Advantages of nanocarriers for basic research in the field of traumatic brain injury

A major challenge for the efficient treatment of traumatic brain injury is the need for therapeutic molecules to cross the blood-brain barrier to enter and accumulate in brain tissue.To overcome this problem,researchers have begun to focus on nanocarriers and other brain-targeting drug delivery systems.In this review,we summarize the epidemiology,basic pathophysiology,current clinical treatment,the establishment of models,and the evaluation indicators that are commonly used for traumatic brain injury.We also report the current status of traumatic brain injury when treated with nanocarriers such as liposomes and vesicles.Nanocarriers can overcome a variety of key biological barriers,improve drug bioavailability,increase intracellular penetration and retention time,achieve drug enrichment,control drug release,and achieve brain-targeting drug delivery.However,the application of nanocarriers remains in the basic research stage and has yet to be fully translated to the clinic.

Using restored two-dimensional X-ray images to reconstruct the three-dimensional magnetopause

Astronomical imaging technologies are basic tools for the exploration of the universe,providing basic data for the research of astronomy and space physics.The Soft X-ray Imager(SXI)carried by the Solar wind Magnetosphere Ionosphere Link Explorer(SMILE)aims to capture two-dimensional(2-D)images of the Earth’s magnetosheath by using soft X-ray imaging.However,the observed 2-D images are affected by many noise factors,destroying the contained information,which is not conducive to the subsequent reconstruction of the three-dimensional(3-D)structure of the magnetopause.The analysis of SXI-simulated observation images shows that such damage cannot be evaluated with traditional restoration models.This makes it difficult to establish the mapping relationship between SXIsimulated observation images and target images by using mathematical models.We propose an image restoration algorithm for SXIsimulated observation images that can recover large-scale structure information on the magnetosphere.The idea is to train a patch estimator by selecting noise–clean patch pairs with the same distribution through the Classification–Expectation Maximization algorithm to achieve the restoration estimation of the SXI-simulated observation image,whose mapping relationship with the target image is established by the patch estimator.The Classification–Expectation Maximization algorithm is used to select multiple patch clusters with the same distribution and then train different patch estimators so as to improve the accuracy of the estimator.Experimental results showed that our image restoration algorithm is superior to other classical image restoration algorithms in the SXI-simulated observation image restoration task,according to the peak signal-to-noise ratio and structural similarity.The restoration results of SXI-simulated observation images are used in the tangent fitting approach and the computed tomography approach toward magnetospheric reconstruction techniques,significantly improving the reconstruction results.Hence,the proposed technology may be feasible for processing SXI-simulated observation images.

深海环境海洋生态系统监测与修复新技术

The United Nations(UN)’s call for a decade of“ecosystem restoration”was prompted by the need to address the extensive impact of anthropogenic activities on natural ecosystems.Marine ecosystem restoration is increasingly necessary due to increasing habitat degredation in deep waters(>200 m depth).At these depths,which are far beyond those accessible by divers,only established and emerging robotic platforms such as remotely operated vehicles(ROVs),autonomous underwater vehicles(AUVs),landers,and crawlers can operate through manipulators and multiparametric sensor arrays(e.g.,optoacoustic imaging,omics,and environmental probes).The use of advanced technologies for deep-sea ecosystem restoration can provide:①high-resolution three-dimensional(3D)imaging and acoustic mapping of substrates and key taxa,②physical manipulation of substrates and key taxa,③real-time supervision of remote operations and long-term ecological monitoring,and④the potential to work autonomously.Here,we describe how robotic platforms with in situ manipulation capabilities and payloads of innovative sensors could autonomously conduct active restoration and monitoring across large spatial scales.We expect that these devices will be particularly useful in deep-sea habitats,such as①reef-building cold-water corals,②soft-bottom bamboo corals,and③soft-bottom fishery resources that have already been damaged by offshore industries(i.e.,fishing and oil/gas).

