Currently,psychiatry lacks a field that can be called“theoretical psychiatry”,which uses theoretical concepts and explanatory models:The main stream of research is to collect data of all kinds in the hope that the c...Currently,psychiatry lacks a field that can be called“theoretical psychiatry”,which uses theoretical concepts and explanatory models:The main stream of research is to collect data of all kinds in the hope that the computational Big Data approach will shed a bright light on the black box of mental disorders.Accordingly,the biology-based Research Domain Criteria of the National Institute of Mental Health have been established.However,as philosophical analyses of concepts and methods have shown,several epistemological gaps stand in the way of a consistent multilevel understanding of mental disorders.Also,the implicit ontological problems in the biological reduction of the psychosocial level and in the integration of so-called hard and soft disciplines are mostly left out.As a consequence,a non-reductive psychological theory of mental disorders is sought that also integrates correlating biological and sociological issues.In this context,one example of promising nonreductive psychiatric research is the option of systems/network psychopathology.The possibilities for integrating different psychological perspectives are highlighted for the field of addiction research and treatment,where pragmatic behaviorist approaches dominate over the theorybased practice of psychoanalysis.In comparing the theoretical constructs of these two approaches,the relevance of the concept of“(social)environment”as the wealth of influential sociocultural factors is discussed at levels superior to the interpersonal micro-level,namely the organizational meso-and societal macro level,which is not sufficiently considered in current biopsychiatry.On this basis of argumentation,the usefulness of grounding and framing psychiatry through the field of ecological sciences,especially human ecology,is demonstrated.Finally,to this end,an outline of an ecological model of mental health and illness is presented.展开更多
BACKGROUND Identifying biomarkers for the risk of developing degenerative processes linked to aging and colorectal cancer(CRC) onset that could improve clinical strategies.AIM To determine valid targets and a predicti...BACKGROUND Identifying biomarkers for the risk of developing degenerative processes linked to aging and colorectal cancer(CRC) onset that could improve clinical strategies.AIM To determine valid targets and a predictive biomarker's system of chronicization of inflammation for cancer treatment.METHODS A group of 147 CRC patients was studied. Clinical diagnosis was confirmed histopathologically, and patients were sub-typed using the pathological tumornode-metastasis classification. Thirteen colon adenoma patients and 219 healthy subjects were also studied. A system biology study on Thioredoxin1/CD30 redox-immune systems(Trx1/CD30), T helper cytokines and polymorphisms of killer immunoglobulin-like receptors, FcγRIIa-131 H/R and FcγRIIIa-158 V/F was carried out. Enzyme-linked immunosorbent assay was performed to analyze sera.Genetic study was executed by polymerase chain reaction sequence-specific primers and sequence-based typing method. Statistical analysis was performed by using the "Statgraphics software systems".RESULTS We found a positive increase between Trx1/RTrx1 levels and sCD30 level and increased age. With respect to the gender relationships, there were distinct differences. Females showed a primary relationship between transforming growth factor beta(TGFβ) with Trx1, whereas males had one with TGFβ and RTrx1. Trx1/CD30 controls the redox immune homeostasis, and an imbalance in the relationship between the Trx1/RTrx1 and sCD30 levels is linked to the onset and progression of tumor. This event happens through different gender-specific cytokine pathways. Our study demonstrated that the serum levels ofTrx1/RTrx1, TGFβ/interleukin(IL)6 and TGFβ/IL4 combinations and the sCD30,IFNγ and IL2 combination constitute a predictive gender specific biomarker system. This is relevant for clinical screening to detect the risk of the potential development or progression of a tumor.CONCLUSION Oxidative stress on Trx1/CD30 is a trigger of cancer disease, and the selected oxidation and immune products are a biomarker system for aging and cancer.展开更多
Visible-infrared person re-identification(VIPR), is a cross-modal retrieval task that searches a target from a gallery captured by cameras of different spectrums.The severe challenge for VIPR is the large intra-class ...Visible-infrared person re-identification(VIPR), is a cross-modal retrieval task that searches a target from a gallery captured by cameras of different spectrums.The severe challenge for VIPR is the large intra-class variation caused by the modal discrepancy between visible and infrared images.For that, this paper proposes a query related cluster(QRC) method for VIPR.Firstly, this paper uses an attention mechanism to calculate the similarity relation between a visible query and infrared images with the same identity in the gallery.Secondly, those infrared images with the same query images are aggregated by using the similarity relation to form a dynamic clustering center corresponding to the query image.Thirdly, QRC loss function is designed to enlarge the similarity between the query image and its dynamic cluster center to achieve query related clustering, so as to compact the intra-class variations.Consequently, in the proposed QRC method, each query has its own dynamic clustering center, which can well characterize intra-class variations in VIPR.Experimental results demonstrate that the proposed QRC method is superior to many state-of-the-art approaches, acquiring a 90.77% rank-1 identification rate on the RegDB dataset.展开更多
