20（R）-ginsenoside-Rh2,ginsenoside-Rg3 and 20（S）-ginsenoside Rg3 were prepared by the hydrolysis of leaf saponins of Panax notoginseng（Burk.）F.H.Chen with solution of 50% acetic acid and then column chromatograph...20（R）-ginsenoside-Rh2,ginsenoside-Rg3 and 20（S）-ginsenoside Rg3 were prepared by the hydrolysis of leaf saponins of Panax notoginseng（Burk.）F.H.Chen with solution of 50% acetic acid and then column chromatography on silica gel.Their structures were characterized by spectroscopic analysis,chemical degradation and comparison with authentic samples.展开更多
Five minor compounds isolated from the leaves of Panax ginseng C. A. Meyer were characterized as 20（R）-protopanaxatriol （1）, daucosterin （2）, 3β, 12β-dihydroxy-dammar-20 （22）, 24-diene-3-O-β-D-glucopyranosi...Five minor compounds isolated from the leaves of Panax ginseng C. A. Meyer were characterized as 20（R）-protopanaxatriol （1）, daucosterin （2）, 3β, 12β-dihydroxy-dammar-20 （22）, 24-diene-3-O-β-D-glucopyranoside （3）, 20 （R）-protopanaxadiol-3-O-β-D-glucopyranoside （4） and ginsenoside-Rh2 （5）, respectively, on the basis of spectral analyses and chemical evidence. The two new saponins, 3 and 4, were named as ginsenoside-Rh3 and 20（R）-ginsenoside-Rh2.Nine other major saponins obtained simultaneously were identical with ginsenoside-Rh1（6）,-Rg3 （7）, -Rg2 （8）, -Rg1 （9）,-Re（10）,-Rd （11）, -Rc （12）, -Rb2（13） and Rb1 （14）, respectively.展开更多
As a steroid skeleton-based saponin,ginsenoside Rh_(2)(G-Rh_(2))is one of the major bioactive ginsenosides from the plants of genus Panax L.Many studies have reported the notable pharmacological activities of G-Rh_(2)...As a steroid skeleton-based saponin,ginsenoside Rh_(2)(G-Rh_(2))is one of the major bioactive ginsenosides from the plants of genus Panax L.Many studies have reported the notable pharmacological activities of G-Rh_(2)such as anticancer,antiinflammatory,antiviral,antiallergic,antidiabetic,and anti-Alzheimer’s activities.Numerous preclinical studies have demonstrated the great potential of G-Rh_(2)in the treatment of a wide range of carcinomatous diseases in vitro and in vivo.G-Rh_(2)is able to inhibit proliferation,induce apoptosis and cell cycle arrest,retard metastasis,promote differentiation,enhance chemotherapy and reverse multi-drug resistance against multiple tumor cells.The present review mainly summarizes the anticancer effects and related mechanisms of G-Rh_(2)in various models as well as the recent advances in G-Rh_(2)delivery systems and structural modification to ameliorate its anticancer activity and pharmacokinetics characteristics.展开更多
文摘20（R）-ginsenoside-Rh2,ginsenoside-Rg3 and 20（S）-ginsenoside Rg3 were prepared by the hydrolysis of leaf saponins of Panax notoginseng（Burk.）F.H.Chen with solution of 50% acetic acid and then column chromatography on silica gel.Their structures were characterized by spectroscopic analysis,chemical degradation and comparison with authentic samples.
文摘Five minor compounds isolated from the leaves of Panax ginseng C. A. Meyer were characterized as 20（R）-protopanaxatriol （1）, daucosterin （2）, 3β, 12β-dihydroxy-dammar-20 （22）, 24-diene-3-O-β-D-glucopyranoside （3）, 20 （R）-protopanaxadiol-3-O-β-D-glucopyranoside （4） and ginsenoside-Rh2 （5）, respectively, on the basis of spectral analyses and chemical evidence. The two new saponins, 3 and 4, were named as ginsenoside-Rh3 and 20（R）-ginsenoside-Rh2.Nine other major saponins obtained simultaneously were identical with ginsenoside-Rh1（6）,-Rg3 （7）, -Rg2 （8）, -Rg1 （9）,-Re（10）,-Rd （11）, -Rc （12）, -Rb2（13） and Rb1 （14）, respectively.
基金This work was supports by the National Natural Science Foundation of China(Nos.82173913,81603272,81803492)the High-level Talent Innovation Support Program of Dalian City(No.2017RQ152)+4 种基金Dalian High-level Talent Innovation Support Program-Cutting-edge and Leading Talent(No.2021RD10)the Science and Technology Innovation Foundation of Dalian City(No.2018J12SN062)Key R&D Projects of Liaoning Province(No.2020JH2/10300054)Science and Technology Innovation Foundation of Dalian City(No.2021JJ13SN51)Open Fund of Key Laboratory of Biotechnology and Bioresources Utilization(Dalian Minzu University),Ministry of Education(No.KF2020004).
文摘As a steroid skeleton-based saponin,ginsenoside Rh_(2)(G-Rh_(2))is one of the major bioactive ginsenosides from the plants of genus Panax L.Many studies have reported the notable pharmacological activities of G-Rh_(2)such as anticancer,antiinflammatory,antiviral,antiallergic,antidiabetic,and anti-Alzheimer’s activities.Numerous preclinical studies have demonstrated the great potential of G-Rh_(2)in the treatment of a wide range of carcinomatous diseases in vitro and in vivo.G-Rh_(2)is able to inhibit proliferation,induce apoptosis and cell cycle arrest,retard metastasis,promote differentiation,enhance chemotherapy and reverse multi-drug resistance against multiple tumor cells.The present review mainly summarizes the anticancer effects and related mechanisms of G-Rh_(2)in various models as well as the recent advances in G-Rh_(2)delivery systems and structural modification to ameliorate its anticancer activity and pharmacokinetics characteristics.
