施工现场技术管理在钻孔联合地质剖面探测工作中起着重要作用. 展开更多
关键词 活动断层 钻孔联合地质剖面 断层活动性鉴定 断层上断点 岩芯采取率
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从肾脾论治缺血性脑卒中后功能障碍的中医机制探析及研究进展
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作者 宋文君 刘伟 +3 位作者 门伟业 熊紫怡 张鸿宇 英振昊 《辽宁中医药大学学报》 CAS 2025年第1期197-202,共6页
缺血性脑卒中因其高发病率和病死率历来是临床防治重点,而抢救存活后的高致残率又严重影响患者生存质量。中医药在改善功能障碍、预防残疾方面具备天然优势,但现有缺血性脑卒中的中医康复尚缺乏精准理论指导,亟需深入研究。运动、认知... 缺血性脑卒中因其高发病率和病死率历来是临床防治重点,而抢救存活后的高致残率又严重影响患者生存质量。中医药在改善功能障碍、预防残疾方面具备天然优势,但现有缺血性脑卒中的中医康复尚缺乏精准理论指导,亟需深入研究。运动、认知、语言等功能恢复基于脑和脊髓中突触重塑,元神恢复、神机运转有赖先后天之精充盈髓海,借助中医髓理论,中西医学在卒中后功能恢复的治疗逻辑上达成共识。欲复髓海,肾脾所藏先后天之精首当其责,变生血、津液等精微物质,最终化髓充脑,以养元神。故而缺血性脑卒中患者的功能恢复宜重视调补肾脾,填精益髓,生液养髓,髓海得充,神机以复。当下临床治疗缺血性脑卒中多以益气活血、清热化瘀、养阴活血等法,少有人基于中医髓认知聚焦卒中后功能障碍的中医康复机制研究。因此,通过对中医典籍和历代名家医案的深入挖掘,基于肾脾全面地分析影响缺血性脑卒中急性期病情演进与恢复期功能恢复的多种因素,从病理指标与功能评价对从肾脾论治缺血性脑卒中方药的效果进行综合论述,系统呈现肾脾同补方药的研究进展,进而丰富缺血性脑卒中的中医治疗理论,并为探求缺血性脑卒中的康复治疗提供新思路。 展开更多
关键词 缺血性脑卒中 肾脾论治 功能恢复
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腰椎退行性疾病患者术后恐动症的研究进展
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作者 范志英 仝伟伟 +2 位作者 郑喜灿 臧建峰 李勇 《中国疗养医学》 2025年第1期101-104,共4页
腰椎退行性疾病是脊柱外科常见病和多发病,以腰腿痛、麻木或间歇性跛行为主要临床表现。手术是改善腰腿痛快速有效的治疗方法,术后早期功能锻炼对康复具有重要意义,但患者因受长期强烈疼痛折磨,害怕造成腰部的二次损伤而对运动锻炼出现... 腰椎退行性疾病是脊柱外科常见病和多发病,以腰腿痛、麻木或间歇性跛行为主要临床表现。手术是改善腰腿痛快速有效的治疗方法,术后早期功能锻炼对康复具有重要意义,但患者因受长期强烈疼痛折磨,害怕造成腰部的二次损伤而对运动锻炼出现恐惧心理,产生恐动症。恐动症是因受到疼痛性损害或刺激导致机体对疼痛敏感性增强,对运动产生过度非理性的恐惧行为,可导致患者术后器官功能障碍甚至出现废用综合征,严重影响康复进程,增加医疗经济负担。本文综述腰椎退行性疾病患者术后恐动症的概念、发生现状、影响因素、不良影响和干预策略,以期为医护人员深入探索恐动症的发生机制并制定个性化的干预措施,提高患者对恐动症的正确认知和康复锻炼的参与度,提高生活质量提供理论依据。 展开更多
关键词 腰椎退行性疾病 术后 恐动症 康复 综述
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Enhancing perianal disease management with integrated physical and psychological approaches
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作者 Uchenna E Okpete Haewon Byeon 《World Journal of Clinical Cases》 SCIE 2025年第2期59-63,共5页
This article provides a comprehensive analysis of the study by Hou et al,focusing on the complex interplay between psychological and physical factors in the postoperative recovery(POR)of patients with perianal disease... This article provides a comprehensive analysis of the study by Hou et al,focusing on the complex interplay between psychological and physical factors in the postoperative recovery(POR)of patients with perianal diseases.The study sheds light on how illness perception,anxiety,and depression significantly influence recovery outcomes.Hou et al developed a predictive model that demonstrated high accuracy in identifying patients at risk of poor recovery.The article explores the critical role of pre-operative psychological assessment,highlighting the need for mental health support and personalized recovery plans in enhancing POR quality.A multidisciplinary approach,integrating mental health professionals with surgeons,anesthesiologists,and other specialists,is emphasized to ensure comprehensive care for patients.The study’s findings serve as a call to integrate psychological care into surgical practice to optimize outcomes for patients with perianal diseases. 展开更多
关键词 Perianal disease Post-operative recovery ANXIETY DEPRESSION Pain management Emotional well-being Multidisciplinary approach
