Analysis of HAZMAT truck driver fatigue and distracted driving with warning-based data and association rules mining

Professional drivers are more frequently exposed to longer driving distance and travel time,leading to a higher possibility of safety risk for distraction and fatigue.The widespread and common use of commercial driver monitoring systems(DMS)provides a potential for data collection.It increases the amount of data characterizing driver behavior that can be used for further safety research.This study utilized DMS warning-based data and applied an association rule mining approach to explore risk factors contributing to hazardous materials(HAZMAT)truck driver inattention.A total of 499 HAZMAT truck driver inattentive warning events were used to find rules that will predict the occurrence of driver’s fatigue and distraction.First,Fisher’s exact tests were performed to examine the association between the frequency of driver inattentive behavior warnings and risk factors.Second,support,confidence,and lift values were used as measurements to quantify the relative strength of the association rules generated by the Apriori algorithm.Results show that speed between 40and 49 km/h,relatively longer travel time(3-6 h),freeway,tangent section,off-peak hour and clear weather condition are found to be highly associated with fatigue driving,while nighttime during 18:00 to 23:59,speed between 70 and 80 km/h,travel time between 1 and 3 h,freeways,acceleration less than 0.5 m/s^(2),visibility greater than 1000 m,and tangent roadway section are found to be highly associated with distracted driving.By focusing on the specific feature groups,these association rules would help in the development of mitigating distraction and fatigue driving countermeasures and enforcement approaches.

Discovering hidden patterns:Association rules for cardiovascular diseases in type 2 diabetes mellitus

BACKGROUND It is increasingly common to find patients affected by a combination of type 2 diabetes mellitus(T2DM)and coronary artery disease(CAD),and studies are able to correlate their relationships with available biological and clinical evidence.The aim of the current study was to apply association rule mining(ARM)to discover whether there are consistent patterns of clinical features relevant to these diseases.ARM leverages clinical and laboratory data to the meaningful patterns for diabetic CAD by harnessing the power help of data-driven algorithms to optimise the decision-making in patient care.AIM To reinforce the evidence of the T2DM-CAD interplay and demonstrate the ability of ARM to provide new insights into multivariate pattern discovery.METHODS This cross-sectional study was conducted at the Department of Biochemistry in a specialized tertiary care centre in Delhi,involving a total of 300 consented subjects categorized into three groups:CAD with diabetes,CAD without diabetes,and healthy controls,with 100 subjects in each group.The participants were enrolled from the Cardiology IPD&OPD for the sample collection.The study employed ARM technique to extract the meaningful patterns and relationships from the clinical data with its original value.RESULTS The clinical dataset comprised 35 attributes from enrolled subjects.The analysis produced rules with a maximum branching factor of 4 and a rule length of 5,necessitating a 1%probability increase for enhancement.Prominent patterns emerged,highlighting strong links between health indicators and diabetes likelihood,particularly elevated HbA1C and random blood sugar levels.The ARM technique identified individuals with a random blood sugar level>175 and HbA1C>6.6 are likely in the“CAD-with-diabetes”group,offering valuable insights into health indicators and influencing factors on disease outcomes.CONCLUSION The application of this method holds promise for healthcare practitioners to offer valuable insights for enhancing patient treatment targeting specific subtypes of CAD with diabetes.Implying artificial intelligence techniques with medical data,we have shown the potential for personalized healthcare and the development of user-friendly applications aimed at improving cardiovascular health outcomes for this high-risk population to optimise the decision-making in patient care.

Effective Diagnosis of Lung Cancer via Various Data-Mining Techniques

One of the leading cancers for both genders worldwide is lung cancer.The occurrence of lung cancer has fully augmented since the early 19th century.In this manuscript,we have discussed various data mining techniques that have been employed for cancer diagnosis.Exposure to air pollution has been related to various adverse health effects.This work is subject to analysis of various air pollutants and associated health hazards and intends to evaluate the impact of air pollution caused by lung cancer.We have introduced data mining in lung cancer to air pollution,and our approach includes preprocessing,data mining,testing and evaluation,and knowledge discovery.Initially,we will eradicate the noise and irrelevant data,and following that,we will join the multiple informed sources into a common source.From that source,we will designate the information relevant to our investigation to be regained from that assortment.Following that,we will convert the designated data into a suitable mining process.The patterns are abstracted by utilizing a relational suggestion rule mining process.These patterns have revealed information,and this information is categorized with the help of an Auto Associative Neural Network classification method(AANN).The proposed method is compared with the existing method in various factors.In conclusion,the projected Auto associative neural network and relational suggestion rule mining methods accomplish a high accuracy status.

