Background:Cardiovascular disorders(CVD)are the single greatest cause of mortality worldwide.In the UK,the National Health Service(NHS)has launched an initiative of health checks over and above current care to tackle ...Background:Cardiovascular disorders(CVD)are the single greatest cause of mortality worldwide.In the UK,the National Health Service(NHS)has launched an initiative of health checks over and above current care to tackle CVD.However,the uptake of Health Checks is poor in disadvantaged communities.This protocol paper sets out a UK-based study(Sussex and Nottingham)aiming to co-produce a community delivered CVD risk assessment and coaching intervention to support community members to reduce their risk of CVD.The overall aim of the project is to implement a tailored-to-context community engagement(CE)intervention on awareness of CVD risks in vulnerable populations in high,middle and low-income countries.The specific objectives of the study are to enhance stakeholder’engagement;to implement lifestyle interventions for cardiovascular primary prevention,in disadvantaged populations and motivate uptake of NHS health checks.Methods:This study uses both qualitative and quantitative methods in three phases of evaluation,including pre-,per-and post-implementation.To ensure contextual appropriateness the‘Scaling-up Packages of Interventions for Cardiovascular disease prevention in selected sites in Europe and Sub-Saharan Africa:An implementation research’(SPICES)project will organize a multi-component community-engagement intervention.For the qualitative component,the pre-implementation phase will involve a contextual assessment and stakeholder mapping,exploring potentials for CVD risk profiling strategies and led by trained Community Health Volunteers(CHV)to identify accessibility and acceptability.The per-implementation phase will involve healthy lifestyle counselling provided by CHVs and evaluation of the outcome to identify fidelity and scalability.The post-implementation phase will involve developing sustainable community-based strategies for CVD risk reduction.All three components will include a process evaluation.A stepped wedge cluster randomised trial of the roll out will focus on implementation outcomes including uptake and engagement and changes in risk profiles.The quantitative component includes pre and post-intervention surveys.The theory of the socio-ecological framework will be applied to analyse the community engagement approach.Discussion:Based on the results ultimately a sustainable community engagement-based strategy for the primary prevention of CVD risk will be developed to enhance the performance of NHS health care in the UK.展开更多
Over the years,more attention has been focused on the implementation than on the preparation of the research budget in the agricultural institutes of China,resulting in the unscientific and unreasonable budgeting of r...Over the years,more attention has been focused on the implementation than on the preparation of the research budget in the agricultural institutes of China,resulting in the unscientific and unreasonable budgeting of research funds. The practical implementation of the research funds has also been adversely affected. In this paper,the problems as well as the root causes of those problems in the budgeting and implementation of research funds were analyzed,and corresponding solutions and suggestions were also presented.展开更多
The aim of the study was to identify the most important research priorities as well as future strategies for promoting and implementing evidence-based care of depressed elderly persons. An interdisciplinary workshop w...The aim of the study was to identify the most important research priorities as well as future strategies for promoting and implementing evidence-based care of depressed elderly persons. An interdisciplinary workshop was organized using a focus group format and the transcript of the discussion was interpreted by means of the qualitative content analysis. The most important research priorities for improving the care of depressed elderly persons, implementation levels, theoretical approaches as well as possible outcomes were analysed on individual consumer, healthcare system, and policy level. A wide range of theories and methods are necessary to identify and explain implementation processes and results. Qualitative and quantitative methodologies in combination with knowledge synthesis were discussed. In addition, the need to summarize the literature in terms of specific issues was emphasized. In conclusion, the implementation strategies for improving the care of depressed elderly persons should be addressed on three levels: individual consumer, healthcare system and policy. Although some aspects of the implementation model may need to be enhanced, the fact that it includes conditions on individual level, i.e. self-management support, is of importance. The expansion and maintenance of evidence-based care generate potential for change in mental healthcare, thus improving outcomes for individual elderly patients. Areas that require further research are organization, cost and leadership. The use of mixed methods could strengthen future studies. Implementation researchers need a broad repertoire in order to plan and perform evidence-based research. To improve practice, implementation strategies should be developed in clinical and community guidelines.展开更多
