Magnetron-sputter deposition was used to produce Ti-48Al-8Cr-2Ag coating on a cast alloy substrate with the same composition. Hot corrosion was carried out in molten (Na,K)2SO4 and Na2SO4+NaCl at 900 ℃. The sputtered...Magnetron-sputter deposition was used to produce Ti-48Al-8Cr-2Ag coating on a cast alloy substrate with the same composition. Hot corrosion was carried out in molten (Na,K)2SO4 and Na2SO4+NaCl at 900 ℃. The sputtered nanocrystalline coating shows much better hot-corrosion resistance in molten (Na,K)2SO4 as a result of the formation of a continuous and compact Al2O3 scale. The nanocrystallization of TiAlCrAg alloy prolongs the incubation of breakaway corrosion and improves the hot-corrosion resistance of TiAlCrAg alloy in molten Na2SO4+NaCl. The relevant corrosion mechanism was discussed.展开更多
The effects of aging temperature on shape memory effect, mechanical properties and microstruc-ture of Fe-14Mn-5Si-8Cr-4Ni-0.2C shape memory alloy have been studied. The results showed that the second phase particles r...The effects of aging temperature on shape memory effect, mechanical properties and microstruc-ture of Fe-14Mn-5Si-8Cr-4Ni-0.2C shape memory alloy have been studied. The results showed that the second phase particles rich in chromium, manganese and silicon precipitate during aging, and thereby increase the hardness and strength of the alloy. The shape recovery ratio can be remarkably improved by aging and a maximum value can be obtained at 1223 K, which is 68% higher than that of the specimen in solid solution state. When the aging temperature is below 1223 K, the amount of second phase particles increases as the aging temperature increases. The size of austenite grain increases with increasing aging temperature. When the temperature is over 1223 K, the second phase particles can not precipitate. The lack of second phase particles and the increase of grain size make the hardness and shape recovery ratio drastically decrease, when the temperature is over 1223 K.展开更多
Traumatic brain injury induces secondary injury that contributes to neuroinflammation, neuronal loss, and neurological dysfunction. One important injury mechanism is cell cycle activation which causes neuronal apoptos...Traumatic brain injury induces secondary injury that contributes to neuroinflammation, neuronal loss, and neurological dysfunction. One important injury mechanism is cell cycle activation which causes neuronal apoptosis and glial activation. The neuroprotective effects of both non-selective （Flavopiridol） and selective （Roscovitine and CR-8） cyclin-dependent kinase inhibitors have been shown across mukiple experimental traumatic brain injury models and species. Cyclin-depen- dent kinaseinhibitors, administered as a single systemic dose up to 24 hours after traumatic brain injury, provide strong neuroprotection-reducing neuronal cell death, neuroinflammation and neurological dysfunction. Given their effectiveness and long therapeutic window, cyclin-dependent kinase inhibitors appear to be promising candidates for clinical traumatic brain injury trials.展开更多
基金Project(59971052) supported by the National Natural Science Foundation of China
文摘Magnetron-sputter deposition was used to produce Ti-48Al-8Cr-2Ag coating on a cast alloy substrate with the same composition. Hot corrosion was carried out in molten (Na,K)2SO4 and Na2SO4+NaCl at 900 ℃. The sputtered nanocrystalline coating shows much better hot-corrosion resistance in molten (Na,K)2SO4 as a result of the formation of a continuous and compact Al2O3 scale. The nanocrystallization of TiAlCrAg alloy prolongs the incubation of breakaway corrosion and improves the hot-corrosion resistance of TiAlCrAg alloy in molten Na2SO4+NaCl. The relevant corrosion mechanism was discussed.
文摘The effects of aging temperature on shape memory effect, mechanical properties and microstruc-ture of Fe-14Mn-5Si-8Cr-4Ni-0.2C shape memory alloy have been studied. The results showed that the second phase particles rich in chromium, manganese and silicon precipitate during aging, and thereby increase the hardness and strength of the alloy. The shape recovery ratio can be remarkably improved by aging and a maximum value can be obtained at 1223 K, which is 68% higher than that of the specimen in solid solution state. When the aging temperature is below 1223 K, the amount of second phase particles increases as the aging temperature increases. The size of austenite grain increases with increasing aging temperature. When the temperature is over 1223 K, the second phase particles can not precipitate. The lack of second phase particles and the increase of grain size make the hardness and shape recovery ratio drastically decrease, when the temperature is over 1223 K.
文摘Traumatic brain injury induces secondary injury that contributes to neuroinflammation, neuronal loss, and neurological dysfunction. One important injury mechanism is cell cycle activation which causes neuronal apoptosis and glial activation. The neuroprotective effects of both non-selective （Flavopiridol） and selective （Roscovitine and CR-8） cyclin-dependent kinase inhibitors have been shown across mukiple experimental traumatic brain injury models and species. Cyclin-depen- dent kinaseinhibitors, administered as a single systemic dose up to 24 hours after traumatic brain injury, provide strong neuroprotection-reducing neuronal cell death, neuroinflammation and neurological dysfunction. Given their effectiveness and long therapeutic window, cyclin-dependent kinase inhibitors appear to be promising candidates for clinical traumatic brain injury trials.