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Pharmacological targeting cGAS/STING/NF-κB axis by tryptanthrin induces microglia polarization toward M2 phenotype and promotes functional recovery in a mouse model of spinal cord injury
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作者 Ziwei Fan Mengxian Jia +16 位作者 Jian Zhou Zhoule Zhu Yumin Wu Xiaowu Lin Yiming Qian Jiashu Lian Xin Hua Jianhong Dong Zheyu Fang Yuqing Liu Sibing Chen Xiumin Xue Juanqing Yue Minyu Zhu Ying Wang Zhihui Huang Honglin Teng 《Neural Regeneration Research》 SCIE CAS 2025年第11期3287-3301,共15页
The M1/M2 phenotypic shift of microglia after spinal cord injury plays an important role in the regulation of neuroinflammation during the secondary injury phase of spinal cord injury.Regulation of shifting microglia ... The M1/M2 phenotypic shift of microglia after spinal cord injury plays an important role in the regulation of neuroinflammation during the secondary injury phase of spinal cord injury.Regulation of shifting microglia polarization from M1(neurotoxic and proinflammatory type)to M2(neuroprotective and anti-inflammatory type)after spinal cord injury appears to be crucial.Tryptanthrin possesses an anti-inflammatory biological function.However,its roles and the underlying molecular mechanisms in spinal cord injury remain unknown.In this study,we found that tryptanthrin inhibited microglia-derived inflammation by promoting polarization to the M2 phenotype in vitro.Tryptanthrin promoted M2 polarization through inactivating the cGAS/STING/NF-κB pathway.Additionally,we found that targeting the cGAS/STING/NF-κB pathway with tryptanthrin shifted microglia from the M1 to M2 phenotype after spinal cord injury,inhibited neuronal loss,and promoted tissue repair and functional recovery in a mouse model of spinal cord injury.Finally,using a conditional co-culture system,we found that microglia treated with tryptanthrin suppressed endoplasmic reticulum stress-related neuronal apoptosis.Taken together,these results suggest that by targeting the cGAS/STING/NF-κB axis,tryptanthrin attenuates microglia-derived neuroinflammation and promotes functional recovery after spinal cord injury through shifting microglia polarization to the M2 phenotype. 展开更多
关键词 cGAS/STING functional recovery MICROGLIA neuroinflammation neuroprotection nuclear factor-κB POLARIZATION spinal cord injury TRYPTANTHRIN
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Chondroitinase ABC combined with Schwann cell transplantation enhances restoration of neural connection and functional recovery following acute and chronic spinal cord injury
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作者 Wenrui Qu Xiangbing Wu +13 位作者 Wei Wu Ying Wang Yan Sun Lingxiao Deng Melissa Walker Chen Chen Heqiao Dai Qi Han Ying Ding Yongzhi Xia George Smith Rui Li Nai-Kui Liu Xiao-Ming Xu 《Neural Regeneration Research》 SCIE CAS 2025年第5期1467-1482,共16页
