Summary BRI1-ASSOCIATED RECEPTOR KINASE 1 （BAK1） plays critical roles in plant developmental and immune signaling pathways. BAKI and a large number of leucine-rich repeat receptor-like kinases （LRR-RLKs） harbor a ...Summary BRI1-ASSOCIATED RECEPTOR KINASE 1 （BAK1） plays critical roles in plant developmental and immune signaling pathways. BAKI and a large number of leucine-rich repeat receptor-like kinases （LRR-RLKs） harbor a mysterious carboxyl-terminal tail （CT） beyond their kinase domain. In this study we analyzed the biological significance of this CT region using a unique bak~ mutant allele which causes deletion of the CT region. We showed that BAKt CT promotes its kinase activity and is required for pathogen-associated molec- ular pattern （PAMP）-triggered immunity, but it is dispensable for brassinosteroid responses and BAK1/ BKKl-inhibited cell death signaling. Therefore the BAK1 C-terminal tail is differentially required for its functions in development and immunity.展开更多
基金Natural Sciences and Engineering Research Council(NSERC)of CanadaCanada Foundation for Innovation(CFI)
文摘Summary BRI1-ASSOCIATED RECEPTOR KINASE 1 （BAK1） plays critical roles in plant developmental and immune signaling pathways. BAKI and a large number of leucine-rich repeat receptor-like kinases （LRR-RLKs） harbor a mysterious carboxyl-terminal tail （CT） beyond their kinase domain. In this study we analyzed the biological significance of this CT region using a unique bak~ mutant allele which causes deletion of the CT region. We showed that BAKt CT promotes its kinase activity and is required for pathogen-associated molec- ular pattern （PAMP）-triggered immunity, but it is dispensable for brassinosteroid responses and BAK1/ BKKl-inhibited cell death signaling. Therefore the BAK1 C-terminal tail is differentially required for its functions in development and immunity.