Healthcare systems face many competing demands and insufficient resources.Service innovations to improve efficiency are important to address this challenge.Innovations can range from new pharmaceuticals,alternate mode...Healthcare systems face many competing demands and insufficient resources.Service innovations to improve efficiency are important to address this challenge.Innovations can range from new pharmaceuticals,alternate models of care,novel devices,and the use other technologies.Suboptimal implementation can mean lost benefits.This review article aims to highlight the role of implementation science,summarize how settings have leveraged this methodology to promote translation of innovation into practice,and describe our own experience of embedding implementation science into an academic medical center in Singapore.Implementation science offers a range of methods to promote systematic uptake of research findings about innovations and is gaining recognition worldwide as an important discipline for health services researchers.Health systems around the world have tried to promote implementation research in their settings by establishing(1)dedicated centers/programs,(2)offering funding,and(3)building knowledge and capacity among staff.Implementation science is a critical piece in the translational pathway of“evidence to innovation”.The three efforts we describe should be strengthened to integrate implementation science into the innovation ecosystem around the world.展开更多
Background: Mother to child transmission (MTCT) of HIV constitutes a major source of new pediatric infections in Cameroon. Objective: The aim of this implementation research was to assess outcomes and effectiveness of...Background: Mother to child transmission (MTCT) of HIV constitutes a major source of new pediatric infections in Cameroon. Objective: The aim of this implementation research was to assess outcomes and effectiveness of providing life-long antiretroviral therapy (ART) for HIV-positive pregnant and breastfeeding women (Option B+). Methods: From October 2013 to July 2014, HIV-positive pregnant and breastfeeding women, not on antiretroviral (ARV) prophylaxis and ART, were recruited from 22 purposefully selected health facilities in the Northwest and Southwest regions for a prospective, observational cohort evaluation. Option B+ was offered to participants and outcome indicators were measured. Results: Out of 680 women eligible for this assessment, 669 (98%) were initiated on Option B+. Retention-in-care was 90% (95% CI, 87.85 - 92.61) and 79% (95% CI, 75.20 - 81.88), and loss to follow up (LTFU) was 7% (95% CI: 4.95 - 8.90) and 15% (95% CI: 12.06 - 17.56) at 6 and 12 months respectively. Maternal mortality at 12 months after ART initiation was 2% (13). As of March 2015, 538 HIV exposed infants (HEIs) were enrolled and received postpartum nevirapine prophylaxis within 72 hours of birth and 84% (454) were on cotrimoxazole at 6 to 8 weeks. By 8 weeks of age, 498 (93%) infants had HIV DNA PCR test with 486 (97.6%) negative and 12 (2.4%) positive. Conclusion: In Cameroon, successful implementation of Option B+ increased retention-in-care to 79% at one year for pregnant and breastfeeding women and reduced MTCT rate below 5% for HEIs at 8 weeks of age. Long term retention, maternal and infant mortality and final MTCT rate after cessation of breastfeeding require further evaluation.展开更多
<strong>Introduction:</strong> Improving maternal and newborn survival needs robust data on patterns of morbidity and mortality from well-characterized cohorts. It is equally important for researchers to d...<strong>Introduction:</strong> Improving maternal and newborn survival needs robust data on patterns of morbidity and mortality from well-characterized cohorts. It is equally important for researchers to document and understand the contextual challenges of data collection and how they are addressed. <strong>Methods:</strong> This was a prospective cohort study implemented from December 2012 to August 2014 in Matiari, Pakistan. A total of 11,315 pregnancies were enrolled. Participants were approached at home for sequential data collection through the standard pretested structured questionnaires. Some indicators were sourced through health facility records. Information on field challenges gathered through field diaries and minutes of meetings with field staff. <strong>Results:</strong> Inaccurate reporting of last menstrual period (LMP) dates caused difficulties in the planning and completion of antenatal data collection visits at scheduled gestational weeks. We documented ultrasound reports wherever available, relied on quickening technique, and implemented a seasonal event calendar to help mothers’ recall their LMP. Health system coordinators of public sector and private healthcare providers were individually approached for maximum data collection. But an unregulated private health system with poor record maintenance and health care providers’ reluctance for cooperation posed a greater challenge in data collection. <strong>Conclusions:</strong> Within a broader understanding of the health systems and socio-cultural environment, temporal and spatial feasibility of data collection should be considered thoroughly at the early stages of study designing, planning, resource allocation, and implementation. Pre-defined regular and need-based meetings with each tier of data collection teams and study managers help to reinvigorate field execution plans and optimize both quantity and quality of study data.展开更多
