Mitochondria sense,shape and integrate signals,and thus function as central players in cellular signal transduction. Ca2+ waves and redox reactions are two such intracellular signals modulated by mitochondria. Mitocho...Mitochondria sense,shape and integrate signals,and thus function as central players in cellular signal transduction. Ca2+ waves and redox reactions are two such intracellular signals modulated by mitochondria. Mitochondrial Ca2+ transport is of utmost physio-pathological relevance with a strong impact on metabolism and cell fate. Despite its importance,the molecular nature of the proteins involvedin mitochondrial Ca2+ transport has been revealed only recently. Mitochondrial Ca2+ promotes energy metabolism through the activation of matrix dehydrogenases and downstream stimulation of the respiratory chain. These changes also alter the mitochondrial NAD(P)H/NAD(P)+ ratio,but at the same time will increase reactive oxygen species(ROS) production. Reducing equivalents and ROS are having opposite effects on the mitochondrial redox state,which are hard to dissect. With the recent development of genetically encoded mitochondrial-targeted redoxsensitive sensors,real-time monitoring of matrix thiol redox dynamics has become possible. The discoveries of the molecular nature of mitochondrial transporters of Ca2+ combined with the utilization of the novel redox sensors is shedding light on the complex relation between mitochondrial Ca2+ and redox signals and their impact on cell function. In this review,we describe mitochondrial Ca2+ handling,focusing on a number of newly identified proteins involved in mitochondrial Ca2+ uptake and release. We further discuss our recent findings,revealing how mitochondrial Ca2+ influences the matrix redox state. As a result,mitochondrial Ca2+ is able to modulate the many mitochondrial redox-regulated processes linked to normal physiology and disease.展开更多
Senile hypertension is a common disor-der frequently seen in senile persons, its in-cidence being 7.73% in the general popula-tion and 20.6% in persons aged over 60years in China. In Beijing, hypertensionheads the lis...Senile hypertension is a common disor-der frequently seen in senile persons, its in-cidence being 7.73% in the general popula-tion and 20.6% in persons aged over 60years in China. In Beijing, hypertensionheads the list of senile diseases. In Europeand America, one third of the展开更多
A new modification of false position method for solving nonlinear equations is presented by applying homotopy analysis method （HAM）. Some numerical illustrations are given to show the efficiency of algorithm.
Regulator streamlines M&A process The China Securities Regulatory Commission will simplify the review process for major asset restructuring programs and takeovers of listed companies,the market regulator said in a...Regulator streamlines M&A process The China Securities Regulatory Commission will simplify the review process for major asset restructuring programs and takeovers of listed companies,the market regulator said in a statement,China Daily reported.Listed companies will no longer need CSRC approval for major asset restructuring programs,except in the case of backdoor listings.展开更多
Recently, the China National Management Method for Organic Products Certification and the national standards on organic products have officially come into effect. The Certification and Accreditation Administration of ...Recently, the China National Management Method for Organic Products Certification and the national standards on organic products have officially come into effect. The Certification and Accreditation Administration of the People’s Republic of China (CNCA), in accordance with the unified basic specifications and regulations of organic products certification, the unified procedure of conformity assessment, the unified standard and mark, will carry out the unified management of the activities on organic products certification in the whole nation, which indicates that the management of certification activities on organic products has stepped into a new development stage of legalization and regularization and it will play an active and significant role in promoting the development of organic products and assuring the food safety in our country.展开更多
Structural neural network pruning aims to remove the redundant channels in the deep convolutional neural networks(CNNs)by pruning the filters of less importance to the final output accuracy.To reduce the degradation o...Structural neural network pruning aims to remove the redundant channels in the deep convolutional neural networks(CNNs)by pruning the filters of less importance to the final output accuracy.To reduce the degradation of performance after pruning,many methods utilize the loss with sparse regularization to produce structured sparsity.In this paper,we analyze these sparsity-training-based methods and find that the regularization of unpruned channels is unnecessary.Moreover,it restricts the network′s capacity,which leads to under-fitting.To solve this problem,we propose a novel pruning method,named Mask Sparsity,with pruning-aware sparse regularization.Mask Sparsity imposes the fine-grained sparse regularization on the specific filters selected by a pruning mask,rather than all the filters of the model.Before the fine-grained sparse regularization of Mask Sparity,we can use many methods to get the pruning mask,such as running the global sparse regularization.Mask Sparsity achieves a 63.03%float point operations(FLOPs)reduction on Res Net-110 by removing 60.34%of the parameters,with no top-1 accuracy loss on CIFAR-10.On ILSVRC-2012,Mask Sparsity reduces more than 51.07%FLOPs on Res Net-50,with only a loss of 0.76%in the top-1 accuracy.The code of this paper is released at https://github.com/CASIA-IVA-Lab/Mask Sparsity.We have also integrated the code into a self-developed Py Torch pruning toolkit,named Easy Pruner,at https://gitee.com/casia_iva_engineer/easypruner.展开更多
