Ribonuclease P(RNase P)was first described in the 1970’s as an endoribonuclease acting in the maturation of precursor transfer RNAs(tRNAs).More recent studies,however,have uncovered non-canonical roles for RNase P an...Ribonuclease P(RNase P)was first described in the 1970’s as an endoribonuclease acting in the maturation of precursor transfer RNAs(tRNAs).More recent studies,however,have uncovered non-canonical roles for RNase P and its components.Here,we review the recent progress of its involvement in chromatin assembly,DNA damage response,and maintenance of genome stability with implications in tumorigenesis.The possibility of RNase P as a therapeutic target in cancer is also discussed.展开更多
基金supported by the National Natural Science Foundation of China(Grant No.32090031)the Shenzhen Science and Technology Innovation Commission(Grant Nos.JCYJ20220818095616035 and JCYJ201805073000163).
文摘Ribonuclease P(RNase P)was first described in the 1970’s as an endoribonuclease acting in the maturation of precursor transfer RNAs(tRNAs).More recent studies,however,have uncovered non-canonical roles for RNase P and its components.Here,we review the recent progress of its involvement in chromatin assembly,DNA damage response,and maintenance of genome stability with implications in tumorigenesis.The possibility of RNase P as a therapeutic target in cancer is also discussed.
