As drilling wells continue to move into deep ultra-deep layers,the requirements for temperature resistance of drilling fluid treatments are getting higher and higher.Among them,blocking agent,as one of the key treatme...As drilling wells continue to move into deep ultra-deep layers,the requirements for temperature resistance of drilling fluid treatments are getting higher and higher.Among them,blocking agent,as one of the key treatment agents,has also become a hot spot of research.In this study,a high temperature resistant strong adsorption rigid blocking agent(QW-1)was prepared using KH570 modified silica,acrylamide(AM)and allyltrimethylammonium chloride(TMAAC).QW-1 has good thermal stability,average particle size of 1.46μm,water contact angle of 10.5.,has a strong hydrophilicity,can be well dispersed in water.The experimental results showed that when 2 wt%QW-1 was added to recipe A(4 wt%bentonite slurry+0.5 wt%DSP-1(filtration loss depressant)),the API filtration loss decreased from 7.8to 6.4 m L.After aging at 240.C,the API loss of filtration was reduced from 21 to 14 m L,which has certain performance of high temperature loss of filtration.At the same time,it is effective in sealing 80-100mesh and 100-120 mesh sand beds as well as 3 and 5μm ceramic sand discs.Under the same conditions,the blocking performance was superior to silica(5μm)and calcium carbonate(2.6μm).In addition,the mechanism of action of QW-1 was further investigated.The results show that QW-1 with amide and quaternary ammonium groups on the molecular chain can be adsorbed onto the surface of clay particles through hydrogen bonding and electrostatic interaction to form a dense blocking layer,thus preventing further intrusion of drilling fluid into the formation.展开更多
Rigid barrier deflectors can effectively prevent overspilling landslides,and can satisfy disaster prevention requirements.However,the mechanisms of interaction between natural granular flow and rigid barrier deflector...Rigid barrier deflectors can effectively prevent overspilling landslides,and can satisfy disaster prevention requirements.However,the mechanisms of interaction between natural granular flow and rigid barrier deflectors require further investigation.To date,few studies have investigated the impact of deflectors on controlling viscous debris flows for geological disaster prevention.To investigate the effect of rigid barrier deflectors on impact mechanisms,a numerical model using the smoothed particle hydrodynamics(SPH)method with the Herschel–Bulkley model is proposed to simulate the interaction between natural viscous flow and single/dual barriers with and without deflectors.This model was validated using laboratory flume test data from the literature.Then,the model was used to investigate the influence of the deflector angle and multi-barrier arrangements.The optimal configuration of multi-barriers was analyzed with consideration to the barrier height and distance between the barriers,because these metrics have a significant impact on the viscous flow pile-up,run-up,and overflow mechanisms.The investigation considered the energy dissipation process,retention efficiency,and dead-zone formation.Compared with bare barriers with similar geometric characteristics and spatial distribution,rigid barriers with deflectors exhibit superior effectiveness in preventing the overflow and overspilling of viscous debris flow.Recommendations for the rational design of deflectors and the optimal arrangement of multi-barriers are provided to mitigate geological disasters.展开更多
By introducing the Carathéodory metric,we establish the Schwarz lemma at the boundary for holomorphic self-mappings on the unit p-ball B_(p)^(n) of C^(n).Furthermore,the boundary rigidity theorem for holomorphic ...By introducing the Carathéodory metric,we establish the Schwarz lemma at the boundary for holomorphic self-mappings on the unit p-ball B_(p)^(n) of C^(n).Furthermore,the boundary rigidity theorem for holomorphic self-mappings defined on B_(n)^(p) is obtained.These results cover the boundary Schwarz lemma and rigidity result for holomorphic self-mappings on the unit ball for p=2,and the unit polydisk for p=∞,respectively.展开更多
The deteriorated continuous rigid frame bridge is strengthened by external prestressing. Static loading tests wereconducted before and after the bridge rehabilitation to verify the effectiveness of the rehabilitation ...The deteriorated continuous rigid frame bridge is strengthened by external prestressing. Static loading tests wereconducted before and after the bridge rehabilitation to verify the effectiveness of the rehabilitation process. Thestiffness of the repaired bridge is improved, and the maximum deflection of the load test is reduced from 37.9 to27.6 mm. A bridge health monitoring system is installed after the bridge is reinforced. To achieve an easy assessmentof the bridge’s safety status by directly using transferred data, a real-time safety warning system is createdbased on a five-level safety standard. The threshold for each safety level will be determined by theoretical calculationsand the outcomes of static loading tests. The highest risk threshold will be set at the ultimate limit statevalue. The remaining levels, namely middle risk, low risk, and very low risk, will be determined usingreduction coefficients of 0.95, 0.9, and 0.8, respectively.展开更多