Schwann cell transplantation is considered one of the most promising cell-based therapy to repair injured spinal cord due to its unique growth-promoting and myelin-forming properties.A the Food and Drug Administration... Schwann cell transplantation is considered one of the most promising cell-based therapy to repair injured spinal cord due to its unique growth-promoting and myelin-forming properties.A the Food and Drug Administration-approved Phase I clinical trial has been conducted to evaluate the safety of transplanted human autologous Schwann cells to treat patients with spinal cord injury.A major challenge for Schwann cell transplantation is that grafted Schwann cells are confined within the lesion cavity,and they do not migrate into the host environment due to the inhibitory barrier formed by injury-induced glial scar,thus limiting axonal reentry into the host spinal cord.Here we introduce a combinatorial strategy by suppressing the inhibitory extracellular environment with injection of lentivirus-mediated transfection of chondroitinase ABC gene at the rostral and caudal borders of the lesion site and simultaneously leveraging the repair capacity of transplanted Schwann cells in adult rats following a mid-thoracic contusive spinal cord injury.We report that when the glial scar was degraded by chondroitinase ABC at the rostral and caudal lesion borders,Schwann cells migrated for considerable distances in both rostral and caudal directions.Such Schwann cell migration led to enhanced axonal regrowth,including the serotonergic and dopaminergic axons originating from supraspinal regions,and promoted recovery of locomotor and urinary bladder functions.Importantly,the Schwann cell survival and axonal regrowth persisted up to 6 months after the injury,even when treatment was delayed for 3 months to mimic chronic spinal cord injury.These findings collectively show promising evidence for a combinatorial strategy with chondroitinase ABC and Schwann cells in promoting remodeling and recovery of function following spinal cord injury. 展开更多
关键词 axonal regrowth bladder function chondroitinase ABC functional recovery glial scar LENTIVIRUS migration Schwann cell spinal cord injury TRANSPLANTATION
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Microglia:a promising therapeutic target in spinal cord injury
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作者 Xiaowei Zha Guoli Zheng +3 位作者 Thomas Skutella Karl Kiening Andreas Unterberg Alexander Younsi 《Neural Regeneration Research》 SCIE CAS 2025年第2期454-463,共10页
Microglia are present throughout the central nervous system and are vital in neural repair,nutrition,phagocytosis,immunological regulation,and maintaining neuronal function.In a healthy spinal cord,microglia are accou... Microglia are present throughout the central nervous system and are vital in neural repair,nutrition,phagocytosis,immunological regulation,and maintaining neuronal function.In a healthy spinal cord,microglia are accountable for immune surveillance,however,when a spinal cord injury occurs,the microenvironment drastically changes,leading to glial scars and failed axonal regeneration.In this context,microglia vary their gene and protein expression during activation,and proliferation in reaction to the injury,influencing injury responses both favorably and unfavorably.A dynamic and multifaceted injury response is mediated by microglia,which interact directly with neurons,astrocytes,oligodendrocytes,and neural stem/progenitor cells.Despite a clear understanding of their essential nature and origin,the mechanisms of action and new functions of microglia in spinal cord injury require extensive research.This review summarizes current studies on microglial genesis,physiological function,and pathological state,highlights their crucial roles in spinal cord injury,and proposes microglia as a therapeutic target. 展开更多
