Background: Preterm labor is a serious cause of neonatal morbidity and mortality. This study aims to compare the effects of nifedipine, Magnesium sulfate and ritodrine as tocolytic drugs in patients presented with thr...Background: Preterm labor is a serious cause of neonatal morbidity and mortality. This study aims to compare the effects of nifedipine, Magnesium sulfate and ritodrine as tocolytic drugs in patients presented with threatened preterm labor. Patients and Methods: The current study was randomized controlled trial conducted in Sohag Teaching Hospital between November 2015 and September 2016. Patients were divided into: Group A: 101 patients received intravenous ritodrine infusion;Group B: 101 patients received intravenous magnesium sulfate;Group C: 101 patients received oral nifedipine. Different maternal and neonatal outcomes were assessed. Results: The baseline criteria were homogenous among the study groups with no statistically significant differences. There is no difference between each other group regarding the need for additional tocolysis or the rate of recurrence of labour pains. Nifedipine was associated with the least length of hospital stay. There is no difference between all groups regarding the rate of preterm delivery before full steroid dose (p > 0.05). However, nifedipine group was the least one in the rate of occurrence of preterm delivery within 7 days from initiation of tocolytic therapy. Similarly, nifedipine group was associated with higher gestational age at delivery and significant prolongation of pregnancy than the other groups. Conclusion: Oral nifedipine use was associated with less recurrence of labor pains, less need for additional tocolysis, less duration of hospital stay, and more patient satisfaction in patients with threatened preterm labour.展开更多
BACKGROUND Preterm birth accounts for about 12%of all pregnancies worldwide and is the leading cause of neonatal morbidity and mortality.In order to avoid premature birth and prolong gestational age,tocolytics are the...BACKGROUND Preterm birth accounts for about 12%of all pregnancies worldwide and is the leading cause of neonatal morbidity and mortality.In order to avoid premature birth and prolong gestational age,tocolytics are the first and the best choice.Ritodrine is the most commonly used tocolytic medication.However,side effects such as pulmonary edema,hypokalemia,and hyperglycemia are known.Here we report a rare but serious side effect–toxic epidermal necrolysis(TEN)–caused by ritodrine.CASE SUMMARY A woman(31 years,gravida 4,para 2)was hospitalized because of premature contractions at 27+6 wk of gestation.A skin rash with pruritus appeared at 32+3 wk of gestation after administration of ritodrine,indomethacin,and dexamethasone,and it spread throughout the whole body in 3 d,particularly the four limbs.After 11 d’treatment,she was diagnosed with TEN.An emergency cesarean section was performed immediately to deliver the baby and intensive symptomatic treatment was promptly commenced after delivery.She recovered from the severe condition without any sequelae except for slight pigmentation after symptomatic treatment.CONCLUSION When a skin rash appears during the administration of ritodrine,we are supposed to consider the risk of TEN.展开更多
Objective:To evaluate the possible effects of ritodrine on the heart structure and function of pregnant women who had threat of preterm birth by echocardiography.Methods:From September 2012 to December 2018,totally 11...Objective:To evaluate the possible effects of ritodrine on the heart structure and function of pregnant women who had threat of preterm birth by echocardiography.Methods:From September 2012 to December 2018,totally 112 women in the second and third trimester pregnancy with sign and symptom of preterm birth were included,and those with contraindication to ritodrine and other several diseases were excluded.Firstly they were divided into four groups according to the time of medication and