Apoptosis proteins play an important role in the development and homeostasis of an organism. The elucidation of the subcellular locations and functions of these proteins is helpful for understanding the mechanism of p...Apoptosis proteins play an important role in the development and homeostasis of an organism. The elucidation of the subcellular locations and functions of these proteins is helpful for understanding the mechanism of programmed cell death. In this paper, the recurrent quantification analysis, Hilbert-Huang transform methods, the maximum relevance and minimum redundancy method and support vector machine are used to predict the subcellular location of apoptosis proteins. The validation of the jackknife test suggests that the proposed method can improve the prediction accuracy of the subcellular location of apoptosis proteins and its application may be promising in other fields.展开更多
Gas-solid fluidized beds are widely considered as nonlinear and chaotic dynamic systems. Pressure fluc- tuations were measured in a fluidized bed of 0.15 m in diameter and were analyzed using multiple approaches: dis...Gas-solid fluidized beds are widely considered as nonlinear and chaotic dynamic systems. Pressure fluc- tuations were measured in a fluidized bed of 0.15 m in diameter and were analyzed using multiple approaches: discrete Fourier transform (DFT), discrete wavelet transform (DWT), and nonlinear recur- rence quantification analysis (RQA). Three different methods proposed that the complex dynamics of a fluidized bed system can be presented as macro, meso and micro structures. It was found from DFT and DWT that a minimum in wide band energy with an increase in the velocity corresponds to the transition between macro structures and finer structures of the fluidization system. Corresponding transition veloc- ity occurs at gas velocities of 0.3, 0.5 and 0.6 m]s for sands with mean diameters of 150, 280 and 490/~m, respectively. DFT, DWT, and RQA could determine frequency range of0-3.125 Hz for macro, 3. ! 25-50 Hz for meso, and 50-200 Hz for micro structures. The RQA showed that the micro structures have the least periodicity and consequently their determinism and laminarity are the lowest. The results show that a combination of DFT, DWT, and RQA can be used as an effective approach to characterize multi-scale flow behavior in gas-solid fluidized beds.展开更多
Most proteins adopt an approximate structural symmetry. However, they have no symmetry detectable in their sequences and it is unclear for most of these proteins whether their structural symmetry originates from dupli...Most proteins adopt an approximate structural symmetry. However, they have no symmetry detectable in their sequences and it is unclear for most of these proteins whether their structural symmetry originates from duplication. As one of the six popular folds (super-folds) possessing an approximate structural symmetry, the triosephosphate isomerase barrel (TIM-barrel) domain has been widely studied. Using modified recurrent quantification analysis of primary sequences, we identified the same 2-, 3-, and 4-fold symmetry pattern as their tertiary structures. This result indicates that the symmetry in tertiary structure is coded by symmetry in the primary sequence and that the TIM-barrel adopts a 2-, 3-, or 4-fold repeat pattern during evolution. This discovery will be useful for understanding the evolutionary mechanisms of this protein family and the symmetry pattern that may be a clue into the ancient origin of duplication of half-barrels or the β a unit.展开更多
The expanded disability status scale (EDSS) is frequently used to classify the patients with multiple sclerosis (MS). We presented in this paper a novel method to automatically assess the EDSS score from posturologic ...The expanded disability status scale (EDSS) is frequently used to classify the patients with multiple sclerosis (MS). We presented in this paper a novel method to automatically assess the EDSS score from posturologic data (center of pres-sure signals) using a decision tree. Two groups of participants (one for learning and the other for test) with EDSS rang-ing from 0 to 4.5 performed our balance experiment with eyes closed. Two linear measures (the length and the surface) and twelve non-linear measures (the recurrence rate, the Shannon entropy, the averaged diagonal line length and the trapping time for the position, the instantaneous velocity and the instantaneous acceleration of the center of pressure respectively) were calculated for all the participants. Several decision trees were constructed with learning data and tested with test data. By comparing clinical and estimated EDSS scores in the test group, we selected one decision tree with five measures which revealed a 75% of agreement. The results have signified that our tree model is able to auto-matically assess the EDSS scores and that it is possible to distinguish the EDSS scores by using linear and non-linear postural sway measures.展开更多
Pressure fluctuations of a fluidized bed of nanoparticles were measured during the fluidization of nanoparticles with and without a magnetic field at a frequency of 50 Hz.Recurrence quantification analysis(RQA)and wav...Pressure fluctuations of a fluidized bed of nanoparticles were measured during the fluidization of nanoparticles with and without a magnetic field at a frequency of 50 Hz.Recurrence quantification analysis(RQA)and wavelet transform were used to determine the frequency range of various flow structures in the bed at three scales.The frequency ranges of the macro-,meso-,and micro-structures were determined to be 0-49Hz,49-781 Hz,and 781+Hz,respectively.Comparison of the determinisms of the sub-signals with and without the external field revealed that in the presence the field,breakage of larger agglomerates occurs faster than re-agglomeration of small agglomerates into larger ones.The power spectral density function of the pressure fluctuations indicated that with an external magnetic field,the power and the frequency range of the pressure signal of macro-structures do not change noticeably.However,the power of the meso-structure signal increases and its frequency range is widened toward higher frequencies,confirming that the number of small bubbles and agglomerates increase in the bed.ln addition,the energy of signal analysis indicated that the external field significantly increases the share of meso-structures in the bed,confirming the RQA results.展开更多
基金supported by the National Natural Science Foundation of China (Grant No. 11071282)the Chinese Program for New Century Excellent Talents in University (Grant No. NCET-08-06867)+4 种基金the Natural Science Foundation of Hunan Province of China(Grant No. 10JJ7001)the Lotus Scholars Program of Hunan Province of Chinathe Aid Program for Science and Technology Innovative Research Team in Higher Educational Institutions of Hunan Province of Chinathe Australian Research Council (GrantNo. DP0559807)the Postgraduate Research and Innovation Project of Hunan Province of China (Grant No. CX2010B243)
文摘Apoptosis proteins play an important role in the development and homeostasis of an organism. The elucidation of the subcellular locations and functions of these proteins is helpful for understanding the mechanism of programmed cell death. In this paper, the recurrent quantification analysis, Hilbert-Huang transform methods, the maximum relevance and minimum redundancy method and support vector machine are used to predict the subcellular location of apoptosis proteins. The validation of the jackknife test suggests that the proposed method can improve the prediction accuracy of the subcellular location of apoptosis proteins and its application may be promising in other fields.