关键词 ASTROCYTES CYTOKINES functional recovery immune regulation M1/M2 activation MACROPHAGES MICROGLIA NEUROINFLAMMATION spinal cord injury therapy
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Silk-based nerve guidance conduits with macroscopic holes modulate the vascularization of regenerating rat sciatic nerve
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作者 Carina Hromada Patrick Heimel +10 位作者 Markus Kerbl LászlóGál Sylvia Nürnberger Barbara Schaedl James Ferguson Nicole Swiadek Xavier Monforte Johannes C.Heinzel Antal Nógrádi Andreas H.Teuschl-Woller David Hercher 《Neural Regeneration Research》 SCIE CAS 2025年第6期1789-1800,共12页
Peripheral nerve injuries induce a severe motor and sensory deficit. Since the availability of autologous nerve transplants for nerve repair is very limited, alternative treatment strategies are sought, including the ... Peripheral nerve injuries induce a severe motor and sensory deficit. Since the availability of autologous nerve transplants for nerve repair is very limited, alternative treatment strategies are sought, including the use of tubular nerve guidance conduits(tNGCs). However, the use of tNGCs results in poor functional recovery and central necrosis of the regenerating tissue, which limits their application to short nerve lesion defects(typically shorter than 3 cm). Given the importance of vascularization in nerve regeneration, we hypothesized that enabling the growth of blood vessels from the surrounding tissue into the regenerating nerve within the tNGC would help eliminate necrotic processes and lead to improved regeneration. In this study, we reported the application of macroscopic holes into the tubular walls of silk-based tNGCs and compared the various features of these improved silk^(+) tNGCs with the tubes without holes(silk^(–) tNGCs) and autologous nerve transplants in an 8-mm sciatic nerve defect in rats. Using a combination of micro-computed tomography and histological analyses, we were able to prove that the use of silk^(+) tNGCs induced the growth of blood vessels from the adjacent tissue to the intraluminal neovascular formation. A significantly higher number of blood vessels in the silk^(+) group was found compared with autologous nerve transplants and silk^(–), accompanied by improved axon regeneration at the distal coaptation point compared with the silk^(–) tNGCs at 7 weeks postoperatively. In the 15-mm(critical size) sciatic nerve defect model, we again observed a distinct ingrowth of blood vessels through the tubular walls of silk^(+) tNGCs, but without improved functional recovery at 12 weeks postoperatively. Our data proves that macroporous tNGCs increase the vascular supply of regenerating nerves and facilitate improved axonal regeneration in a short-defect model but not in a critical-size defect model. This study suggests that further optimization of the macroscopic holes silk^(+) tNGC approach containing macroscopic holes might result in improved grafting technology suitable for future clinical use. 展开更多