Quantum Algorithm for Mining Frequent Patterns for Association Rule Mining

Maximum frequent pattern generation from a large database of transactions and items for association rule mining is an important research topic in data mining. Association rule mining aims to discover interesting correlations, frequent patterns, associations, or causal structures between items hidden in a large database. By exploiting quantum computing, we propose an efficient quantum search algorithm design to discover the maximum frequent patterns. We modified Grover’s search algorithm so that a subspace of arbitrary symmetric states is used instead of the whole search space. We presented a novel quantum oracle design that employs a quantum counter to count the maximum frequent items and a quantum comparator to check with a minimum support threshold. The proposed derived algorithm increases the rate of the correct solutions since the search is only in a subspace. Furthermore, our algorithm significantly scales and optimizes the required number of qubits in design, which directly reflected positively on the performance. Our proposed design can accommodate more transactions and items and still have a good performance with a small number of qubits.

Unlocking new potential of clinical diagnosis with artificial intelligence:Finding new patterns of clinical and lab data

Recent advancements in science and technology,coupled with the proliferation of data,have also urged laboratory medicine to integrate with the era of artificial intelligence(AI)and machine learning(ML).In the current practices of evidencebased medicine,the laboratory tests analysing disease patterns through the association rule mining(ARM)have emerged as a modern tool for the risk assessment and the disease stratification,with the potential to reduce cardiovascular disease(CVD)mortality.CVDs are the well recognised leading global cause of mortality with the higher fatality rates in the Indian population due to associated factors like hypertension,diabetes,and lifestyle choices.AI-driven algorithms have offered deep insights in this field while addressing various challenges such as healthcare systems grappling with the physician shortages.Personalized medicine,well driven by the big data necessitates the integration of ML techniques and high-quality electronic health records to direct the meaningful outcome.These technological advancements enhance the computational analyses for both research and clinical practice.ARM plays a pivotal role by uncovering meaningful relationships within databases,aiding in patient survival prediction and risk factor identification.AI potential in laboratory medicine is vast and it must be cautiously integrated while considering potential ethical,legal,and privacy concerns.Thus,an AI ethics framework is essential to guide its responsible use.Aligning AI algorithms with existing lab practices,promoting education among healthcare professionals,and fostering careful integration into clinical settings are imperative for harnessing the benefits of this transformative technology.

Alarm Correlation Rules Generation Algorithm Based on Confidence Covered Value

In communication alarm correlation analysis,traditional association rules generation(ARG) algorithm usually has low efficiency and high error rate.This paper proposes an alarm correlation rules generation algorithm based on the confidence covered value.Confidence covered value method can judge whether a rule is redundant or not scientific After the rules that based on weighted frequent patterns(WFPs) generated,the association rules were deleted by the confidence covered value,in order to delete the redundant rules and keep the rules with more information.Experiments show that the alarm correlation rules generation algorithm based on the confidence covered value has higher efficiency than the traditional method,and can effectively remove redundant rules.Thus it is very suitable for telecommunication alarm association rules processing.

Hydraulic metal structure health diagnosis based on data mining technology

In conjunction with association rules for data mining, the connections between testing indices and strong and weak association rules were determined, and new derivative rules were obtained by further reasoning. Association rules were used to analyze correlation and check consistency between indices. This study shows that the judgment obtained by weak association rules or non-association rules is more accurate and more credible than that obtained by strong association rules. When the testing grades of two indices in the weak association rules are inconsistent, the testing grades of indices are more likely to be erroneous, and the mistakes are often caused by human factors. Clustering data mining technology was used to analyze the reliability of a diagnosis, or to perform health diagnosis directly. Analysis showed that the clustering results are related to the indices selected, and that if the indices selected are more significant, the characteristics of clustering results are also more significant, and the analysis or diagnosis is more credible. The indices and diagnosis analysis function produced by this study provide a necessary theoretical foundation and new ideas for the development of hydraulic metal structure health diagnosis technology.

