Objective:This study aimed to evaluate the safety and efficacy outcomes of percutaneous radiofrequency ablation(RFA)for localised renal cell carcinoma(RCC)in a tertiary hospital patient who remained unfit for surgical...Objective:This study aimed to evaluate the safety and efficacy outcomes of percutaneous radiofrequency ablation(RFA)for localised renal cell carcinoma(RCC)in a tertiary hospital patient who remained unfit for surgical intervention.Methods:We retrospectively analysed survival outcomes for patients with biopsy proven RCC treated by RFA at Royal Perth Hospital between September 2009 and May 2018.Complication data were gathered for all patients that underwent renal RFA along with 2-and 5-year recurrence-free survival(RFS)rate and compared the outcomes with data from previous studies.Results:A total of 69 patients(73 procedures)were eligible for the study,and those patients had biopsy-proven RCC with a minimum of 2-year follow-up.The complication rate was 8.2%(6/73)and local recurrence rate 9.6%(7/73).Two-year RFS is 95.7% and 5-year RFS is 78.8% on a median 3.82-year follow-up(interquartile range 1.90-5.75 years).Conclusion:RFA performed at our centre was found to be safe and effective with low complication rates and durable RFS in line with expectations from existing research.Our study demonstrated that RFA is an alternative modality of treatment for small renal tumours in patients unfit for surgical approach.展开更多
Primary vascular tumours of the kidney are rare and may pose diagnostic difficulties because of their similar clinical,morphological,and immunohistochemical features.This article summarizes the clinical and pathologic...Primary vascular tumours of the kidney are rare and may pose diagnostic difficulties because of their similar clinical,morphological,and immunohistochemical features.This article summarizes the clinical and pathological features of primary renal angiosarcoma and anastomosing haemangioma of the kidney including epidemiology,genetics,and prognosis.Renal anastomosing haemangiomas are benign neoplasms characterized by anastomosing capillary-sized vascular channels.These tumours are rare,with about 75 cases reported in the literature.Most anastomosing haemangiomas are found incidentally on ultrasound,computed tomography,or magnetic resonance imaging.Common symptoms include abdominal pain,haematuria,and abdominal mass.Renal anastomosing haemangiomas are characterized by recurrent mutations in GNAQ and GNA14 genes.The prognosis of anastomosing haemangioma is excellent.Primary renal angiosarcomas are malignant tumours showing endothelial differentiation.To date,76 cases have been described in the literature.Primary renal angiosarcomas are frequently symptomatic.The clinical features of renal angiosarcomas are similar to those of renal anastomosing haemangiomas,including abdominal pain,haematuria,and abdominal mass.Angiogenesis-related genes and vascular-specific receptor tyrosine kinases such as KDR,TIE1,SNRK,TEK,and FLT1 are upregulated in angiosarcomas.Primary renal angiosarcomas are highly aggressive neoplasms with a poor prognosis despite surgical treatment,chemotherapy,radiotherapy,or targeted therapy.展开更多
Mixed epithelial and stromal tumour(MEST)is an uncommon renal tumour with a tendency to protrude into the collecting system.We present a 50-year-old woman with a renal tumour extending up to the vesicoureteric junctio...Mixed epithelial and stromal tumour(MEST)is an uncommon renal tumour with a tendency to protrude into the collecting system.We present a 50-year-old woman with a renal tumour extending up to the vesicoureteric junction(VUJ)who was suspected to have an upper tract transitional cell carcinoma for which a nephroureterectomy was performed.Histopathologic examination revealed a MEST arising from the kidney and extending up to the VUJ.To the best of our knowledge,this is the first report of a renal MEST with extension to the VUJ.展开更多
Hiccups are involuntary spasms of the diaphragm with closure of the glottis. This involves a complex neural pathway which includes the phrenic, vagus and the sympathetic pathways, it is usually self-limiting and resol...Hiccups are involuntary spasms of the diaphragm with closure of the glottis. This involves a complex neural pathway which includes the phrenic, vagus and the sympathetic pathways, it is usually self-limiting and resolves within a few minutes after onset. Hiccups are described as chronic when it lasts more than 48 hours and intractable when it persists for more than a month. Intractable hiccups are said to have an organic cause in 80% of cases and the remaining 20% psychogenic in origin, Some of the organic causes of intractable hiccups include: liver cancer, adrenal tumours, and kidney tumours. We present a case of right renal cell carcinoma which presented as intractable hiccups and was successfully managed by performing a radical right nephrectomy.展开更多
