Rejuvenating Northeastern Area and Reforming the System of Investing and Financing

The system of investing and financing in northeastern area has the character of planned economy. Project conducting is our main strategy in any large-scale area rejuvenating plan, which has been proved lack of sustainable development. This paper proposes some suggestion to reform the system of investing and financing.

Cyberloafing:The line between rejuvenating and wasting time

Research shows that workers drift from their contracted tasks to personal email,social networks and the far corners of the internet for anything between a few hours a week to a few hours a day.Six out of 10people admit they can’t get through the workday without checking their social media.

Rejuvenating a Hotel Legend

Politely speaking, immaculately dressed and wearing a pair of glasses, John Dick is a typical British gentleman.He represents the Langham hotel brand well. Dick was recently appointed managing director of Langham Place,Beijing, a 26-story five-star hotel located in

Fat management in upper blepharoplasty:Addition or subtraction blepharoplasties,how and when

BACKGROUND As one of the most common aesthetic surgical procedures carried out today,blepharoplasty should be in the repertoire of every plastic surgeon.The term blepharoplasty encompasses a wide range of techniques and options that must be tailored to the specific defect and patient one has to treat.A sound knowledge of the upper and lower eyelids’anatomy is essential for proper surgical execution.Trends have shifted towards more conservative methods(especially of the fat compartment)and sometimes in combination with augmentation techniques,helping to reach a rejuvenated appearance.AIM To present an overview of the surgical techniques considered for upper lid blepharoplasty and fat pad management,in addition to information on how a surgeon may approach the best treatment for his patient based on current publications in literature.METHODS We searched the literature published between 2013,to 2023 using Medline and Reference Citation Analysis.The database was searched using the keywords“upper blepharoplasty”AND“fat”.Papers without full text/abstracts and reviews were excluded.The search strategy followed the PRISMA.The American Society of Plastic Surgeons guidelines for Therapeutic Studies checklist was used to assess all articles.Two authors individually reviewed each article and rated them for importance and relevance to the topic.A consensus was sought and the most relevant studies.RESULTS After the application of the selection criteria used in our review,13 publications were found to address upper lid blepharoplasty specifically.Three of these studies were reviews and three were retrospective studies.Five publications were comparative studies and a further two were clinical trials.CONCLUSION The tendency of modern surgery is to be conservative,by removing adipose tissue only if strictly necessary and restoring the volume of the upper eyelid in a concept of beauty that espouses a"full"sight.There is no gold standard technique to achieve younger and enhanced eyelids.Long-term prospective comparative studies are fundamental in understanding which path is the best to follow.

Transcriptome profiling of indole-3-butyric acid-induced adventitious root formation in softwood cuttings of walnut

Inducing adventitious root(AR)formation in mature walnut species(Juglans L.)is challenging.However,the AR formation of mature trees can be improved by rejuvenation.In rejuvenated cuttings,exogenous indole-3-butyric acid(IBA)is essential for AR formation,and the underlying mechanism is still not well understood.Therefore,we utilized transcriptome sequencing to investigate the mechanism of IBA-induced AR formation.Our results revealed that,in comparison to the control group,IBA treatment(9 mmol·L^(-1))significantly increased the endogenous indole-3-acetic acid(IAA)content,leading to an enhanced rooting rate.We performed RNA sequencing to identify differentially expressed genes(DEGs)between the IBA-treated and control(CK)groups at 1,2,3,and 5 days after cutting(DAC).The results showed that,compared to the control cuttings,there were 1539,889,785,and 984 up-regulated genes and 2791,2936,3017,and 1752 down-regulated genes,at 1,2,3,and 5 DAC,respectively.Analysis of RNA-seq data revealed that G-type ATP-binding cassette 36/37(ABCG36/37)and ATP-binding cassette subfamily D 1(ABCD1),associated with IBA transport,were down-regulated in the rejuvenation cuttings.In contrast,PIN-FORMED(PIN)and PINOID(PID),associated with auxin efflux,were up-regulated.We identified 49 auxin/indole-3-acetic acid(AUX/IAA)-encoding genes,including IAA1,IAA3,IAA5,IAA6,IAA8,IAA11,IAA12,IAA19,and IAA20,which were up-regulated at 1-5 DAC in the rejuvenated cuttings.This study highlights that the overexpression of JrWOX5/11 in poplar significantly enhance AR growth,as evidenced by increased root length,surface area,volume,and quantity.Moreover,the co-expression network analysis involving JrWOX11 and JrWOX5 in walnut cuttings elucidates complex genetic interactions,underscoring their pivotal role in the formation of AR.Our data supported the following molecular mechanism of IBA-induced adventitious root formation.Firstly,IBA is converted to free IAA in peroxisomes.Then,the highly concentrated IAA in the procambium and parenchyma cells induces WUSCHEL-related homeobox 11(WOX11)expression at two days.Finally,WOX11 acts redundantly to up-regulate WOX5,initiating the development of root primordia cells.

