BACKGROUND Immune checkpoint inhibitor-associated interstitial lung disease(ICI-ILD)and opportunistic pneumonias are the main pulmonary complications during immunotherapy for malignancies.The organizing pneumonia(OP)p...BACKGROUND Immune checkpoint inhibitor-associated interstitial lung disease(ICI-ILD)and opportunistic pneumonias are the main pulmonary complications during immunotherapy for malignancies.The organizing pneumonia(OP)pattern is one of the common radiological manifestations of ICI-ILD,and OP is the most common cause of reversed halo cycles and consolidations.However,opportunistic pneumonias should be excluded.CASE SUMMARY In this report,we described a case of a 44-year-old man with esophageal cancer who showed multiple reversed-halo cycles and consolidations on chest computed tomography(CT)after he had a cold during immunotherapy.He was diagnosed with esophageal squamous-cell cancer(T2NIM0)after surgery.Then,he was successfully treated with 6 cycles of chemotherapy plus tislelizumab,one cycle of radiotherapy and 9 cycles of tislelizumab.Two months later,he complained of low-grade fever and cough with nonpurulent sputum after he had a cold.Community-acquired pneumonia was considered,but moxifloxacin was ineffective.Chest CT showed multiple reversed-halo cycles and consolidations.Mycobacterium tuberculosis was identified with next-generation sequence analysis of bronchoalveolar lavage fluid(BALF).Two months later,he improved with standard anti-tuberculosis medications.Both the cycles and consolidations disappeared in the repeat CT after 6 mo of medications.CONCLUSION When chest CT shows reversed-halo cycles and consolidations in patients during anticancer immunotherapy,both ICI-ILD and infectious pneumonia should be considered.BALF microbiological analysis was helpful to differentiate them.展开更多
To improve the coefficient of performance （COP） of CO2 transcritical reverse cycle and determine the most efficient cycle, comparison analysis on （single-and） two-stage CO2 transcritical cycles with internal heat ...To improve the coefficient of performance （COP） of CO2 transcritical reverse cycle and determine the most efficient cycle, comparison analysis on （single-and） two-stage CO2 transcritical cycles with internal heat exchanger （IHX） or expander is presented adopting the principle of thermodynamics. Results indicate that the COP of four cycles,namely single-stage compression with IHX （SI）, single-stage compression with expander （SE）, two-stage compression with IHX （TI） and two-stage compression with expander （TE）, can be ranged as TE>SE>TI>SI. It presents that adopting an expander to recover expansion power is the primary method to improve the COP of CO2 transcritical reverse cycle if the efficiency of the expander is up to a certain value. Under supposed operating condition, where the outlet temperature of gas cooler is 35 ℃ and the evaporating temperature is 5 ℃, the COP of TE cycle is about 4200 higher than that of SI cycle when the expander efficiency is 0.6 and the degree of superheat of IHX is 15 ℃. Therefore TE cycle is the most recommendatory one and it is better to adopt TE in those high-cooling capacity systems because its technology cost will be higher.展开更多
NiOOH was prepared by one-step electrolysis of spherical Ni（OH）2 and the effects of electrolysis parameters were examined. The highly pure NiOOH was obtained after electrolysis at a current density of 60mA.g^-1 and...NiOOH was prepared by one-step electrolysis of spherical Ni（OH）2 and the effects of electrolysis parameters were examined. The highly pure NiOOH was obtained after electrolysis at a current density of 60mA.g^-1 and 30℃ with anodic potential controlled in the range of 1.73-1.85V （vs. Zn/ZnO） for 360min. The NiOOH samriles were characterized bv X-ray oowder diffraction （XRD） and scanning electron microscope （SEM） analysis.Resuits indicate that the electrolysis product is spherical NiOOH doped with graphite. Charge and discharge tests show that the prepared NiOOH offers a discharge capacity of over 270mAh·g^-1 at current density of 30mA·g^-1 and can be directly used as cathode material of alkaline Zn/NiOOH batteries. Galvanostatic charge/discharge and cyclic voltammetry （CV） tests reveal good cycling reversibility, of the NiOOH electrode.展开更多
On the hypothesis that telomerase reverse transcriptase (TERT) of cardiac myocytes (CMs) is consistent with cell cycle distribution as well as tumour cells, we plan to investigate the expression of TERT in CMs and how...On the hypothesis that telomerase reverse transcriptase (TERT) of cardiac myocytes (CMs) is consistent with cell cycle distribution as well as tumour cells, we plan to investigate the expression of TERT in CMs and how TERT is in keeping with CMs cycle distribution after birth and under hypoxia, and roughly understand how hypoxia affects activity of TERT promoter.展开更多
基金Supported by National High Level Hospital Clinical Research Funding,No.2022-PUMCH-C-069 and No.2022-PUMCH-A-009.
