目的 本研究主要观察 L ASIK中负压吸引对视网膜微循环血流的影响。方法 采用海德堡视网膜血流仪分别对实施 L ASIK手术的低度、中度和高度的近视患者共 38例6 2眼进行检测 ,测量视盘大血管、视盘颞侧盘沿、视盘鼻侧盘沿、颞侧视盘旁...目的 本研究主要观察 L ASIK中负压吸引对视网膜微循环血流的影响。方法 采用海德堡视网膜血流仪分别对实施 L ASIK手术的低度、中度和高度的近视患者共 38例6 2眼进行检测 ,测量视盘大血管、视盘颞侧盘沿、视盘鼻侧盘沿、颞侧视盘旁视网膜、鼻侧视盘旁视网膜和巩膜筛板的血流 ,并对其手术前后的血流量、血流速和红细胞移动速率进行统计分析。结果 L ASIK手术前后 ,视盘大血管、视盘颞侧盘沿、视盘鼻侧盘沿、颞侧视盘旁视网膜、鼻侧视盘旁视网膜和筛板的血流量、血流速和红细胞移动速率均无显著性差异。结论 L展开更多
Background Inner retinal oxygenation response （△PO2） is a worldwide study focus. However, the relevant reports on its radiological measurments are limited. In this study, magnetic resonance imaging （MRI）, employi...Background Inner retinal oxygenation response （△PO2） is a worldwide study focus. However, the relevant reports on its radiological measurments are limited. In this study, magnetic resonance imaging （MRI）, employing T1 weighted image （T1WI）, was used to detect changes in APO2 following 100% oxygen inhalation in human subjects. Methods MRI was performed on a 1.5-T GE scanner system. After obtaining ophthalmologic data, eleven healthy individuals were given room air and 100% oxygen inhalation in order with different intervals. The MRI TlWl data were collected for 50 minutes. Data were analyzed with NIH IMAGE software. Results APO2 was not panretinally uniform, and changes in oxygenation response were spatially inhomogeneous. During the initial phase （before 5 minutes） of 100% oxygen inhalation, preretinal vitreous water signals in the region of papilla optica increased rapidly. On the contrary, in other regions signals declined. In a later period （35 minutes）, APO2 was panretinally fluctuated and increased slowly and attained homeostasis. After hyperoxia （45 minutes）, delayed-enhancement of preretinal vitreous water signals in regions other than the papilla optica occurred, and then dropped down. There was no significant difference （P 〉0.05） at any consecutive time point during and after hyperoixa. Conclusions These results reveal that hyperoxia can induce region-specific signal changes in preretinal vitreous water. Regulatory activity of the retinal vessel network may be the mechanism during 100% oxygen inhalation. Moreover, MRI is a valuable tool for investigating APO2 and exploring the mechanism of retinal oxygenation response physiologically or pathologically in vivo.展开更多
文摘目的 本研究主要观察 L ASIK中负压吸引对视网膜微循环血流的影响。方法 采用海德堡视网膜血流仪分别对实施 L ASIK手术的低度、中度和高度的近视患者共 38例6 2眼进行检测 ,测量视盘大血管、视盘颞侧盘沿、视盘鼻侧盘沿、颞侧视盘旁视网膜、鼻侧视盘旁视网膜和巩膜筛板的血流 ,并对其手术前后的血流量、血流速和红细胞移动速率进行统计分析。结果 L ASIK手术前后 ,视盘大血管、视盘颞侧盘沿、视盘鼻侧盘沿、颞侧视盘旁视网膜、鼻侧视盘旁视网膜和筛板的血流量、血流速和红细胞移动速率均无显著性差异。结论 L
文摘Background Inner retinal oxygenation response （△PO2） is a worldwide study focus. However, the relevant reports on its radiological measurments are limited. In this study, magnetic resonance imaging （MRI）, employing T1 weighted image （T1WI）, was used to detect changes in APO2 following 100% oxygen inhalation in human subjects. Methods MRI was performed on a 1.5-T GE scanner system. After obtaining ophthalmologic data, eleven healthy individuals were given room air and 100% oxygen inhalation in order with different intervals. The MRI TlWl data were collected for 50 minutes. Data were analyzed with NIH IMAGE software. Results APO2 was not panretinally uniform, and changes in oxygenation response were spatially inhomogeneous. During the initial phase （before 5 minutes） of 100% oxygen inhalation, preretinal vitreous water signals in the region of papilla optica increased rapidly. On the contrary, in other regions signals declined. In a later period （35 minutes）, APO2 was panretinally fluctuated and increased slowly and attained homeostasis. After hyperoxia （45 minutes）, delayed-enhancement of preretinal vitreous water signals in regions other than the papilla optica occurred, and then dropped down. There was no significant difference （P 〉0.05） at any consecutive time point during and after hyperoixa. Conclusions These results reveal that hyperoxia can induce region-specific signal changes in preretinal vitreous water. Regulatory activity of the retinal vessel network may be the mechanism during 100% oxygen inhalation. Moreover, MRI is a valuable tool for investigating APO2 and exploring the mechanism of retinal oxygenation response physiologically or pathologically in vivo.
