After the introduction of tourist resources in Wunvfeng National Forest Park, the paper had planed its overall image from the perspectives of concept design, visual identity, behavioral norms and audio identity. The s...After the introduction of tourist resources in Wunvfeng National Forest Park, the paper had planed its overall image from the perspectives of concept design, visual identity, behavioral norms and audio identity. The slogan of Wunvfeng National Forest Park had been identified as "tour of nature and mythology-Wunvfeng", and the park's emblem, symbolic mascots, spokesman of tourism image and tourist souvenirs had been set, so as to better display tourist advantages of Wunvfeng National Forest Park and create more economic and social benefits.展开更多
The PARK2 gene is a common disease gene in Han Chinese patients with Parkinson＇s disease.The detection of mutations in the PARK2 gene remains low.To investigate the role PARK2 gene mutations play in the pathogenesis ...The PARK2 gene is a common disease gene in Han Chinese patients with Parkinson＇s disease.The detection of mutations in the PARK2 gene remains low.To investigate the role PARK2 gene mutations play in the pathogenesis of Parkinson＇s disease,30 Han Chinese patients with early-onset Parkinson＇s disease and 38 normal controls were studied to determine the sequence changes of 1,4,6 and 7 exon sections.In the 30 patients with Parkinson＇s disease,a heterozygous intron mutation（nt 119,G→G/A）in exon 1 was detected in one case;a homozygous intron mutation（nt 526500,T→C）between intron 3 and exon 4 in fourteen cases was found;a heterozygous intron mutation（nt 526607,G→G/A）between intron 3 and exon 4 was observed in eight cases;an exon 6missense mutation（nt 754317,C→C/T;codon 193,CGG→CGG/TGG;aa 193,Arg→Arg/Trp）in three cases was seen;and an exon 7 missense mutation（nt 941943,C→A/C;codon 272,CTC→CTC/ATC;aa 272,Leu→Leu/lle）was found in one case.These changes were not found in the normal population.The results indicated that the PARK2 exons 6 and 7 mutations are possibly pathogenic mutations,along with the intron 3-exert 4 and exon 1 mutations.PARK2 gene mutations are possible factors leading to the onset of Parkinson＇s disease.展开更多
Accessibility is a factor affecting national park visitation.However,the effect of accessibility on national park visitation is not fully understood.This paper examines the relationship between U.S.national park visit...Accessibility is a factor affecting national park visitation.However,the effect of accessibility on national park visitation is not fully understood.This paper examines the relationship between U.S.national park visitation and accessibility.First,the global and local accessibility indexes of each park unit are computed based on an accessibility model that takes into account the surrounding population and its proximity to the park unit.Integrated in the model is a distance decay coefficient that is derived from U.S.national park visitor surveys and therefore pertinent to the case of study.Then correlation analysis is performed between park visitation and accessibility based on park types,regions,and visitation types.Results show that total visitation is positively related to accessibility in National Memorials,Military Parks and Battlefield Parks/Sites but negatively related to accessibility in national parks and national monuments.However,recreational overnight stay visits are commonly negatively correlated to accessibility for almost all park types.Moreover,local accessibility index displays enhanced correlation coefficients with improved significance levels in many categories of analysis.Results suggest that historical/cultural national parks which often show positive correlations tend to attract more local visitors,but nature-based parks which mainly show negative correlations tend to attract more distant visitors.展开更多
Taking into account problems existing in urban children’s recreational spaces, this paper mainly discussed the method to design natural children’s recreational spaces and facilities, analyzed the characteristics and...Taking into account problems existing in urban children’s recreational spaces, this paper mainly discussed the method to design natural children’s recreational spaces and facilities, analyzed the characteristics and influencing factors of natural children’s recreational spaces and facilities based on the characteristics of behavioral and psychological cognition of preschool children, and concluded that children’s recreational spaces consist of five parts, namely, the border, entrance, internal activity space, viewing space and supporting space and that the design of recreational facilities should meet the four points of naturalness, appropriate fuzziness, appropriate scale and size, and diversities and opportunities, with a view to providing a reference for the design of children’s recreational spaces and facilities.展开更多
Studies have shown that PARK1 gene is associated with the autosomal dominant inheritance of Parkinson＇s disease. PARK1 gene contains two mutation sites, namely Ala30Pro and Ala53Thr, which are located on exons 3 and ...Studies have shown that PARK1 gene is associated with the autosomal dominant inheritance of Parkinson＇s disease. PARK1 gene contains two mutation sites, namely Ala30Pro and Ala53Thr, which are located on exons 3 and 4, respectively. However, the genetic loci of the pathogenic genes remain unclear. In this study, blood samples were collected from 11 members of a family with high prevalence of Parkinson＇s disease, including four affected cases, five suspected cases and two non-affected cases. Point mutation screening of common mutation sites on PARK1 gene exon 4 was conducted using PCR, to determine the genetic loci of the causative gene for Parkinson＇s disease. Gene identification and sequencing results showed that a T base deletion mutation was observed in the PARK1 gene exon 4 of all 11 collected samples. It was confirmed that the PARK1 gene exon 4 gene mutation is an important pathogenic mutation for Parkinson＇s disease.展开更多