Pavement infrastructure is vital in providing services and links between various sectors of society. Therefore, thepreservation and maintenance of these roads are critical to attaining a pavement network in good condi...Pavement infrastructure is vital in providing services and links between various sectors of society. Therefore, thepreservation and maintenance of these roads are critical to attaining a pavement network in good conditionthroughout its service life. Various performance indicators like the international roughness index (IRI), pavementcondition index (PCI), and present serviceability rating (PSR) have been used by the state department of transportation (DOT) and highway agencies for evaluating pavement surface conditions and planning future maintenance strategies. Limited data availability, multiple distresses depending on region, lack of correlation of thesecondition indices to maintenance strategies, and data collection limitations pose a challenge for applying theseindices to local conditions. This paper compares condition indices of different states for rigid pavements. Further,using a specific condition index for local conditions is also highlighted. For this purpose, five states and theircorresponding condition indices were evaluated and compared to the Michigan DOT distress index (DI). Thesestates include Virginia, Minnesota, North Dakota, Louisiana, and Oregon. The corresponding distresses of eachcondition index were converted to make them compatible with the MDOT DI. This study used the MDOT'spavement management system (PMS) database to evaluate each condition index for 433 rigid pavement sections.Each distress index was plotted against MDOT DI and compared using a paired t-test. Results show that thecondition indices of Virginia and Minnesota are comparable to DI in terms of the Spearman correlation value. Thet-test results show that except for Virgina, condition indices from other states statistically differ from DI.Therefore, one can't use those directly for local conditions in Michigan. This paper presents the evaluation anddata requirements for each condition index and its impact on selecting a maintenance treatment.展开更多
In this study,an iterative-based three-dimensional finite element lower bound in association with the second-order cone programming method is adopted to evaluate the limit load of a single pile embedded in cross-aniso...In this study,an iterative-based three-dimensional finite element lower bound in association with the second-order cone programming method is adopted to evaluate the limit load of a single pile embedded in cross-anisotropic soils under general loading condition.The lower bound solutions of the pile embedded in an anisotropic soil deposit can be found by formulating the element equilibrium,equilibrium of shear and normal stresses along discontinuities,boundary conditions,yield function,and optimizing the objective function through the second-order cone programming method in conjunction with an iterative-based update procedure.A general loading condition is considered to profile the expansion of the safe load in the vertical-horizontal-moment(V-H-M)space.The results of this study are compared and validated against three different cases including an isotropic lateral loading,anisotropic end bearing capacity,and a pile embedded in an isotropic soil deposit under general loading condition.A parametric study is conducted to evaluate the impact of different influencing factors.It was found that the effect of anisotropy on the variation of lateral limit load of a single pile is more pronounced than the corresponding vertical and bending moment limit loads,whereas the interface properties have more significant effects on the vertical and bending moment limit loads in comparison to the lateral limit load.展开更多
Osteosarcoma(OS)is the most common primary malignant pediatric bone tumor and is characterized by high heterogeneity.Studies have revealed a wide range of phenotypic differences among OS cell lines in terms of their i...Osteosarcoma(OS)is the most common primary malignant pediatric bone tumor and is characterized by high heterogeneity.Studies have revealed a wide range of phenotypic differences among OS cell lines in terms of their in vivo tumorigenicity and in vitro colony-forming abilities.However,the underlying molecular mechanism of these discrepancies remains unclear.The potential role of mechanotransduction in tumorigenicity is of particular interest.To this end,we tested the tumorigenicity and anoikis resistance of OS cell lines both in vitro and in vivo.We utilized a sphere culture model,a soft agar assay,and soft and rigid hydrogel surface culture models to investigate the function of rigidity sensing in the tumorigenicity of OS cells.Additionally,we quantified the expression of sensor proteins,including four kinases and seven cytoskeletal proteins,in OS cell lines.The upstream core transcription factors of rigidity-sensing proteins were further investigated.We detected anoikis resistance in transformed OS cells.The mechanosensing function of transformed OS cells was also impaired,with general downregulation of rigidity-sensing components.We identified toggling between normal and transformed growth based on the expression pattern of rigidity-sensing proteins in OS cells.We further uncovered a novel TP53 mutation(R156P)in transformed OS cells,which acquired gain of function to inhibit rigidity sensing,thus sustaining transformed growth.Our findings suggest a fundamental role of rigidity-sensing components in OS tumorigenicity as mechanotransduction elements through which cells can sense their physical microenvironment.In addition,the gain of function of mutant TP53 appears to serve as an executor for such malignant programs.展开更多
