Multisensory mechanisms of gait and balance in Parkinson’s disease:an integrative review

Understanding the neural underpinning of human gait and balance is one of the most pertinent challenges for 21st-century translational neuroscience due to the profound impact that falls and mobility disturbances have on our aging population.Posture and gait control does not happen automatically,as previously believed,but rather requires continuous involvement of central nervous mechanisms.To effectively exert control over the body,the brain must integrate multiple streams of sensory information,including visual,vestibular,and somatosensory signals.The mechanisms which underpin the integration of these multisensory signals are the principal topic of the present work.Existing multisensory integration theories focus on how failure of cognitive processes thought to be involved in multisensory integration leads to falls in older adults.Insufficient emphasis,however,has been placed on specific contributions of individual sensory modalities to multisensory integration processes and cross-modal interactions that occur between the sensory modalities in relation to gait and balance.In the present work,we review the contributions of somatosensory,visual,and vestibular modalities,along with their multisensory intersections to gait and balance in older adults and patients with Parkinson’s disease.We also review evidence of vestibular contributions to multisensory temporal binding windows,previously shown to be highly pertinent to fall risk in older adults.Lastly,we relate multisensory vestibular mechanisms to potential neural substrates,both at the level of neurobiology(concerning positron emission tomography imaging)and at the level of electrophysiology(concerning electroencephalography).We hope that this integrative review,drawing influence across multiple subdisciplines of neuroscience,paves the way for novel research directions and therapeutic neuromodulatory approaches,to improve the lives of older adults and patients with neurodegenerative diseases.

Study on Characteristics of 3-D Translating-Pulsating Source Green Function of Deep-Water Havelock Form and Its Fast Integration Method

The singularities, oscillatory performances and the contributing factors to the 3-＇D translating-pulsating source Green function of deep-water Havelock form which consists of a local disturbance part and a far-field wave-like part, are analyzed systematically. Relative numerical integral methods about the two parts are presented in this paper. An improved method based on LOBATTO rule is used to eliminate singularities caused respectively by infinite discontinuity and jump discontinuous node from the local disturbance part function, which makes the improvement of calculation efficiency and accuracy possible. And variable substitution is applied to remove the singularity existing at the end of the integral interval of the far-field wave-like part function. Two auxiliary techniques such as valid interval calculation and local refinement of integral steps technique in narrow zones near false singularities are applied so as to avoid unnecessary integration of invalid interval and improve integral accordance. Numerical test results have proved the efficiency and accuracy in these integral methods that thus can be applied to calculate hydrodynamic performance of floating structures moving in waves.

Integration and implementation of precision medicine in the multifaceted inflammatory bowel disease

Inflammatory bowel disease(IBD)is a complex disease with variability in genetic,environmental,and lifestyle factors affecting disease presentation and course.Precision medicine has the potential to play a crucial role in managing IBD by tailoring treatment plans based on the heterogeneity of clinical and temporal variability of patients.Precision medicine is a population-based approach to managing IBD by integrating environmental,genomic,epigenomic,transcriptomic,proteomic,and metabolomic factors.It is a recent and rapidly developing medicine.The widespread adoption of precision medicine worldwide has the potential to result in the early detection of diseases,optimal utilization of healthcare resources,enhanced patient outcomes,and,ultimately,improved quality of life for individuals with IBD.Though precision medicine is promising in terms of better quality of patient care,inadequacies exist in the ongoing research.There is discordance in study conduct,and data collection,utilization,interpretation,and analysis.This review aims to describe the current literature on precision medicine,its multiomics approach,and future directions for its application in IBD.

Solving Large Scale Nonlinear Equations by a New ODE Numerical Integration Method

In this paper a new ODE numerical integration method was successfully applied to solving nonlinear equations. The method is of same simplicity as fixed point iteration, but the efficiency has been significantly improved, so it is especially suitable for large scale systems. For Brown’s equations, an existing article reported that when the dimension of the equation N = 40, the subroutines they used could not give a solution, as compared with our method, we can easily solve this equation even when N = 100. Other two large equations have the dimension of N = 1000, all the existing available methods have great difficulties to handle them, however, our method proposed in this paper can deal with those tough equations without any difficulties. The sigularity and choosing initial values problems were also mentioned in this paper.