A new customization approach based on support vector regression （SVR） is proposed to obtain individual headrelated impulse response （HRIR） without complex measurement and special equipment. Principal component ana...A new customization approach based on support vector regression （SVR） is proposed to obtain individual headrelated impulse response （HRIR） without complex measurement and special equipment. Principal component analysis （PCA） is first applied to obtain a few principal components and corresponding weight vectors correlated with individual anthropometric parameters. Then the weight vectors act as output of the nonlinear regression model. Some measured anthropometric parameters are selected as input of the model according to the correlation coefficients between the parameters and the weight vectors. After the regression model is learned from the training data, the individual HRIR can be predicted based on the measured anthropometric parameters. Compared with a back-propagation neural network （BPNN） for nonlinear regression, better generalization and prediction performance for small training samples can be obtained using the proposed PCA-SVR algorithm.展开更多
In the novel,A Passage to India,E.M.Foster showed the failure of Mrs.Moore and Adela Quested to build intimate“personal relations”with the natives in India under the imperial and colonial rule of Britain.As colonist...In the novel,A Passage to India,E.M.Foster showed the failure of Mrs.Moore and Adela Quested to build intimate“personal relations”with the natives in India under the imperial and colonial rule of Britain.As colonists,the British rationalized and strengthened the racial separation and the prejudice and stereotypes against Indians to secure their superior status,while the national conflicts aroused the national awareness among Indian people.Under the adverse political pressure,Mrs.Moore and Adela were not strong enough to hold their grounds but only retreated.展开更多
Absractive:This article try to illustrate the re lationship of self-value and person ality by paraphrasing these two concepts,and deduce the effects of self-value to personalit y from this.This article also point out ...Absractive:This article try to illustrate the re lationship of self-value and person ality by paraphrasing these two concepts,and deduce the effects of self-value to personalit y from this.This article also point out the questions how to direct and help university students to set proper s elf-value and then modle healthy personality.It bring forward supposition of the r esolvement of the questions.On the b ase of the demonstrative research we carry out a validative research.展开更多
文摘Currently,psychiatry lacks a field that can be called“theoretical psychiatry”,which uses theoretical concepts and explanatory models:The main stream of research is to collect data of all kinds in the hope that the computational Big Data approach will shed a bright light on the black box of mental disorders.Accordingly,the biology-based Research Domain Criteria of the National Institute of Mental Health have been established.However,as philosophical analyses of concepts and methods have shown,several epistemological gaps stand in the way of a consistent multilevel understanding of mental disorders.Also,the implicit ontological problems in the biological reduction of the psychosocial level and in the integration of so-called hard and soft disciplines are mostly left out.As a consequence,a non-reductive psychological theory of mental disorders is sought that also integrates correlating biological and sociological issues.In this context,one example of promising nonreductive psychiatric research is the option of systems/network psychopathology.The possibilities for integrating different psychological perspectives are highlighted for the field of addiction research and treatment,where pragmatic behaviorist approaches dominate over the theorybased practice of psychoanalysis.In comparing the theoretical constructs of these two approaches,the relevance of the concept of“(social)environment”as the wealth of influential sociocultural factors is discussed at levels superior to the interpersonal micro-level,namely the organizational meso-and societal macro level,which is not sufficiently considered in current biopsychiatry.On this basis of argumentation,the usefulness of grounding and framing psychiatry through the field of ecological sciences,especially human ecology,is demonstrated.Finally,to this end,an outline of an ecological model of mental health and illness is presented.