The transient and static anti-plane problem of a rigid line inclusion pulled out from an elastic medium is studied.The singular integral equation method is used to solve the stress field.Under the static load,the stre...The transient and static anti-plane problem of a rigid line inclusion pulled out from an elastic medium is studied.The singular integral equation method is used to solve the stress field.Under the static load,the stress intensity factor(SIF)at the inclusion tips increases with the medium length.The problem becomes equivalent to an inclusion in a medium with an infinite length when the length of the medium is 3.5times longer than that of the inclusion.However,under the transient load,the maximum value of the SIF occurs when the medium length is about two times the inclusion length.Besides,the relation between the pull-out force and the anti-plane displacement is given.The conclusions are useful in guiding the design of fiber reinforced composite materials.展开更多
This paper describes the quasi-static testing and analytical modelling of the hysteretic behavior of aluminum alloy rigid bus-flexible connectors of 220 kV electrical substations.The main objective of the study is to ...This paper describes the quasi-static testing and analytical modelling of the hysteretic behavior of aluminum alloy rigid bus-flexible connectors of 220 kV electrical substations.The main objective of the study is to experimentally investigate the hysteretic behavior of six different types of rigid bus-flexible connectors 220 kV electrical substations when subjected to cyclic loading.Another objective is to theoretically study the flexibility and effectiveness of a previously proposed analytical model in fitting the experimental hysteresis loops of the tested rigid bus-flexible connectors.The experimental investigation indicates that the tested rigid bus-flexible connectors exhibit highly asymmetric hysteresis behavior along with tension stiffening effect.The theoretical study demonstrates that the generalized Bouc-Wen model has high flexibility and is effective in fitting the experimental hysteresis resisting force-displacement curves of the six tested rigid bus-flexible connectors.展开更多
In this paper,we mainly study the global rigidity theorem of Riemannian submanifolds in space forms.Let Mn(n≥3)be a complete minimal submanifold in the unit sphere Sn+p(1).Forλ∈[0,n2−1/p),there is an explicit posit...In this paper,we mainly study the global rigidity theorem of Riemannian submanifolds in space forms.Let Mn(n≥3)be a complete minimal submanifold in the unit sphere Sn+p(1).Forλ∈[0,n2−1/p),there is an explicit positive constant C(n,p,λ),depending only on n,p,λ,such that,if∫MSn/2dM<∞,∫M(S−λ)n/2+dM<C(n,p,λ),then Mn is a totally geodetic sphere,where S denotes the square of the second fundamental form of the submanifold and∫+=max{0,f}.Similar conclusions can be obtained for a complete submanifold with parallel mean curvature in the Euclidean space Rn+p.展开更多
Based on the as-built load test of a large bridge,this paper introduces the procedure of the prestressed concrete continuous rigid frame bridge load test.Numerical analysis of the bridge was carried out by simulating ...Based on the as-built load test of a large bridge,this paper introduces the procedure of the prestressed concrete continuous rigid frame bridge load test.Numerical analysis of the bridge was carried out by simulating and establishing a finite element model,and comparative analysis was carried out with the measured values.The results show that the calculated values were basically consistent with the measured values,which showed that the establishment method of the model was reasonable,and the mechanical performance of the bridge met the service requirements of the designed live load.展开更多
The fatigue of concrete structures will gradually appear after being subjected to alternating loads for a long time,and the accidents caused by fatigue failure of bridge structures also appear from time to time.Aiming...The fatigue of concrete structures will gradually appear after being subjected to alternating loads for a long time,and the accidents caused by fatigue failure of bridge structures also appear from time to time.Aiming at the problem of degradation of long-span continuous rigid frame bridges due to fatigue and environmental effects,this paper suggests a method to analyze the fatigue degradation mechanism of this type of bridge,which combines long-term in-site monitoring data collected by the health monitoring system(HMS)and fatigue theory.In the paper,the authors mainly carry out the research work in the following aspects:First of all,a long-span continuous rigid frame bridge installed with HMS is used as an example,and a large amount of health monitoring data have been acquired,which can provide efficient information for fatigue in terms of equivalent stress range and cumulative number of stress cycles;next,for calculating the cumulative fatigue damage of the bridge structure,fatigue stress spectrum got by rain flow counting method,S-N curves and damage criteria are used for fatigue damage analysis.Moreover,it was considered a linear accumulation damage through the Palmgren-Miner rule for the counting of stress cycles.The health monitoring data are adopted to obtain fatigue stress data and the rain flow counting method is used to count the amplitude varying fatigue stress.The proposed fatigue reliability approach in the paper can estimate the fatigue damage degree and its evolution law of bridge structures well,and also can help bridge engineers do the assessment of future service duration.展开更多