Ecological problems and ecological restoration zoning of the Aral Sea

The Aral Sea was the fourth largest lake in the world but it has shrunk dramatically as a result of irrational human activities, triggering the "Aral Sea ecological crisis". The ecological problems of the Aral Sea have attracted widespread attention, and the alleviation of the Aral Sea ecological crisis has reached a consensus among the five Central Asian countries(Kazakhstan, Uzbekistan, Tajikistan, Kyrgyzstan, and Turkmenistan). In the past decades, many ecological management measures have been implemented for the ecological restoration of the Aral Sea. However, due to the lack of regional planning and zoning, the results are not ideal. In this study, we mapped the ecological zoning of the Aral Sea from the perspective of ecological restoration based on soil type, soil salinity, surface water, groundwater table, Normalized Difference Vegetation Index(NDVI), land cover, and aerosol optical depth(AOD) data. Soil salinization and salt dust are the most prominent ecological problems in the Aral Sea. We divided the Aral Sea into 7 first-level ecological restoration subregions(North Aral Sea catchment area in the downstream of the Syr Darya River(Subregion Ⅰ);artificial flood overflow area in the downstream of the Aral Sea(Subregion Ⅱ);physical/chemical remediation area of the salt dust source area in the eastern part of the South Aral Sea(Subregion Ⅲ);physical/chemical remediation area of severe salinization in the central part of the South Aral Sea(Subregion Ⅳ);existing water surface and potential restoration area of the South Aral Sea(Subregion Ⅴ);Aral Sea vegetation natural recovery area(Subregion Ⅵ);and vegetation planting area with slight salinization in the South Aral Sea(Subregion Ⅶ)) and 14 second-level ecological restoration subregions according to the ecological zoning principles. Implementable measures are proposed for each ecological restoration subregion. For Subregion Ⅰ and Subregion Ⅱ with lower elevations, artificial flooding should be carried out to restore the surface of the Aral Sea. Subregion Ⅲ and Subregion Ⅳ have severe salinization, making it difficult for vegetation to grow. In these subregions, it is recommended to cover and pave the areas with green biomatrix coverings and environmentally sustainable bonding materials. In Subregion Ⅴ located in the central and western parts of the South Aral Sea, surface water recharge should be increased to ensure that this subregion can maintain normal water levels. In Subregion Ⅵ and Subregion Ⅶ where natural conditions are suitable for vegetation growth, measures such as afforestation and buffer zones should be implemented to protect vegetation. This study could provide a reference basis for future comprehensive ecological management and restoration of the Aral Sea.

Mangrove wetlands distribution status identification, changing trend analyzation and carbon storage assessment of China

This research investigates the ecological importance,changes,and status of mangrove wetlands along China’s coastline.Visual interpretation,geological surveys,and ISO clustering unsupervised classification methods are employed to interpret mangrove distribution from remote sensing images from 2021,utilizing ArcGIS software platform.Furthermore,the carbon storage capacity of mangrove wetlands is quantified using the carbon storage module of InVEST model.Results show that the mangrove wetlands in China covered an area of 278.85 km2 in 2021,predominantly distributed in Hainan,Guangxi,Guangdong,Fujian,Zhejiang,Taiwan,Hong Kong,and Macao.The total carbon storage is assessed at 2.11×10^(6) t,with specific regional data provided.Trends since the 1950s reveal periods of increase,decrease,sharp decrease,and slight-steady increases in mangrove areas in China.An important finding is the predominant replacement of natural coastlines adjacent to mangrove wetlands by artificial ones,highlighting the need for creating suitable spaces for mangrove restoration.This study is poised to guide future mangroverelated investigations and conservation strategies.

Prevalence of vegetation browning in China’s drylands under climate change

Vegetation greening has long been acknowledged,but recent studies have pointed out that vegetation greening is possibly stalled or even reversed.However,detailed analyses about greening reversal or increased browning of vegetation remain scarce.In this study,we utilized the normalized difference vegetation index(NDVI)as an indicator of vegetation to investigate the trends of vegetation greening and browning(monotonic,interruption,and reversal)through the breaks for the additive season and trend(BFAST)method across China’s drylands from 1982 to 2022.It also reveals the impacts of ecological restoration programs(ERPs)and climate change on these vegetation trends.We find that the vegetation displays an obvious pattern of east-greening and west-browning in China’s drylands.Greening trends mainly exhibits monotonic greening(29.8%)and greening with setback(36.8%),whereas browning shows a greening to browning reversal(19.2%).The increase rate of greening to browning reversal is 0.0342/yr,which is apparently greater than that of greening with setback,0.0078/yr.This research highlights that,under the background of widespread vegetation greening,vegetation browning is pro-gressively increasing due to the effects of climate change.Furthermore,the ERPs have significantly increased vegetation coverage,with the increase rate in 2000-2022 being twice as much as that of 1982-1999 in reveg-etation regions.Vegetation browning in southwestern Qingzang Plateau is primarily driven by adverse climatic factors and anthropogenic disturbances,which offset the efforts of ERPs.

