Time-frequency analysis is a successfully used tool for analyzing the local features of seismic data.However,it suffers from several inevitable limitations,such as the restricted time-frequency resolution,the difficul...Time-frequency analysis is a successfully used tool for analyzing the local features of seismic data.However,it suffers from several inevitable limitations,such as the restricted time-frequency resolution,the difficulty in selecting parameters,and the low computational efficiency.Inspired by deep learning,we suggest a deep learning-based workflow for seismic time-frequency analysis.The sparse S transform network(SSTNet)is first built to map the relationship between synthetic traces and sparse S transform spectra,which can be easily pre-trained by using synthetic traces and training labels.Next,we introduce knowledge distillation(KD)based transfer learning to re-train SSTNet by using a field data set without training labels,which is named the sparse S transform network with knowledge distillation(KD-SSTNet).In this way,we can effectively calculate the sparse time-frequency spectra of field data and avoid the use of field training labels.To test the availability of the suggested KD-SSTNet,we apply it to field data to estimate seismic attenuation for reservoir characterization and make detailed comparisons with the traditional time-frequency analysis methods.展开更多
Artificial intelligence is increasingly entering everyday healthcare.Large language model(LLM)systems such as Chat Generative Pre-trained Transformer(ChatGPT)have become potentially accessible to everyone,including pa...Artificial intelligence is increasingly entering everyday healthcare.Large language model(LLM)systems such as Chat Generative Pre-trained Transformer(ChatGPT)have become potentially accessible to everyone,including patients with inflammatory bowel diseases(IBD).However,significant ethical issues and pitfalls exist in innovative LLM tools.The hype generated by such systems may lead to unweighted patient trust in these systems.Therefore,it is necessary to understand whether LLMs(trendy ones,such as ChatGPT)can produce plausible medical information(MI)for patients.This review examined ChatGPT’s potential to provide MI regarding questions commonly addressed by patients with IBD to their gastroenterologists.From the review of the outputs provided by ChatGPT,this tool showed some attractive potential while having significant limitations in updating and detailing information and providing inaccurate information in some cases.Further studies and refinement of the ChatGPT,possibly aligning the outputs with the leading medical evidence provided by reliable databases,are needed.展开更多
为提高非平稳响应信号瞬时频率的识别效果,提出基于滑动窗宽优化的局部最大同步挤压广义S变换(local maximum synchrosqueezing generalized S-transform,LMSSGST)。该方法首先对非平稳响应信号进行广义S变换获得相应的时频系数;其次,...为提高非平稳响应信号瞬时频率的识别效果,提出基于滑动窗宽优化的局部最大同步挤压广义S变换(local maximum synchrosqueezing generalized S-transform,LMSSGST)。该方法首先对非平稳响应信号进行广义S变换获得相应的时频系数;其次,利用该响应信号的功率谱密度特征曲线确定局部最大同步挤压算子中滑动窗的宽度;再次,通过局部最大同步挤压算子进行时频重排;最后,采用模极大值改进算法提取瞬时频率曲线。通过两个数值算例、一个滑动窗宽参数分析和一个时变拉索试验验证了所提方法的有效性,研究结果表明:利用功率谱密度特征曲线能够有效确定滑动窗的窗宽和模极大值算法的提取范围。相比局部最大同步挤压变换算法,基于滑动窗宽优化的LMSSGST具有更佳的瞬时频率识别效果。展开更多
AIM To explore the role and mechanism of total flavone of Abelmoschus manihot(TFA) on epithelial-mesenchymal transition(EMT) progress of Crohn's disease(CD) intestinal fibrosis.METHODS First,CCK-8 assay was perfor...AIM To explore the role and mechanism of total flavone of Abelmoschus manihot(TFA) on epithelial-mesenchymal transition(EMT) progress of Crohn's disease(CD) intestinal fibrosis.METHODS First,CCK-8 assay was performed to assess TFA on the viability of intestinal epithelial(IEC-6) cells and select the optimal concentrations of TFA for our further studies.Then cell morphology,wound healing and transwell assays were performed to examine the effect of TFA on morphology,migration and invasion of IEC-6 cells treated with TGF-β1.In addition,immunofluorescence,real-time PCR analysis(q RT-PCR) and western blotting assays were carried out to detect the impact of TFA on EMT progress.Moreover,western blotting assay was performed to evaluate the function of TFA on the Smad and MAPK signaling pathways.Further,the role of co-treatment of TFA and si-Smad or MAPK inhibitors has been examined by q RTPCR,western blotting,morphology,wound healing andtranswell assays.RESULTS In this study,TFA promoted transforming growth factor-β1(TGF-β1)-induced(IEC-6) morphological change,migration and invasion,and increased the expression of epithelial markers and reduced the levels of mesenchymal markers,along with the inactivation of Smad and MAPK signaling pathways.Moreover,we revealed that si-Smad and MAPK inhibitors effectively attenuated TGF-β1-induced EMT in IEC-6 cells.Importantly,co-treatment of TFA and si-Smad or MAPK inhibitors had better inhibitory effects on TGF-β1-induced EMT in IEC-6 cells than either one of them.CONCLUSION These findings could provide new insight into the molecular mechanisms of TFA on TGF-β1-induced EMT in IEC-6 cells and TFA is expected to advance as a new therapy to treat CD intestinal fibrosis.展开更多