A data mining approach to characterize road accident locations

Data mining has been proven as a reliable technique to analyze road accidents and provide productive results. Most of the road accident data analysis use data mining techniques, focusing on identifying factors that affect the severity of an accident. However, any damage resulting from road accidents is always unacceptable in terms of health, property damage and other economic factors. Sometimes, it is found that road accident occurrences are more frequent at certain specific locations. The analysis of these locations can help in identifying certain road accident features that make a road accident to occur frequently in these locations. Association rule mining is one of the popular data mining techniques that identify the correlation in various attributes of road accident. In this paper, we first applied k-means algorithm to group the accident locations into three categories, high-frequency, moderate-frequency and low-frequency accident locations. k-means algorithm takes accident frequency count as a parameter to cluster the locations. Then we used association rule mining to characterize these locations. The rules revealed different factors associated with road accidents at different locations with varying accident frequencies. Theassociation rules for high-frequency accident location disclosed that intersections on highways are more dangerous for every type of accidents. High-frequency accident locations mostly involved two-wheeler accidents at hilly regions. In moderate-frequency accident locations, colonies near local roads and intersection on highway roads are found dangerous for pedestrian hit accidents. Low-frequency accident locations are scattered throughout the district and the most of the accidents at these locations were not critical. Although the data set was limited to some selected attributes, our approach extracted some useful hidden information from the data which can be utilized to take some preventive efforts in these locations.

An Effective Network Traffic Data Control Using Improved Apriori Rule Mining

The increasing usage of internet requires a significant system for effective communication. To pro- vide an effective communication for the internet users, based on nature of their queries, shortest routing path is usually preferred for data forwarding. But when more number of data chooses the same path, in that case, bottleneck occurs in the traffic this leads to data loss or provides irrelevant data to the users. In this paper, a Rule Based System using Improved Apriori (RBS-IA) rule mining framework is proposed for effective monitoring of traffic occurrence over the network and control the network traffic. RBS-IA framework integrates both the traffic control and decision making system to enhance the usage of internet trendier. At first, the network traffic data are ana- lyzed and the incoming and outgoing data information is processed using apriori rule mining algorithm. After generating the set of rules, the network traffic condition is analyzed. Based on the traffic conditions, the decision rule framework is introduced which derives and assigns the set of suitable rules to the appropriate states of the network. The decision rule framework improves the effectiveness of network traffic control by updating the traffic condition states for identifying the relevant route path for packet data transmission. Experimental evaluation is conducted by extrac- ting the Dodgers loop sensor data set from UCI repository to detect the effectiveness of theproposed Rule Based System using Improved Apriori (RBS-IA) rule mining framework. Performance evaluation shows that the proposed RBS-IA rule mining framework provides significant improvement in managing the network traffic control scheme. RBS-IA rule mining framework is evaluated over the factors such as accuracy of the decision being obtained, interestingness measure and execution time.

Examining data visualization pitfalls in scientific publications

Data visualization blends art and science to convey stories from data via graphical representations.Considering different problems,applications,requirements,and design goals,it is challenging to combine these two components at their full force.While the art component involves creating visually appealing and easily interpreted graphics for users,the science component requires accurate representations of a large amount of input data.With a lack of the science component,visualization cannot serve its role of creating correct representations of the actual data,thus leading to wrong perception,interpretation,and decision.It might be even worse if incorrect visual representations were intentionally produced to deceive the viewers.To address common pitfalls in graphical representations,this paper focuses on identifying and understanding the root causes of misinformation in graphical representations.We reviewed the misleading data visualization examples in the scientific publications collected from indexing databases and then projected them onto the fundamental units of visual communication such as color,shape,size,and spatial orientation.Moreover,a text mining technique was applied to extract practical insights from common visualization pitfalls.Cochran’s Q test and McNemar’s test were conducted to examine if there is any difference in the proportions of common errors among color,shape,size,and spatial orientation.The findings showed that the pie chart is the most misused graphical representation,and size is the most critical issue.It was also observed that there were statistically significant differences in the proportion of errors among color,shape,size,and spatial orientation.

Mining φ-Frequent Itemset Using FP-Tree

The problem of association rule mining has gained considerable prominence in the data mining community for its use as an important tool of knowledge discovery from large scale databases. And there has been a spurt of research activities around this problem. However, traditional association rule mining may often derive many rules in which people are uninterested. This paper reports a generalization of association rule mining called φ association rule mining. It allows people to have different interests on different itemsets that arethe need of real application. Also, it can help to derive interesting rules and substantially reduce the amount of rules. An algorithm based on FP tree for mining φ frequent itemset is presented. It is shown by experiments that the proposed methodis efficient and scalable over large databases.

