Rejuvenating Northeastern Area and Reforming the System of Investing and Financing

The system of investing and financing in northeastern area has the character of planned economy. Project conducting is our main strategy in any large-scale area rejuvenating plan, which has been proved lack of sustainable development. This paper proposes some suggestion to reform the system of investing and financing.

Cyberloafing:The line between rejuvenating and wasting time

Research shows that workers drift from their contracted tasks to personal email,social networks and the far corners of the internet for anything between a few hours a week to a few hours a day.Six out of 10people admit they can’t get through the workday without checking their social media.

Direct Correlation among Telomere Length, Cellular Aging, and Rejuvenation Effects of Honey Child Powder

Purpose: Telomere length (TL) is an indicator of age;however, hormonal influences complicate individual aging. It remains unclear whether TL shortening is a direct factor in both individual and cellular aging. Therefore, we examined the direct relationship between TL and cellular senescence at the cellular level. Methods: Telomerase activity, TL, and gene expression were measured in cultured human lung-, fetal-, and skin-derived fibroblasts, human skin keratinocytes, and telomerase reverse transcriptase (TERT) gene-immortalized cells using detection kits, Cawthon’s method, and reverse transcription-quantitative polymerase chain reaction, respectively. Novel substances that elongate telomeres were screened to confirm cell rejuvenation effects. Results: Long-term cell culture of TIG-1-20 normal human fibroblasts resulted in TL shortening, decreased division rate, and senescence progression, whereas in OUMS-36T-2 cells, TL elongation via TERT gene transfer increased the division rate, reduced endoplasmic reticulum stress, and upregulated genes associated with young individuals, indicating that cellular rejuvenation occurs via TL elongation. In addition, a honey child powder (HCP) extract was found through screening, and the HCP extract strongly suppressed the menin gene, resulting in increased telomerase activity and extended cell lifespan. Upon addition of the HCP extract to skin fibroblasts, gene expression of moisturizing components, including collagen, hyaluronic acid, and elastin, increased, and exhibited a rejuvenating effect with an increase in elastin amount. Conclusions: TL elongation or shortening is involved in cell proliferation rate and cellular aging, and TL elongation rejuvenates cells. In addition, HCP extract has a rejuvenating effect on cells and is expected to be a rejuvenating compound.

Bio-based rejuvenators in asphalt pavements:A comprehensive review and analytical study

The pressing demand for sustainable advancements in road infrastructure has catalyzed extensive research into environmentally conscious alternatives for the maintenance and restoration of asphalt concrete pavements.This paper offers a comprehensive review and analysis of bio-based rejuvenators as a promising avenue for enhancing the longevity and sustainability of asphalt.Through a multifaceted exploration,it delves into various aspects of this innovative approach.Providing a thorough overview of bio-based rejuvenators,the study highlights their renewable and environmentally friendly characteristics.It conducts an in-depth examination of a wide spectrum of bio-derived materials,including vegetable oils,waste-derived bio-products,and biopolymers,through a comprehensive survey.The paper evaluates how bio-based rejuvenators enhance aged asphalt binders and mixes,effectively mitigating the adverse impacts of aging.Furthermore,it investigates how these rejuvenators address environmental concerns by identifying compatibility issues,assessing long-term performance,and evaluating economic feasibility.Finally,the paper outlines potential advancements and research pathways aimed at optimizing the utilization of bio-based rejuvenators in asphalt concrete,thereby contributing to the sustainable evolution of road infrastructure.

基于检查点和Rejuvenation的软件可靠性建模分析

处于运行阶段的软件往往存在老化现象,即性能的逐渐下降或失效。为了避免软件老化造成的影响,人们提出了软件rejuvenation技术。这是一种预防性的软件容错策略,能有效的提高软件系统的可靠性和可用性。但由于rejuvenation操作过程的复杂性,它的成本也是不可忽略的。相对于rejuvenation来说,检查点是一种轻量级的软件容错策略,其成本远小于rejuvenation的成本。本文旨在结合rejuvenation和检查点技术,在rejuvenation周期间插入适当数目的检查点,以降低系统的宕机成本。文中给出了系统的petri网模型,并结合实例进行了分析。

基于Rejuvenation的程序执行时间优化算法

Rejuvenation是为了防止软件老化而提出的一种主动性、预防性的软件容错策略.把定时Rejuvenation策略引入到执行时间有限的单任务程序中,分析了存在老化时,软件Rejuvenation对程序总执行时间所起的影响.仿真结果表明,定时的Rejuvenation策略能有效地避免软件老化带来的突发性失效,从而减少程序的执行时间.