Unifying the theory of integration within normal-,Weyl- and antinormal-ordering of operators and the s-ordered operator expansion formula of density operators

By introducing the s-parameterized generalized Wigner operator into phase-space quantum mechanics we invent the technique of integration within s-ordered product of operators （which considers normally ordered, antinormally ordered and Weyl ordered product of operators as its special cases）. The s-ordered operator expansion （denoted by s…s ） formula of density operators is derived, which isρ=2/1-s∫d^2β/π〈-β｜ρ｜β〉sexp{2/s-1（s｜β｜^2-β＊α＋βa-αα）}s The s-parameterized quantization scheme is thus completely established.

Inevitability and Emergent Problems of Science &Technology Innovation Access to Integration

The causes and the problems of integration of scientific ＆ technical innovation （ISTI） and inevitability are proposed. The status of domestic scientific ＆ technical innovation is analysed. A series of emergent managerial problems caused by the system ISTI （SISTI） are pointed out. Because of Hall three dimensions structure＇s enlightenment, a three dimensional logical net diagram in which the system integration of innovation based on problem in real world but not on disciplinary logic is drawn. The intelligent group＇ s need span is greater under the conditions of relatively low material level than common groups who have lower degree of education. The SISTI is composed by multi-rule and intelligent multi-agent behavior. It is concluded that the logical relationships of integrated technology which based on the author＇s experience and observation must be considerded for a valid management of SISTI.

Reduction of signal reflection along through silicon via channel in high-speed three-dimensional integration circuit

The through silicon via （TSV） technology has proven to be the critical enabler to realize a three-dimensional （3D） gigscale system with higher performance but shorter interconnect length. However, the received digital signal after trans- mission through a TSV channel, composed of redistribution layers （RDLs）, TSVs, and bumps, is degraded at a high data-rate due to the non-idealities of the channel. We propose the Chebyshev multisection transformers to reduce the signal reflec- tion of TSV channel when operating frequency goes up to 20 GHz, by which signal reflection coefficient （$11） and signal transmission coefficient （$21） are improved remarkably by 150% and 73.3%, respectively. Both the time delay and power dissipation are also reduced by 4% and 13.3%, respectively. The resistance-inductance-conductance-capacitance （RLGC） elements of the TSV channel are iterated from scattering （S）-parameters, and the proposed method of weakening the signal reflection is verified using high frequency simulator structure （HFSS） simulation software by Ansoft.

The Generalization on Inequalities of Hermite-Hadamard's Integration

Some new inequalities of Hermite-Hadamard's integration are established. As for as inequalities about the righthand side of the classical Hermite-Hadamard's integral inequality refined by S Qaisar in [3], a new upper bound is given. Under special conditions,the bound is smaller than that in [3].

U.S. National Strategy: betweem Offensive and Integration

As the hegemonic country in the world system, U. S. national strategy is global and multi-directional. Since September 11, 2001, America has made series of adjustments in its global strategy, including adjustment in security focus and change of security means. Come what may, since America has become the superpower in the world system, its national strategy has always been between offensive and integration. In a sense, current American strategy is the combination of the two. Although different government would tilt toward one direction, none

Coordinated development of Yunnan's frontier culture and economy under the regional economic integration pattern

This paper constructs the index system by means of quantitative analysis. We choose the coordination degree of Yunnan province from 2012 to 2015. The regional cultural and economic development in Yunnan's frontier are analyzed so that we can provide the reference for the sustainable development of Yunnan's frontier and realize the coordinated development of culture in Yunnan's frontier and economic system in order. The results show that the culture and economy in Yunnan's frontier are coupled with formation of the coordinated development of culture and economy; economic development is the main reason to promote the coordinated development of culture and economy in Yunnan's frontier, and it contributes to the main force of improving the coordinated development of evolution types; the coordinated development degree of the overall level is low and still in the China's backward level.