A Fast Distributed Algorithm for Association Rule Mining Based on Binary Coding Mapping Relation

Association rule mining is an important issue in data mining. The paper proposed an binary system based method to generate candidate frequent itemsets and corresponding supporting counts efficiently, which needs only some operations such as ＂and＂, ＂or＂ and ＂xor＂. Applying this idea in the existed distributed association rule mining al gorithm FDM, the improved algorithm BFDM is proposed. The theoretical analysis and experiment testify that BFDM is effective and efficient.

Short Text Mining for Classifying Educational Objectives and Outcomes

Most of the international accreditation bodies in engineering education(e.g.,ABET)and outcome-based educational systems have based their assess-ments on learning outcomes and program educational objectives.However,map-ping program educational objectives(PEOs)to student outcomes(SOs)is a challenging and time-consuming task,especially for a new program which is applying for ABET-EAC(American Board for Engineering and Technology the American Board for Engineering and Technology—Engineering Accreditation Commission)accreditation.In addition,ABET needs to automatically ensure that the mapping(classification)is reasonable and correct.The classification also plays a vital role in the assessment of students’learning.Since the PEOs are expressed as short text,they do not contain enough semantic meaning and information,and consequently they suffer from high sparseness,multidimensionality and the curse of dimensionality.In this work,a novel associative short text classification tech-nique is proposed to map PEOs to SOs.The datasets are extracted from 152 self-study reports(SSRs)that were produced in operational settings in an engineering program accredited by ABET-EAC.The datasets are processed and transformed into a representational form appropriate for association rule mining.The extracted rules are utilized as delegate classifiers to map PEOs to SOs.The proposed asso-ciative classification of the mapping of PEOs to SOs has shown promising results,which can simplify the classification of short text and avoid many problems caused by enriching short text based on external resources that are not related or relevant to the dataset.

A Deep Learning Based Sentiment Analytic Model for the Prediction of Traffic Accidents

The severity of traffic accidents is a serious global concern,particularly in developing nations.Knowing the main causes and contributing circumstances may reduce the severity of traffic accidents.There exist many machine learning models and decision support systems to predict road accidents by using datasets from different social media forums such as Twitter,blogs and Facebook.Although such approaches are popular,there exists an issue of data management and low prediction accuracy.This article presented a deep learning-based sentiment analytic model known as Extra-large Network Bi-directional long short term memory(XLNet-Bi-LSTM)to predict traffic collisions based on data collected from social media.Initially,a Tweet dataset has been formed by using an exhaustive keyword-based searching strategy.In the next phase,two different types of features named as individual tokens and pair tokens have been obtained by using POS tagging and association rule mining.The output of this phase has been forwarded to a three-layer deep learning model for final prediction.Numerous experiment has been performed to test the efficiency of the proposed XLNet-Bi-LSTM model.It has been shown that the proposed model achieved 94.2%prediction accuracy.

Chimp Optimization Algorithm Based Feature Selection with Machine Learning for Medical Data Classification

Datamining plays a crucial role in extractingmeaningful knowledge fromlarge-scale data repositories,such as data warehouses and databases.Association rule mining,a fundamental process in data mining,involves discovering correlations,patterns,and causal structures within datasets.In the healthcare domain,association rules offer valuable opportunities for building knowledge bases,enabling intelligent diagnoses,and extracting invaluable information rapidly.This paper presents a novel approach called the Machine Learning based Association Rule Mining and Classification for Healthcare Data Management System(MLARMC-HDMS).The MLARMC-HDMS technique integrates classification and association rule mining(ARM)processes.Initially,the chimp optimization algorithm-based feature selection(COAFS)technique is employed within MLARMC-HDMS to select relevant attributes.Inspired by the foraging behavior of chimpanzees,the COA algorithm mimics their search strategy for food.Subsequently,the classification process utilizes stochastic gradient descent with a multilayer perceptron(SGD-MLP)model,while the Apriori algorithm determines attribute relationships.We propose a COA-based feature selection approach for medical data classification using machine learning techniques.This approach involves selecting pertinent features from medical datasets through COA and training machine learning models using the reduced feature set.We evaluate the performance of our approach on various medical datasets employing diverse machine learning classifiers.Experimental results demonstrate that our proposed approach surpasses alternative feature selection methods,achieving higher accuracy and precision rates in medical data classification tasks.The study showcases the effectiveness and efficiency of the COA-based feature selection approach in identifying relevant features,thereby enhancing the diagnosis and treatment of various diseases.To provide further validation,we conduct detailed experiments on a benchmark medical dataset,revealing the superiority of the MLARMCHDMS model over other methods,with a maximum accuracy of 99.75%.Therefore,this research contributes to the advancement of feature selection techniques in medical data classification and highlights the potential for improving healthcare outcomes through accurate and efficient data analysis.The presented MLARMC-HDMS framework and COA-based feature selection approach offer valuable insights for researchers and practitioners working in the field of healthcare data mining and machine learning.