基金received funding from the European Commission through the Horizon 2020 Research and Innovation Action Grant Agreement No 733356 to implement and evaluate a comprehensive CVD prevention programme in five settings:a rural&semi-urban community in a low-income country(Uganda),middle income(South Africa)and vulnerable groups in three highincome。
文摘Background:Cardiovascular disorders(CVD)are the single greatest cause of mortality worldwide.In the UK,the National Health Service(NHS)has launched an initiative of health checks over and above current care to tackle CVD.However,the uptake of Health Checks is poor in disadvantaged communities.This protocol paper sets out a UK-based study(Sussex and Nottingham)aiming to co-produce a community delivered CVD risk assessment and coaching intervention to support community members to reduce their risk of CVD.The overall aim of the project is to implement a tailored-to-context community engagement(CE)intervention on awareness of CVD risks in vulnerable populations in high,middle and low-income countries.The specific objectives of the study are to enhance stakeholder’engagement;to implement lifestyle interventions for cardiovascular primary prevention,in disadvantaged populations and motivate uptake of NHS health checks.Methods:This study uses both qualitative and quantitative methods in three phases of evaluation,including pre-,per-and post-implementation.To ensure contextual appropriateness the‘Scaling-up Packages of Interventions for Cardiovascular disease prevention in selected sites in Europe and Sub-Saharan Africa:An implementation research’(SPICES)project will organize a multi-component community-engagement intervention.For the qualitative component,the pre-implementation phase will involve a contextual assessment and stakeholder mapping,exploring potentials for CVD risk profiling strategies and led by trained Community Health Volunteers(CHV)to identify accessibility and acceptability.The per-implementation phase will involve healthy lifestyle counselling provided by CHVs and evaluation of the outcome to identify fidelity and scalability.The post-implementation phase will involve developing sustainable community-based strategies for CVD risk reduction.All three components will include a process evaluation.A stepped wedge cluster randomised trial of the roll out will focus on implementation outcomes including uptake and engagement and changes in risk profiles.The quantitative component includes pre and post-intervention surveys.The theory of the socio-ecological framework will be applied to analyse the community engagement approach.Discussion:Based on the results ultimately a sustainable community engagement-based strategy for the primary prevention of CVD risk will be developed to enhance the performance of NHS health care in the UK.
基金Supported by the Key Laboratory Fund of "Exploration on the Fund Management in Provincial Agricultural Research Institutes"for the Genetic Improvement and Cultivation of Cotton in Huang-Huai-Hai District,Ministry of Agriculture(2012KL09)the Soft Science Program of Shandong Province "Management of the Research Fund in Non-profitable Agricultural Institutes"(2013RKC02003)
文摘Over the years,more attention has been focused on the implementation than on the preparation of the research budget in the agricultural institutes of China,resulting in the unscientific and unreasonable budgeting of research funds. The practical implementation of the research funds has also been adversely affected. In this paper,the problems as well as the root causes of those problems in the budgeting and implementation of research funds were analyzed,and corresponding solutions and suggestions were also presented.
文摘The aim of the study was to identify the most important research priorities as well as future strategies for promoting and implementing evidence-based care of depressed elderly persons. An interdisciplinary workshop was organized using a focus group format and the transcript of the discussion was interpreted by means of the qualitative content analysis. The most important research priorities for improving the care of depressed elderly persons, implementation levels, theoretical approaches as well as possible outcomes were analysed on individual consumer, healthcare system, and policy level. A wide range of theories and methods are necessary to identify and explain implementation processes and results. Qualitative and quantitative methodologies in combination with knowledge synthesis were discussed. In addition, the need to summarize the literature in terms of specific issues was emphasized. In conclusion, the implementation strategies for improving the care of depressed elderly persons should be addressed on three levels: individual consumer, healthcare system and policy. Although some aspects of the implementation model may need to be enhanced, the fact that it includes conditions on individual level, i.e. self-management support, is of importance. The expansion and maintenance of evidence-based care generate potential for change in mental healthcare, thus improving outcomes for individual elderly patients. Areas that require further research are organization, cost and leadership. The use of mixed methods could strengthen future studies. Implementation researchers need a broad repertoire in order to plan and perform evidence-based research. To improve practice, implementation strategies should be developed in clinical and community guidelines.
