We propose a scheme for information concentration of three remote two-level atoms in cavity QED. Our scheme does not involve the Bell-state measurement. During the interaction between atom and cavity, the cavity frequ...We propose a scheme for information concentration of three remote two-level atoms in cavity QED. Our scheme does not involve the Bell-state measurement. During the interaction between atom and cavity, the cavity frequency is largely detuned from the atomic transition frequency, thus the scheme is insensitive to both the cavity decay and the thermal field. The idea can also be used to realize the remote information concentration of trapped ions.展开更多
We present an effective scheme to teleport an unknown ionic entangled internal state via trapped ions without joint Bell-state measurement. In the constructed quantum channel process, we adopt entanglement swapping to...We present an effective scheme to teleport an unknown ionic entangled internal state via trapped ions without joint Bell-state measurement. In the constructed quantum channel process, we adopt entanglement swapping to avoid decrease of entanglement during the distribution of particles. Thus our scheme provides new prospects for quantum teleportation over longer distance. The distinct advantages of our scheme are that our scheme is insensitive to heating of vibrational mode and can be generalized to teleport an N-ion electronic entangled GHZ class state. Furthermore, in our scheme the success probability can reach 1.展开更多
Neuroscience has been extensively developed for more than seventy years;however,there still remains lack of breakthrough understanding in the neural information field.A quantum coherent state of ion channels is recent...Neuroscience has been extensively developed for more than seventy years;however,there still remains lack of breakthrough understanding in the neural information field.A quantum coherent state of ion channels is recently proposed in neural system as an information carrier,but its physical expression is still not fixed.Here,employing a simple K^(+)channel as a typical instance,we theoretically build a conceptual model for the quantum state of a neural ion channel and demonstrate the macroscopic coherence state of multiple ion channels.The underlying mechanism is revealed to the mid-infrared photons released by ion oscillation in one ion channel together with their resonant and coherent coupling with the oscillations in other channels.An additional environment field(e.g.,brain wave)may regulate the coherence,potentially relating to the human consciousness.Clearly,there exist the channels of other ions in a neural system,which also potentially form a macroscopic coherence state of themselves,with the mechanism identical to that of K^(+)channels.An environment field can be expected to further regulate the quantum states of various ionic channels,leading to a total macroscopic coherence state of these channels,which is like the conductor in a symphony to achieve the harmony in music.These findings are expected to provide a promising viewpoint for neuroscience,as well as to improve treatments of the diseases and health problems related to neural system.展开更多
After spinal cord injury,microglia as the first responders to the lesion display both beneficial and detrimental characteristics.Activated microglia phagocyte and eliminate cell debris,release cytokines to recruit per...After spinal cord injury,microglia as the first responders to the lesion display both beneficial and detrimental characteristics.Activated microglia phagocyte and eliminate cell debris,release cytokines to recruit peripheral immune cells to the injury site.Excessively activated microglia can aggravate the secondary damage by producing extravagant reactive oxygen species and pro-inflammatory cytokines.Recent studies demonstrated that the voltage-gated proton channel Hv1 is selectively expressed in microglia and regulates microglial activation upon injury.In mouse models of spinal cord injury,Hv1 deficiency ameliorates microglia activation,resulting in alleviated production of reactive oxygen species and pro-inflammatory cytokines.The reduced secondary damage subsequently decreases neuronal loss and correlates with improved locomotor recovery.This review provides a brief historical perspective of advances in investigating voltage-gated proton channel Hv1 and home in on microglial Hv1.We discuss recent studies on the roles of Hv1 activation in pathophysiological activities of microglia,such as production of NOX-dependent reactive oxygen species,microglia polarization,and tissue acidosis,particularly in the context of spinal cord injury.Further,we highlight the rationale for targeting Hv1 for the treatment of spinal cord injury and related disorders.展开更多
目的采用双荧光素酶报告基因等手段,探讨心房颤动(房颤)相关微小RNA4279(miR-4279)与房颤相关离子通道蛋白的靶向调控关系。方法利用在线数据库Targetscan,miRanda,miRDB预测可能的靶基因后,分别将靶基因的重组荧光素酶报告质粒与miR-4...目的采用双荧光素酶报告基因等手段,探讨心房颤动(房颤)相关微小RNA4279(miR-4279)与房颤相关离子通道蛋白的靶向调控关系。方法利用在线数据库Targetscan,miRanda,miRDB预测可能的靶基因后,分别将靶基因的重组荧光素酶报告质粒与miR-4279及阴性对照质粒共转染于人胚胎肾HEK293细胞,实验分为转染组,阴性组和空白组检测各组相对荧光素酶的活性。并将miR-4279模拟体导入大鼠胚胎心肌H9c2细胞,观察其对靶基因的表达调控。结果 CACNA1C基因转染中,与阴性组比较,转染组相对荧光素酶活性降低18%(0.300±0.012 vs 0.366±0.011,P<0.01),转染组CACNA1C基因mRNA表达水平下调31%(0.820±0.058 vs 1.193±0.060,P<0.01),miR-4279模拟体转入H9c2细胞可抑制CACNA1C基因的表达。结论电压门控L型钙通道α亚基CACNA1C基因可能是miR-4279的直接靶基因,miR-4279可能通过抑制CACNA1C表达参与房颤电重构,有可能成为未来房颤干预治疗的靶点。展开更多
基金Supported by the National Natural Science Foundation of China under Grant No 10374025.
