动物出生前后阶段是发育可塑性的关键时期,众多生理或环境因素可长期改变个体的生长发育和代谢表型。双亲效应是造成后代表型差异的重要原因。为研究双亲体重对后代断乳后的生长发育及成年期体重和能量代谢的影响,选取了体重差异显著的...动物出生前后阶段是发育可塑性的关键时期,众多生理或环境因素可长期改变个体的生长发育和代谢表型。双亲效应是造成后代表型差异的重要原因。为研究双亲体重对后代断乳后的生长发育及成年期体重和能量代谢的影响,选取了体重差异显著的布氏田鼠,分别雌雄配对,形成高体重双亲组后代(雌性,51.5 g±1.6 g;雄性,60.4 g±2.5 g;Parental high body mass,HBM)和低体重双亲组后代(雌性,35.5 g±1.2 g;雄性,49.6 g±2.8 g;Parental low body mass,LBM)。检测了后代(胎仔数为6-8)4-13周龄的体重、能量摄入(摄入能、消化能和消化率);12周龄时静止代谢率、非颤抖性产热、葡萄糖耐受;13周龄的血清瘦素水平及身体组织器官重等。发现:(1)低体重双亲组后代发育过程中的摄入能和消化能均显著高于高体重双亲组,雄性后代睾丸湿重和干重显著降低。(2)在雄性后代,双亲低体重导致静止代谢率显著升高,但雌性后代组间差异不显著。(3)成年(12周龄后)时的体重、非颤抖性产热、血清瘦素和葡萄糖耐受在高、低体重双亲组间无显著差异。结果表明:双亲低体重导致后代发育过程中将更多的能量用于生长,雄性后代繁殖器官的发育明显受到抑制,表现出生长和繁殖间的权衡。展开更多
In this paper, the normal derivative of the radial basis function （RBF） is introduced into the reproducing kernel particle method （RKPM）, and the improved reproducing kernel particle method （IRKPM） is proposed. ...In this paper, the normal derivative of the radial basis function （RBF） is introduced into the reproducing kernel particle method （RKPM）, and the improved reproducing kernel particle method （IRKPM） is proposed. The method can decrease the errors on the boundary and improve the accuracy and stability of the algorithm. The proposed method is applied to the numerical simulation of piezoelectric materials and the corresponding governing equations are derived. The numerical results show that the IRKPM is more stable and accurate than the RKPM.展开更多
Two independent measurements of cross sections for the 19F+93Nb dissipative heavy-ion collision (DHIC) have been performed at incident energies from 100 to 108 MeV in steps of 250 keV. Two independently prepared targe...Two independent measurements of cross sections for the 19F+93Nb dissipative heavy-ion collision (DHIC) have been performed at incident energies from 100 to 108 MeV in steps of 250 keV. Two independently prepared targets were used respectively with all other experimental conditions being identical in both experiments. The data indicate non-reproducibility of the non-self-averaging oscillation yields in the two measurements. The statistical analysis of this non-reproducibility supports recent theoretical predictions of spontaneous coherence, slow phase randomization and extreme sensitivity in highly excited quantum many-body systems.展开更多
The endosymbiont Wolbachia manipulates host reproduction by several strategies, one of the most important of which is cytoplasmic incompatibility (CI). CI can be rescued when Wolbachia-infected males mate with females...The endosymbiont Wolbachia manipulates host reproduction by several strategies, one of the most important of which is cytoplasmic incompatibility (CI). CI can be rescued when Wolbachia-infected males mate with females infected with the same Wolbachia strain. However, the potential rescue mechanism of CI in the small brown planthopper Laodelphax striatellus is unclear. In this study, comparative transcriptome analysis was applied to explore the effect of Wolbachia on L. striatellus eggs. A total of 1387 differentially expressed genes were identified. RNA interference of 7 Wolbachia-upregulated key planthopper genes reduced egg reproduction, suggesting that Wolbachia might improve fecundity in L. striatellus by affecting these 7 genes. Suppressing the expression of another upregulated gene, NDUFA8 (encoding NADH dehydrogenase [ubiquinone] 1 α subcomplex subunit 8-like) by RNA interference significantly increased the mortality of early embryos without affecting the number of deposited eggs. Wolbachia infection upregulated the mRNA level of NDUFA8, and dsNDUFA8 treatment of Wolbachia-infected females recreated CI-like symptoms, suggesting that NDUFA8 is associated with the rescue phenotype. Because all L. striatellus populations worldwide are infected with Wolbachia, NDUFA8 is a potential pest control target.展开更多