AIM: To explore different roles of TGF-β (transforming growth factor beta) and bone morphogenetic proteins (BMPs)in hepatic stellate cell proliferation and trans-differentiation.METHODS: Hepatic stellate cells were i...AIM: To explore different roles of TGF-β (transforming growth factor beta) and bone morphogenetic proteins (BMPs)in hepatic stellate cell proliferation and trans-differentiation.METHODS: Hepatic stellate cells were isolated from male Sprague-Dawley rats. Sub-cultured hepatic stellate cells were employed for cell proliferation assay with WST-1 reagent and Western blot analysis with antibody against smooth muscle alpha actin (SMA).RESULTS: The results indicated that TGF-β1 significantly inhibited cell proliferation at concentration as low as 0.1 ng/ml, but both BMP-2 and BMP-4 did not affect cell proliferation at concentration as high as 10 ng/ml. The effect on hepatic stellate cell trans-differentiation was similar between TGFβ1 and BMPs. However, BMPs was more potent at transdifferentiation of hepatic stellate cells than TGF-β1. In addition, we observed that TGF-β1 transient reduced the abundance of SMA in hepatic stellate cells.CONCLUSION: TGF-β may be more important in regulation of hepatic stellate cell proliferation while BMPs may be the major cytokines regulating hepatic stellate cell transdifferentiation.展开更多
In this work, the image reconstruction in π-scheme short-scan single-photon emission computed tomography (SPECT) with nonuniform attenuation is derived in its most general form when π-scheme short-scan SPECT entai...In this work, the image reconstruction in π-scheme short-scan single-photon emission computed tomography (SPECT) with nonuniform attenuation is derived in its most general form when π-scheme short-scan SPECT entails data acquisition over disjoint angular intervals without conjugate views totaling to π radians. The reconstruction results are based on decomposition of Novikov's inversion operator into three parts bounded in the L2 sense. The first part involves the measured partial data; the second part is a skew-symmetric operator; the third part is a symmetric and compact contribution. It is showed firstly that the operators involved belong to L(L^2(B). Furthermore numerical simulations are conducted to demonstrate the effectiveness of the developed method.展开更多
When a high impedance fault(HIF)occurs in a distribution network,the detection efficiency of traditional protection devices is strongly limited by the weak fault information.In this study,a method based on S-transform...When a high impedance fault(HIF)occurs in a distribution network,the detection efficiency of traditional protection devices is strongly limited by the weak fault information.In this study,a method based on S-transform(ST)and average singular entropy(ASE)is proposed to identify HIFs.First,a wavelet packet transform(WPT)was applied to extract the feature frequency band.Thereafter,the ST was investigated in each half cycle.Afterwards,the obtained time-frequency matrix was denoised by singular value decomposition(SVD),followed by the calculation of the ASE index.Finally,an appropriate threshold was selected to detect the HIFs.The advantages of this method are the ability of fine band division,adaptive time-frequency transformation,and quantitative expression of signal complexity.The performance of the proposed method was verified by simulated and field data,and further analysis revealed that it could still achieve good results under different conditions.展开更多
An alternative method was introduced for voltage sag source location based on S and TT transformed disturbance powers. It is done to avoid the wrong and inconclusive detection of conventional disturbance power method ...An alternative method was introduced for voltage sag source location based on S and TT transformed disturbance powers. It is done to avoid the wrong and inconclusive detection of conventional disturbance power method proposed in the literature. Unlike in the case of the traditional method, the proposed method first transforms the recorded voltage and current during the sag event to some special features before calculating the new version of disturbance powers. The effectiveness of the proposed method has been verified through simulation and actual data from an industrial power system. The results show that the presented method can correctly detect the location of voltage sag source.展开更多