Achievements and challenges of primate conservation in China

The dual impact of climate change and human activities has precipitated a sharp decline in primate biodiversity globally.China is home to the most diverse primate species in the Northern hemisphere,which face severe ecological threats due to the expansion of modern agriculture,extensive exploitation and consumption of natural resources,and excessive land development during its transition from an agricultural to a modern society.In response,China has implemented various ecological conservation measures,including habitat restoration and protection.These efforts have made substantial strides in biodiversity conservation,with certain regions witnessing an increase in primate populations.In the current study,we conducted a systematic review of historical documents and field research data related to Chinese primates,evaluating the endangered status of primate species in China.Despite improvements in the habitats of most primate species and some population growth,many species still face severe threats,including declining and small populations.Species such as the Myanmar snub-nosed monkey(Rhinopithecus strykeri),eastern black crested gibbon(Nomascus nasutus),and Hainan gibbon(N.hainanus)remain particularly vulnerable due to their limited distribution ranges and extremely small populations.Insufficient scientific data,fragmented information,and not enough studies in conservation biology further compound the challenges.Moreover,there is a notable lack of detailed population monitoring data for species such as the Bengal slow loris(Nycticebus bengalensis),pygmy slow loris(N.pygmaeus),Indochinese gray langur(Trachypithecus crepusculus),Shortridge’s langur(T.shortridgei),and capped langur(T.pileatus),which hinders the development of practical and targeted conservation management strategies.Therefore,for national biodiversity conservation,there is an urgent need for specialized primate surveys,enhancing habitat protection and restoration,and increasing focus on cross-border conservation strategies and regional cooperation.There is also a need to establish a comprehensive and systematic research database platform,conduct continuous and in-depth research in primate biology,and actively engage in the scientific assessment of ecotourism.Additionally,strengthening public awareness and education on wildlife conservation remains essential.Such integrated and systematic efforts will provide scientific support for the current and future conservation and management of primate species in China.

Temperature is a cryptic factor shaping the geographical pattern of genetic variation in Ceratophyllum demersum across a subtropical freshwater lake

Macrophyte habitats exhibit remarkable heterogeneity,encompassing the spatial variation of abiotic and biotic components such as changes in water conditions and weather as well as anthropogenic stressors.Environmental factors are thought to be important drivers shaping the genetic and epigenetic variation of aquatic plants.However,the links among genetic diversity,epigenetic variation,and environmental variables remain largely unclear,especially for clonal aquatic plants.Here,we performed population genetic and epigenetic analyses in conjunction with habitat discrimination to elucidate the environmental factors driving intraspecies genetic and epigenetic variation in hornwort(Ceratophyllum demersum)in a subtropical lake.Environmental factors were highly correlated with the genetic and epigenetic variation of C.demersum,with temperature being a key driver of the genetic variation.Lower temperature was detected to be correlated with greater genetic and epigenetic variation.Genetic and epigenetic variation were positively driven by water temperature,but were negatively affected by ambient air temperature.These findings indicate that the genetic and epigenetic variation of this clonal aquatic herb is not related to the geographic feature but is instead driven by environmental conditions,and demonstrate the effects of temperature on local genetic and epigenetic variation in aquatic systems.