Improving Decision Tree Performance by Exception Handling

This paper focuses on improving decision tree induction algorithms when a kind of tie appears during the rule generation procedure for specific training datasets. The tie occurs when there are equal proportions of the target class outcome in the leaf node＇s records that leads to a situation where majority voting cannot be applied. To solve the above mentioned exception, we propose to base the prediction of the result on the naive Bayes （NB） estimate, k-nearest neighbour （k-NN） and association rule mining （ARM）. The other features used for splitting the parent nodes are also taken into consideration.

Association Rule Analysis-Based Identification of Influential Users in the Social Media

The exchange of information is an innate and natural process that assist in content dispersal.Social networking sites emerge to enrich their users by providing the facility for sharing information and social interaction.The extensive adoption of social networking sites also resulted in user content generation.There are diverse research areas explored by the researchers to investigate the influence of social media on users and confirmed that social media sites have a significant impact on markets,politics and social life.Facebook is extensively used platform to share information,thoughts and opinions through posts and comments.The identification of influential users on the social web has grown as hot research field because of vast applications in diverse areas for instance political campaigns marketing,e-commerce,commercial and,etc.Prior research studies either uses linguistic content or graph-based representation of social network for the detection of influential users.In this article,we incorporate association rule mining algorithms to identify the top influential users through frequent patterns.The association rules have been computed using the standard evaluation measures such as support,confidence,lift,and conviction.To verify the results,we also involve conventional metrics for example accuracy,precision,recall and F1-measure according to the association rules perspective.The detailed experiments are carried out using the benchmark College-Msg dataset extracted by Facebook.The obtained results validate the quality and visibility of the proposed approach.The outcome of propose model verify that the association rule mining is able to generate rules to identify the temporal influential users on Facebook who are consistent on regular basis.The preparation of rule set help to create knowledge-based systems which are efficient and widely used in recent era for decision making to solve real-world problems.

Examining patterns of traditional chinese medicine use in pediatric oncology: A systematic review, meta-analysis and data-mining study

Background Traditional Chinese medicine(TCM)is becoming a popular complementary approach in pediatric oncology.However,few or no meta-analyses have focused on clinical studies of the use of TCM in pediatric oncology.Objective We explored the patterns of TCM use and its efficacy in children with cancer,using a systematic review,meta-analysis and data mining study.Search strategy We conducted a search of five English(Allied and Complementary Medicine Database,Embase,PubMed,Cochrane Central Register of Controlled Trials,and ClinicalTrials.gov)and four Chinese databases(Wanfang Data,China National Knowledge Infrastructure,Chinese Biomedical Literature Database,and VIP Chinese Science and Technology Periodicals Database)for clinical studies published before October 2021,using keywords related to“pediatric,”“cancer,”and“TCM.”Inclusion criteria We included studies which were randomized controlled trials(RCTs)or observational clinical studies,focused on patients aged<19 years old who had been diagnosed with cancer,and included at least one group of subjects receiving TCM treatment.Data extraction and analysis The methodological quality of RCTs and observational studies was assessed using the six-item Jadad scale and the Effective Public Healthcare Panacea Project Quality Assessment Tool,respectively.Meta-analysis was used to evaluate the efficacy of combining TCM with chemotherapy.Study outcomes included the treatment response rate and occurrence of cancer-related symptoms.Association rule mining(ARM)was used to investigate the associations among medicinal herbs and patient symptoms.Results The fifty-four studies included in this analysis were comprised of RCTs(63.0%)and observational studies(37.0%).Most RCTs focused on hematological malignancies(41.2%).The study outcomes included chemotherapy-induced toxicities(76.5%),infection rate(35.3%),and response,survival or relapse rate(23.5%).The methodological quality of most of the RCTs(82.4%)and observational studies(80.0%)was rated as“moderate.”In studies of leukemia patients,adding TCM to conventional treatment significantly improved the clinical response rate(odds ratio[OR]=2.55;95%confidence interval[CI]=1.49-4.36),lowered infection rate(OR=0.23;95%CI=0.13-0.40),and reduced nausea and vomiting(OR=0.13;95%CI=0.08-0.23).ARM showed that Radix Astragali,the most commonly used medicinal herb(58.0%),was associated with treating myelosuppression,gastrointestinal complications,and infection.Conclusion There is growing evidence that TCM is an effective adjuvant therapy for children with cancer.We proposed a checklist to improve the quality of TCM trials in pediatric oncology.Future work will examine the use of ARM techniques on real-world data to evaluate the efficacy of medicinal herbs and drug-herb interactions in children receiving TCM as a part of integrated cancer therapy.

