Hutchinson-Gilford progeria syndrome(HGPS,OMIM176670)is an extremely rare,sporadic genetic syndrome with a reported prevalence of one in4-8million children worldwide.At April2012,the total number of known living child...Hutchinson-Gilford progeria syndrome(HGPS,OMIM176670)is an extremely rare,sporadic genetic syndrome with a reported prevalence of one in4-8million children worldwide.At April2012,the total number of known living children with HGPS was89worldwide,according to data from the Progeria Research Foundation.展开更多
Autosomal recessive mutations in the PARK7 gene,which encodes for the protein DJ-1,result in a loss of function and are a cause of familial Parkinson’s disease（PD）,while increased wild-type DJ-1protein levels are a...Autosomal recessive mutations in the PARK7 gene,which encodes for the protein DJ-1,result in a loss of function and are a cause of familial Parkinson’s disease（PD）,while increased wild-type DJ-1protein levels are associated with some forms of cancer.Several functions of DJ-1 have been described,with the greatest evidence indicating that DJ-1 is a redox-sensitive protein involved in the regulation of oxidative stress and cell survival.展开更多
Objective To analyze the correlation of autophagylevel and carotid plaque of ischemic cerebrovascular disease,so as to provide data evidence to its pathomechanism.Methods 127 patients with ischemic cerebrovascular dis...Objective To analyze the correlation of autophagylevel and carotid plaque of ischemic cerebrovascular disease,so as to provide data evidence to its pathomechanism.Methods 127 patients with ischemic cerebrovascular disease were divided into 3 groups according to carotid plague scores.The count and degree of cranial artery stenosis were observed with digital subtraction angiogra-展开更多
文摘Hutchinson-Gilford progeria syndrome(HGPS,OMIM176670)is an extremely rare,sporadic genetic syndrome with a reported prevalence of one in4-8million children worldwide.At April2012,the total number of known living children with HGPS was89worldwide,according to data from the Progeria Research Foundation.
基金funded by a Medical Research Council(UK)Experimental Medicine grant[MR/M006646/1]
文摘Autosomal recessive mutations in the PARK7 gene,which encodes for the protein DJ-1,result in a loss of function and are a cause of familial Parkinson’s disease（PD）,while increased wild-type DJ-1protein levels are associated with some forms of cancer.Several functions of DJ-1 have been described,with the greatest evidence indicating that DJ-1 is a redox-sensitive protein involved in the regulation of oxidative stress and cell survival.
文摘Objective To analyze the correlation of autophagylevel and carotid plaque of ischemic cerebrovascular disease,so as to provide data evidence to its pathomechanism.Methods 127 patients with ischemic cerebrovascular disease were divided into 3 groups according to carotid plague scores.The count and degree of cranial artery stenosis were observed with digital subtraction angiogra-