文摘Healthcare systems face many competing demands and insufficient resources.Service innovations to improve efficiency are important to address this challenge.Innovations can range from new pharmaceuticals,alternate models of care,novel devices,and the use other technologies.Suboptimal implementation can mean lost benefits.This review article aims to highlight the role of implementation science,summarize how settings have leveraged this methodology to promote translation of innovation into practice,and describe our own experience of embedding implementation science into an academic medical center in Singapore.Implementation science offers a range of methods to promote systematic uptake of research findings about innovations and is gaining recognition worldwide as an important discipline for health services researchers.Health systems around the world have tried to promote implementation research in their settings by establishing(1)dedicated centers/programs,(2)offering funding,and(3)building knowledge and capacity among staff.Implementation science is a critical piece in the translational pathway of“evidence to innovation”.The three efforts we describe should be strengthened to integrate implementation science into the innovation ecosystem around the world.
文摘Background: Mother to child transmission (MTCT) of HIV constitutes a major source of new pediatric infections in Cameroon. Objective: The aim of this implementation research was to assess outcomes and effectiveness of providing life-long antiretroviral therapy (ART) for HIV-positive pregnant and breastfeeding women (Option B+). Methods: From October 2013 to July 2014, HIV-positive pregnant and breastfeeding women, not on antiretroviral (ARV) prophylaxis and ART, were recruited from 22 purposefully selected health facilities in the Northwest and Southwest regions for a prospective, observational cohort evaluation. Option B+ was offered to participants and outcome indicators were measured. Results: Out of 680 women eligible for this assessment, 669 (98%) were initiated on Option B+. Retention-in-care was 90% (95% CI, 87.85 - 92.61) and 79% (95% CI, 75.20 - 81.88), and loss to follow up (LTFU) was 7% (95% CI: 4.95 - 8.90) and 15% (95% CI: 12.06 - 17.56) at 6 and 12 months respectively. Maternal mortality at 12 months after ART initiation was 2% (13). As of March 2015, 538 HIV exposed infants (HEIs) were enrolled and received postpartum nevirapine prophylaxis within 72 hours of birth and 84% (454) were on cotrimoxazole at 6 to 8 weeks. By 8 weeks of age, 498 (93%) infants had HIV DNA PCR test with 486 (97.6%) negative and 12 (2.4%) positive. Conclusion: In Cameroon, successful implementation of Option B+ increased retention-in-care to 79% at one year for pregnant and breastfeeding women and reduced MTCT rate below 5% for HEIs at 8 weeks of age. Long term retention, maternal and infant mortality and final MTCT rate after cessation of breastfeeding require further evaluation.
文摘<strong>Introduction:</strong> Improving maternal and newborn survival needs robust data on patterns of morbidity and mortality from well-characterized cohorts. It is equally important for researchers to document and understand the contextual challenges of data collection and how they are addressed. <strong>Methods:</strong> This was a prospective cohort study implemented from December 2012 to August 2014 in Matiari, Pakistan. A total of 11,315 pregnancies were enrolled. Participants were approached at home for sequential data collection through the standard pretested structured questionnaires. Some indicators were sourced through health facility records. Information on field challenges gathered through field diaries and minutes of meetings with field staff. <strong>Results:</strong> Inaccurate reporting of last menstrual period (LMP) dates caused difficulties in the planning and completion of antenatal data collection visits at scheduled gestational weeks. We documented ultrasound reports wherever available, relied on quickening technique, and implemented a seasonal event calendar to help mothers’ recall their LMP. Health system coordinators of public sector and private healthcare providers were individually approached for maximum data collection. But an unregulated private health system with poor record maintenance and health care providers’ reluctance for cooperation posed a greater challenge in data collection. <strong>Conclusions:</strong> Within a broader understanding of the health systems and socio-cultural environment, temporal and spatial feasibility of data collection should be considered thoroughly at the early stages of study designing, planning, resource allocation, and implementation. Pre-defined regular and need-based meetings with each tier of data collection teams and study managers help to reinvigorate field execution plans and optimize both quantity and quality of study data.