A novel aged mouse model of recurrent intracerebral hemorrhage in the bilateral striatum

The current animal models of stroke primarily model a single intracerebral hemorrhage(ICH)attack,and there is a lack of a reliable model of recurrent ICH.In this study,we established 16-month-old C57 B L/6 male mouse models of ICH by injecting collagenaseⅦ-S into the left striatum.Twenty-one days later,we injected collagenaseⅦ-S into the right striatum to simulate recurrent ICH.Our results showed that mice subjected to bilateral striatal hemorrhage had poorer neurological function at the early stage of hemorrhage,delayed recovery in locomotor function,motor coordination,and movement speed,and more obvious emotional and cognitive dysfunction than mice subjected to unilate ral striatal hemorrhage.These findings indicate that mouse models of bilateral striatal hemorrhage can well simulate clinically common recurrent ICH.These models should be used as a novel tool for investigating the pathogenesis and treatment targets of recurrent ICH.

Analysis on Risk Factors for Recurrent Hemorrhage after Surgery for Hypertensive Cerebral Hemorrhage

Objectives To analyze the risk factors for recurrent hemorrhage after craniotomy for hypertensive cerebral hemorrhage （HCH）. Methods Clinical data from 162 HCH patients who underwent surgery were retrospectively analyzed for the correlation between recurrent hemorrhage and gender, age, duration of hypertension, history of diabetes mellitus and hypercholesterolemia, site and volume of hemorrhage and post-surgical systolic and diastolic pressure. Results Post-surgical recurrent hemorrhage was found in 24 patients. With multi-variate regression analysis, history of diabetes, long-term hypertension and higher post-surgical systolic pressure were proved positively correlated to the incidence of recurrent hemorrhage after craniotomy for hypertensive cerebral hemorrhage （ P 〈 0.05 ）. Conclusions Risk factors for recurrent hemorrhage after craniotomy for hypertensive cerebral hemorrhage are history of diabetes, long-term hypertension and higher post-surgical systolic pressure. Patients with diabetes and hypertension are at higher risk for cerebral hemorrhage or post-surgical recurrent hemorrhage. Effective control on blood pressure after surgery can reduce the incidence of recurrent hemorrhage after surgery for hypertensive cerebral hemorrhage. （ S Chin J Cardiol 2009 ; 10 （4） ： 204 -207）

Biliary hemorrhage caused by a malignant small round cell tumor in the common bile duct:A case report

BACKGROUND Malignant small round cell tumor(MSRCT)metastasis to the common bile duct associated with recurrent biliary hemorrhage is extremely rare.Thus far,there have been no reports of metastatic small round cell tumors of the common bile duct.CASE SUMMARY Herein,we report the case of a 77-year-old female patient with an MSRCT in the common bile duct.The patient was admitted to hospital due to gastrointestinal hemorrhage and abdominal pain.We found a neoplasm in the common bile duct with active bleeding through a spyglass.We performed biopsy through the spyglass and placed a metal stent to stop bleeding.The pathological result suggested that it was an MSRCT metastasized from the back to the common bile duct.Later,we found using fluorescence in situ hybridization that the SS18 gene break test was negative,ruling out the diagnosis of synovial sarcoma.CONCLUSION MSRCT is a group of tumors with similar cell morphology and diffuse histological structure.Complete tumor resection results in improved survival in patients with MSRCT.Roux-en-Y cholangiojejunostomy was performed.After excision of the common bile duct tumor,the patient felt that the abdominal pain improved and hemorrhage disappeared.The patient underwent routine fecal examination one month after surgery,indicating a negative fecal occult blood test.On May 22,2023,the patient was reexamined by abdominal computed tomography,and no abdominal space occupying lesions or abdominal lymphadenopathy was found.