number of fetuses:Group A:Twin pregnancy,the first time of ritodrine medication was in 48 h;Group B:Twin pregnancy,the last time of ritodrine medication;Group C:Single pregnancy,the first time of ritodrine medication was in 48 h;Group D:Single pregnancy,the last time of ritodrine medication.Secondly,singleton pregnancies were divided into four groups according to the time of ritodrine medication and the age of pregnant women:Group E:Single pregnancy of age 21-34 years old,the first time of ritodrine medication was in 48 h;Group F:Single pregnancy of age 21-34 years old,the last time of ritodrine medication;Group G:Single pregnancy of age 35-49 years old,the first time of ritodrine medication was in 48h;Group H:Single pregnancy of age 35-49 years old,the last time of ritodrine medication.Ehocardiography were used to examine the hearts of pregnant women,and relevant parameters were filed,including LAD1,LAD2,LVD,RA,RVD,IVST,LVPWT,EF,E,A,AVmax,TRVmax,and PE.Results:Comparing the heart parameters between group A and group B,there were no significant difference(all P>0.05);there were significant differences of LAD1,LVD,and EF between group A and group C(P<0.05);there was significant difference in E between group C and group D(P<0.05);Comparing group E with group G,there was only significant difference in PE(P<0.05);Comparing with group H,LVD,E,and TRVmax in group F,there were significant differences(P<0.05).Comparing the rest items,there was no significant difference(all P>0.05).Conclusion:The treatment of preterm birth using ritodrine may bring effect on the heart structure and function of pregnant women,and echocardiography can early find and assess the changes of maternal heart structure and function.展开更多
目的探析抗B族链球菌(group B Streptococcus,GBS)类抗生素联合利托君治疗对未足月胎膜早破患者宫缩抑制的影响。方法方便选取2016年5月—2021年5月福建省武夷山市中医院治疗的胎膜早破患者96例,采用电脑随机分组,将其分为参照组与治疗...目的探析抗B族链球菌(group B Streptococcus,GBS)类抗生素联合利托君治疗对未足月胎膜早破患者宫缩抑制的影响。方法方便选取2016年5月—2021年5月福建省武夷山市中医院治疗的胎膜早破患者96例,采用电脑随机分组,将其分为参照组与治疗组,各48例。参照组采取抗GBS类抗生素治疗,治疗组在参照组基础上进行利托君治疗,比较两组患者临床疗效、宫缩抑制时间和孕周延长时间、炎症指标、不良反应发生情况。结果治疗组总有效率为95.83%高于参照组的77.08%,差异有统计学意义(χ^(2)=7.207,P<0.05);治疗组宫缩抑制时间、延长孕周时间及产后出血量均优于参照组,差异有统计学意义(t=11.310、31.350、10.200,P<0.05);治疗后,治疗组NF-κBP65、TREM-1指标均低于参照组,差异有统计学意义(t=7.307、10.110,P<0.05);治疗组不良反应发生率为6.25%与参照组的10.41%比较,差异无统计学意义(P>0.05)。结论针对孕周在28~34+6周胎膜早破患者,采取抗GBS类抗生素联合利托君治疗,可以提高其疗效,改善患者的宫缩抑制时间和孕周延长时间,使其炎症指标下降,且安全性较高。展开更多
文摘Background: Preterm labor is a serious cause of neonatal morbidity and mortality. This study aims to compare the effects of nifedipine, Magnesium sulfate and ritodrine as tocolytic drugs in patients presented with threatened preterm labor. Patients and Methods: The current study was randomized controlled trial conducted in Sohag Teaching Hospital between November 2015 and September 2016. Patients were divided into: Group A: 101 patients received intravenous ritodrine infusion;Group B: 101 patients received intravenous magnesium sulfate;Group C: 101 patients received oral nifedipine. Different maternal and neonatal outcomes were assessed. Results: The baseline criteria were homogenous among the study groups with no statistically significant differences. There is no difference between each other group regarding the need for additional tocolysis or the rate of recurrence of labour pains. Nifedipine was associated with the least length of hospital stay. There is no difference between all groups regarding the rate of preterm delivery before full steroid dose (p > 0.05). However, nifedipine group was the least one in the rate of occurrence of preterm delivery within 7 days from initiation of tocolytic therapy. Similarly, nifedipine group was associated with higher gestational age at delivery and significant prolongation of pregnancy than the other groups. Conclusion: Oral nifedipine use was associated with less recurrence of labor pains, less need for additional tocolysis, less duration of hospital stay, and more patient satisfaction in patients with threatened preterm labour.