Stratified sampling for data mining on the deep web

In recent years, the deep web has become ex- tremely popular. Like any other data source, data mining on the deep web can produce important insights or summaries of results. However, data mining on the deep web is chal- lenging because the databases cannot be accessed directly, and therefore, data mining must be performed by sampling the datasets. The samples, in turn, can only be obtained by querying deep web databases with specific inputs. In this pa- per, we target two related data mining problems, association mining and differential rule mining. These are proposed to ex- tract high-level summaries of the differences in data provided by different deep web data sources in the same domain. We develop stratified sampling methods to perform these min- ing tasks on a deep web source. Our contributions include a novel greedy stratification approach, which recursively pro- cesses the query space of a deep web data source, and con- siders both the estimation error and the sampling costs. We have also developed an optimized sample allocation method that integrates estimation error and sampling costs. Our ex- perimental results show that our algorithms effectively and consistently reduce sampling costs, compared with a strat- ified sampling method that only considers estimation error. In addition, compared with simple random sampling, our al- gorithm has higher sampling accuracy and lower sampling costs.

Towards integrated oncogenic marker recognition through mutual information-based statist!cally significant feature extraction： an association rule mining based study on cancer expression and methylation profiles

Background： Marker detection is an important task in complex disease studies. Here we provide an association rule mining （ARM） based approach for identifying integrated markers through mutual information （MI） based statistically significant feature extraction, and apply it to acute myeloid leukemia （AML） and prostate carcinoma （PC） gene expression and methylation profiles. Methods： We first collect the genes having both expression and methylation values in AML as well as PC. Next, we run Jarque-Bera normality test on the expression/methylation data to divide the whole dataset into two parts： one that follows normal distribution and the other that does not follow normal distribution. Thus, we have now four parts of the dataset： normally distributed expression data, normally distributed methylation data, non-normally distributed expression data, and non-normally distributed methylated data. A feature-extraction technique, ＂mRMR＂ is then utilized on each part. This results in a list of top-ranked genes. Next, we apply Welch t-test （parametric test） and Shrink t-test （non-parametric test） on the expression/methylation data for the top selected normally distributed genes and non-normally distributed genes, respectively. We then use a recent weighted ARM method, ＂RANWAR＂ to combine all/specific resultant genes to generate top oncogenic rules along with respective integrated markers. Finally, we perform literature search as well as KEGG pathway and Gene-Ontology （GO） analyses using Enrichr database for in silico validation of the prioritized oncogenes as the markers and labeling the markers as existing or novel. Results： The novel markers of AML are {ABCB11↑ U KRT17↓} （i.e., ABCBll as up-regulated, ＆ KRT17 as down- regulated）, and {AP1SI-UKRT17↓ U NEIL2-UDYDC1↓}） （i.e., AP1S1 and NEIL2 both as hypo-methylated, ＆ KRT17 and DYDC1 both as down-regulated）. The novel marker of PC is {UBIAD1 ｜｜U APBA2 U C4orf31： （i.e., UBIAD1 as up-regulated and hypo-methylated, ＆ APBA2 and C4orf31 both as down-regulated and hyper- methylated）. Conclusion： The identified novel markers might have critical roles in AML as well as PC. The approach can be applied to other complex disease.