Prof.Qin Jianhua’s group at the Division of Biotechnology,Dalian Institute of Chemical Physics,Chinese Academy of Sciences,reported the exploration of the anti-aging role of polydatin in Caenorhabditis elegans(C.eleg...Prof.Qin Jianhua’s group at the Division of Biotechnology,Dalian Institute of Chemical Physics,Chinese Academy of Sciences,reported the exploration of the anti-aging role of polydatin in Caenorhabditis elegans(C.elegans)on a novel microfluidic chip,which was published in Integrative Biology(2014,6:35—43).C.elegans is a prominent model organism in aging study and the effects of polydatin on the lifespan of展开更多
Objective To study the influence of omentin on the expression of collagenⅠ/Ⅳin the human aortic smooth muscle cells subjected to oxidative stress.Methods Human aortic smooth muscle cells were cultured in vitro.When ...Objective To study the influence of omentin on the expression of collagenⅠ/Ⅳin the human aortic smooth muscle cells subjected to oxidative stress.Methods Human aortic smooth muscle cells were cultured in vitro.When cell density reached above 90%,cells were randomly divided into 5 groups:control group。展开更多
Objective To investigate the expression of Notch signaling molecules,transforming growth factor-β(TGF-β)and fibronectin(FN)in mesangial cell induced by high glucose,and the underlying mechanism of cordyceps sinensis...Objective To investigate the expression of Notch signaling molecules,transforming growth factor-β(TGF-β)and fibronectin(FN)in mesangial cell induced by high glucose,and the underlying mechanism of cordyceps sinensis.Methods Rat glomerular mesangial cells were divided into following groups:normal展开更多
9.1.Liver cirrhosis and fatty liver2005376 The role of ribosomal S6 kinase in thepathogenesis of rat hepatic fibrosis.YANG Miaofang(杨妙芳),et al.Dept Gastroenterol,Changzheng Hosp,2nd Milit Med Univ,Shanghai 200003.C...9.1.Liver cirrhosis and fatty liver2005376 The role of ribosomal S6 kinase in thepathogenesis of rat hepatic fibrosis.YANG Miaofang(杨妙芳),et al.Dept Gastroenterol,Changzheng Hosp,2nd Milit Med Univ,Shanghai 200003.Chin J Dig 2005;25(2):98-100.展开更多
Objective To explore the prognostic value of regulatory T cells (Tregs) and M2 macrophages in diffuse large B-cell lymphoma (DLBCL) tissues.Methods The expression of CD163 and Foxp3 was detected by immunohistochemistr...Objective To explore the prognostic value of regulatory T cells (Tregs) and M2 macrophages in diffuse large B-cell lymphoma (DLBCL) tissues.Methods The expression of CD163 and Foxp3 was detected by immunohistochemistry in 92 cases of DLBCL,and it展开更多
Nekredeble,mi sukcesis,li pensis.La laboro estis pli malfaeila ol enerale,kaj en lia nuna situacio…Pot sukcese starigikaj funkciigi la rnainaron,kiel li jus faris,necesas povi pensi,zorge rigardi ion vidindan,
文摘Mitochondria sense,shape and integrate signals,and thus function as central players in cellular signal transduction. Ca2+ waves and redox reactions are two such intracellular signals modulated by mitochondria. Mitochondrial Ca2+ transport is of utmost physio-pathological relevance with a strong impact on metabolism and cell fate. Despite its importance,the molecular nature of the proteins involvedin mitochondrial Ca2+ transport has been revealed only recently. Mitochondrial Ca2+ promotes energy metabolism through the activation of matrix dehydrogenases and downstream stimulation of the respiratory chain. These changes also alter the mitochondrial NAD(P)H/NAD(P)+ ratio,but at the same time will increase reactive oxygen species(ROS) production. Reducing equivalents and ROS are having opposite effects on the mitochondrial redox state,which are hard to dissect. With the recent development of genetically encoded mitochondrial-targeted redoxsensitive sensors,real-time monitoring of matrix thiol redox dynamics has become possible. The discoveries of the molecular nature of mitochondrial transporters of Ca2+ combined with the utilization of the novel redox sensors is shedding light on the complex relation between mitochondrial Ca2+ and redox signals and their impact on cell function. In this review,we describe mitochondrial Ca2+ handling,focusing on a number of newly identified proteins involved in mitochondrial Ca2+ uptake and release. We further discuss our recent findings,revealing how mitochondrial Ca2+ influences the matrix redox state. As a result,mitochondrial Ca2+ is able to modulate the many mitochondrial redox-regulated processes linked to normal physiology and disease.
