BACKGROUND Diabetic vitreous hemorrhage(DVH)is a common complication of diabetes.While the diagnostic methods nowadays only concentrate on the eye injury in DVH patients,whether DVH leads to abnormalities of other vis...BACKGROUND Diabetic vitreous hemorrhage(DVH)is a common complication of diabetes.While the diagnostic methods nowadays only concentrate on the eye injury in DVH patients,whether DVH leads to abnormalities of other visual systems,including the eye,the visual cortex,and other brain regions,remains unknown.AIM To explore the potential changes of brain activity in DVH using regional homogeneity(ReHo)and their relationships with clinical features.METHODS Thirty-one DVH patients and 31 matched healthy controls(HCs)were recruited.All subjects were examined by resting-state functional magnetic resonance imaging.The neural homogeneity in the brain region was estimated by ReHo method.Pearson correlation analysis was used to evaluate the relationships between average ReHo values and clinical manifestations in DVH patients.RESULTS Compared with HCs,the ReHo values in the bilateral cerebellar posterior lobes,right superior(RS)/middle occipital gyrus(MOG),and bilateral superior frontal gyrus were significantly increased.In contrast,in the right insula,bilateral medial frontal gyri,and right middle frontal gyrus,the ReHo values were significantly decreased.Furthermore,we found that best-corrected visual acuity of the contralateral eye in patients with DVH presented a positive correlation with the mean ReHo value of the RS/MOG.We also found that depression score of the DVH group presented a negative correlation with the mean ReHo values of the right insula,bilateral medial frontal gyrus,and right middle frontal gyrus.CONCLUSION We found that DVH may cause dysfunction in multiple brain areas,which may benefit the exploration of pathologic mechanisms in DVH patients.展开更多
Background Alexithymia is a multidimensional personality construct.Objective This study aims to investigate the neuronal correlates of each alexithymia dimension by examining the regional homogeneity （ReHo） of int...Background Alexithymia is a multidimensional personality construct.Objective This study aims to investigate the neuronal correlates of each alexithymia dimension by examining the regional homogeneity （ReHo） of intrinsic brain activity in a resting situation.Methods From university freshmen, students with alexithymia and non-alexithymia were recruited. Their alexithymic traits were assessed using the Toronto Alexithymia Scale-20. The ReHo was examined using a resting-state functional MRI approach.Results This study suggests signifcant group differences in ReHo in multiple brain regions distributed in the frontal lobe, parietal lobe, temporal lobe, occipital lobe and insular cortex. However, only the ReHo in the insula was positively associated with diffculty identifying feelings, a main dimension of alexithymia. The ReHo in the lingual gyrus, precentral gyrus and postcentral gyrus was？positively associated with diffculty describing feelings in？participants with？alexithymia. Lastly, the ReHo in the right dorsomedial prefrontal cortex （DMPFC_R） was negatively related to the externally oriented thinking style of participants with？alexithymia.Conclusion In conclusion, these results suggest that the main dimensions of alexithymia are correlated with specifc brain regions’ function, and the role of the insula, lingual gyrus, precentral gyrus, postcentral gyrus and DMPFC_R in the neuropathology of alexithymia should be further investigated.展开更多
BACKGROUND Diabetes is a common chronic disease.Given the increasing incidence of diabetes,more individuals are affected by diabetic optic neuropathy(DON),which results in decreased vision.Whether DON leads to abnorma...BACKGROUND Diabetes is a common chronic disease.Given the increasing incidence of diabetes,more individuals are affected by diabetic optic neuropathy(DON),which results in decreased vision.Whether DON leads to abnormalities of other visual systems,including the eye,the visual cortex,and other brain regions,remains unknown.AIM To investigate the local characteristics of spontaneous brain activity using regional homogeneity(ReHo)in patients with DON.METHODS We matched 22 patients with DON with 22 healthy controls(HCs).All subjects underwent resting-state functional magnetic resonance imaging.The ReHo technique was used to record spontaneous changes in brain activity.Receiver operating characteristic(ROC)curves were applied to differentiate between ReHo values for patients with DON and HCs.We also assessed the correlation between Hospital Anxiety and Depression Scale scores and ReHo values in DON patients using Pearson correlation