Efficacy of intraovarian autologous platelet-rich plasma administration in women with low ovarian reserve: A systematic review and meta-analysis

Objective:To conduct a systematic examination and meta-analysis of the most reliable data from experimental studies evaluating the efficacy of autologous platelet-rich plasma(PRP)on low ovarian reserve.Methods:A comprehensive search was performed utilizing pertinent search terms across electronic databases,including PubMed,Cochrane,and Google Scholar.We included studies that assigned infertile women with low ovarian reserve in experimental studies.Ovarian reserve parameters were measured before and after PRP injection into ovaries.The data of each study was retrieved and subsequently compiled.Results:Of 301 articles collected and reviewed,six studies were finally included in the meta-analysis.Following PRP injection,infertile women showed a non-significant increase in anti-Mullerian hormone(AMH)level(MD=0.10;95%CI-0.04,0.23),a significant increase in antral follicular count(AFC)(MD=1.88;95%CI 0.47,3.29),and a non-significant reduction in follicle-stimulating hormone(FSH)level(MD=-0.22;95%CI-8.32,7.87).Conclusions:Autologous PRP may increase AFC,but not AMH.Although it is found beneficial in enhancing ovarian reserve(AFC),further research with strong evidence is still required.

Insights into upper blepharoplasty: Conservative volume-preserving techniques

This editorial commentary critically examines the systematic review by Miotti et al,which discusses the evolving trends in upper lid blepharoplasty towards a conservative,volume-preserving approach.The review emphasizes the shift from traditional tissue resection to techniques that maintain anatomical integrity,paralleling broader trends in panfacial rejuvenation.Miotti et al delve into the nuances of fat pad management,advocating for conservation over reduction to sustain natural contours and improve long-term aesthetic outcomes.This perspective is supported by comparative studies and empirical data,such as those from Massry and Alghoul et al,highlighting the benefits of conservative approaches in terms of patient satisfaction and aesthetic longevity.The review also stresses the importance of surgeon discretion in adapting procedures to diverse patient demographics,particularly in addressing distinct features such as the Asian upper eyelid.However,it identifies a significant gap in long-term comparative research,underscoring the need for future studies to substantiate the safety and efficacy of these minimalist techniques.Overall,Miotti et al.'s work contributes profoundly to the discourse on personalized,conservative cosmetic surgery,urging ongoing research to refine and validate surgical best practices in upper eyelid blepharoplasty.

Bio-based rejuvenators in asphalt pavements:A comprehensive review and analytical study

The pressing demand for sustainable advancements in road infrastructure has catalyzed extensive research into environmentally conscious alternatives for the maintenance and restoration of asphalt concrete pavements.This paper offers a comprehensive review and analysis of bio-based rejuvenators as a promising avenue for enhancing the longevity and sustainability of asphalt.Through a multifaceted exploration,it delves into various aspects of this innovative approach.Providing a thorough overview of bio-based rejuvenators,the study highlights their renewable and environmentally friendly characteristics.It conducts an in-depth examination of a wide spectrum of bio-derived materials,including vegetable oils,waste-derived bio-products,and biopolymers,through a comprehensive survey.The paper evaluates how bio-based rejuvenators enhance aged asphalt binders and mixes,effectively mitigating the adverse impacts of aging.Furthermore,it investigates how these rejuvenators address environmental concerns by identifying compatibility issues,assessing long-term performance,and evaluating economic feasibility.Finally,the paper outlines potential advancements and research pathways aimed at optimizing the utilization of bio-based rejuvenators in asphalt concrete,thereby contributing to the sustainable evolution of road infrastructure.