文摘Gas-solid fluidized beds are widely considered as nonlinear and chaotic dynamic systems. Pressure fluc- tuations were measured in a fluidized bed of 0.15 m in diameter and were analyzed using multiple approaches: discrete Fourier transform (DFT), discrete wavelet transform (DWT), and nonlinear recur- rence quantification analysis (RQA). Three different methods proposed that the complex dynamics of a fluidized bed system can be presented as macro, meso and micro structures. It was found from DFT and DWT that a minimum in wide band energy with an increase in the velocity corresponds to the transition between macro structures and finer structures of the fluidization system. Corresponding transition veloc- ity occurs at gas velocities of 0.3, 0.5 and 0.6 m]s for sands with mean diameters of 150, 280 and 490/~m, respectively. DFT, DWT, and RQA could determine frequency range of0-3.125 Hz for macro, 3. ! 25-50 Hz for meso, and 50-200 Hz for micro structures. The RQA showed that the micro structures have the least periodicity and consequently their determinism and laminarity are the lowest. The results show that a combination of DFT, DWT, and RQA can be used as an effective approach to characterize multi-scale flow behavior in gas-solid fluidized beds.
文摘Most proteins adopt an approximate structural symmetry. However, they have no symmetry detectable in their sequences and it is unclear for most of these proteins whether their structural symmetry originates from duplication. As one of the six popular folds (super-folds) possessing an approximate structural symmetry, the triosephosphate isomerase barrel (TIM-barrel) domain has been widely studied. Using modified recurrent quantification analysis of primary sequences, we identified the same 2-, 3-, and 4-fold symmetry pattern as their tertiary structures. This result indicates that the symmetry in tertiary structure is coded by symmetry in the primary sequence and that the TIM-barrel adopts a 2-, 3-, or 4-fold repeat pattern during evolution. This discovery will be useful for understanding the evolutionary mechanisms of this protein family and the symmetry pattern that may be a clue into the ancient origin of duplication of half-barrels or the β a unit.
文摘The expanded disability status scale (EDSS) is frequently used to classify the patients with multiple sclerosis (MS). We presented in this paper a novel method to automatically assess the EDSS score from posturologic data (center of pres-sure signals) using a decision tree. Two groups of participants (one for learning and the other for test) with EDSS rang-ing from 0 to 4.5 performed our balance experiment with eyes closed. Two linear measures (the length and the surface) and twelve non-linear measures (the recurrence rate, the Shannon entropy, the averaged diagonal line length and the trapping time for the position, the instantaneous velocity and the instantaneous acceleration of the center of pressure respectively) were calculated for all the participants. Several decision trees were constructed with learning data and tested with test data. By comparing clinical and estimated EDSS scores in the test group, we selected one decision tree with five measures which revealed a 75% of agreement. The results have signified that our tree model is able to auto-matically assess the EDSS scores and that it is possible to distinguish the EDSS scores by using linear and non-linear postural sway measures.
文摘Pressure fluctuations of a fluidized bed of nanoparticles were measured during the fluidization of nanoparticles with and without a magnetic field at a frequency of 50 Hz.Recurrence quantification analysis(RQA)and wavelet transform were used to determine the frequency range of various flow structures in the bed at three scales.The frequency ranges of the macro-,meso-,and micro-structures were determined to be 0-49Hz,49-781 Hz,and 781+Hz,respectively.Comparison of the determinisms of the sub-signals with and without the external field revealed that in the presence the field,breakage of larger agglomerates occurs faster than re-agglomeration of small agglomerates into larger ones.The power spectral density function of the pressure fluctuations indicated that with an external magnetic field,the power and the frequency range of the pressure signal of macro-structures do not change noticeably.However,the power of the meso-structure signal increases and its frequency range is widened toward higher frequencies,confirming that the number of small bubbles and agglomerates increase in the bed.ln addition,the energy of signal analysis indicated that the external field significantly increases the share of meso-structures in the bed,confirming the RQA results.