analysis.RESULTS ReHo values of the right middle frontal gyrus(RMFG),left anterior cingulate(LAC),and superior frontal gyrus(SFG)/left frontal superior orbital gyrus(LFSO)were significantly lower in DON patients compared to HCs.Among these,the greatest difference was observed in the RMFG.The result of the ROC curves suggest that ReHo values in altered brain regions may help diagnose DON,and the RMFG and LAC ReHo values are more clinically relevant than SFG/LFSO.We also found that anxiety and depression scores of the DON group were extremely negatively correlated with the LAC ReHo values(r=-0.9336,P<0.0001 and r=-0.8453,P<0.0001,respectively).CONCLUSION Three different brain regions show ReHo changes in DON patients,and these changes could serve as diagnostic and/or prognostic biomarkers to further guide the prevention and treatment of DON patients.展开更多
Regional homogeneity analysis of low-frequency blood oxygenation level-dependent signals from neighboring voxels enables the analysis of local neuronal synchrony. Both structural magnetic resonance imaging and resting...Regional homogeneity analysis of low-frequency blood oxygenation level-dependent signals from neighboring voxels enables the analysis of local neuronal synchrony. Both structural magnetic resonance imaging and resting-state functional magnetic resonance imaging scans were collected from nine Parkinson＇s disease patients with right resting tremor, and from eight age-matched normal controls. Regional homogeneity was compared between Parkinson＇s disease patients and controls. The results revealed that regional homogeneity was increased in several brain regions, including the right precuneus, right superior parietal gyrus, left anterior cingulate cortex, right middle frontal gyrus and right inferior frontal gyrus. Conversely, regional homogeneity was decreased in the cerebellar vermis in Parkinson＇s disease patients compared with healthy controls.展开更多
Eastern Black Sea Region in northeastern part of Turkey has the highest precipitation total in the country, approaching 2500 mm per a year. It is therefore an important region as it frequently encounters with flash fl...Eastern Black Sea Region in northeastern part of Turkey has the highest precipitation total in the country, approaching 2500 mm per a year. It is therefore an important region as it frequently encounters with flash floods due to heavy rains. For future planning of water resources, environment and urbanization, it is important to know the expected behavior of hydrometeorological processes, mainly precipitation and flow. Due to these facts, in this study, homogeneity of long-term annual precipitation and streamflow series of the Eastern Black Sea Region, Turkey is checked using double mass curve method and trends are determined by means of the Mann-Kendall test. The data network consists of 38 precipitation gauging stations and 40 flow gauging stations across the Eastern Black Sea Region. It is found that 27 precipitation stations out of 38 are homogeneous and no trend is available. Out of the remaining stations, nine are found non-homogeneous and four with trend. For annual flow data, it is found that 22 stations out of 40 are homogeneous and no trend is available. The remaining 18 stations are found non-homogeneous, among which 5 stations have trend at the same time.展开更多
The world animal geographical regionalization scheme and the plant geographical regionalization scheme have been formulated by zoologists and botanists respectively since the biogeography has been established.This res...The world animal geographical regionalization scheme and the plant geographical regionalization scheme have been formulated by zoologists and botanists respectively since the biogeography has been established.This research team initially confirmed the homogeneity of Chinese animal and plant geography.To explore the relationship between the distribution pattern of global animals,plants,and microorganisms,global 141,814 genera of terrestrial animals,17,526 genera of plants,21,321 genera of microorganisms,and their major taxa were analyzed using their proposed SGF(Similarity General Formula)and a new multivariate similarity clustering analysis method.Almost identical analytical results were obtained,meeting the requirements of statistics,geography,ecology and biology respectively.The expected consistency of their distribution pattern was achieved for the first time.We prove that the earth’s ecological conditions affect the homogeneity and accumulation of the distribution of animals,plants and microorganisms.Homogeneity determines the distribution pattern of global kinds of biological consistency,accumulation determines the impact of the evolutionary period on the breadth of distribution,microorganisms appear earliest,plants second,animals later,and their average distribution domain decreases in turn,reflecting these differences.Therefore,this study not only provides a theoretical basis and quantitative basis for the establishment of geographical regionalization scheme but also advances the development of biogeography to a new stage and raises the theory of biogeographic analysis to a new height.展开更多