文摘BACKGROUND Immune checkpoint inhibitor-associated interstitial lung disease(ICI-ILD)and opportunistic pneumonias are the main pulmonary complications during immunotherapy for malignancies.The organizing pneumonia(OP)pattern is one of the common radiological manifestations of ICI-ILD,and OP is the most common cause of reversed halo cycles and consolidations.However,opportunistic pneumonias should be excluded.CASE SUMMARY In this report,we described a case of a 44-year-old man with esophageal cancer who showed multiple reversed-halo cycles and consolidations on chest computed tomography(CT)after he had a cold during immunotherapy.He was diagnosed with esophageal squamous-cell cancer(T2NIM0)after surgery.Then,he was successfully treated with 6 cycles of chemotherapy plus tislelizumab,one cycle of radiotherapy and 9 cycles of tislelizumab.Two months later,he complained of low-grade fever and cough with nonpurulent sputum after he had a cold.Community-acquired pneumonia was considered,but moxifloxacin was ineffective.Chest CT showed multiple reversed-halo cycles and consolidations.Mycobacterium tuberculosis was identified with next-generation sequence analysis of bronchoalveolar lavage fluid(BALF).Two months later,he improved with standard anti-tuberculosis medications.Both the cycles and consolidations disappeared in the repeat CT after 6 mo of medications.CONCLUSION When chest CT shows reversed-halo cycles and consolidations in patients during anticancer immunotherapy,both ICI-ILD and infectious pneumonia should be considered.BALF microbiological analysis was helpful to differentiate them.
文摘To improve the coefficient of performance （COP） of CO2 transcritical reverse cycle and determine the most efficient cycle, comparison analysis on （single-and） two-stage CO2 transcritical cycles with internal heat exchanger （IHX） or expander is presented adopting the principle of thermodynamics. Results indicate that the COP of four cycles,namely single-stage compression with IHX （SI）, single-stage compression with expander （SE）, two-stage compression with IHX （TI） and two-stage compression with expander （TE）, can be ranged as TE>SE>TI>SI. It presents that adopting an expander to recover expansion power is the primary method to improve the COP of CO2 transcritical reverse cycle if the efficiency of the expander is up to a certain value. Under supposed operating condition, where the outlet temperature of gas cooler is 35 ℃ and the evaporating temperature is 5 ℃, the COP of TE cycle is about 4200 higher than that of SI cycle when the expander efficiency is 0.6 and the degree of superheat of IHX is 15 ℃. Therefore TE cycle is the most recommendatory one and it is better to adopt TE in those high-cooling capacity systems because its technology cost will be higher.
文摘NiOOH was prepared by one-step electrolysis of spherical Ni（OH）2 and the effects of electrolysis parameters were examined. The highly pure NiOOH was obtained after electrolysis at a current density of 60mA.g^-1 and 30℃ with anodic potential controlled in the range of 1.73-1.85V （vs. Zn/ZnO） for 360min. The NiOOH samriles were characterized bv X-ray oowder diffraction （XRD） and scanning electron microscope （SEM） analysis.Resuits indicate that the electrolysis product is spherical NiOOH doped with graphite. Charge and discharge tests show that the prepared NiOOH offers a discharge capacity of over 270mAh·g^-1 at current density of 30mA·g^-1 and can be directly used as cathode material of alkaline Zn/NiOOH batteries. Galvanostatic charge/discharge and cyclic voltammetry （CV） tests reveal good cycling reversibility, of the NiOOH electrode.
文摘On the hypothesis that telomerase reverse transcriptase (TERT) of cardiac myocytes (CMs) is consistent with cell cycle distribution as well as tumour cells, we plan to investigate the expression of TERT in CMs and how TERT is in keeping with CMs cycle distribution after birth and under hypoxia, and roughly understand how hypoxia affects activity of TERT promoter.