软件Rejuvenation周期的优化

软件Rejuvenation技术通过定期对软件系统执行Rejuvenation操作来有效改善软件系统性能,执行Rejuvenation操作的周期直接关系到软件系统性能的改善.目前,主要通过单个指标的优化对软件Rejuvenation周期进行研究,这并不能整体提高性能.鉴于此,提出了综合考虑整体性能指标的方法来优化软件Rejuvenation周期,将所关心的指标综合考虑,在适当降低某个指标性能的同时有效提高其他指标性能,起到整体提高软件系统性能的目的.以综合考虑系统可用性、系统停机时间以及系统损失3个指标为例进行探讨,并寻找到了2个可以用之对软件Rejuvenation周期进行优化的目标函数.实验结果表明,通过该目标函数得到的周期可以很好地改善软件系统的整体性能.

The Purification and Rejuvenation and Breeding Technology of Rice Variety Yunjing 29 with Fragrant and Soft Rice

Yunjing 29 bred by Institute of Food Crops of Yunnan Academy of Agricultural Sciences is a new conventional japonica rice variety with fragrant and sof rice, it was examined and approved by Yunnan Provincial Variety Examination and Approval Committee in March of 2011. The variety is early-maturing, high-yield and good-quality, and has resistances to lodging, blast and bacterial leaf blight, its rice is sweet soft, goluptious and lucidus as well as not coarse when it is cold, so it is a good commodity. To further promote the popularization and cultivation of the variety, maintain its characteristics of high quality and high yield, and prevent commingling and degeneration, the purification and rejuvenation as well as breeding technology of high-quality seeds were proposed after continuous exploration and study.

基于检查点和Rejuvenation的软件运行模型分析

近来的研究表明 ,长时间运行的通信软件往往存在老化现象。为防止软件老化引起的突发性系统停机 ,提高系统的可靠性 ,人们提出了一种预防性的软件容错策略 ,称为rejuvenation。由于它的过程复杂 ,总的停机成本仍然是可观的。检查点是一种轻量级的软件容错策略 ,其成本远小于rejuvenation的成本。该文通过合理结合rejuvenation和检查点技术 ,实现了降低总的系统停机成本的目的。文中给出了系统的Petri网模型 ,并结合实例进行了分析。

Effect of Rejuvenators on Performance and Microstructure of Aged Asphalt

A composite rejuvenator was used for the rejuvenation of aged asphalt in comparison with the common rejuvenator. The effects of the rejuvenators on the performance and microstructure of the aged asphalt were investigated by physical properties tests, dynamic shear rheometer and atomic force microscopy. The results indicate that the physical and rheological properties of the aged asphalt are restored more significantly by the composite rejuvenator than the common rejuvenator, which can be ascribed to the effective recovery of microstmcture of the aged asphalt. The composite rejuvenator has the potential to be used for the rejuvenation of severely aged asphalt since it can restore the colloidal structure of the aged asphalt effectively through composition regulation and chemical reactions between the composite rejuvenator and asphaltenes.

A New Approach for Evaluating Rejuvenator Diffusing into Aged Bitumen

Rejuvenator diffusing into aged bitumen was evaluated by determining penetration and chemical components of aged bitumen with rejuvenator coat before and after diffusing experiment. Effects of temperature, time and viscosity of rejuvenator on the diffusing ability of rejuvenator into aged bitumen were investigated. Results indicated that the diffusing ability of rejuvenator into aged bitumen could be enhanced with the increasing of temperature and time, however, the diffusing of rejuvenator into aged bitumen would be restricted due to the volatilization of light component and aging of rejuvenator under high temperature （over 170 ℃）. Rejuvenator with low viscosity diffused into aged bitumen more easily.

Compound Rejuvenation of Polymer Modified Asphalt Binder

The objective of this research was to show a way to conduct rejuvenation of aged polymer modified asphalt binder（PMB） successfully.To fully evaluate and understand the rejuvenation of aged PMB,the Penetration grade tests including penetration,soften point,ductility and elastic recovery and SuperpaveTM PG grade tests including DSR,BBR and DDT were conducted.The rejuvenation effect of aged PMB by utilizing a fluid recycling agent in common use for binder rejuvenation was evaluated.And then the compound rejuvenation effect of aged PMB by utilizing the recycling agent with a new modifying additive for binder modification was evaluated.The experimental results indicated that the recycling agent in common use currently does not apply to polymer modified asphalt binder rejuvenation.But the recycling agent together with the modifying additive can restore the characteristics of aged polymer modified binder very well.Therefore,compound rejuvenation of polymer modified asphalt binder is recommended.