目的探讨体素镜像同伦连接(voxel-mirrored homotopic connectivity,VMHC)与局部一致性(regional homogeneity,ReHo)在评价经颅直流电刺激(transcranial direct current stimulation,tDCS)改善脑卒中后认知障碍中的应用价值。材料与方...目的探讨体素镜像同伦连接(voxel-mirrored homotopic connectivity,VMHC)与局部一致性(regional homogeneity,ReHo)在评价经颅直流电刺激(transcranial direct current stimulation,tDCS)改善脑卒中后认知障碍中的应用价值。材料与方法前瞻性纳入47名脑卒中后认知障碍(post-stroke cognitive impairment,PSCI)患者,随机分配到tDCS组与假刺激组,其中tDCS组23人,假刺激组24人,应用Mann-Whitney U检验比较两组患者在基线期与15天tDCS或假刺激治疗后认知量表评分变化值的差异,应用配对t检验比较两组患者在基线期与15天tDCS或假刺激治疗后VMHC与ReHo指标的差异,并提取差异脑区的VMHC与ReHo值与治疗前后认知量表评分的变化值进行相关性分析。结果tDCS组与假刺激组在治疗后的简易智能精神状态量表(Mini-Mental State Examination,MMSE)与蒙特利尔认知评估量表(Montreal Cognitive Assessment,MoCA)评分均优于治疗前,但tDCS组具有更好的治疗效果,治疗后相较于治疗前MMSE与MoCA量表评分改善值更大,差异具有统计学意义(P<0.05);VMHC指标结果:tDCS组患者在治疗后,双侧岛叶、楔前叶的VMHC值升高(P<0.05,FDR校正),假刺激组患者在治疗后,在双侧枕上回的VMHC值升高(P<0.05,FDR校正);ReHo指标结果:tDCS组患者在治疗后,前扣带回和顶下缘角回的ReHo值升高(P<0.05,FDR校正),假刺激组患者在治疗后相较于治疗前,未见明显差异脑区;相关性分析:tDCS组患者在治疗后,双侧楔前叶VMHC增加的值与MMSE、MoCA量表评分的变化值呈现正相关,MMSE(r=0.47,P=0.02);MoCA(r=0.43,P=0.04);其他差异脑区与MMSE与MoCA量表评分变化值无明显相关性。结论tDCS联合常规康复治疗对PSCI患者的认知康复效果优于仅进行常规康复治疗手段,应用VMHC与ReHo发现tDCS的治疗机制可能与改善默认模式网络(default mode network,DMN)与突显网络(salience network,SN)中部分脑区在双侧大脑半球之间的功能连接与自发活动有关。展开更多
Although many functional magnetic resonance imaging(f MRI) studies have investigated the neurophysiology of attention deficit hyperactivity disorder(ADHD),the existing studies have not yielded consistent findings.This...Although many functional magnetic resonance imaging(f MRI) studies have investigated the neurophysiology of attention deficit hyperactivity disorder(ADHD),the existing studies have not yielded consistent findings.This may be related to the different properties of different frequency bands. To investigate the frequency-specific regional homogeneity(Re Ho) of spontaneous neural activities in ADHD, the current study used resting-state f MRI to explore the Re Ho properties of five frequency bands, slow-5(0.01–0.027 Hz), slow-4(0.027–0.073 Hz),slow-3(0.073–0.198 Hz), slow-2(0.198–0.25 Hz) and the extra-low frequency(0–0.01 Hz), in 30 drug-naive boys with ADHD and 30 healthy controls. Compared with controls, the ADHD group showed decreased Re Ho in the default mode network(DMN) including the medial prefrontal cortex and precuneus, middle frontal gyrus and angular gyrus. ADHD patients also showed increased Re Ho in the posterior cerebellum. Significant interactions between frequency band and group were observed predominantly in the dorsolateral prefrontal and parietal cortices, orbital frontal cortex, supplementary motor area,inferior occipital gyrus, thalamus and anterior cerebellum.In particular, we found that the between-group difference in the extra-low frequency band(0–0.01 Hz) seemed to be greater than that in the other frequency bands for most brain regions. The findings suggest that ADHD children display widespread abnormalities in regional brain activity,particularly in the DMN and attention network, and these abnormalities show frequency specificity.展开更多
Backgroud Functional imaging studies indicate abnormal activities in cortico-limbic network in depression during either task or resting state. The present work was to explore the abnormal spontaneous activity shown wi...Backgroud Functional imaging studies indicate abnormal activities in cortico-limbic network in depression during either task or resting state. The present work was to explore the abnormal spontaneous activity shown with regional homogeneity （ReHo） in depression by resting-state functional magnetic resonance imaging （fMRI）.Methods Using fMRI, the differences of regional brain activity were measured in resting state in depressed vs. healthy participants. Sixteen participants firstly diagnosed with major depressive disorder and 16 controls were scanned during resting state. A novel method based on ReHo was used to detect spontaneous hemodynamic responses across the whole brain.Results ReHo in the left thalamus, left temporal lobe, left cerebellar posterior lobe, and the bilateral occipital lobe was found to be significantly decreased in depression compared to healthy controls in resting state of depression.Conclusions Abnormal spontaneous activity exists in the left thalamus, left temporal lobe, left cerebellar posterior lobe,and the bilateral occipital lobe. And the ReHo may be a potential reference in understanding the distinct brain activity in resting state of depression.展开更多