文摘BACKGROUND Identifying biomarkers for the risk of developing degenerative processes linked to aging and colorectal cancer(CRC) onset that could improve clinical strategies.AIM To determine valid targets and a predictive biomarker's system of chronicization of inflammation for cancer treatment.METHODS A group of 147 CRC patients was studied. Clinical diagnosis was confirmed histopathologically, and patients were sub-typed using the pathological tumornode-metastasis classification. Thirteen colon adenoma patients and 219 healthy subjects were also studied. A system biology study on Thioredoxin1/CD30 redox-immune systems(Trx1/CD30), T helper cytokines and polymorphisms of killer immunoglobulin-like receptors, FcγRIIa-131 H/R and FcγRIIIa-158 V/F was carried out. Enzyme-linked immunosorbent assay was performed to analyze sera.Genetic study was executed by polymerase chain reaction sequence-specific primers and sequence-based typing method. Statistical analysis was performed by using the "Statgraphics software systems".RESULTS We found a positive increase between Trx1/RTrx1 levels and sCD30 level and increased age. With respect to the gender relationships, there were distinct differences. Females showed a primary relationship between transforming growth factor beta(TGFβ) with Trx1, whereas males had one with TGFβ and RTrx1. Trx1/CD30 controls the redox immune homeostasis, and an imbalance in the relationship between the Trx1/RTrx1 and sCD30 levels is linked to the onset and progression of tumor. This event happens through different gender-specific cytokine pathways. Our study demonstrated that the serum levels ofTrx1/RTrx1, TGFβ/interleukin(IL)6 and TGFβ/IL4 combinations and the sCD30,IFNγ and IL2 combination constitute a predictive gender specific biomarker system. This is relevant for clinical screening to detect the risk of the potential development or progression of a tumor.CONCLUSION Oxidative stress on Trx1/CD30 is a trigger of cancer disease, and the selected oxidation and immune products are a biomarker system for aging and cancer.
基金Supported by the National Natural Science Foundation of China (No.61976098)the Natural Science Foundation for Outstanding Young Scholars of Fujian Province (No.2022J06023)。
文摘Visible-infrared person re-identification(VIPR), is a cross-modal retrieval task that searches a target from a gallery captured by cameras of different spectrums.The severe challenge for VIPR is the large intra-class variation caused by the modal discrepancy between visible and infrared images.For that, this paper proposes a query related cluster(QRC) method for VIPR.Firstly, this paper uses an attention mechanism to calculate the similarity relation between a visible query and infrared images with the same identity in the gallery.Secondly, those infrared images with the same query images are aggregated by using the similarity relation to form a dynamic clustering center corresponding to the query image.Thirdly, QRC loss function is designed to enlarge the similarity between the query image and its dynamic cluster center to achieve query related clustering, so as to compact the intra-class variations.Consequently, in the proposed QRC method, each query has its own dynamic clustering center, which can well characterize intra-class variations in VIPR.Experimental results demonstrate that the proposed QRC method is superior to many state-of-the-art approaches, acquiring a 90.77% rank-1 identification rate on the RegDB dataset.
基金Project supported by the Shanghai Natural Science Foundation (Grant No.08ZR1408300)the Shanghai Leading Academic Discipline Project (Grant No.S30108)
文摘A new customization approach based on support vector regression （SVR） is proposed to obtain individual headrelated impulse response （HRIR） without complex measurement and special equipment. Principal component analysis （PCA） is first applied to obtain a few principal components and corresponding weight vectors correlated with individual anthropometric parameters. Then the weight vectors act as output of the nonlinear regression model. Some measured anthropometric parameters are selected as input of the model according to the correlation coefficients between the parameters and the weight vectors. After the regression model is learned from the training data, the individual HRIR can be predicted based on the measured anthropometric parameters. Compared with a back-propagation neural network （BPNN） for nonlinear regression, better generalization and prediction performance for small training samples can be obtained using the proposed PCA-SVR algorithm.
文摘In the novel,A Passage to India,E.M.Foster showed the failure of Mrs.Moore and Adela Quested to build intimate“personal relations”with the natives in India under the imperial and colonial rule of Britain.As colonists,the British rationalized and strengthened the racial separation and the prejudice and stereotypes against Indians to secure their superior status,while the national conflicts aroused the national awareness among Indian people.Under the adverse political pressure,Mrs.Moore and Adela were not strong enough to hold their grounds but only retreated.
文摘Absractive:This article try to illustrate the re lationship of self-value and person ality by paraphrasing these two concepts,and deduce the effects of self-value to personalit y from this.This article also point out the questions how to direct and help university students to set proper s elf-value and then modle healthy personality.It bring forward supposition of the r esolvement of the questions.On the b ase of the demonstrative research we carry out a validative research.
