In order to study the effects of Ampelopsis grossedentata on endogenous cholesterol biosynthesis and the effects of reducing blood lipid in hyperlipidemia rats,extraction of flavonoids from Ampelopsis grossedentata by...In order to study the effects of Ampelopsis grossedentata on endogenous cholesterol biosynthesis and the effects of reducing blood lipid in hyperlipidemia rats,extraction of flavonoids from Ampelopsis grossedentata by using ethanol(TFAG),and the effects of TFAG on intracellular cholesterol synthesis were detected by amphotericin B-cell model;SD hyperlipidemia rat model was established by feeding high fat diet.A formulated medicine called Xuezhikang was used as a positive control,and TFAG of different doses were administered to the stomach for 30 d continuously to measure the indexes of heart,liver tissue homogenate and serum;part of the liver was taken for pathological observation.The results showed that TFAG could significantly inhibit the synthesis of cholesterol in cells.TFAG of different doses could significantly reduce the content of TC and TG in serum of hyperlipidemia rats,and increase the content of HDL;TC and TG in heart and liver were also decreased;besides,it could increase the content of SOD,CAT and GSH in the liver of hyperlipidemia rats,and reduce the content of MDA.The results of pathological section showed that TFAG could improve the damage degree of hepatocytes in hyperlipidemia rats,and the effect of high dose group was similar to that of Xuezhikang group.In general,TFAG has good antioxidant and reducing blood lipid effects,and can effectively inhibit liver steatosis.展开更多
笔者每日的工作就是坐于电脑前,不停地操作。久坐之下,必患痼疾。果然,我的血压逐年上升。30出头的我,万分焦急。常去健身中心,不锻炼到大汗淋漓,绝不回家。后来,有朋传经:锻炼不必“劳其筋骨”,适度即可。于是,我每日步行30分钟上班,...笔者每日的工作就是坐于电脑前,不停地操作。久坐之下,必患痼疾。果然,我的血压逐年上升。30出头的我,万分焦急。常去健身中心,不锻炼到大汗淋漓,绝不回家。后来,有朋传经:锻炼不必“劳其筋骨”,适度即可。于是,我每日步行30分钟上班,半年下来,我的血压渐趋正常。今在网上读此文,大悟!朋友,记住:Even 30 to 60 minutes of exercise per week were sufficient!文章的调查方法真科学,我国的医学界怎么就不作如此调查呢?展开更多
Objective To investigate the effects of Jiaosanxian(JSX,consisted of stir-baked Hordei Fructus GerminatusCrataegi Fructus-Massa Fermentata Medicinalis) on reducing blood lipid. Methods The model of hyperlipidemic mice...Objective To investigate the effects of Jiaosanxian(JSX,consisted of stir-baked Hordei Fructus GerminatusCrataegi Fructus-Massa Fermentata Medicinalis) on reducing blood lipid. Methods The model of hyperlipidemic mice was established by feeding high-fat diet. Kunming mice were randomly divided into six groups: blank,hyperlipidemic,Zhibituo,low-,mid-,and high-dose [100,200,and 400 mg/(kg·d)] JSX groups,and were continuously ig administered for 28 d. The contents of total cholesterol(TC),triglyceride(TG),low-density lipoprotein cholesterol(LDL-C),and high density lipoprotein cholesterol(HDL-C) in serum and liver and liver index were determined. Results The contents of TC,TG,and LDL-C in serum or liver were decreased significantly but the contents of HDL-C were increased more significantly in the mid- and high-dose JSX groups than those in hyperlipemic group. The weight and liver index were decreased significantly with the dose increasing of JSX. The lipid-decreasing effects were improved with the dose increasing. Conclusion These results suggest that JSX has the significant effects on hyperlipidemia. It could provide the experimental basis for the clinical use of JSX for the treatment of hyperlipidemia.展开更多
文摘In order to study the effects of Ampelopsis grossedentata on endogenous cholesterol biosynthesis and the effects of reducing blood lipid in hyperlipidemia rats,extraction of flavonoids from Ampelopsis grossedentata by using ethanol(TFAG),and the effects of TFAG on intracellular cholesterol synthesis were detected by amphotericin B-cell model;SD hyperlipidemia rat model was established by feeding high fat diet.A formulated medicine called Xuezhikang was used as a positive control,and TFAG of different doses were administered to the stomach for 30 d continuously to measure the indexes of heart,liver tissue homogenate and serum;part of the liver was taken for pathological observation.The results showed that TFAG could significantly inhibit the synthesis of cholesterol in cells.TFAG of different doses could significantly reduce the content of TC and TG in serum of hyperlipidemia rats,and increase the content of HDL;TC and TG in heart and liver were also decreased;besides,it could increase the content of SOD,CAT and GSH in the liver of hyperlipidemia rats,and reduce the content of MDA.The results of pathological section showed that TFAG could improve the damage degree of hepatocytes in hyperlipidemia rats,and the effect of high dose group was similar to that of Xuezhikang group.In general,TFAG has good antioxidant and reducing blood lipid effects,and can effectively inhibit liver steatosis.
文摘笔者每日的工作就是坐于电脑前,不停地操作。久坐之下,必患痼疾。果然,我的血压逐年上升。30出头的我,万分焦急。常去健身中心,不锻炼到大汗淋漓,绝不回家。后来,有朋传经:锻炼不必“劳其筋骨”,适度即可。于是,我每日步行30分钟上班,半年下来,我的血压渐趋正常。今在网上读此文,大悟!朋友,记住:Even 30 to 60 minutes of exercise per week were sufficient!文章的调查方法真科学,我国的医学界怎么就不作如此调查呢?
基金Construct Program of the Key Discipline in Hunan Province(2011-76)Aid Program for Science and Technology Innovative Research Team in Higher Educational Institutions of Hunan Province(2012-318)
文摘Objective To investigate the effects of Jiaosanxian(JSX,consisted of stir-baked Hordei Fructus GerminatusCrataegi Fructus-Massa Fermentata Medicinalis) on reducing blood lipid. Methods The model of hyperlipidemic mice was established by feeding high-fat diet. Kunming mice were randomly divided into six groups: blank,hyperlipidemic,Zhibituo,low-,mid-,and high-dose [100,200,and 400 mg/(kg·d)] JSX groups,and were continuously ig administered for 28 d. The contents of total cholesterol(TC),triglyceride(TG),low-density lipoprotein cholesterol(LDL-C),and high density lipoprotein cholesterol(HDL-C) in serum and liver and liver index were determined. Results The contents of TC,TG,and LDL-C in serum or liver were decreased significantly but the contents of HDL-C were increased more significantly in the mid- and high-dose JSX groups than those in hyperlipemic group. The weight and liver index were decreased significantly with the dose increasing of JSX. The lipid-decreasing effects were improved with the dose increasing. Conclusion These results suggest that JSX has the significant effects on hyperlipidemia. It could provide the experimental basis for the clinical use of JSX for the treatment of hyperlipidemia.