Objective: To study the effect of contralateral acupuncture(CAT) at acupoints of Quchi(LI 11) and Zusanli(ST 36) on the unaffected limbs of ischemic stroke patients with left hemiplegia based on regional homogeneity(R...Objective: To study the effect of contralateral acupuncture(CAT) at acupoints of Quchi(LI 11) and Zusanli(ST 36) on the unaffected limbs of ischemic stroke patients with left hemiplegia based on regional homogeneity(ReHo) indices. Methods: Ten ischemic stroke patients with left hemiplegia received CAT on right side at LI 11 and ST 36. Functional magnetic resonance imaging(fMRI) was performed before and after acupuncture. A ReHo analytical method was used to compare brain responses of patients before and after CAT operated by REST software. Results: The stimulation at both LI 11 and ST 36 on the unaffected limbs produced significantly different neural activities. CAT elicited increased ReHo values at the right precentral gyrus and superior frontal gyrus, decreased ReHo value at right superior parietal lobule, left fusiform gyrus and left supplementary motor area. Conclusions: Acupuncture at one side could stimulate bilateral regions. CAT could evoke the gyrus which was possibly related to motor recovery from stroke. A promising indicator of neurobiological deficiencies could be represented by ReHo values in post-stroke patients.展开更多
文摘BACKGROUND Diabetic vitreous hemorrhage(DVH)is a common complication of diabetes.While the diagnostic methods nowadays only concentrate on the eye injury in DVH patients,whether DVH leads to abnormalities of other visual systems,including the eye,the visual cortex,and other brain regions,remains unknown.AIM To explore the potential changes of brain activity in DVH using regional homogeneity(ReHo)and their relationships with clinical features.METHODS Thirty-one DVH patients and 31 matched healthy controls(HCs)were recruited.All subjects were examined by resting-state functional magnetic resonance imaging.The neural homogeneity in the brain region was estimated by ReHo method.Pearson correlation analysis was used to evaluate the relationships between average ReHo values and clinical manifestations in DVH patients.RESULTS Compared with HCs,the ReHo values in the bilateral cerebellar posterior lobes,right superior(RS)/middle occipital gyrus(MOG),and bilateral superior frontal gyrus were significantly increased.In contrast,in the right insula,bilateral medial frontal gyri,and right middle frontal gyrus,the ReHo values were significantly decreased.Furthermore,we found that best-corrected visual acuity of the contralateral eye in patients with DVH presented a positive correlation with the mean ReHo value of the RS/MOG.We also found that depression score of the DVH group presented a negative correlation with the mean ReHo values of the right insula,bilateral medial frontal gyrus,and right middle frontal gyrus.CONCLUSION We found that DVH may cause dysfunction in multiple brain areas,which may benefit the exploration of pathologic mechanisms in DVH patients.
基金supported by the Natural Science Foundation of Zhejiang Province(no Q14H090014)
文摘Background Alexithymia is a multidimensional personality construct.Objective This study aims to investigate the neuronal correlates of each alexithymia dimension by examining the regional homogeneity （ReHo） of intrinsic brain activity in a resting situation.Methods From university freshmen, students with alexithymia and non-alexithymia were recruited. Their alexithymic traits were assessed using the Toronto Alexithymia Scale-20. The ReHo was examined using a resting-state functional MRI approach.Results This study suggests signifcant group differences in ReHo in multiple brain regions distributed in the frontal lobe, parietal lobe, temporal lobe, occipital lobe and insular cortex. However, only the ReHo in the insula was positively associated with diffculty identifying feelings, a main dimension of alexithymia. The ReHo in the lingual gyrus, precentral gyrus and postcentral gyrus was？positively associated with diffculty describing feelings in？participants with？alexithymia. Lastly, the ReHo in the right dorsomedial prefrontal cortex （DMPFC_R） was negatively related to the externally oriented thinking style of participants with？alexithymia.Conclusion In conclusion, these results suggest that the main dimensions of alexithymia are correlated with specifc brain regions’ function, and the role of the insula, lingual gyrus, precentral gyrus, postcentral gyrus and DMPFC_R in the neuropathology of alexithymia should be further investigated.