文摘Senile hypertension is a common disor-der frequently seen in senile persons, its in-cidence being 7.73% in the general popula-tion and 20.6% in persons aged over 60years in China. In Beijing, hypertensionheads the list of senile diseases. In Europeand America, one third of the
文摘A new modification of false position method for solving nonlinear equations is presented by applying homotopy analysis method （HAM）. Some numerical illustrations are given to show the efficiency of algorithm.
文摘Regulator streamlines M&A process The China Securities Regulatory Commission will simplify the review process for major asset restructuring programs and takeovers of listed companies,the market regulator said in a statement,China Daily reported.Listed companies will no longer need CSRC approval for major asset restructuring programs,except in the case of backdoor listings.
文摘Recently, the China National Management Method for Organic Products Certification and the national standards on organic products have officially come into effect. The Certification and Accreditation Administration of the People’s Republic of China (CNCA), in accordance with the unified basic specifications and regulations of organic products certification, the unified procedure of conformity assessment, the unified standard and mark, will carry out the unified management of the activities on organic products certification in the whole nation, which indicates that the management of certification activities on organic products has stepped into a new development stage of legalization and regularization and it will play an active and significant role in promoting the development of organic products and assuring the food safety in our country.
基金supported by National Natural Science Foundation of China(Nos.62176254,61976210,61876086,62076235,62002356,62006230 and 62002357)National Key R&D Program of China(No.2021ZD0110403).
文摘Structural neural network pruning aims to remove the redundant channels in the deep convolutional neural networks(CNNs)by pruning the filters of less importance to the final output accuracy.To reduce the degradation of performance after pruning,many methods utilize the loss with sparse regularization to produce structured sparsity.In this paper,we analyze these sparsity-training-based methods and find that the regularization of unpruned channels is unnecessary.Moreover,it restricts the network′s capacity,which leads to under-fitting.To solve this problem,we propose a novel pruning method,named Mask Sparsity,with pruning-aware sparse regularization.Mask Sparsity imposes the fine-grained sparse regularization on the specific filters selected by a pruning mask,rather than all the filters of the model.Before the fine-grained sparse regularization of Mask Sparity,we can use many methods to get the pruning mask,such as running the global sparse regularization.Mask Sparsity achieves a 63.03%float point operations(FLOPs)reduction on Res Net-110 by removing 60.34%of the parameters,with no top-1 accuracy loss on CIFAR-10.On ILSVRC-2012,Mask Sparsity reduces more than 51.07%FLOPs on Res Net-50,with only a loss of 0.76%in the top-1 accuracy.The code of this paper is released at https://github.com/CASIA-IVA-Lab/Mask Sparsity.We have also integrated the code into a self-developed Py Torch pruning toolkit,named Easy Pruner,at https://gitee.com/casia_iva_engineer/easypruner.
基金support by the National Natural Science Foundation of China(Grant Nos.81273483,91227123 and 11161160552)
文摘Prof.Qin Jianhua’s group at the Division of Biotechnology,Dalian Institute of Chemical Physics,Chinese Academy of Sciences,reported the exploration of the anti-aging role of polydatin in Caenorhabditis elegans(C.elegans)on a novel microfluidic chip,which was published in Integrative Biology(2014,6:35—43).C.elegans is a prominent model organism in aging study and the effects of polydatin on the lifespan of
文摘Objective To study the influence of omentin on the expression of collagenⅠ/Ⅳin the human aortic smooth muscle cells subjected to oxidative stress.Methods Human aortic smooth muscle cells were cultured in vitro.When cell density reached above 90%,cells were randomly divided into 5 groups:control group。
文摘Objective To investigate the expression of Notch signaling molecules,transforming growth factor-β(TGF-β)and fibronectin(FN)in mesangial cell induced by high glucose,and the underlying mechanism of cordyceps sinensis.Methods Rat glomerular mesangial cells were divided into following groups:normal
文摘9.1.Liver cirrhosis and fatty liver2005376 The role of ribosomal S6 kinase in thepathogenesis of rat hepatic fibrosis.YANG Miaofang(杨妙芳),et al.Dept Gastroenterol,Changzheng Hosp,2nd Milit Med Univ,Shanghai 200003.Chin J Dig 2005;25(2):98-100.
文摘Objective To explore the prognostic value of regulatory T cells (Tregs) and M2 macrophages in diffuse large B-cell lymphoma (DLBCL) tissues.Methods The expression of CD163 and Foxp3 was detected by immunohistochemistry in 92 cases of DLBCL,and it
文摘Nekredeble,mi sukcesis,li pensis.La laboro estis pli malfaeila ol enerale,kaj en lia nuna situacio…Pot sukcese starigikaj funkciigi la rnainaron,kiel li jus faris,necesas povi pensi,zorge rigardi ion vidindan,