Microspace Revitalization Design around Xihuangcun Railway Station from the Perspective of Urban Renewal

Railways within the city carry the historical memory of urban development and are important industrial heritage resources.However,with urban development and changes in transportation functions,railways lose their original application value and are gradually left unused or even abandoned,affecting the vitality of the region.Taking the space around Xihuangcun Railway Station as the research object,the public activity space on both sides of the railway is reshaped through five strategies:function revitalization,traffic revitalization,heritage revitalization,spatial revitalization,and landscape revitalization,and the grey area of the city is transformed into a vibrant development zone of the city.

Chinese Culture,Classical Philosophy,and the Cultivation of Life

This paper explores the intricate relationship between Chinese culture and the nation’s rise,emphasizing the indispensable role of cultural education in fostering a robust national spirit and civilization.Drawing from classical Chinese texts and contemporary philosophical insights,the study examines how cultural virtues and educational practices can lead to societal harmony,national rejuvenation,and global contributions.The analysis highlights the enduring relevance of Confucian principles and their potential to address modern challenges,advocating for a renewed focus on cultural education to achieve a prosperous and peaceful world.Additionally,it underscores the necessity of integrating traditional values with modern educational practices to create a holistic approach that fosters ethical leadership and global cooperation.

Direct Correlation among Telomere Length, Cellular Aging, and Rejuvenation Effects of Honey Child Powder

Purpose: Telomere length (TL) is an indicator of age;however, hormonal influences complicate individual aging. It remains unclear whether TL shortening is a direct factor in both individual and cellular aging. Therefore, we examined the direct relationship between TL and cellular senescence at the cellular level. Methods: Telomerase activity, TL, and gene expression were measured in cultured human lung-, fetal-, and skin-derived fibroblasts, human skin keratinocytes, and telomerase reverse transcriptase (TERT) gene-immortalized cells using detection kits, Cawthon’s method, and reverse transcription-quantitative polymerase chain reaction, respectively. Novel substances that elongate telomeres were screened to confirm cell rejuvenation effects. Results: Long-term cell culture of TIG-1-20 normal human fibroblasts resulted in TL shortening, decreased division rate, and senescence progression, whereas in OUMS-36T-2 cells, TL elongation via TERT gene transfer increased the division rate, reduced endoplasmic reticulum stress, and upregulated genes associated with young individuals, indicating that cellular rejuvenation occurs via TL elongation. In addition, a honey child powder (HCP) extract was found through screening, and the HCP extract strongly suppressed the menin gene, resulting in increased telomerase activity and extended cell lifespan. Upon addition of the HCP extract to skin fibroblasts, gene expression of moisturizing components, including collagen, hyaluronic acid, and elastin, increased, and exhibited a rejuvenating effect with an increase in elastin amount. Conclusions: TL elongation or shortening is involved in cell proliferation rate and cellular aging, and TL elongation rejuvenates cells. In addition, HCP extract has a rejuvenating effect on cells and is expected to be a rejuvenating compound.