文摘Objective:This study aimed to evaluate the safety and efficacy outcomes of percutaneous radiofrequency ablation(RFA)for localised renal cell carcinoma(RCC)in a tertiary hospital patient who remained unfit for surgical intervention.Methods:We retrospectively analysed survival outcomes for patients with biopsy proven RCC treated by RFA at Royal Perth Hospital between September 2009 and May 2018.Complication data were gathered for all patients that underwent renal RFA along with 2-and 5-year recurrence-free survival(RFS)rate and compared the outcomes with data from previous studies.Results:A total of 69 patients(73 procedures)were eligible for the study,and those patients had biopsy-proven RCC with a minimum of 2-year follow-up.The complication rate was 8.2%(6/73)and local recurrence rate 9.6%(7/73).Two-year RFS is 95.7% and 5-year RFS is 78.8% on a median 3.82-year follow-up(interquartile range 1.90-5.75 years).Conclusion:RFA performed at our centre was found to be safe and effective with low complication rates and durable RFS in line with expectations from existing research.Our study demonstrated that RFA is an alternative modality of treatment for small renal tumours in patients unfit for surgical approach.
文摘Primary vascular tumours of the kidney are rare and may pose diagnostic difficulties because of their similar clinical,morphological,and immunohistochemical features.This article summarizes the clinical and pathological features of primary renal angiosarcoma and anastomosing haemangioma of the kidney including epidemiology,genetics,and prognosis.Renal anastomosing haemangiomas are benign neoplasms characterized by anastomosing capillary-sized vascular channels.These tumours are rare,with about 75 cases reported in the literature.Most anastomosing haemangiomas are found incidentally on ultrasound,computed tomography,or magnetic resonance imaging.Common symptoms include abdominal pain,haematuria,and abdominal mass.Renal anastomosing haemangiomas are characterized by recurrent mutations in GNAQ and GNA14 genes.The prognosis of anastomosing haemangioma is excellent.Primary renal angiosarcomas are malignant tumours showing endothelial differentiation.To date,76 cases have been described in the literature.Primary renal angiosarcomas are frequently symptomatic.The clinical features of renal angiosarcomas are similar to those of renal anastomosing haemangiomas,including abdominal pain,haematuria,and abdominal mass.Angiogenesis-related genes and vascular-specific receptor tyrosine kinases such as KDR,TIE1,SNRK,TEK,and FLT1 are upregulated in angiosarcomas.Primary renal angiosarcomas are highly aggressive neoplasms with a poor prognosis despite surgical treatment,chemotherapy,radiotherapy,or targeted therapy.
文摘Mixed epithelial and stromal tumour(MEST)is an uncommon renal tumour with a tendency to protrude into the collecting system.We present a 50-year-old woman with a renal tumour extending up to the vesicoureteric junction(VUJ)who was suspected to have an upper tract transitional cell carcinoma for which a nephroureterectomy was performed.Histopathologic examination revealed a MEST arising from the kidney and extending up to the VUJ.To the best of our knowledge,this is the first report of a renal MEST with extension to the VUJ.
文摘Hiccups are involuntary spasms of the diaphragm with closure of the glottis. This involves a complex neural pathway which includes the phrenic, vagus and the sympathetic pathways, it is usually self-limiting and resolves within a few minutes after onset. Hiccups are described as chronic when it lasts more than 48 hours and intractable when it persists for more than a month. Intractable hiccups are said to have an organic cause in 80% of cases and the remaining 20% psychogenic in origin, Some of the organic causes of intractable hiccups include: liver cancer, adrenal tumours, and kidney tumours. We present a case of right renal cell carcinoma which presented as intractable hiccups and was successfully managed by performing a radical right nephrectomy.