The two kinds of rigid polyurethane (PU) foams were prepared with respectively adding the refined alkali lignin and alkali lignin modified by 3-chloro-1,2-epoxypropane to be instead of 15% of the polyether glycol in...The two kinds of rigid polyurethane (PU) foams were prepared with respectively adding the refined alkali lignin and alkali lignin modified by 3-chloro-1,2-epoxypropane to be instead of 15% of the polyether glycol in weight. The indexes of mechanical performance, apparent density, thermal stability and aging resistance were separately tested for the prepared PU foams. The results show that the mechanical property, thermal insulation and thermal stability for PU foam with modified alkali lignin are excellent among two kinds of PU foams and control samples. The additions of the refined alkali lignin and modified alkali lignin to PU foam have little effect on the natural aging or heat aging resistance except for decreasing hot alkali resistance apparently. Additionally, the thermal conductivity of modified alkali lignin PU foam is lowest among two kinds of PU foams and control samples. The alkali lignin PU foam modified by 3-chloro-1,2-epoxypropane could be applied in the heat preservation field.展开更多
A general analytical method to calculate the passive rigid retaining wall pressure was deduced considering all displacement modes. First, the general displacement mode function was setup, then the hypotheses were made...A general analytical method to calculate the passive rigid retaining wall pressure was deduced considering all displacement modes. First, the general displacement mode function was setup, then the hypotheses were made that the lateral passive pressure is linear to the corresponding horizontal displacement and the soil behind retaining wall is composed of a set of springs and ideal rigid plasticity body, the general analytical method was proposed to calculate the passive rigid retaining wall pressure based on Coulomb theory. The analytical results show that the resultant forces of the passive earth pressure are equal to those of Coulomb's theory, but the distribution of the passive pressure and the position of the resultant force depend on the passive displacement mode parameter, and the former is a parabolic function of the soil depth. The analytical results are also in good agreement with the experimental ones.展开更多
A novel seismic design method, namely split-pier seismic design, is proposed. A vertical gap and connect elements are set in split-piers. The lateral stiffness of piers is reduced by cracking of the connect elements u...A novel seismic design method, namely split-pier seismic design, is proposed. A vertical gap and connect elements are set in split-piers. The lateral stiffness of piers is reduced by cracking of the connect elements under severe earthquake, and the seismic response of bridges is reduced by avoiding the site predominant periods. A model of tied-arch rigid frame bridge with split-piers was designed. Seismic performance was investigated by pseudo-static experimentation on the scale model, The failure process of split-piers, the hysteresis characteristic and the effect of split-piers on the superstructure are presented. Results show that the split-pier has better seismic performance than common ductile piers do.展开更多
Parkinson's disease(PD)is a progressive neurodegenerative disorder characterized primarily by classical motor signs of bradykinesia,rigidity,tremors,and postural instability usually manifesti ng unilate rally or a...Parkinson's disease(PD)is a progressive neurodegenerative disorder characterized primarily by classical motor signs of bradykinesia,rigidity,tremors,and postural instability usually manifesti ng unilate rally or at least asymmetrically.The disease involves a loss of dopaminergic neurons projecting from the substantia nigra pars compacta to the dorsal striatum.展开更多
Parkinson's disease is a chronic and progressive neurodegenerative disorder characterized by the loss of dopaminergic neurons in the substantia nigra pars compacta,which leads to the featured motor impairment of p...Parkinson's disease is a chronic and progressive neurodegenerative disorder characterized by the loss of dopaminergic neurons in the substantia nigra pars compacta,which leads to the featured motor impairment of parkinsonism,including akinesia,bradykinesia,rigidity,and tremor(McGregor and Nelson,2019).展开更多
A set of laboratory experiments are carried out to investigate the effect of following/opposing currents on wave attenuation.Rigid vegetation canopies with aligned and staggered configurations were tested under the co...A set of laboratory experiments are carried out to investigate the effect of following/opposing currents on wave attenuation.Rigid vegetation canopies with aligned and staggered configurations were tested under the condition of various regular wave heights and current velocities,with the constant water depth being 0.60 m to create the desired submerged scenarios.Results show that the vegetation-induced wave dissipation is enhanced with the increasing incident wave height.A larger velocity magnititude leads to a greater wave height attenuation for both following and opposing current conditions.Moreover,there is a strong positive linear correlation between the damping coefficientβand the relative wave height H_(0)/h,especially for pure wave conditions.For the velocity profile,the distributions of U_(min)and U_(max)show different patterns under combined wave and current.The time-averaged turbulent kinetic energy(TKE)vary little under pure wave and U_(c)=±0.05 m/s conditions.With the increase of flow velocity amplitude,the time-averaged TKE shows a particularly pronounced increase trend at the top of the canopy.The vegetation drag coefficients are obtained by a calibration approach.The empirical relations of drag coefficient with Reynolds and Keulegane-Carpenter numbers are proposed to further understand the wave-current-vegetation interaction mechanism.展开更多