Totally three articles regarding associations of Nurrl gene mutations, LRRK2 gene polymorphism sites $1647T and R1398H, and polymorphism of PARK2 gene mutations with Han Chinese patients with Parkinson＇s disease were...Totally three articles regarding associations of Nurrl gene mutations, LRRK2 gene polymorphism sites $1647T and R1398H, and polymorphism of PARK2 gene mutations with Han Chinese patients with Parkinson＇s disease were published in Neural Regeneration Research. We hope that our readers find these papers useful to their research.展开更多
This text combines authors＇ visits and examinations on the spot of Silicon Valley of U.S.A. and Park of Singapore, after analyzing the Park development experience of U.S.A. and Singapore, elucidates ＂three culture e...This text combines authors＇ visits and examinations on the spot of Silicon Valley of U.S.A. and Park of Singapore, after analyzing the Park development experience of U.S.A. and Singapore, elucidates ＂three culture effects＂ of Park development in terms of cultural system emphatically, then proposes some suggestions of cultural innovation in the Park of China.展开更多
The Tlemcen region is located in north-western Algeria and is characterized by a semi-arid bioclimate. An approach to the diversity of the malacofauna associated with Salvia officinalis was carried out in three statio...The Tlemcen region is located in north-western Algeria and is characterized by a semi-arid bioclimate. An approach to the diversity of the malacofauna associated with Salvia officinalis was carried out in three stations belonging to this area from February to June 2015. The specific richness of the Gastropods is 9 divided into three families: Milacidae, Helicidae and Subulinidae. The second includes two subfamilies including that of Helicinae and that of Helicellinae. Two species are constant, 01 is incidental and the 06 others are very accidental. The relative importance of snails fluctuates according to the stations and according to the months and the seasons. In winter, in the first station the malacological richness is equal to 6. In February, the specific richness is relatively important in the 2nd station with a value equal to 7. Milax nigricans (Milacidae) has a frequency of 10% in station 1 and has a density of 0.1 in this same station. It is absent in the other two stations. Euparypha pisana has a frequency of 60% in station 3 and an abundance of 0.57 in this same station.展开更多
Parkinson’s disease(PD)is a complex fatal chronic neurodegenerative disease most common in elderly people.The early genome-wide association studies(GWAS)found that the minor allele variant of PARK16 rs708730 polymorp...Parkinson’s disease(PD)is a complex fatal chronic neurodegenerative disease most common in elderly people.The early genome-wide association studies(GWAS)found that the minor allele variant of PARK16 rs708730 polymorphism is a significant protective factor for PD in Caucasian populations.However,these results cannot be repeated by the following studies in Caucasian populations and other populations.We considered that the inconsistency of the findings may be caused by the small-scale samples or the heterogeneity among different populations.Therefore,in this study,we synthesized the previous related GWAS studies through three authoritative sources,and used the large-scale samples(10,645 PD cases and 30,499 controls)to reevaluate the association between rs708730 polymorphism and PD.The results showed that there is no association between them in Asian ancestry population.While,in European ancestry population,we found that the minor allele variant(G)of rs708730 polymorphism is significantly associated with a decreased risk of PD.Collectively,our findings further verified the association of rs708730 with PD and show its genetic heterogeneity among different populations,which can help to develop a better understanding of the PD’s pathogenesis.展开更多
The inductances in d-q axis have an important influence on the behavior of PMSM （PM （permanent-magnet） synchronous machines）. Their calculation is fundamental not only to evaluate the performance such as torque an...The inductances in d-q axis have an important influence on the behavior of PMSM （PM （permanent-magnet） synchronous machines）. Their calculation is fundamental not only to evaluate the performance such as torque and field weakening capability but also to design the control system to maximize performance and power factor. This paper presents a study of inductance in the d-q axis for buried （i.e., IPMSM （interior） PM Synchronous Machines）. This study is achieved using 2-D （two-dimensional） FEM （finite-element method） and Park＇s transformation.展开更多
文摘After the introduction of tourist resources in Wunvfeng National Forest Park, the paper had planed its overall image from the perspectives of concept design, visual identity, behavioral norms and audio identity. The slogan of Wunvfeng National Forest Park had been identified as "tour of nature and mythology-Wunvfeng", and the park's emblem, symbolic mascots, spokesman of tourism image and tourist souvenirs had been set, so as to better display tourist advantages of Wunvfeng National Forest Park and create more economic and social benefits.