Evolution mechanism and treatment timing of penetrating fissures

The Inner Mongolia mining area in western China are characterized by the development of numerous penetrating fissures,resulting in severe land damage.It is significant to reveal the underlying evolution mechanism and identify treatment timing for restoring the ecological environment.The Guanbanwusu mining subsidence area in Inner Mongolia,China was selected as the research case for this study.The evolution mechanism of different penetrating fissures was revealed by field measurement,physical simulation and theoretical analysis.The treatment timing prediction model for the mining subsidence area was established based on the enhanced Weibull time function.The results show that the ground fissures are mainly step-type and collapse-type fissures.The breaking form of overlying strata determines their vertical opening and horizontal dislocation.The high mining intensity in the western mining area results in a shortened period of dynamic fissure expansion and reduced closure degree.The damage extent of the overlying strata exhibits zoning characteristics both vertically and horizontally.The relative standard deviation of the prediction model is only 3.7%.Concurrently,the prediction model is employed to determine the optimal timing for treatment in the study area,estimated to be 259 days.Subsequently,once this threshold is reached,the study area undergoes treatment and restoration of its e cological environment.This study addresses the knowledge gap in this field by highlighting the interconnectedness between rock strata structure and evolution mechanism of penetrating fissures,thereby providing a method for determining the treatment timing in mining subsidence areas.

Stepwise Ecological Restoration:A framework for improving restoration outcomes

Ecosystem degradation is one of the critical constraints for the sustainable development of our planet.However,recovering an ecosystem to a pre-impairment condition is often not practical.The International Restoration Standards provide the first framework for practical guidance on what constitutes the process of ecological repair and how this repair process can be influenced to improve net ecological benefits.In these Standards,Restorative Continuum is highlighted and it recognises that many do not,yet there is still value in aspiring to improvements to the highest extent possible,with some sites potentially being able to be improved in a stepwise manner.Here we elaborate on these Standards by providing a cross-ecosystem theoretical framework of Stepwise Ecological Restoration(STERE)for promoting higher environmental benefits.STERE allows the selection of suitable restorative modes by considering the degree of degradation while encouraging a transition to a higher state.These models include environmental remediation for completely modified and degraded ecosystems,ecological rehabilitation for highly modified and degraded ecosystems,and ecological restoration for degraded native ecosystems.STERE requires selecting tailored restorative modes,setting clear restorative targets and reference ecosystems,applying a systematic-thinking approach,and implementing a continuous monitoring program at all process stages to achieve a resilient trajectory.STERE allows adaptive management in the context of climate change,and when the evidence is available,to“adapt to the future”to ensure climate resilience.The STERE framework could assist in initiating and implementing restoration projects worldwide,especially in developing countries.

Lactate is a potentially harmful substitute for brain glucose fuel:consequences for metabolic restoration of neurotransmission

The metabolite lactate (L-lactate) can be generated and released by diverse brain cells,including neurons,astrocytes,and oligodendrocytes (Kann,2023;Rae et al.,2024).Lactate production usually requires the degradation of glucose (D-glucose)-and glycogen in astrocytes-to pyruvate by glycolysis and subsequent conversion of pyruvate to lactate by the enzyme lactate dehydrogenase(Figure 1A;Dienel,2019;Rae et al.,2024).

Restoration of the JPEG Maximum Lossy Compressed Face Images with Hourglass Block-GAN

In the context of high compression rates applied to Joint Photographic Experts Group(JPEG)images through lossy compression techniques,image-blocking artifacts may manifest.This necessitates the restoration of the image to its original quality.The challenge lies in regenerating significantly compressed images into a state in which these become identifiable.Therefore,this study focuses on the restoration of JPEG images subjected to substantial degradation caused by maximum lossy compression using Generative Adversarial Networks(GAN).The generator in this network is based on theU-Net architecture.It features a newhourglass structure that preserves the characteristics of the deep layers.In addition,the network incorporates two loss functions to generate natural and high-quality images:Low Frequency(LF)loss and High Frequency(HF)loss.HF loss uses a pretrained VGG-16 network and is configured using a specific layer that best represents features.This can enhance the performance in the high-frequency region.In contrast,LF loss is used to handle the low-frequency region.The two loss functions facilitate the generation of images by the generator,which can mislead the discriminator while accurately generating high-and low-frequency regions.Consequently,by removing the blocking effects frommaximum lossy compressed images,images inwhich identities could be recognized are generated.This study represents a significant improvement over previous research in terms of the image resolution performance.