文摘We propose a scheme for information concentration of three remote two-level atoms in cavity QED. Our scheme does not involve the Bell-state measurement. During the interaction between atom and cavity, the cavity frequency is largely detuned from the atomic transition frequency, thus the scheme is insensitive to both the cavity decay and the thermal field. The idea can also be used to realize the remote information concentration of trapped ions.
基金Supported by the National Natural Science Foundation of China under Grant No 10374025.
文摘We present an effective scheme to teleport an unknown ionic entangled internal state via trapped ions without joint Bell-state measurement. In the constructed quantum channel process, we adopt entanglement swapping to avoid decrease of entanglement during the distribution of particles. Thus our scheme provides new prospects for quantum teleportation over longer distance. The distinct advantages of our scheme are that our scheme is insensitive to heating of vibrational mode and can be generalized to teleport an N-ion electronic entangled GHZ class state. Furthermore, in our scheme the success probability can reach 1.
基金supported by the National Key Research and Development Program of China(2018YFE0205501)the National Natural Science Foundation of China Project(21988102)the National Supercomputer Center in Tianjin。
文摘Neuroscience has been extensively developed for more than seventy years;however,there still remains lack of breakthrough understanding in the neural information field.A quantum coherent state of ion channels is recently proposed in neural system as an information carrier,but its physical expression is still not fixed.Here,employing a simple K^(+)channel as a typical instance,we theoretically build a conceptual model for the quantum state of a neural ion channel and demonstrate the macroscopic coherence state of multiple ion channels.The underlying mechanism is revealed to the mid-infrared photons released by ion oscillation in one ion channel together with their resonant and coherent coupling with the oscillations in other channels.An additional environment field(e.g.,brain wave)may regulate the coherence,potentially relating to the human consciousness.Clearly,there exist the channels of other ions in a neural system,which also potentially form a macroscopic coherence state of themselves,with the mechanism identical to that of K^(+)channels.An environment field can be expected to further regulate the quantum states of various ionic channels,leading to a total macroscopic coherence state of these channels,which is like the conductor in a symphony to achieve the harmony in music.These findings are expected to provide a promising viewpoint for neuroscience,as well as to improve treatments of the diseases and health problems related to neural system.
基金the National Institutes of Health(Nos.R01NS110949,R01NS088627,R01NS112144,R01NS110825,R21AG064159)to LJW.
文摘After spinal cord injury,microglia as the first responders to the lesion display both beneficial and detrimental characteristics.Activated microglia phagocyte and eliminate cell debris,release cytokines to recruit peripheral immune cells to the injury site.Excessively activated microglia can aggravate the secondary damage by producing extravagant reactive oxygen species and pro-inflammatory cytokines.Recent studies demonstrated that the voltage-gated proton channel Hv1 is selectively expressed in microglia and regulates microglial activation upon injury.In mouse models of spinal cord injury,Hv1 deficiency ameliorates microglia activation,resulting in alleviated production of reactive oxygen species and pro-inflammatory cytokines.The reduced secondary damage subsequently decreases neuronal loss and correlates with improved locomotor recovery.This review provides a brief historical perspective of advances in investigating voltage-gated proton channel Hv1 and home in on microglial Hv1.We discuss recent studies on the roles of Hv1 activation in pathophysiological activities of microglia,such as production of NOX-dependent reactive oxygen species,microglia polarization,and tissue acidosis,particularly in the context of spinal cord injury.Further,we highlight the rationale for targeting Hv1 for the treatment of spinal cord injury and related disorders.
基金supported by the Biotechnology and Biological Sciences Research Council and the Cystic Fibrosis Trust.H Li was supported by EuroCareCF(LSHM-CT-2005-018932)while J-H Chen and Z Xu were supported by scholarships from the University of Bristol and ORS awards from Universities UK.
文摘目的采用双荧光素酶报告基因等手段,探讨心房颤动(房颤)相关微小RNA4279(miR-4279)与房颤相关离子通道蛋白的靶向调控关系。方法利用在线数据库Targetscan,miRanda,miRDB预测可能的靶基因后,分别将靶基因的重组荧光素酶报告质粒与miR-4279及阴性对照质粒共转染于人胚胎肾HEK293细胞,实验分为转染组,阴性组和空白组检测各组相对荧光素酶的活性。并将miR-4279模拟体导入大鼠胚胎心肌H9c2细胞,观察其对靶基因的表达调控。结果 CACNA1C基因转染中,与阴性组比较,转染组相对荧光素酶活性降低18%(0.300±0.012 vs 0.366±0.011,P<0.01),转染组CACNA1C基因mRNA表达水平下调31%(0.820±0.058 vs 1.193±0.060,P<0.01),miR-4279模拟体转入H9c2细胞可抑制CACNA1C基因的表达。结论电压门控L型钙通道α亚基CACNA1C基因可能是miR-4279的直接靶基因,miR-4279可能通过抑制CACNA1C表达参与房颤电重构,有可能成为未来房颤干预治疗的靶点。