Rural transformation can improve poverty reduction,living standards,and health outcomes in developing countries.However,impacts associated with rural transformation vary by region,household,and individual trait(includ...Rural transformation can improve poverty reduction,living standards,and health outcomes in developing countries.However,impacts associated with rural transformation vary by region,household,and individual trait(including gender).While research on rural transformation has been increasing over the last decade,there has been no comprehensive review conducted on the relationships between gender and rural transformation.Here,we conduct a systematic literature review to investigate the impacts of rural transformation on gender and the influence of gender inclusiveness on rural transformation.We reviewed 82 studies from 1960-2021 that explore the relationships between rural transformation and gender.We then developed a framework that captures incidences and flow directions between indicators.Results show that most studies examined the impacts of rural transformation on women and between gender indicators.Few investigated the role of women and the influence of gender inclusiveness on rural transformation.Overall,studies showed that rural transformation typically leads to positive outcomes for women regarding employment,income,and empowerment.However,negative impacts on women’s control over income,stability of new income sources,and access to healthy food are also common.Tailoring future development policies and programs to explicitly account for gender inclusiveness can lead to more successful rural transformation.展开更多
BACKGROUND The TGF-β/SMAD3 and VEGFR-1 signaling pathways play important roles in gastric cancer metastasis.SMAD3 phosphorylation is a crucial prognostic marker in gastric cancer.AIM To determine the prognostic value...BACKGROUND The TGF-β/SMAD3 and VEGFR-1 signaling pathways play important roles in gastric cancer metastasis.SMAD3 phosphorylation is a crucial prognostic marker in gastric cancer.AIM To determine the prognostic value and relationship of SMAD3 phospho-isoforms and VEGFR-1 in gastric cancer.METHODS This was a single-center observational study which enrolled 98 gastric cancer patients and 82 adjacent normal gastric tissues from patients aged 32-84 years(median age 65)between July 2006 and April 2007.Patients were followed up until death or the study ended(median follow-up duration of 28.5 mo).The samples were used to generate tissue microarrays(TMAs)for immunohistochemical(IHC)staining.The expressions of TGF-β1,pSMAD3C(S423/425),pSMAD3L(S204),and VEGFR-1 in gastric cancer(GC)tumor tissue and normal tissue were measured by IHC staining using TMAs obtained from 98 GC patients.Prognosis and survival information of the patients was recorded by Outdo Biotech from May 2007 to July 2015.The relationship between TGF-β1,pSMAD3C(S423/425),pSMAD3L(S204),and VEGFR-1 protein expression levels was analyzed using Pearson's correlation coefficient.The relationship between protein expression levels and clinicopathological parameters was analyzed using the Chi-squared test.A survival curve was generated using the Kaplan-Meier survival analysis.RESULTS TGFβ-1 and VEGFR-1 expression was significantly upregulated in gastric cancer tissue compared to adjacent noncancerous tissue.The positive expression of phosphorylated isoforms of Smad3 varied depending on the phosphorylation site[pSMAD3C(S423/425):51.0%and pSMAD3L(S204):31.6%].High expression of pSMAD-3L(S204)was significantly correlated with larger tumors(P=0.038)and later N stages(P=0.035).Additionally,high expression of VEGFR-1 was closely correlated with tumor size(P=0.015)and pathological grading(P=0.013).High expression of both pSMAD3L(S204)and VEGFR-1 was associated with unfavorable outcomes in terms of overall survival(OS).Multivariate analysis indicated that high expression of pSMAD3L(S204)and VEGFR-1 were independent risk factors for prognosis in GC patients.VEGFR-1 protein expression was correlated with TGF-β1(r=0.220,P=0.029),pSMAD3C(S423/425)(r=0.302,P=0.002),and pSMAD3L(S204)(r=0.201,P=0.047),respectively.Simultaneous overexpression of pSMAD3L(S204)and VEGFR-1 was associated with poor OS in gastric cancer patients.CONCLUSION Co-upregulation of pSMAD3L(S204)and VEGFR-1 can serve as a predictive marker for poor gastric cancer prognosis,and pSMAD3L(204)may be involved in enhanced gastric cancer metastasis in a VEGFR-1-dependent manner.展开更多