Floristic composition and edaphic relationships in ferruginous campo rupestre reference ecosystems

Land use change and occupation have led to modifications in the environment causing loss of biodiversity and ecosystem services throughout the planet.Some environments with high economic relevance,such as the ferruginous campo rupestre(rupestrian grassland known as Canga in Brazil),are even more susceptible to severe impacts due to their extreme habitat conditions and low resilience.The determination of reference ecosystems based on the intrinsic characteristics of the ecosystem is essential for conservation as well as to the implementation of ecological restoration.We proposed the reference ecosystem of the three main types of habitats of the ferruginous campo rupestre based on their floristic composition.We described the floristic composition of each habitat and evaluated the physicochemical properties of the soils and the relationship between plants and soils.All three habitats showed high diversity of plant species and many endemic species,such as Chamaecrista choriophylla,Cuphea pseudovaccinium,Lychnophora pinaster,and Vellozia subalata.The distribution of vegetation was strongly related with the edaphic characteristics,with a set of species more adapted to high concentration of base saturation,fine sand,organic carbon,and iron,while another set of species succeeded in more acidic soils with higher S and silt concentration.We provide support for the contention that the ferruginous campo rupestre is a mosaic of different habitats shaped by intrinsic local conditions.Failure to recognize the floristic composition of each particular habitat can lead to inappropriate restoration,increased habitat homogenization and increased loss of biodiversity and ecosystem services.This study also advances the knowledge base for building the reference ecosystem for the different types of ferruginous campo rupestre habitats,as well as a key database for highlighting those species contribute most to community assembly in this diverse and threatened tropical mountain ecosystem.

Spatiotemporal characteristics of seed rain and soil seed bank of artificial Caragana korshinskii Kom. forest in the Tengger Desert, China

Vegetation restoration and reconstruction are effective approaches to desertification control and achieving social and economic sustainability in desert areas.However,the self-succession ability of native plants during the later periods of vegetation restoration remains unclear.Therefore,this study was conducted to bridge the knowledge gap by investigating the regeneration dynamics of artificial forest under natural conditions.The information of seed rain and soil seed bank was collected and quantified from an artificial Caragana korshinskii Kom.forest in the Tengger Desert,China.The germination tests were conducted in a laboratory setting.The analysis of species quantity and diversity in seed rain and soil seed bank was conducted to assess the impact of different durations of sand fixation(60,40,and 20 a)on the progress of vegetation restoration and ecological conditions in artificial C.korshinskii forest.The results showed that the top three dominant plant species in seed rain were Echinops gmelinii Turcz.,Eragrostis minor Host.,and Agropyron mongolicum Keng.,and the top three dominant plant species in soil seed bank were E.minor,Chloris virgata Sw.,and E.gmelinii.As restoration period increased,the density of seed rain and soil seed bank increased first and then decreased.While for species richness,as restoration period increased,it gradually increased in seed rain but decreased in soil seed bank.There was a positive correlation between seed rain density and soil seed bank density among all the three restoration periods.The species similarity between seed rain or soil seed bank and aboveground vegetation decreased with the extension of restoration period.The shape of the seeds,specifically those with external appendages such as spines and crown hair,clearly had an effect on their dispersal,then resulting in lower seed density in soil seed bank.In addition,precipitation was a crucial factor in promoting rapid germination,also resulting in lower seed density in soil seed bank.Our findings provide valuable insights for guiding future interventions during the later periods of artificial C.korshinskii forest,such as sowing and restoration efforts using unmanned aerial vehicles.