关键词 axon regeneration blood vessel functional recovery macroporous nerve lesion peripheral nerve repair sciatic nerve silk-based nerve guidance conduit VASCULARIZATION
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Optimizing the key parameter to accelerate the recovery of AMOC under a rapid increase of greenhouse gas forcing
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作者 Haolan Ren Fei Zheng +1 位作者 Tingwei Cao Qiang Wang 《Atmospheric and Oceanic Science Letters》 2025年第1期39-45,共7页
Atlantic Meridional Overturning Circulation(AMOC)plays a central role in long-term climate variations through its heat and freshwater transports,which can collapse under a rapid increase of greenhouse gas forcing in c... Atlantic Meridional Overturning Circulation(AMOC)plays a central role in long-term climate variations through its heat and freshwater transports,which can collapse under a rapid increase of greenhouse gas forcing in climate models.Previous studies have suggested that the deviation of model parameters is one of the major factors in inducing inaccurate AMOC simulations.In this work,with a low-resolution earth system model,the authors try to explore whether a reasonable adjustment of the key model parameter can help to re-establish the AMOC after its collapse.Through a new optimization strategy,the extra freshwater flux(FWF)parameter is determined to be the dominant one affecting the AMOC’s variability.The traditional ensemble optimal interpolation(EnOI)data assimilation and new machine learning methods are adopted to optimize the FWF parameter in an abrupt 4×CO_(2) forcing experiment to improve the adaptability of model parameters and accelerate the recovery of AMOC.The results show that,under an abrupt 4×CO_(2) forcing in millennial simulations,the AMOC will first collapse and then re-establish by the default FWF parameter slowly.However,during the parameter adjustment process,the saltier and colder sea water over the North Atlantic region are the dominant factors in usefully improving the adaptability of the FWF parameter and accelerating the recovery of AMOC,according to their physical relationship with FWF on the interdecadal timescale. 展开更多
关键词 Recovery of AMOC 4×CO_(2)forcing Key parameter Parameter estimation Data assimilation Machine learning
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Improving postoperative outcomes in patients with pancreatic cancer:Inflammatory and nutritional biomarkers
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作者 Chun-Han Cheng Wen-Rui Hao Tzu-Hurng Cheng 《World Journal of Clinical Oncology》 2025年第1期59-64,共6页
This editorial assesses the prognostic value of preoperative inflammatory and nutritional biomarkers in patients undergoing surgical resection for pancreatic cancer.Lu et al evaluated the ability of seven biomarkers t... This editorial assesses the prognostic value of preoperative inflammatory and nutritional biomarkers in patients undergoing surgical resection for pancreatic cancer.Lu et al evaluated the ability of seven biomarkers to predict postoperative recovery and long-term outcomes.These biomarkers were albumin-to-globulin ratio,prognostic nutritional index(PNI),systemic immune-inflammation index,neutrophil-to-lymphocyte ratio,platelet-to-lymphocyte ratio,nutritional risk index,and geriatric nutritional risk index.The PNI was found to be a strong predictor of both overall and recurrence-free survival,underscoring its clinical relevance in managing patients with pancreatic cancer. 展开更多