基金National Natural Science Foundation of China,No.81660158 and No.81400372Natural Science Research Foundation of Jiangxi Province,No.20161ACB21017Medical Science Foundation of Jiangxi Province,No.20181BBG70004 and No.20164017.
文摘BACKGROUND Diabetes is a common chronic disease.Given the increasing incidence of diabetes,more individuals are affected by diabetic optic neuropathy(DON),which results in decreased vision.Whether DON leads to abnormalities of other visual systems,including the eye,the visual cortex,and other brain regions,remains unknown.AIM To investigate the local characteristics of spontaneous brain activity using regional homogeneity(ReHo)in patients with DON.METHODS We matched 22 patients with DON with 22 healthy controls(HCs).All subjects underwent resting-state functional magnetic resonance imaging.The ReHo technique was used to record spontaneous changes in brain activity.Receiver operating characteristic(ROC)curves were applied to differentiate between ReHo values for patients with DON and HCs.We also assessed the correlation between Hospital Anxiety and Depression Scale scores and ReHo values in DON patients using Pearson correlation analysis.RESULTS ReHo values of the right middle frontal gyrus(RMFG),left anterior cingulate(LAC),and superior frontal gyrus(SFG)/left frontal superior orbital gyrus(LFSO)were significantly lower in DON patients compared to HCs.Among these,the greatest difference was observed in the RMFG.The result of the ROC curves suggest that ReHo values in altered brain regions may help diagnose DON,and the RMFG and LAC ReHo values are more clinically relevant than SFG/LFSO.We also found that anxiety and depression scores of the DON group were extremely negatively correlated with the LAC ReHo values(r=-0.9336,P<0.0001 and r=-0.8453,P<0.0001,respectively).CONCLUSION Three different brain regions show ReHo changes in DON patients,and these changes could serve as diagnostic and/or prognostic biomarkers to further guide the prevention and treatment of DON patients.
基金the Science and Technology Planning Project of Guangdong Province, China, No. 2008B080703041
文摘Regional homogeneity analysis of low-frequency blood oxygenation level-dependent signals from neighboring voxels enables the analysis of local neuronal synchrony. Both structural magnetic resonance imaging and resting-state functional magnetic resonance imaging scans were collected from nine Parkinson＇s disease patients with right resting tremor, and from eight age-matched normal controls. Regional homogeneity was compared between Parkinson＇s disease patients and controls. The results revealed that regional homogeneity was increased in several brain regions, including the right precuneus, right superior parietal gyrus, left anterior cingulate cortex, right middle frontal gyrus and right inferior frontal gyrus. Conversely, regional homogeneity was decreased in the cerebellar vermis in Parkinson＇s disease patients compared with healthy controls.
文摘Eastern Black Sea Region in northeastern part of Turkey has the highest precipitation total in the country, approaching 2500 mm per a year. It is therefore an important region as it frequently encounters with flash floods due to heavy rains. For future planning of water resources, environment and urbanization, it is important to know the expected behavior of hydrometeorological processes, mainly precipitation and flow. Due to these facts, in this study, homogeneity of long-term annual precipitation and streamflow series of the Eastern Black Sea Region, Turkey is checked using double mass curve method and trends are determined by means of the Mann-Kendall test. The data network consists of 38 precipitation gauging stations and 40 flow gauging stations across the Eastern Black Sea Region. It is found that 27 precipitation stations out of 38 are homogeneous and no trend is available. Out of the remaining stations, nine are found non-homogeneous and four with trend. For annual flow data, it is found that 22 stations out of 40 are homogeneous and no trend is available. The remaining 18 stations are found non-homogeneous, among which 5 stations have trend at the same time.
文摘The world animal geographical regionalization scheme and the plant geographical regionalization scheme have been formulated by zoologists and botanists respectively since the biogeography has been established.This research team initially confirmed the homogeneity of Chinese animal and plant geography.To explore the relationship between the distribution pattern of global animals,plants,and microorganisms,global 141,814 genera of terrestrial animals,17,526 genera of plants,21,321 genera of microorganisms,and their major taxa were analyzed using their proposed SGF(Similarity General Formula)and a new multivariate similarity clustering analysis method.Almost identical analytical results were obtained,meeting the requirements of statistics,geography,ecology and biology respectively.The expected consistency of their distribution pattern was achieved for the first time.We prove that the earth’s ecological conditions affect the homogeneity and accumulation of the distribution of animals,plants and microorganisms.Homogeneity determines the distribution pattern of global kinds of biological consistency,accumulation determines the impact of the evolutionary period on the breadth of distribution,microorganisms appear earliest,plants second,animals later,and their average distribution domain decreases in turn,reflecting these differences.Therefore,this study not only provides a theoretical basis and quantitative basis for the establishment of geographical regionalization scheme but also advances the development of biogeography to a new stage and raises the theory of biogeographic analysis to a new height.