Research on Restoration of Murals Based on Diffusion Model and Transformer

Due to the limitations of a priori knowledge and convolution operation,the existing image restoration techniques cannot be directly applied to the cultural relics mural restoration,in order to more accurately restore the original appearance of the cultural relics mural images,an image restoration based on the denoising diffusion probability model(Denoising Diffusion Probability Model(DDPM))and the Transformer method.The process involves two steps:in the first step,the damaged mural image is firstly utilized as the condition to generate the noise image,using the time,condition and noise image patch as the inputs to the noise prediction network,capturing the global dependencies in the input sequence through the multi-attentionmechanismof the input sequence and feedforward neural network processing,and designing a long skip connection between the shallow and deep layers in the Transformer blocks between the shallow and deep layers using long skip connections to fuse the feature information of global and local outputs to maintain the overall consistency of the restoration results;In the second step,taking the noisy image as a condition to direct the diffusion model to back sample to generate the restored image.Experiment results show that the PSNR and SSIM of the proposedmethod are improved by 2%to 9%and 1%to 3.3%,respectively,which are compared to the comparison methods.This study proposed synthesizes the advantages of the diffusionmodel and deep learningmodel to make themural restoration results more accurate.

Kentish Plover(Charadrius alexandrinus) and Little Tern(Sternula albifrons) prefer shells for nesting:A field experiment

Shorebird populations are declining worldwide,mainly due to human disturbances and loss of coastal wetlands.However,supratidal habitats as saltpans could play a role in buffering human impact.Saltpans have shown to be important as feeding or breeding sites of some shorebird species.A potential conservation strategy to increase shorebird populations in saltpans is to manipulate the cues that birds use to select optimal breeding habitat.Here it is hypothesized that shorebirds are attracted to bivalve shells due to the advantages they offer.Following this hypothesis,we supplemented a restored saltpan in 2019 and 2021 with bivalve shells,expecting an increase in the number of breeding birds’ nests.More than 75% of Kentish Plover(Charadrius alexandrinus) and Little Tern(Sternula albifrons) nests were found in patches with shells in both years.The best model for both species indicates that the presence of shells is the factor that most correlates with the location of nests.The probability of choosing one place over another to settle their nest increases in areas with an abundance of shells,double in the case of the Kentish Plover and triple in the case of the Little Tern.The result of this study may constitute a valuable tool for attracting birds to restored saltpans and could contribute to the success of expensive restoration projects where time is usually a constraint.

Shear resistance characteristics and influencing factors of root-soil composite on an alpine metal mine dump slope with different recovery periods

Artificial vegetation restoration is the main measure for vegetation restoration and soil and water conservation in alpine mine dumps on the Qinghai-Tibet Plateau,China.However,there are few reports on the dynamic changes and the influencing factors of the soil reinforcement effect of plant species after artificial vegetation restoration under different recovery periods.We selected dump areas of the Delni Copper Mine in Qinghai Province,China to study the relationship between the shear strength and the peak displacement of the root-soil composite on the slope during the recovery period,and the influence of the root traits and soil physical properties on the shear resistance characteristics of the root-soil composite via in situ direct shear tests.The results indicate that the shear strength and peak displacement of the rooted soil initially decreased and then increased with the increase of the recovery period.The shear strength of the rooted soil and the recovery period exhibited a quadratic function relationship.There is no significant function relationship between the peak displacement and the recovery period.Significant positive correlations(P<0.05)exists between the shear strength of the root-soil composite and the root biomass density,root volume density,and root area ratio,and they show significant linear correlations(P<0.05).There are no significant correlations(P>0.05)between the shear strength of the root-soil composite and the root length density,and the root volume ratio of the coarse roots to the fine roots.A significant negative linear correlation(P<0.05)exists between the peak displacement of the rooted soil and the coarse-grain content,but no significant correlations(P>0.05)with the root traits,other soil physical property indices(the moisture content and dry density of the soil),and slope gradient.The coarse-grain content is the main factor controlling the peak displacement of the rooted soil.

Ecological effect of the plantation of Sabina vulgaris in the Mu Us Sandy Land,China