Rejuvenation of Fossil Sutures and Related Mesozoic Intracontinental Orogenies in South China

The Huanan (South China) subcontinent was created by amalgamation of the Yangtze, Xianggan, Cathaysia and Zhemin microcontinents by the Guangxi orogeny in the Early Palaeozoic. The closure of the Tethyan Ocean and subsequent collision event outside the amalgamated continent reactivated fossil sutures and resulted in intracontinental (ensialic) orogenies in the Mesozoic. Based on evidence from deformation, molasse and granitoids, the Sichuan-Guizhou-Hunan—southern Hubei and Hunan-Jiangxi-Fujian Yanshanian fold-thrust systems and the Lower Yangtze-northwestern Fujian Indosinian fold-thrust system are thought to be intracontinental orogens. Their main features are as follows: intracontinental orogenies occurred areally, thrusting propagated towards the interior of the continental, they extend parallelly to the strikes of the fossil sutures, and the details of the temporal-spatial evolution of the orogens depend on subduction-collision events.

Structural evolution in deformation-induced rejuvenation in metallic glasses: A cavity perspective

Classical molecular dynamics simulations have been performed to investigate the structural evolution in deformationinduced rejuvenation in Cu_(80)Zr_(20) metallic glass. Metallic glasses obtained by different cooling rates can be rejuvenated into the glassy state with almost the same potential energy by compressive deformation. The aging effect in different metallic glasses in cooling process can be completely erased by the deformation-induced rejuvenation. The evolution of cavities has been analyzed to understand the structural evolution in rejuvenation. It is found that as metallic glasses are rejuvenated by mechanical deformation, a lot of cavities are created. The lower the potential energy is, the more the cavities are created. The cavities are mainly created in the regions without cavities or with small cavities populated, indicating that the irreversible rearrangements induced by deformation are accompanied by the creation of cavity. This finding elucidates the underlying structural basis for rejuvenation and aging in metallic glasses from the cavity perspective.

Evaluation of Mixture Performance Recycled Asphalt Pavement Materials as Base Layer with or without Rejuvenator into the Asphalt

The binder properties were determined in accordance with Chinese standard such as ductility test, which allowed to measure the distance in centimeters that a standard briquette of asphalt had been stretched before breaking. Then, penetration test was carried out in order to know some properties of the asphalt, which are the hardness and the softness. Finally, softening point test was carried out in order to determine the temperature at which the bitumen attains a particular degree of softening under the specification of the test. According to Chinese standard for performance tests, firstly, Marshall test was carried out in order to measure the theoretical density, air voids, voids filled with asphalt, stability, flow, and voids in mineral aggregate of asphalt specimens. Secondly, Freeze-thaw splitting test was carried out in order to determine Splitting strength ratio. Finally, dynamic stability (rutting) test was carried out to determine average dynamic stability. Beside the tests carried out, the gradation of the extracted aggregate in accordance with American Association of State Highway and Transportation Officials was carried out to determine the dimensions of the particles weight distribution. Furthermore, both the percentage of recycled asphalt pavement materials and binder in mixture were determined to know how much of the new material during the mixture was needed. However, two specimens were used to evaluate the performance of recycled asphalt pavement materials. One specimen of recycled asphalt pavement materials was ten years old, and another one of recycled asphalt pavement materials was five years old. The results show that the conditions of the environment such as moisture, temperature, and age, decrease the ductility and penetration properties of binder when increase the softening point property of binder. Then the gradation of recycled asphalt pavement aggregate is of the required values to reuse in the mixture, while the flow ratio, the splitting strength ratio, and the dynamic stability ratio, are less than the required value test. With regard to the properties of mixture of recycled asphalt pavement material binder with rejuvenator, the results show that when the penetration and ductility versus percentage of rejuvenator increase, softening point versus percentage of rejuvenator decreases. Also, when the bitumen and rejuvenator percentage increase, the air voids decrease. Consequently, voids filled with asphalt and voids in the mineral aggregate increase. Moreover, the theoretical density and stability values decrease in a mixture containing four-point fifty percent to six percent of bitumen and rejuvenator, whereas the flow values increase. More interestingly, with four percent to four-point fifty percent mixture ratio of bitumen and rejuvenator, density, stability, and flow values increase. The splitting strength ratio values of mixtures and the dynamic stability test (rutting test) values of mixtures with forty percent of specimen one and specimen two respectively are greater than the required value of the standard test. In addition, the high percentage of rejuvenator increases the rut of pavement, in the same manner, the low percentage of rejuvenator induces low rut. In conclusion, the binder content from recycled materials without rejuvenator seems not be sufficient to be reused on the new pavement while the aged recycled material seems to be performed better than no aged recycled material with rejuvenator into bitumen. Then, the rejuvenator can influence the bitumen properties and performance of the pavement. Finally, the pavement made by only recycled pavement materials as a base layer appears to be more economical but cannot be more effective than the pavement made by mixture of new and recycled pavement materials as a base layer.

Preventing aging with stem cell rejuvenation:Feasible or infeasible?