The objective of this research was to determine the mechanical parameter from EVA foam and also investigate its behavior by using Blatz-Ko,Neo-Hookean,Mooney model and experimental test.The physical characteristic of ...The objective of this research was to determine the mechanical parameter from EVA foam and also investigate its behavior by using Blatz-Ko,Neo-Hookean,Mooney model and experimental test.The physical characteristic of EVA foam was also evaluated by scanning electron microscopy(SEM).The results show that Blatz-Ko and Neo-Hookean model can fit the curve at 5%and 8%strain,respectively.The Mooney model can fit the curve at 50%strain.The modulus of rigidity evaluated from Mooney model is 0.0814±0.0027 MPa.The structure of EVA foam from SEM image shows that EVA structure is a closed cell with homogeneous porous structure.From the result,it is found that Mooney model can adjust the data better than other models.This model can be applied for mechanical response prediction of EVA foam and also for reference value in engineering application.展开更多
基金supported by the National Natural Science Foundation of China (No.52074330,No.52288101)。
文摘As drilling wells continue to move into deep ultra-deep layers,the requirements for temperature resistance of drilling fluid treatments are getting higher and higher.Among them,blocking agent,as one of the key treatment agents,has also become a hot spot of research.In this study,a high temperature resistant strong adsorption rigid blocking agent(QW-1)was prepared using KH570 modified silica,acrylamide(AM)and allyltrimethylammonium chloride(TMAAC).QW-1 has good thermal stability,average particle size of 1.46μm,water contact angle of 10.5.,has a strong hydrophilicity,can be well dispersed in water.The experimental results showed that when 2 wt%QW-1 was added to recipe A(4 wt%bentonite slurry+0.5 wt%DSP-1(filtration loss depressant)),the API filtration loss decreased from 7.8to 6.4 m L.After aging at 240.C,the API loss of filtration was reduced from 21 to 14 m L,which has certain performance of high temperature loss of filtration.At the same time,it is effective in sealing 80-100mesh and 100-120 mesh sand beds as well as 3 and 5μm ceramic sand discs.Under the same conditions,the blocking performance was superior to silica(5μm)and calcium carbonate(2.6μm).In addition,the mechanism of action of QW-1 was further investigated.The results show that QW-1 with amide and quaternary ammonium groups on the molecular chain can be adsorbed onto the surface of clay particles through hydrogen bonding and electrostatic interaction to form a dense blocking layer,thus preventing further intrusion of drilling fluid into the formation.
基金supported by the National Natural Science Foundation of China(Grant Nos.42120104008 and 42207198).
文摘Rigid barrier deflectors can effectively prevent overspilling landslides,and can satisfy disaster prevention requirements.However,the mechanisms of interaction between natural granular flow and rigid barrier deflectors require further investigation.To date,few studies have investigated the impact of deflectors on controlling viscous debris flows for geological disaster prevention.To investigate the effect of rigid barrier deflectors on impact mechanisms,a numerical model using the smoothed particle hydrodynamics(SPH)method with the Herschel–Bulkley model is proposed to simulate the interaction between natural viscous flow and single/dual barriers with and without deflectors.This model was validated using laboratory flume test data from the literature.Then,the model was used to investigate the influence of the deflector angle and multi-barrier arrangements.The optimal configuration of multi-barriers was analyzed with consideration to the barrier height and distance between the barriers,because these metrics have a significant impact on the viscous flow pile-up,run-up,and overflow mechanisms.The investigation considered the energy dissipation process,retention efficiency,and dead-zone formation.Compared with bare barriers with similar geometric characteristics and spatial distribution,rigid barriers with deflectors exhibit superior effectiveness in preventing the overflow and overspilling of viscous debris flow.Recommendations for the rational design of deflectors and the optimal arrangement of multi-barriers are provided to mitigate geological disasters.
基金supported by the National Natural Science Foundation of China(12071161,11971165)supported by the National Natural Science Foundation of China(11971042)the Natural Science Foundation of Zhejiang Province(Z24A010005)。
文摘By introducing the Carathéodory metric,we establish the Schwarz lemma at the boundary for holomorphic self-mappings on the unit p-ball B_(p)^(n) of C^(n).Furthermore,the boundary rigidity theorem for holomorphic self-mappings defined on B_(n)^(p) is obtained.These results cover the boundary Schwarz lemma and rigidity result for holomorphic self-mappings on the unit ball for p=2,and the unit polydisk for p=∞,respectively.
文摘The deteriorated continuous rigid frame bridge is strengthened by external prestressing. Static loading tests wereconducted before and after the bridge rehabilitation to verify the effectiveness of the rehabilitation process. Thestiffness of the repaired bridge is improved, and the maximum deflection of the load test is reduced from 37.9 to27.6 mm. A bridge health monitoring system is installed after the bridge is reinforced. To achieve an easy assessmentof the bridge’s safety status by directly using transferred data, a real-time safety warning system is createdbased on a five-level safety standard. The threshold for each safety level will be determined by theoretical calculationsand the outcomes of static loading tests. The highest risk threshold will be set at the ultimate limit statevalue. The remaining levels, namely middle risk, low risk, and very low risk, will be determined usingreduction coefficients of 0.95, 0.9, and 0.8, respectively.