文摘BACKGROUND Preterm birth accounts for about 12%of all pregnancies worldwide and is the leading cause of neonatal morbidity and mortality.In order to avoid premature birth and prolong gestational age,tocolytics are the first and the best choice.Ritodrine is the most commonly used tocolytic medication.However,side effects such as pulmonary edema,hypokalemia,and hyperglycemia are known.Here we report a rare but serious side effect–toxic epidermal necrolysis(TEN)–caused by ritodrine.CASE SUMMARY A woman(31 years,gravida 4,para 2)was hospitalized because of premature contractions at 27+6 wk of gestation.A skin rash with pruritus appeared at 32+3 wk of gestation after administration of ritodrine,indomethacin,and dexamethasone,and it spread throughout the whole body in 3 d,particularly the four limbs.After 11 d’treatment,she was diagnosed with TEN.An emergency cesarean section was performed immediately to deliver the baby and intensive symptomatic treatment was promptly commenced after delivery.She recovered from the severe condition without any sequelae except for slight pigmentation after symptomatic treatment.CONCLUSION When a skin rash appears during the administration of ritodrine,we are supposed to consider the risk of TEN.
基金Hainan Provincial Health and Family Planning Commission Project(1601032064A2001).
文摘Objective:To evaluate the possible effects of ritodrine on the heart structure and function of pregnant women who had threat of preterm birth by echocardiography.Methods:From September 2012 to December 2018,totally 112 women in the second and third trimester pregnancy with sign and symptom of preterm birth were included,and those with contraindication to ritodrine and other several diseases were excluded.Firstly they were divided into four groups according to the time of medication and number of fetuses:Group A:Twin pregnancy,the first time of ritodrine medication was in 48 h;Group B:Twin pregnancy,the last time of ritodrine medication;Group C:Single pregnancy,the first time of ritodrine medication was in 48 h;Group D:Single pregnancy,the last time of ritodrine medication.Secondly,singleton pregnancies were divided into four groups according to the time of ritodrine medication and the age of pregnant women:Group E:Single pregnancy of age 21-34 years old,the first time of ritodrine medication was in 48 h;Group F:Single pregnancy of age 21-34 years old,the last time of ritodrine medication;Group G:Single pregnancy of age 35-49 years old,the first time of ritodrine medication was in 48h;Group H:Single pregnancy of age 35-49 years old,the last time of ritodrine medication.Ehocardiography were used to examine the hearts of pregnant women,and relevant parameters were filed,including LAD1,LAD2,LVD,RA,RVD,IVST,LVPWT,EF,E,A,AVmax,TRVmax,and PE.Results:Comparing the heart parameters between group A and group B,there were no significant difference(all P>0.05);there were significant differences of LAD1,LVD,and EF between group A and group C(P<0.05);there was significant difference in E between group C and group D(P<0.05);Comparing group E with group G,there was only significant difference in PE(P<0.05);Comparing with group H,LVD,E,and TRVmax in group F,there were significant differences(P<0.05).Comparing the rest items,there was no significant difference(all P>0.05).Conclusion:The treatment of preterm birth using ritodrine may bring effect on the heart structure and function of pregnant women,and echocardiography can early find and assess the changes of maternal heart structure and function.
文摘目的探析抗B族链球菌(group B Streptococcus,GBS)类抗生素联合利托君治疗对未足月胎膜早破患者宫缩抑制的影响。方法方便选取2016年5月—2021年5月福建省武夷山市中医院治疗的胎膜早破患者96例,采用电脑随机分组,将其分为参照组与治疗组,各48例。参照组采取抗GBS类抗生素治疗,治疗组在参照组基础上进行利托君治疗,比较两组患者临床疗效、宫缩抑制时间和孕周延长时间、炎症指标、不良反应发生情况。结果治疗组总有效率为95.83%高于参照组的77.08%,差异有统计学意义(χ^(2)=7.207,P<0.05);治疗组宫缩抑制时间、延长孕周时间及产后出血量均优于参照组,差异有统计学意义(t=11.310、31.350、10.200,P<0.05);治疗后,治疗组NF-κBP65、TREM-1指标均低于参照组,差异有统计学意义(t=7.307、10.110,P<0.05);治疗组不良反应发生率为6.25%与参照组的10.41%比较,差异无统计学意义(P>0.05)。结论针对孕周在28~34+6周胎膜早破患者,采取抗GBS类抗生素联合利托君治疗,可以提高其疗效,改善患者的宫缩抑制时间和孕周延长时间,使其炎症指标下降,且安全性较高。