Vegetation restoration through artificial plantation is an effective method to combat desertification,especially in arid and semi-arid areas.This study aimed to explore the ecological effect of the plantation of Sabina vulgaris on soil physical and chemical properties on the southeastern fringe of the Mu Us Sandy Land,China.We collected soil samples from five depth layers(0-20,20-40,40-60,60-80,and 80-100 cm)in the S.vulgaris plantation plots across four plantation ages(4,7,10,and 16 years)in November 2019,and assessed soil physical(soil bulk density,soil porosity,and soil particle size)and chemical(soil organic carbon(SOC),total nitrogen(TN),available nitrogen(AN),available phosphorus(AP),available potassium(AK),cation-exchange capacity(CEC),salinity,p H,and C/N ratio)properties.The results indicated that the soil predominantly consisted of sand particles(94.27%-99.67%),with the remainder being silt and clay.As plantation age increased,silt and very fine sand contents progressively rose.After 16 years of planting,there was a marked reduction in the mean soil particle size.The initial soil fertility was low and declined from 4 to 10 years of planting before witnessing an improvement.Significant positive correlations were observed for the clay,silt,and very fine sand(mean diameter of 0.000-0.100 mm)with SOC,AK,and p H.In contrast,fine sand and medium sand(mean diameter of 0.100-0.500 mm)showed significant negative correlations with these indicators.Our findings ascertain that the plantation of S.vulgaris requires 10 years to effectively act as a windbreak and contribute to sand fixation,and needs 16 years to improve soil physical and chemical properties.Importantly,these improvements were found to be highly beneficial for vegetation restoration in arid and semi-arid areas.This research can offer valuable insights for the protection and restoration of the vegetation ecosystem in the sandy lands in China.

The carrying capacity for vegetation of forest land across China:Near real-time monitoring and short-term forecasting based on satellite observation

Ecological restoration projects implemented over the past 20 years have substantially increased forest coverage in China,but the high tree mortality of new afforestation forest remains a challenging but unsolved problem.It is still not clear how much vegetation can be sustained by the forest lands with given water,energy and soil conditions,i.e.,the carrying capacity for vegetation(CCV)of forest lands,which is the prerequisite for planning and implementing forest restoration projects.Here,we used a simplified method to evaluate the CCV across forest lands nationwide.Specifically,based on leaf area index(LAI)dataset,we use boosted regression tree and multiple linear regression model to analyze the CCV during 2001-2020 and 2021-2030 and explore the contribution of environmental factors.We find that there are three typical regions with lower CCV located in the Loess Plateau and the southern region of the Inner Mongolia Plateau,the Hengduan Mountain region,and the Tianshan Mountains.More importantly,the vegetation in the regions near the dry-wet climate transition zone show excess local carrying capacity for vegetation over the past two decades and they are more susceptible to potential climatic stress.In comparison,in the Greater Khingan Mountains and Hengduan Mountains,there is high potential to improve the forest growth.Temperature,precipitation and soil affects the CCV by shaping the vegetation in the optimal range.This indicates that more consideration should be given to restrictions of regional environmental constraints when planning afforestation and forest management.This study has important implications for guiding future forest scheme in China.

From single to combinatorial therapies in spinal cord injuries for structural and functional restoration

Spinal cord injury results in paralysis, sensory disturbances, sphincter dysfunction, and multiple systemic secondary conditions, most arising from autonomic dysregulation. All this produces profound negative psychosocial implications for affected people, their families, and their communities;the financial costs can be challenging for their families and health institutions. Treatments aimed at restoring the spinal cord after spinal cord injury, which have been tested in animal models or clinical trials, generally seek to counteract one or more of the secondary mechanisms of injury to limit the extent of the initial damage. Most published works on structural/functional restoration in acute and chronic spinal cord injury stages use a single type of treatment: a drug or trophic factor, transplant of a cell type, and implantation of a biomaterial. Despite the significant benefits reported in animal models, when translating these successful therapeutic strategies to humans, the result in clinical trials has been considered of little relevance because the improvement, when present, is usually insufficient. Until now, most studies designed to promote neuroprotection or regeneration at different stages after spinal cord injury have used single treatments. Considering the occurrence of various secondary mechanisms of injury in the acute and sub-acute phases of spinal cord injury, it is reasonable to speculate that more than one therapeutic agent could be required to promote structural and functional restoration of the damaged spinal cord. Treatments that combine several therapeutic agents, targeting different mechanisms of injury, which, when used as a single therapy, have shown some benefits, allow us to assume that they will have synergistic beneficial effects. Thus, this narrative review article aims to summarize current trends in the use of strategies that combine therapeutic agents administered simultaneously or sequentially, seeking structural and functional restoration of the injured spinal cord.