基金supported by the National Basic Research Development Program of China(2014CB846104)the National Natural Science Foundation of China(81371496+3 种基金3097080281101014)the Program for New Century Excellent Talents in University(NCET-11-0013)supported by the‘‘Qian Jiang Distinguished Professor’’Program
文摘Although many functional magnetic resonance imaging(f MRI) studies have investigated the neurophysiology of attention deficit hyperactivity disorder(ADHD),the existing studies have not yielded consistent findings.This may be related to the different properties of different frequency bands. To investigate the frequency-specific regional homogeneity(Re Ho) of spontaneous neural activities in ADHD, the current study used resting-state f MRI to explore the Re Ho properties of five frequency bands, slow-5(0.01–0.027 Hz), slow-4(0.027–0.073 Hz),slow-3(0.073–0.198 Hz), slow-2(0.198–0.25 Hz) and the extra-low frequency(0–0.01 Hz), in 30 drug-naive boys with ADHD and 30 healthy controls. Compared with controls, the ADHD group showed decreased Re Ho in the default mode network(DMN) including the medial prefrontal cortex and precuneus, middle frontal gyrus and angular gyrus. ADHD patients also showed increased Re Ho in the posterior cerebellum. Significant interactions between frequency band and group were observed predominantly in the dorsolateral prefrontal and parietal cortices, orbital frontal cortex, supplementary motor area,inferior occipital gyrus, thalamus and anterior cerebellum.In particular, we found that the between-group difference in the extra-low frequency band(0–0.01 Hz) seemed to be greater than that in the other frequency bands for most brain regions. The findings suggest that ADHD children display widespread abnormalities in regional brain activity,particularly in the DMN and attention network, and these abnormalities show frequency specificity.
文摘Backgroud Functional imaging studies indicate abnormal activities in cortico-limbic network in depression during either task or resting state. The present work was to explore the abnormal spontaneous activity shown with regional homogeneity （ReHo） in depression by resting-state functional magnetic resonance imaging （fMRI）.Methods Using fMRI, the differences of regional brain activity were measured in resting state in depressed vs. healthy participants. Sixteen participants firstly diagnosed with major depressive disorder and 16 controls were scanned during resting state. A novel method based on ReHo was used to detect spontaneous hemodynamic responses across the whole brain.Results ReHo in the left thalamus, left temporal lobe, left cerebellar posterior lobe, and the bilateral occipital lobe was found to be significantly decreased in depression compared to healthy controls in resting state of depression.Conclusions Abnormal spontaneous activity exists in the left thalamus, left temporal lobe, left cerebellar posterior lobe,and the bilateral occipital lobe. And the ReHo may be a potential reference in understanding the distinct brain activity in resting state of depression.
基金Supported by the"Innovation and Strength of Hospital"grants from the First Affiliated Hospital of Guangzhou University of Chinese Medicine(No.2016QN09)
文摘Objective: To study the effect of contralateral acupuncture(CAT) at acupoints of Quchi(LI 11) and Zusanli(ST 36) on the unaffected limbs of ischemic stroke patients with left hemiplegia based on regional homogeneity(ReHo) indices. Methods: Ten ischemic stroke patients with left hemiplegia received CAT on right side at LI 11 and ST 36. Functional magnetic resonance imaging(fMRI) was performed before and after acupuncture. A ReHo analytical method was used to compare brain responses of patients before and after CAT operated by REST software. Results: The stimulation at both LI 11 and ST 36 on the unaffected limbs produced significantly different neural activities. CAT elicited increased ReHo values at the right precentral gyrus and superior frontal gyrus, decreased ReHo value at right superior parietal lobule, left fusiform gyrus and left supplementary motor area. Conclusions: Acupuncture at one side could stimulate bilateral regions. CAT could evoke the gyrus which was possibly related to motor recovery from stroke. A promising indicator of neurobiological deficiencies could be represented by ReHo values in post-stroke patients.