In Vivo Improvements in Facial Appearance and in Vitro Changes in Gene Expression Using a Topical Formulation Designed to Repair Environmentally Induced DNA Damage

Background: While sunscreen has been accepted as a mainline defence against photodamage from ultraviolet, visible light and near-infrared radiation, there appears to be a lack of research into photorepair. The concept of protecting the skin during the day and repairing cellular damage at night is intuitive, yet specific strategies revolving around combinations of proven reparative active ingredients remain unelucidated. Purpose: To investigate the efficacy of a solar repair Formulation following ultraviolet and environmental exposure in order to improve overall skin health and appearance through three hypotheses: The Formulation increases expression of DNA repair mechanisms markers;The Formulation enhances overall skin appearance through reducing signs of inflammation, elevating hydration, reinforcing skin firmness and amplifying radiance;In-Vivo efficacy test results are aligned with measured gene expression changes. Methods: The Formulation (#6NIC1.V1.1-1) was tested for: In-vitro LDH cytotoxicity activity, In-vitro qPCR gene expression with and without ultraviolet exposure on a reconstructed 3-dimensional skin model, and In-Vivo efficacy study on a panel of 22 participants objectively and subjectively. Results: Skin radiance, firmness, hydration, redness, and inflammation are significantly improved after In-Vivo skin exposure to the Formulation and environmental challenges such as ultraviolet radiation. These outcomes were confirmed by in-vitro genetic testing on a reconstructed human skin model. Conclusion: The studies allowed us to identify and group results in four main skin functions that were significantly enhanced following the application of the Formulation: firmness, hydration, radiance and soothing.

Augmenting osteoporotic bone regeneration through a hydrogel-based rejuvenating microenvironment

Osteoporotic bone defects pose a significant challenge for bone regeneration as they exhibit impaired healing capacity and delayed healing period.To address this issue,this study introduces a hydrogel that creates a rejuvenating microenvironment,thereby facilitating efficient bone repair during the initial two weeks following bone defect surgery.The hydrogel,named GelHFS,was created through host-guest polymerization of gelatin and acrylatedβ-cyclodextrin.Incorporation of the human fetal mesenchymal stem cell secretome(HFS)formed GelHFS hydrogel aimed at mimicking a rejuvenated stem cell niche.Our results demonstrated that GelHFS hydrogel promotes cell stellate spreading and osteogenic differentiation via integrinβ1-induced focal adhesion pathway.Implantation of GelHFS hydrogel in an osteoporotic bone defect rat model recruited endogenous integrinβ1-expressing cells and enhanced new bone formation and bone strength.Our findings reveal that GelHFS hydrogel provides a rejuvenating niche for endogenous MSCs and enhances bone regeneration in osteoporotic bone defect.These findings highlight the potential of GelHFS hydrogel as an effective therapeutic strategy for addressing challenging bone healing such as osteoporotic bone regeneration.

Performance evaluation and chemical property analysis of RWMA binders with 100% artificial reclaimed asphalt

The performance evaluation and chemical property analysis of the recycled warm mix asphalt （RWMA） binders containing 100% artificial reclaimed asphalt （ RA） are presented, and the combined effects of different percentages of the rejuvenator and warm mix additive （WMA） additives on RWMA binders are analyzed through laboratory tests. Three types of WMA additives ad one commercial rejuvenator named GST were selected to restore the artificial RA. The laboratory performace tests including the penetration test, softening test ad rotary, viscosity （RV） test were carried out. In addition, the Fourier transform infrared spectroscopy （FTIR） test was performed to explore the chemical property of RWMA binders. The results of the performance tests indicate that the rejuvenator GST has the ability to restore the artificial RA; choosing the optimum content of WMA additives and rejuvenator is the key to restoring 100% artificial RA, since the combined effects of them play an important role in determining the basic laboratory performance of RWMA binders. The FTIR tests show that the process of recycling mainly adjusts the chemical component of aged asphalt and no remarkable change is observed in the FTI1R spectra of RWMA binders in terms of chemical functional groups with the introduction of WMA additives.