文摘Pavement infrastructure is vital in providing services and links between various sectors of society. Therefore, thepreservation and maintenance of these roads are critical to attaining a pavement network in good conditionthroughout its service life. Various performance indicators like the international roughness index (IRI), pavementcondition index (PCI), and present serviceability rating (PSR) have been used by the state department of transportation (DOT) and highway agencies for evaluating pavement surface conditions and planning future maintenance strategies. Limited data availability, multiple distresses depending on region, lack of correlation of thesecondition indices to maintenance strategies, and data collection limitations pose a challenge for applying theseindices to local conditions. This paper compares condition indices of different states for rigid pavements. Further,using a specific condition index for local conditions is also highlighted. For this purpose, five states and theircorresponding condition indices were evaluated and compared to the Michigan DOT distress index (DI). Thesestates include Virginia, Minnesota, North Dakota, Louisiana, and Oregon. The corresponding distresses of eachcondition index were converted to make them compatible with the MDOT DI. This study used the MDOT'spavement management system (PMS) database to evaluate each condition index for 433 rigid pavement sections.Each distress index was plotted against MDOT DI and compared using a paired t-test. Results show that thecondition indices of Virginia and Minnesota are comparable to DI in terms of the Spearman correlation value. Thet-test results show that except for Virgina, condition indices from other states statistically differ from DI.Therefore, one can't use those directly for local conditions in Michigan. This paper presents the evaluation anddata requirements for each condition index and its impact on selecting a maintenance treatment.
文摘In this study,an iterative-based three-dimensional finite element lower bound in association with the second-order cone programming method is adopted to evaluate the limit load of a single pile embedded in cross-anisotropic soils under general loading condition.The lower bound solutions of the pile embedded in an anisotropic soil deposit can be found by formulating the element equilibrium,equilibrium of shear and normal stresses along discontinuities,boundary conditions,yield function,and optimizing the objective function through the second-order cone programming method in conjunction with an iterative-based update procedure.A general loading condition is considered to profile the expansion of the safe load in the vertical-horizontal-moment(V-H-M)space.The results of this study are compared and validated against three different cases including an isotropic lateral loading,anisotropic end bearing capacity,and a pile embedded in an isotropic soil deposit under general loading condition.A parametric study is conducted to evaluate the impact of different influencing factors.It was found that the effect of anisotropy on the variation of lateral limit load of a single pile is more pronounced than the corresponding vertical and bending moment limit loads,whereas the interface properties have more significant effects on the vertical and bending moment limit loads in comparison to the lateral limit load.
基金sponsored by the National Natural Science Foundation of China(82202767)。
文摘Osteosarcoma(OS)is the most common primary malignant pediatric bone tumor and is characterized by high heterogeneity.Studies have revealed a wide range of phenotypic differences among OS cell lines in terms of their in vivo tumorigenicity and in vitro colony-forming abilities.However,the underlying molecular mechanism of these discrepancies remains unclear.The potential role of mechanotransduction in tumorigenicity is of particular interest.To this end,we tested the tumorigenicity and anoikis resistance of OS cell lines both in vitro and in vivo.We utilized a sphere culture model,a soft agar assay,and soft and rigid hydrogel surface culture models to investigate the function of rigidity sensing in the tumorigenicity of OS cells.Additionally,we quantified the expression of sensor proteins,including four kinases and seven cytoskeletal proteins,in OS cell lines.The upstream core transcription factors of rigidity-sensing proteins were further investigated.We detected anoikis resistance in transformed OS cells.The mechanosensing function of transformed OS cells was also impaired,with general downregulation of rigidity-sensing components.We identified toggling between normal and transformed growth based on the expression pattern of rigidity-sensing proteins in OS cells.We further uncovered a novel TP53 mutation(R156P)in transformed OS cells,which acquired gain of function to inhibit rigidity sensing,thus sustaining transformed growth.Our findings suggest a fundamental role of rigidity-sensing components in OS tumorigenicity as mechanotransduction elements through which cells can sense their physical microenvironment.In addition,the gain of function of mutant TP53 appears to serve as an executor for such malignant programs.
基金Project supported by the Guangdong Basic and Applied Basic Research Foundation of China(Nos.2022A1515010801 and 2023A1515012641)the Shenzhen Science and Technology Program of China(Nos.JCYJ20220818102409020 and GXWD20220811165158003)。
文摘The transient and static anti-plane problem of a rigid line inclusion pulled out from an elastic medium is studied.The singular integral equation method is used to solve the stress field.Under the static load,the stress intensity factor(SIF)at the inclusion tips increases with the medium length.The problem becomes equivalent to an inclusion in a medium with an infinite length when the length of the medium is 3.5times longer than that of the inclusion.However,under the transient load,the maximum value of the SIF occurs when the medium length is about two times the inclusion length.Besides,the relation between the pull-out force and the anti-plane displacement is given.The conclusions are useful in guiding the design of fiber reinforced composite materials.