Characterized by dysfunction of tissues, organs, organ systems and the whole organism, aging results fromthe reduced function of effective stem cell populations. Recent advances in aging research have demonstrated that old tissue stem cells can be rejuvenated for the purpose of maintaining the old-organ function by youthful re-calibration of the environment where stem cells reside. Biochemical cues regulating tissue stem cell function include molecular signaling pathways that interact between stem cells themselves and their niches. Historically, plasma fractions have been shown to contain factors capable of controlling age phenotypes; subsequently, signaling pathways involved in the aging process have been identified. Consequently, modulation of signaling pathways such as Notch/Delta, Wnt, transforming growth factor-β, JAK/STAT, mammalian target of rapamycin and p38 mitogen-activated protein kinase has demonstrated potential to rejuvenate stem cell function leading to organismic rejuvenation. Several synthetic agents and natural sources, such as phytochemicals and flavonoids, have been proposed to rejuvenate old stem cells by targeting these pathways. However, several concerns still remain to achieve effective organismic rejuvenation in clinical settings, such as possible carcinogenic actions; thus, further research is still required.

Tendon stem/progenitor cell ageing: Modulation and rejuvenation

Tendon ageing is a complicated process caused by multifaceted pathways and ageing plays a critical role in the occurrence and severity of tendon injury.The role of tendon stem/progenitor cells(TSPCs)in tendon maintenance and regeneration has received increasing attention in recent years.The decreased capacity of TSPCs in seniors contributes to impaired tendon functions and raises questions as to what extent these cells either affect,or cause ageing,and whether these age-related cellular alterations are caused by intrinsic factors or the cellular environment.In this review,recent discoveries concerning the biological characteristics of TSPCs and age-related changes in TSPCs,including the effects of cellular epigenetic alterations and the mechanisms involved in the ageing process,are analyzed.During the ageing process,TSPCs ageing might occur as a natural part of the tendon ageing,but could also result from decreased levels of growth factor,hormone deficits and changes in other related factors.Here,we discuss methods that might induce the rejuvenation of TSPC functions that are impaired during ageing,including moderate exercise,cell extracellular matrix condition,growth factors and hormones;these methods aim to rejuvenate the features of youthfulness with the ultimate goal of improving human health during ageing.

Application Server Aging Model and Multi-Level Rejuvenation Strategy Using Semi-Markov Process

Aiming at the characteristic of the dependency between the application components and the application server platform, a rejuvenation strategy with two different levels of rejuvenation granularities is put forward in this paper including the application component reiuvenation and the application server system rejuvenation. The availability and maintenance cost functions are obtained by means of establishing the application server aging model and the boundary condition of the optimal rejuvenation time is analyzed. Theory analysis indicates that the two-level rejuvenation strategy is superior to the traditional single level one. Finally, evaluation experiments are carried out and numerical result shows that compared with the traditional rejuvenation policy, the rejuvenation strategy proposed in this paper can further increase availability of the application server and reduce maintenance cost.

Diffusion and Regeneration Mechanism of Waste Composite Oils Rejuvenator in Aged Asphalt

The physical performance of recycled asphalt was used as the main evaluation index to study the optimal range of a self-made rejuvenator.Through the penetration,viscosity and gel permeation chromatography(GPC)tests,the diffusion degree of the rejuvenator under different temperatures and time process was analyzed,and the diffusion efficiency of the rejuvenator was evaluated from the macro and micro perspective.The regeneration mechanism of the rejuvenator in the aged asphalt was also analyzed using the Fourier transform infrared spectroscopy(FTIR),scanning electron microscope(SEM)and chemical composition tests.The research results showed that the optimum rejuvenator content was about 3%.Higher temperature and longer time were beneficial to improving the permeability and diffusion of the rejuvenator.During the aging process,the light components were reduced,and more macromolecular asphaltenes were generated as well as a large number of carbonyl and sulfoxide.After diffusion and regeneration,the light components in the asphalt were supplemented,the wrinkles and gullies of the aged asphalt were almost improved to the surface state of the matrix asphalt.

Fractional Ablative Radio-Frequency Resurfacing in Asian and Caucasian Skin: A Novel Method for Deep Radiofrequency Fractional Skin Rejuvenation

This paper reports the clinical experience of a multi-center, multiple physician trial with a novel fractional radiofrequency ablative skin resurfacing and rejuvenation device (Fractora, Invasix, Israel) deployed on both Caucasian skin types I - III and Asian skin type IV. Histological study demonstrated deep ablation and collagen restructuring in the papillary and reticular dermis. The Fractora device combines the more “cone shaped” ablation seen with CO2 and Erbium lasers with a deep non-ablative heating pattern, seen with other bipolar RF fractional needle resurfacing devices. Ablation, coagulation zones and healing dynamics are analyzed for different energy settings. Two different treatment protocols are suggested: one for light skin and then one for darker skin with a higher risk of post-inflammatory hypperpigmentation. Treatment results show improvement in skin texture, pores, wrinkles and skin dyschromia.