文摘The PARK2 gene is a common disease gene in Han Chinese patients with Parkinson＇s disease.The detection of mutations in the PARK2 gene remains low.To investigate the role PARK2 gene mutations play in the pathogenesis of Parkinson＇s disease,30 Han Chinese patients with early-onset Parkinson＇s disease and 38 normal controls were studied to determine the sequence changes of 1,4,6 and 7 exon sections.In the 30 patients with Parkinson＇s disease,a heterozygous intron mutation（nt 119,G→G/A）in exon 1 was detected in one case;a homozygous intron mutation（nt 526500,T→C）between intron 3 and exon 4 in fourteen cases was found;a heterozygous intron mutation（nt 526607,G→G/A）between intron 3 and exon 4 was observed in eight cases;an exon 6missense mutation（nt 754317,C→C/T;codon 193,CGG→CGG/TGG;aa 193,Arg→Arg/Trp）in three cases was seen;and an exon 7 missense mutation（nt 941943,C→A/C;codon 272,CTC→CTC/ATC;aa 272,Leu→Leu/lle）was found in one case.These changes were not found in the normal population.The results indicated that the PARK2 exons 6 and 7 mutations are possibly pathogenic mutations,along with the intron 3-exert 4 and exon 1 mutations.PARK2 gene mutations are possible factors leading to the onset of Parkinson＇s disease.
基金supported by the National Nature Science Foundation of China (Grant No. 41401604)the Central Universities Fund Project of Southwest Minzu University (Grant No. 2019SYB07)
文摘Accessibility is a factor affecting national park visitation.However,the effect of accessibility on national park visitation is not fully understood.This paper examines the relationship between U.S.national park visitation and accessibility.First,the global and local accessibility indexes of each park unit are computed based on an accessibility model that takes into account the surrounding population and its proximity to the park unit.Integrated in the model is a distance decay coefficient that is derived from U.S.national park visitor surveys and therefore pertinent to the case of study.Then correlation analysis is performed between park visitation and accessibility based on park types,regions,and visitation types.Results show that total visitation is positively related to accessibility in National Memorials,Military Parks and Battlefield Parks/Sites but negatively related to accessibility in national parks and national monuments.However,recreational overnight stay visits are commonly negatively correlated to accessibility for almost all park types.Moreover,local accessibility index displays enhanced correlation coefficients with improved significance levels in many categories of analysis.Results suggest that historical/cultural national parks which often show positive correlations tend to attract more local visitors,but nature-based parks which mainly show negative correlations tend to attract more distant visitors.
基金Sponsored by the Sichuan Landscape and Recreation Research Center(JGYQ2014150)the Sichuan Yi Culture Research Center(YZWH1618)
文摘Taking into account problems existing in urban children’s recreational spaces, this paper mainly discussed the method to design natural children’s recreational spaces and facilities, analyzed the characteristics and influencing factors of natural children’s recreational spaces and facilities based on the characteristics of behavioral and psychological cognition of preschool children, and concluded that children’s recreational spaces consist of five parts, namely, the border, entrance, internal activity space, viewing space and supporting space and that the design of recreational facilities should meet the four points of naturalness, appropriate fuzziness, appropriate scale and size, and diversities and opportunities, with a view to providing a reference for the design of children’s recreational spaces and facilities.