基金National Natural Science Foundation of China under Grant No.51978397。
文摘This paper describes the quasi-static testing and analytical modelling of the hysteretic behavior of aluminum alloy rigid bus-flexible connectors of 220 kV electrical substations.The main objective of the study is to experimentally investigate the hysteretic behavior of six different types of rigid bus-flexible connectors 220 kV electrical substations when subjected to cyclic loading.Another objective is to theoretically study the flexibility and effectiveness of a previously proposed analytical model in fitting the experimental hysteresis loops of the tested rigid bus-flexible connectors.The experimental investigation indicates that the tested rigid bus-flexible connectors exhibit highly asymmetric hysteresis behavior along with tension stiffening effect.The theoretical study demonstrates that the generalized Bouc-Wen model has high flexibility and is effective in fitting the experimental hysteresis resisting force-displacement curves of the six tested rigid bus-flexible connectors.
基金supported by the National Natural Science Foundation of China(11531012,12071424,12171423)the Scientific Research Project of Shaoxing University(2021LG016)。
文摘In this paper,we mainly study the global rigidity theorem of Riemannian submanifolds in space forms.Let Mn(n≥3)be a complete minimal submanifold in the unit sphere Sn+p(1).Forλ∈[0,n2−1/p),there is an explicit positive constant C(n,p,λ),depending only on n,p,λ,such that,if∫MSn/2dM<∞,∫M(S−λ)n/2+dM<C(n,p,λ),then Mn is a totally geodetic sphere,where S denotes the square of the second fundamental form of the submanifold and∫+=max{0,f}.Similar conclusions can be obtained for a complete submanifold with parallel mean curvature in the Euclidean space Rn+p.
文摘Based on the as-built load test of a large bridge,this paper introduces the procedure of the prestressed concrete continuous rigid frame bridge load test.Numerical analysis of the bridge was carried out by simulating and establishing a finite element model,and comparative analysis was carried out with the measured values.The results show that the calculated values were basically consistent with the measured values,which showed that the establishment method of the model was reasonable,and the mechanical performance of the bridge met the service requirements of the designed live load.
文摘The fatigue of concrete structures will gradually appear after being subjected to alternating loads for a long time,and the accidents caused by fatigue failure of bridge structures also appear from time to time.Aiming at the problem of degradation of long-span continuous rigid frame bridges due to fatigue and environmental effects,this paper suggests a method to analyze the fatigue degradation mechanism of this type of bridge,which combines long-term in-site monitoring data collected by the health monitoring system(HMS)and fatigue theory.In the paper,the authors mainly carry out the research work in the following aspects:First of all,a long-span continuous rigid frame bridge installed with HMS is used as an example,and a large amount of health monitoring data have been acquired,which can provide efficient information for fatigue in terms of equivalent stress range and cumulative number of stress cycles;next,for calculating the cumulative fatigue damage of the bridge structure,fatigue stress spectrum got by rain flow counting method,S-N curves and damage criteria are used for fatigue damage analysis.Moreover,it was considered a linear accumulation damage through the Palmgren-Miner rule for the counting of stress cycles.The health monitoring data are adopted to obtain fatigue stress data and the rain flow counting method is used to count the amplitude varying fatigue stress.The proposed fatigue reliability approach in the paper can estimate the fatigue damage degree and its evolution law of bridge structures well,and also can help bridge engineers do the assessment of future service duration.
文摘The two kinds of rigid polyurethane (PU) foams were prepared with respectively adding the refined alkali lignin and alkali lignin modified by 3-chloro-1,2-epoxypropane to be instead of 15% of the polyether glycol in weight. The indexes of mechanical performance, apparent density, thermal stability and aging resistance were separately tested for the prepared PU foams. The results show that the mechanical property, thermal insulation and thermal stability for PU foam with modified alkali lignin are excellent among two kinds of PU foams and control samples. The additions of the refined alkali lignin and modified alkali lignin to PU foam have little effect on the natural aging or heat aging resistance except for decreasing hot alkali resistance apparently. Additionally, the thermal conductivity of modified alkali lignin PU foam is lowest among two kinds of PU foams and control samples. The alkali lignin PU foam modified by 3-chloro-1,2-epoxypropane could be applied in the heat preservation field.
基金Project (201012200094) supported by the Freedom Exploration Program of Central South University of ChinaProject (20090461022) supported by the China Postdoctoral Science FoundationProject (2010ZJ05) supported by the Science and Technology supporting Program of Xinjiang Production and Construction Corps in China
文摘A general analytical method to calculate the passive rigid retaining wall pressure was deduced considering all displacement modes. First, the general displacement mode function was setup, then the hypotheses were made that the lateral passive pressure is linear to the corresponding horizontal displacement and the soil behind retaining wall is composed of a set of springs and ideal rigid plasticity body, the general analytical method was proposed to calculate the passive rigid retaining wall pressure based on Coulomb theory. The analytical results show that the resultant forces of the passive earth pressure are equal to those of Coulomb's theory, but the distribution of the passive pressure and the position of the resultant force depend on the passive displacement mode parameter, and the former is a parabolic function of the soil depth. The analytical results are also in good agreement with the experimental ones.