The Use of Curriculum Integration in ELT within Secondary Schools in China

CTMRC - Curriculum and Teaching Materials Reform Commission; CTMRI - Curriculum and Teaching Materials Research Institute; ELT - English Language Teaching; MOE - Ministry of Education;

Study on the Current Situation of Urban Integration of Aboveground Space and Underground Space:Under the Background of China’s Land Spatial Planning

Urban underground public space has a synergistic effect with its surrounding urban aboveground functions or facilities,which reflects the complementarity between underground functions and urban functions.The research analyses the degree of integration through the case study of urban aboveground space and underground space in China.The research method of this paper will give different evaluation criteria to public transport and public space and the influencing factors of space integration.The indicators of public transport include the number of subway lines and underground parking spaces.The evaluation standard of public space is the area of underground space and the number of floors of underground space.The subway entrance and exits are selected as the evaluation index for the aboveground and underground transition space.Through the specific analysis of 7 selected cases,it provides arguments for the research.The average rent in the case is taken as the dependent variable.Through the regression model,the influencing factors of the integration of aboveground and underground space are determined.The purpose of the study is to explore the influencing factors of the integration of aboveground space and underground space,and how to optimize the integration of aboveground and underground space.

Analysis of Migrant Population's Social Integration in Hangzhou

Since China began implementing reform and opening-up policies, along with a fast development of the national economy and great changes of social life, an increasing number of peasan＇s have kept flowing into cities and economically more developed regions. Aspiring to improve their life and yearning for a better urban life, they defy the restraint of the household registry system and, in the process of moving from one place to another, ignore economic and psychological costs. As early as in year 2000 China＇s migrant population reached 140 million, more than 10% of the total population. Since 2000 the migrant poptilation in Zhejiang Province, east China, has kept growing by 20% annually, the second fastest in the country for seven consecutive years.

New Majorized Results on Hilbert's Integral Inequality

In this paper, some new majorized results on Hilbert’s integral inequality are showed.

AN NUMERICAL ALGORI THM FOR LAPLACE′S INTEGRAL BY B-SPLINE

Algorithm for Laplace ′s integral is given when the inverse image function has high order discontinui ty. The multi-node technique of B-spline is used to describe the interruption point, cusp and non-smooth point of the inverse image function. The difference quotient and de Boor algorithm are used to derive the image function of the Lapl ace′s integral under non-uniform partition. And a set of practical formula is got when the partition is quasi-uniform. The scheme enables the image function to be approximated within any prescribed tolerance. Experiments also show that g ood result is achieved. It is much faster than that of Simpsons rule, and much s impler than that of Berge method, the traditional efficient method. It is no lon ger to find the zero points and coefficients of Gauss-Laguerre or Gauss-Legend re polynomials. The image function of Laplace′s integral can also be computed while the inverse image function is hyper-function with high order discontinuity.

教育硕士产教融合“U-G-S&E”育人模式探析

产教融合是教育与产业的深度合作,我国产教融合的政策经历了从职业教育到普通教育的发展。产教融合符合教育硕士人才培养的逻辑,“U-G-S&E”育人模式以高校为主导,政府提供政策引导和资金支持,中小学和企业协同参与教育硕士的培养。通过实践探索发现,“U-G-S&E”模式可以更好地激发学生提升职业能力的动力,助力学生职业生涯规划和就业,提升以赛赋能的效果,帮助高校校内导师、中小学和企业的校外导师加深对教育链、人才链与产业链、创新链有机衔接的理解,助力孵化本地企业参与遴选国家产教融合型企业,推动本地企业更好的融入国家现代教育体系建设。

AN INTEGRAL ESTIMATE AND THE EQUIVALENT NORMS ON F(p, q, s, k) SPACES IN THE UNIT BALL

In this article, the authors give a typical integral＇s bidirectional estimates for allcases. At the same time, several equivalent characterizations on the F（p, q, s, k） space in theunit ball of Cn are given.

Integral Inequalities of Hermite-Hadamard Type for Functions Whose 3rd Derivatives Are <i>s</i>-Convex

In the paper, the authors find some new inequalities of Hermite-Hadamard type for functions whose third derivatives are s-convex and apply these inequalities to discover inequalities for special means.

The discrete variational principle and the first integrals of Birkhoff systems＊

This paper shows that first integrals of discrete equation of motion for Birkhoff systems can be determined explicitly by investigating the invariance properties of the discrete Pfaffian. The result obtained is a discrete analogue of theorem of Noether in the calculus of variations. An example is given to illustrate the application of the results.

Functional Integrals and Excitation Energy in Three-Band Hubbard Model

The normal and anomalous Green＇s functions of antiferromagnetie state in three-band Hubbard model are studied by using functional integrals and temperature Green＇s function method. The equations of energy spectrum are derived. In addition, excitation energy of Fermi fields are calculated under long wave approximation.