基金Supported by a Foundation of Science and Technology Department of Jilin Province, No. 200905152
文摘Studies have shown that PARK1 gene is associated with the autosomal dominant inheritance of Parkinson＇s disease. PARK1 gene contains two mutation sites, namely Ala30Pro and Ala53Thr, which are located on exons 3 and 4, respectively. However, the genetic loci of the pathogenic genes remain unclear. In this study, blood samples were collected from 11 members of a family with high prevalence of Parkinson＇s disease, including four affected cases, five suspected cases and two non-affected cases. Point mutation screening of common mutation sites on PARK1 gene exon 4 was conducted using PCR, to determine the genetic loci of the causative gene for Parkinson＇s disease. Gene identification and sequencing results showed that a T base deletion mutation was observed in the PARK1 gene exon 4 of all 11 collected samples. It was confirmed that the PARK1 gene exon 4 gene mutation is an important pathogenic mutation for Parkinson＇s disease.
文摘Totally three articles regarding associations of Nurrl gene mutations, LRRK2 gene polymorphism sites $1647T and R1398H, and polymorphism of PARK2 gene mutations with Han Chinese patients with Parkinson＇s disease were published in Neural Regeneration Research. We hope that our readers find these papers useful to their research.
文摘This text combines authors＇ visits and examinations on the spot of Silicon Valley of U.S.A. and Park of Singapore, after analyzing the Park development experience of U.S.A. and Singapore, elucidates ＂three culture effects＂ of Park development in terms of cultural system emphatically, then proposes some suggestions of cultural innovation in the Park of China.
文摘The Tlemcen region is located in north-western Algeria and is characterized by a semi-arid bioclimate. An approach to the diversity of the malacofauna associated with Salvia officinalis was carried out in three stations belonging to this area from February to June 2015. The specific richness of the Gastropods is 9 divided into three families: Milacidae, Helicidae and Subulinidae. The second includes two subfamilies including that of Helicinae and that of Helicellinae. Two species are constant, 01 is incidental and the 06 others are very accidental. The relative importance of snails fluctuates according to the stations and according to the months and the seasons. In winter, in the first station the malacological richness is equal to 6. In February, the specific richness is relatively important in the 2nd station with a value equal to 7. Milax nigricans (Milacidae) has a frequency of 10% in station 1 and has a density of 0.1 in this same station. It is absent in the other two stations. Euparypha pisana has a frequency of 60% in station 3 and an abundance of 0.57 in this same station.
基金Lanzhou Science and Technology Bureau Program Funds(2017-RC-16,2018-1-110)Gansu Science and Technology Fund Grant(ID:17ZD2FA009)National Science and Technology Ministry(ID:2017ZX09101001).
文摘Parkinson’s disease(PD)is a complex fatal chronic neurodegenerative disease most common in elderly people.The early genome-wide association studies(GWAS)found that the minor allele variant of PARK16 rs708730 polymorphism is a significant protective factor for PD in Caucasian populations.However,these results cannot be repeated by the following studies in Caucasian populations and other populations.We considered that the inconsistency of the findings may be caused by the small-scale samples or the heterogeneity among different populations.Therefore,in this study,we synthesized the previous related GWAS studies through three authoritative sources,and used the large-scale samples(10,645 PD cases and 30,499 controls)to reevaluate the association between rs708730 polymorphism and PD.The results showed that there is no association between them in Asian ancestry population.While,in European ancestry population,we found that the minor allele variant(G)of rs708730 polymorphism is significantly associated with a decreased risk of PD.Collectively,our findings further verified the association of rs708730 with PD and show its genetic heterogeneity among different populations,which can help to develop a better understanding of the PD’s pathogenesis.
文摘The inductances in d-q axis have an important influence on the behavior of PMSM （PM （permanent-magnet） synchronous machines）. Their calculation is fundamental not only to evaluate the performance such as torque and field weakening capability but also to design the control system to maximize performance and power factor. This paper presents a study of inductance in the d-q axis for buried （i.e., IPMSM （interior） PM Synchronous Machines）. This study is achieved using 2-D （two-dimensional） FEM （finite-element method） and Park＇s transformation.
