Overall, General, Organic, and Biological Chemistry is a very useful text to support a twosemester undergraduate course series in chemistry for health sciences students. Its strengths are the use of the P.A.V.E. way t...Overall, General, Organic, and Biological Chemistry is a very useful text to support a twosemester undergraduate course series in chemistry for health sciences students. Its strengths are the use of the P.A.V.E. way to student learning applications. It is very obvious that the author has the background and the preparation of the student taking the course(s) in mind when she was writing the textbook.展开更多
BACKGROUND Coronavirus disease(COVID-19)patients exhibit different patterns of liver impairment,according to growing evidence.AIM In this study,we sought to provide a comprehensive analysis of liver test parameters in...BACKGROUND Coronavirus disease(COVID-19)patients exhibit different patterns of liver impairment,according to growing evidence.AIM In this study,we sought to provide a comprehensive analysis of liver test parameters in patients with severe and non-severe COVID-19.METHODS We performed a meta-analysis of published liver manifestations and described the liver damage in COVID-19.We searched PubMed,Google Scholar,Embase,Cochrane Library,medRxiv,bioRxiv,and three Chinese electronic databases through April 18,2020,in accordance with the Preferred Reporting Items for Meta-Analyses.We analyzed pooled data on liver chemistries stratified by COVID-19 severity using a fixed or random-effects model.RESULTS A meta-analysis of 56 studies,including 11052 patients,found that the pooled mean alanine aminotransferase(ALT)in severe COVID-19 cases was 35.9 IU/L whereas in non-severe COVID-19 cases was 27.3 IU/L.Average aspa-rtate aminotransferase(AST)levels were 44.3 IU/L in severe cases compared to 27.9 IU/L in non-severe cases.In addition,AST levels are often higher than ALT levels regardless of disease severity.The severe cases tended to have a higher gammaglutamyltransferase level but a lower albumin level than the non-severe cases.CONCLUSION Severe COVID-19 was more likely to be associated with abnormal liver test results.Monitoring liver chemistry closely can help detect disease progression early.展开更多
文摘Overall, General, Organic, and Biological Chemistry is a very useful text to support a twosemester undergraduate course series in chemistry for health sciences students. Its strengths are the use of the P.A.V.E. way to student learning applications. It is very obvious that the author has the background and the preparation of the student taking the course(s) in mind when she was writing the textbook.
文摘BACKGROUND Coronavirus disease(COVID-19)patients exhibit different patterns of liver impairment,according to growing evidence.AIM In this study,we sought to provide a comprehensive analysis of liver test parameters in patients with severe and non-severe COVID-19.METHODS We performed a meta-analysis of published liver manifestations and described the liver damage in COVID-19.We searched PubMed,Google Scholar,Embase,Cochrane Library,medRxiv,bioRxiv,and three Chinese electronic databases through April 18,2020,in accordance with the Preferred Reporting Items for Meta-Analyses.We analyzed pooled data on liver chemistries stratified by COVID-19 severity using a fixed or random-effects model.RESULTS A meta-analysis of 56 studies,including 11052 patients,found that the pooled mean alanine aminotransferase(ALT)in severe COVID-19 cases was 35.9 IU/L whereas in non-severe COVID-19 cases was 27.3 IU/L.Average aspa-rtate aminotransferase(AST)levels were 44.3 IU/L in severe cases compared to 27.9 IU/L in non-severe cases.In addition,AST levels are often higher than ALT levels regardless of disease severity.The severe cases tended to have a higher gammaglutamyltransferase level but a lower albumin level than the non-severe cases.CONCLUSION Severe COVID-19 was more likely to be associated with abnormal liver test results.Monitoring liver chemistry closely can help detect disease progression early.