关键词 Pancreatic cancer Prognostic nutritional index Systemic immune-inflammation index Postoperative recovery PROGNOSIS
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普伐他汀对大鼠坐骨神经压碎损伤功能恢复的影响
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作者 刘赞 安冉 李宝成 《中国组织工程研究》 CAS 北大核心 2025年第5期942-950,共9页
背景:普伐他汀是临床上治疗高胆固醇血症的有效药物,目前发现其在中枢神经损伤的治疗上也能发挥有益作用,然而其机制仍未可知。目的:探究普伐他汀治疗能否加速坐骨神经压碎损伤的功能恢复及其潜在作用机制。方法:将雄性SD大鼠随机分为... 背景:普伐他汀是临床上治疗高胆固醇血症的有效药物,目前发现其在中枢神经损伤的治疗上也能发挥有益作用,然而其机制仍未可知。目的:探究普伐他汀治疗能否加速坐骨神经压碎损伤的功能恢复及其潜在作用机制。方法:将雄性SD大鼠随机分为假手术组(坐骨神经暴露但不损伤+生理盐水灌胃)、阴性对照组(坐骨神经压碎损伤+生理盐水灌胃)、普伐他汀组(坐骨神经压碎损伤+普伐他汀灌胃)。普伐他汀组大鼠术后普伐他汀(5 mg/kg)灌胃治疗1周,其余两组大鼠给予等量生理盐水灌胃。术后观察各组大鼠一般情况;术后第2,4,6,8周末测量各组大鼠的坐骨功能指数;术后8周末测量腓肠肌湿质量比;ELISA法检测血清中炎症细胞因子的水平;组织形态计量学分析坐骨神经有髓神经纤维数目、纤维直径、轴突直径、髓鞘厚度;RT-qPCR检测神经生长因子、脑源性神经营养因子的mRNA表达量,Western blot法检测生长相关蛋白43的蛋白表达量。结果与结论:与阴性对照组相比,普伐他汀组坐骨神经功能指数恢复更快(P<0.05),更接近于假手术组水平,血清中炎症细胞因子肿瘤坏死因子α及白细胞介素6表达更低(P<0.05)且接近假手术组,坐骨神经中神经生长因子、脑源性神经营养因子的mRNA相对表达量增加(P<0.05或P<0.01),坐骨神经中生长相关蛋白43的蛋白相对表达量也明显增加(P<0.05),有髓神经纤维数目增加更多,纤维直径、轴突直径及髓鞘厚度数值更大(P<0.01)且与假手术组更接近。结果说明,普伐他汀的治疗加速了坐骨神经压碎损伤的功能恢复,其可能机制是抑制炎症细胞因子肿瘤坏死因子α及白细胞介素6的表达及促进神经营养因子神经生长因子、脑源性神经营养因子的分泌。 展开更多
关键词 周围神经损伤 普伐他汀 功能恢复 神经营养因子 坐骨神经功能指数
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电动拖拉机复合式振动馈能系统设计及试验
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作者 王旭东 王琪 +2 位作者 王威 陈雨 崔永杰 《农机化研究》 北大核心 2025年第4期230-235,共6页
为了回收和利用电动拖拉机行驶过程中产生的振动能量,基于浮动电池组提出了一种压电-机械电磁复合式振动馈能装置;然后,根据装置的电压输出特性构建了包含整流滤波、LM317稳压、超级电容储能和Boost升压模块的电能提取电路,以满足蓄电... 为了回收和利用电动拖拉机行驶过程中产生的振动能量,基于浮动电池组提出了一种压电-机械电磁复合式振动馈能装置;然后,根据装置的电压输出特性构建了包含整流滤波、LM317稳压、超级电容储能和Boost升压模块的电能提取电路,以满足蓄电池充电需求;最后,进行了复合式振动馈能系统的实车试验。结果表明:电动拖拉机车速为4 km/h时,馈能装置的最大输出电压为34.80 V,平均输出功率为0.57 W;经过等效计算,由复合式馈能系统回收的电能可使电动拖拉机的续航时间延长0.784 7 h。研究结果可为我国电动拖拉机的电能补给和工作时间延长提供理论与技术支撑。 展开更多
关键词 电动拖拉机 振动能量回收 复合式振动馈能装置 电能提取电路
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Activation of adult endogenous neurogenesis by a hyaluronic acid collagen gel containing basic fibroblast growth factor promotes remodeling and functional recovery of the injured cerebral cortex
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作者 Yan Li Peng Hao +6 位作者 Hongmei Duan Fei Hao Wen Zhao Yudan Gao Zhaoyang Yang Kwok-Fai So Xiaoguang Li 《Neural Regeneration Research》 SCIE CAS 2025年第10期2923-2937,共15页
The presence of endogenous neural stem/progenitor cells in the adult mammalian brain suggests that the central nervous system can be repaired and regenerated after injury.However,whether it is possible to stimulate ne... The presence of endogenous neural stem/progenitor cells in the adult mammalian brain suggests that the central nervous system can be repaired and regenerated after injury.However,whether it is possible to stimulate neurogenesis and reconstruct cortical layers II to VI in non-neurogenic regions,such as the cortex,remains unknown.In this study,we implanted a hyaluronic acid collagen gel loaded with basic fibroblast growth factor into the motor cortex immediately following traumatic injury.Our findings reveal that this gel effectively stimulated the proliferation and migration of endogenous neural stem/progenitor cells,as well as their differentiation into mature and functionally integrated neurons.Importantly,these new neurons reconstructed the architecture of cortical layers II to VI,integrated into the existing neural circuitry,and ultimately led to improved brain function.These findings offer novel insight into potential clinical treatments for traumatic cerebral cortex injuries. 展开更多