基金The Natural Science Foundation of Jiangsu Province(NoBK2002061)
文摘A novel seismic design method, namely split-pier seismic design, is proposed. A vertical gap and connect elements are set in split-piers. The lateral stiffness of piers is reduced by cracking of the connect elements under severe earthquake, and the seismic response of bridges is reduced by avoiding the site predominant periods. A model of tied-arch rigid frame bridge with split-piers was designed. Seismic performance was investigated by pseudo-static experimentation on the scale model, The failure process of split-piers, the hysteresis characteristic and the effect of split-piers on the superstructure are presented. Results show that the split-pier has better seismic performance than common ductile piers do.
基金partially supported by the Japan Society for the Promotion of Science Grants-in-Aid for Scientific Research(KAKENHI,Grant numbers 23H02865[to KK],23K14927[to CA])the Brain/MINDS Beyond program of the Japan Agency for Medical Research and Development(Grant Number JP19dm0307101[to KK])。
文摘Parkinson's disease(PD)is a progressive neurodegenerative disorder characterized primarily by classical motor signs of bradykinesia,rigidity,tremors,and postural instability usually manifesti ng unilate rally or at least asymmetrically.The disease involves a loss of dopaminergic neurons projecting from the substantia nigra pars compacta to the dorsal striatum.
基金supported in part by the research grant from the National Institute of Neurological Disorders and Stroke,No.R01NS 12137 (to HYC)funded in whole or in part by Aligning Science Across Parkinson's (No.ASA P-0205 720) through the Michael J.Fox Foundation for Parkinson's Research (MJFF)。
文摘Parkinson's disease is a chronic and progressive neurodegenerative disorder characterized by the loss of dopaminergic neurons in the substantia nigra pars compacta,which leads to the featured motor impairment of parkinsonism,including akinesia,bradykinesia,rigidity,and tremor(McGregor and Nelson,2019).
基金financially supported by the National Key Research and Development Program of China(2023YFC3208501)the National Natural Science Foundation of China(Grant Nos.U2340225,51979172)+2 种基金the Nanjing Hydraulic Research Institute Special Fund for Basic Scientific Research of Central Public Research Institutes(Y223002,Y220013)the CRSRI Open Research Program(Grant No.CKWV20221007/KY)the Post-Three Gorges Sediment Research Project of MWR(ProjectⅢ:Impact and Countermeasures of the Three Gorges Project on the Stability of the Shoal and Channel and Habitat of Yangtze River Estuary)。
文摘A set of laboratory experiments are carried out to investigate the effect of following/opposing currents on wave attenuation.Rigid vegetation canopies with aligned and staggered configurations were tested under the condition of various regular wave heights and current velocities,with the constant water depth being 0.60 m to create the desired submerged scenarios.Results show that the vegetation-induced wave dissipation is enhanced with the increasing incident wave height.A larger velocity magnititude leads to a greater wave height attenuation for both following and opposing current conditions.Moreover,there is a strong positive linear correlation between the damping coefficientβand the relative wave height H_(0)/h,especially for pure wave conditions.For the velocity profile,the distributions of U_(min)and U_(max)show different patterns under combined wave and current.The time-averaged turbulent kinetic energy(TKE)vary little under pure wave and U_(c)=±0.05 m/s conditions.With the increase of flow velocity amplitude,the time-averaged TKE shows a particularly pronounced increase trend at the top of the canopy.The vegetation drag coefficients are obtained by a calibration approach.The empirical relations of drag coefficient with Reynolds and Keulegane-Carpenter numbers are proposed to further understand the wave-current-vegetation interaction mechanism.
基金supported by grants funded by Department of Mechanical Engineering,Faculty of Engineering,Chiang Mai University and the Graduate School of Chiang Mai University.
文摘The objective of this research was to determine the mechanical parameter from EVA foam and also investigate its behavior by using Blatz-Ko,Neo-Hookean,Mooney model and experimental test.The physical characteristic of EVA foam was also evaluated by scanning electron microscopy(SEM).The results show that Blatz-Ko and Neo-Hookean model can fit the curve at 5%and 8%strain,respectively.The Mooney model can fit the curve at 50%strain.The modulus of rigidity evaluated from Mooney model is 0.0814±0.0027 MPa.The structure of EVA foam from SEM image shows that EVA structure is a closed cell with homogeneous porous structure.From the result,it is found that Mooney model can adjust the data better than other models.This model can be applied for mechanical response prediction of EVA foam and also for reference value in engineering application.