文摘动物出生前后阶段是发育可塑性的关键时期,众多生理或环境因素可长期改变个体的生长发育和代谢表型。双亲效应是造成后代表型差异的重要原因。为研究双亲体重对后代断乳后的生长发育及成年期体重和能量代谢的影响,选取了体重差异显著的布氏田鼠,分别雌雄配对,形成高体重双亲组后代(雌性,51.5 g±1.6 g;雄性,60.4 g±2.5 g;Parental high body mass,HBM)和低体重双亲组后代(雌性,35.5 g±1.2 g;雄性,49.6 g±2.8 g;Parental low body mass,LBM)。检测了后代(胎仔数为6-8)4-13周龄的体重、能量摄入(摄入能、消化能和消化率);12周龄时静止代谢率、非颤抖性产热、葡萄糖耐受;13周龄的血清瘦素水平及身体组织器官重等。发现:(1)低体重双亲组后代发育过程中的摄入能和消化能均显著高于高体重双亲组,雄性后代睾丸湿重和干重显著降低。(2)在雄性后代,双亲低体重导致静止代谢率显著升高,但雌性后代组间差异不显著。(3)成年(12周龄后)时的体重、非颤抖性产热、血清瘦素和葡萄糖耐受在高、低体重双亲组间无显著差异。结果表明:双亲低体重导致后代发育过程中将更多的能量用于生长,雄性后代繁殖器官的发育明显受到抑制,表现出生长和繁殖间的权衡。
基金Project supported by the National Natural Science Foundation of China(Grant No.11271234)the Shandong Provincial Science Foundation,China(Grant No.ZR2017MA028)
文摘In this paper, the normal derivative of the radial basis function （RBF） is introduced into the reproducing kernel particle method （RKPM）, and the improved reproducing kernel particle method （IRKPM） is proposed. The method can decrease the errors on the boundary and improve the accuracy and stability of the algorithm. The proposed method is applied to the numerical simulation of piezoelectric materials and the corresponding governing equations are derived. The numerical results show that the IRKPM is more stable and accurate than the RKPM.
基金Supported by the Natural Science Foundation of China(No.19775057 and No.10175083)the Major State Basic Research De-velopment(G2000077401)
文摘Two independent measurements of cross sections for the 19F+93Nb dissipative heavy-ion collision (DHIC) have been performed at incident energies from 100 to 108 MeV in steps of 250 keV. Two independently prepared targets were used respectively with all other experimental conditions being identical in both experiments. The data indicate non-reproducibility of the non-self-averaging oscillation yields in the two measurements. The statistical analysis of this non-reproducibility supports recent theoretical predictions of spontaneous coherence, slow phase randomization and extreme sensitivity in highly excited quantum many-body systems.
基金supported by the National Natural Science Foundation of China(No.32020103011,32001905,and 31871976).
文摘The endosymbiont Wolbachia manipulates host reproduction by several strategies, one of the most important of which is cytoplasmic incompatibility (CI). CI can be rescued when Wolbachia-infected males mate with females infected with the same Wolbachia strain. However, the potential rescue mechanism of CI in the small brown planthopper Laodelphax striatellus is unclear. In this study, comparative transcriptome analysis was applied to explore the effect of Wolbachia on L. striatellus eggs. A total of 1387 differentially expressed genes were identified. RNA interference of 7 Wolbachia-upregulated key planthopper genes reduced egg reproduction, suggesting that Wolbachia might improve fecundity in L. striatellus by affecting these 7 genes. Suppressing the expression of another upregulated gene, NDUFA8 (encoding NADH dehydrogenase [ubiquinone] 1 α subcomplex subunit 8-like) by RNA interference significantly increased the mortality of early embryos without affecting the number of deposited eggs. Wolbachia infection upregulated the mRNA level of NDUFA8, and dsNDUFA8 treatment of Wolbachia-infected females recreated CI-like symptoms, suggesting that NDUFA8 is associated with the rescue phenotype. Because all L. striatellus populations worldwide are infected with Wolbachia, NDUFA8 is a potential pest control target.