关键词 adult endogenous neurogenesis basic fibroblast growth factor-hyaluronic acid collagen gel cortical remodeling functional recovery migration motor cortex injury neural circuits neural stem cells newborn neurons proliferation
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区域医疗系统抗震韧性综述
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作者 裴顺顺 翟长海 胡杰 《哈尔滨工业大学学报》 EI CAS 北大核心 2025年第1期1-12,共12页
韧性作为一种新的灾害风险管理理念,已成为防灾减灾领域的研究热点,考虑到医疗系统在城市运行和灾后救援中的重要作用,在地震期间和之后,区域医疗系统应该具有足够的韧性,并提供连续的医疗服务。如何综合考虑区域范围内多家医院和交通... 韧性作为一种新的灾害风险管理理念,已成为防灾减灾领域的研究热点,考虑到医疗系统在城市运行和灾后救援中的重要作用,在地震期间和之后,区域医疗系统应该具有足够的韧性,并提供连续的医疗服务。如何综合考虑区域范围内多家医院和交通系统的安全性、应急响应能力、多系统的整合与协作,有效评估区域医疗系统的抗震韧性水平,并提出科学的改进建议,对建设韧性城乡具有重要的理论意义。本文通过梳理国内外文献,阐明了区域医疗系统韧性的概念和内涵,总结了地震后短期应急和长期修复两个阶段韧性评估的重点,归纳了现有区域医疗系统韧性的评估框架,从医院集群系统、面向医疗的交通系统、应急医疗服务系统和医疗-交通耦合系统4个方面阐述了现有评估方法。区域医疗系统韧性的研究旨在提高其面对灾害时的抵抗性、短期适应性和长期恢复性,这些研究对于满足紧急和日常的医疗需求以及指导灾后恢复具有重要意义。目前区域医疗系统抗震韧性的研究取得了一些进展,但仍然存在一些挑战,本文最后展望了未来的研究方向。 展开更多
关键词 区域医疗系统 单体医院 交通系统 抗震韧性 功能评估 恢复时间
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高铁低铜萃余液铜回收研究
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作者 刘琦 孙贯永 +3 位作者 郭持皓 梁东东 李拓夫 袁朝新 《有色金属(冶炼部分)》 CAS 北大核心 2025年第1期1-6,33,共7页
浸出—萃取—反萃—电积工艺中,残留在萃余液中的铜具有很高的回收价值。针对现有研究在机理和产物形貌方面分析的不足,开展了置换法从高铁低铜萃余液中回收铜的研究。系统考察时间、温度、加料方式、铁粉用量等条件对置换效果的影响,... 浸出—萃取—反萃—电积工艺中,残留在萃余液中的铜具有很高的回收价值。针对现有研究在机理和产物形貌方面分析的不足,开展了置换法从高铁低铜萃余液中回收铜的研究。系统考察时间、温度、加料方式、铁粉用量等条件对置换效果的影响,实现了铜的高效置换回收。研究表明:在20℃机械搅拌30 min条件下,一次加入用量为Cu^(2+)完全反应所需理论用量7倍的铁粉,Cu^(2+)和Fe^(3+)的转化率分别为99.96%和95.86%,而H+转化率仅为2.37%。对试验结果进行热力学分析,发现反应的优先顺序和限度与热力学计算结果具有一致性。产物铜形貌表征分析表明,产物海绵铜主要由海绵状和类球状两种结构组成。 展开更多
关键词 铜回收 萃余液 置换 海绵铜
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中风回春片对急性脑梗死恢复期患者的影响
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作者 郭东玲 金鑫 董艳丽 《临床研究》 2025年第1期95-99,共5页
目的将中风回春片应用于急性脑梗死(ACI)恢复期患者治疗,观察其临床疗效、神经功能及安全性。方法选取2019年9月至2023年6月郑州市第二人民医院收治的86例ACI恢复期患者,采用随机数字表法将其分为对照组(n=43,常规西药治疗)和试验组(n=... 目的将中风回春片应用于急性脑梗死(ACI)恢复期患者治疗,观察其临床疗效、神经功能及安全性。方法选取2019年9月至2023年6月郑州市第二人民医院收治的86例ACI恢复期患者,采用随机数字表法将其分为对照组(n=43,常规西药治疗)和试验组(n=43,采用中风回春片联合常规西药治疗)。比较两组患者临床疗效、中医症状积分、血清炎症因子[白细胞介素-6(IL-6)、转化生长因子-β(TGF-β)、超敏C反应蛋白(hs-CRP)]、神经营养指标[神经生长因子(NGF)、脑源性神经营养因子(BDNF)、胰岛素样生长因子1(IGF-1)]、神经损伤指标[心型脂肪酸结合蛋白(H-FABP)、S-100B蛋白(S100B)、神经元特异性烯醇化酶(NSE)]及不良反应发生率。结果试验组治疗有效率(93.02%)高于对照组(72.09%)差异具有统计学意义(P<0.05)。治疗前,两组中医症状积分比较,差异无统计学意义(P>0.05);治疗后,两组中医症状积分均降低,且试验组低于对照组,差异均有统计学意义(P<0.05)。治疗前,两组各项炎症因子水平比较,差异无统计学意义(P>0.05);治疗后,两组患者IL-6、hs-CRP水平较治疗前均降低,且试验组低于对照组,TGF-β水平较治疗前升高,且试验组高于对照组,差异均有统计学意义(P<0.05)。治疗前,两组神经营养因子水平比较,差异无统计学意义(P>0.05);治疗后,两组NGF、BDNF、IGF-1水平较治疗前均升高,且试验组高于对照组,差异均有统计学意义(P<0.05)。治疗前,两组神经损伤指标比较,差异无统计学意义(P>0.05);治疗后,两组患者H-FABP、S100B、NSE水平较治疗前均降低,且试验组低于对照组,差异均有统计学意义(P<0.05)。两组患者不良反应发生率比较,差异无统计学意义(P>0.05)。结论中风回春片联合常规西药可有效提高ACI恢复期患者的临床疗效,改善患者的中医症状,促进患者神经功能恢复,且安全性佳。 展开更多
关键词 急性脑梗死恢复期 中风回春片 神经营养 神经损伤
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