基于检查点和Rejuvenation的软件可靠性建模分析

处于运行阶段的软件往往存在老化现象,即性能的逐渐下降或失效。为了避免软件老化造成的影响,人们提出了软件rejuvenation技术。这是一种预防性的软件容错策略,能有效的提高软件系统的可靠性和可用性。但由于rejuvenation操作过程的复杂性,它的成本也是不可忽略的。相对于rejuvenation来说,检查点是一种轻量级的软件容错策略,其成本远小于rejuvenation的成本。本文旨在结合rejuvenation和检查点技术,在rejuvenation周期间插入适当数目的检查点,以降低系统的宕机成本。文中给出了系统的petri网模型,并结合实例进行了分析。

The Purification and Rejuvenation and Breeding Technology of Rice Variety Yunjing 29 with Fragrant and Soft Rice

Yunjing 29 bred by Institute of Food Crops of Yunnan Academy of Agricultural Sciences is a new conventional japonica rice variety with fragrant and sof rice, it was examined and approved by Yunnan Provincial Variety Examination and Approval Committee in March of 2011. The variety is early-maturing, high-yield and good-quality, and has resistances to lodging, blast and bacterial leaf blight, its rice is sweet soft, goluptious and lucidus as well as not coarse when it is cold, so it is a good commodity. To further promote the popularization and cultivation of the variety, maintain its characteristics of high quality and high yield, and prevent commingling and degeneration, the purification and rejuvenation as well as breeding technology of high-quality seeds were proposed after continuous exploration and study.

基于Rejuvenation的程序执行时间优化算法

Rejuvenation是为了防止软件老化而提出的一种主动性、预防性的软件容错策略.把定时Rejuvenation策略引入到执行时间有限的单任务程序中,分析了存在老化时,软件Rejuvenation对程序总执行时间所起的影响.仿真结果表明,定时的Rejuvenation策略能有效地避免软件老化带来的突发性失效,从而减少程序的执行时间.

基于检查点和Rejuvenation的软件运行模型分析

近来的研究表明 ,长时间运行的通信软件往往存在老化现象。为防止软件老化引起的突发性系统停机 ,提高系统的可靠性 ,人们提出了一种预防性的软件容错策略 ,称为rejuvenation。由于它的过程复杂 ,总的停机成本仍然是可观的。检查点是一种轻量级的软件容错策略 ,其成本远小于rejuvenation的成本。该文通过合理结合rejuvenation和检查点技术 ,实现了降低总的系统停机成本的目的。文中给出了系统的Petri网模型 ,并结合实例进行了分析。

Inheritance and Development of Cultures of Traditional Vernacular Dwellings in the Townscape Renovation Project of Guangxi,China

By analyzing background and present situation of townscape renovation project in Guangxi, endeavors for inheriting and developing cultures of traditional vernacular dwellings in the implementation of this project are discussed, and characteristics of traditional vernacular dwellings in the study area are summarized. Local vernacular dwellings can be classified in the following 3 ways on the basis of their own regional features:First, classifying by the origin and development history:stilt building, courtyard and non-courtyard building, western-style building; Second, by building materials:bamboo-wood building, stone building, adobe building, earth-stone building, brick-wood building, building of mixed materials; Third, by architectural form:stilt building, courtyard building, non-courtyard building. Stilt wooden building in northern Guangxi is a representative of traditional vernacular dwellings in the study area. By giving mature consideration to inheritance and development of cultures of traditional vernacular dwellings, this study proposes that proper renovation plans should be made according to actual conditions of the planning site; form renovation of vernacular dwellings should be taken as the new trend of renovation; traditional cultures should be further explored, demonstrated and protected. These suggestions are of great instructive significance for improving the cultural taste of townscapes.

软件Rejuvenation周期的优化

软件Rejuvenation技术通过定期对软件系统执行Rejuvenation操作来有效改善软件系统性能,执行Rejuvenation操作的周期直接关系到软件系统性能的改善.目前,主要通过单个指标的优化对软件Rejuvenation周期进行研究,这并不能整体提高性能.鉴于此,提出了综合考虑整体性能指标的方法来优化软件Rejuvenation周期,将所关心的指标综合考虑,在适当降低某个指标性能的同时有效提高其他指标性能,起到整体提高软件系统性能的目的.以综合考虑系统可用性、系统停机时间以及系统损失3个指标为例进行探讨,并寻找到了2个可以用之对软件Rejuvenation周期进行优化的目标函数.实验结果表明,通过该目标函数得到的周期可以很好地改善软件系统的整体性能.