Hydrogen sulfide(H_(2)S) not only presents significant environmental concerns but also induces severe corrosion in industrial equipment,even at low concentrations.Among various technologies,the selective oxidation of ...Hydrogen sulfide(H_(2)S) not only presents significant environmental concerns but also induces severe corrosion in industrial equipment,even at low concentrations.Among various technologies,the selective oxidation of hydrogen sulfide(SOH_(2)S) to elemental sulfur(S) has emerged as a sustainable and environmentally friendly solution.Due to its unique properties,iron oxide has been extensively investigated as a catalyst for SOH_(2)S;however,rapid deactivation has remained a significant drawback.The causes of iron oxide-based catalysts deactivation mechanisms in SOH_(2)S,including sulfur or sulfate deposition,the transformation of iron species,sintering and excessive oxygen vacancy formation,and active site loss,are thoroughly examined in this review.By focusing on the deactivation mechanisms,this review aims to provide valuable insights into enhancing the stability and efficiency of iron-based catalysts for SOH_(2)S.展开更多
In this paper,a nonlinear wave equation with variable coefficients is studied,interestingly,this equation can be used to describe the travelling waves propagating along the circular rod composed of a general compressi...In this paper,a nonlinear wave equation with variable coefficients is studied,interestingly,this equation can be used to describe the travelling waves propagating along the circular rod composed of a general compressible hyperelastic material with variable cross-sections and variable material densities.With the aid of Lou’s direct method1,the nonlinear wave equation with variable coefficients is reduced and two sets of symmetry transformations and exact solutions of the nonlinear wave equation are obtained.The corresponding numerical examples of exact solutions are presented by using different coefficients.Particularly,while the variable coefficients are taken as some special constants,the nonlinear wave equation with variable coefficients reduces to the one with constant coefficients,which can be used to describe the propagation of the travelling waves in general cylindrical rods composed of generally hyperelastic materials.Using the same method to solve the nonlinear wave equation,the validity and rationality of this method are verified.展开更多
The key parameters for damage detection and localization are eigenfrequencies, related equivalent viscous damping factors and mode shapes. The classical approach is based on the evaluation of these structural paramete...The key parameters for damage detection and localization are eigenfrequencies, related equivalent viscous damping factors and mode shapes. The classical approach is based on the evaluation of these structural parameters before and after a seismic event, but by using a modern approach based on time-frequency transformations it is possible to quantify these parameters throughout the ground shaking phase. In particular with the use of the S-Transform, it is possible to follow the temporal evolution of the structural dynamics parameters before, during and after an earthquake. In this paper, a methodology for damage localization on framed structures subjected to strong motion earthquakes is proposed based on monitoring the modal curvature variation in the natural frequency of a structure. Two examples of application are described to illustrate the technique: Computer simulation of the nonlinear response of a model, and several laboratory(shaking table) tests performed at the University of Basilicata(Italy). Damage detected using the proposed approach and damage revealed via visual inspections in the tests are compared.展开更多
AIM: To study persistence and replication of hepatitis C virus (HCV) in patients' peripheral blood mononuclear cells (PBMC) cultured in vitro. METHODS: Epstein Barr virus (EBV) was used to transform the hepatitis ...AIM: To study persistence and replication of hepatitis C virus (HCV) in patients' peripheral blood mononuclear cells (PBMC) cultured in vitro. METHODS: Epstein Barr virus (EBV) was used to transform the hepatitis C virus from a HCV positive patient to permanent lymphoblastoid cell lines (LCL). Positive and negative HCV RNA strands of the cultured cells and growth media were detected by reverse transcriptase-polymerase chain reaction (RT-PCR) each month. Core and NS5 proteins of HCV were further tested using immunohistochemical SP method and in situ RT-PCR. RESULTS: HCV RNA positive strands were consistently detected the cultured cells for one year. The negative-strand RNA in LCL cells and the positive-strand RNA in supernatants were observed intermittently. Immunohistochemical results medicated expression of HCV NS3 and C proteins in LCL cytoplasm mostly. The positive signal of PCR product was dark blue and mainly localized to the LCL cytoplasm. The RT-PCR signal was eliminated by overnight RNase digestion but not DNase digestion. CONCLUSION: HCV may exist and remain functional in a cultured cell line for a long period.展开更多
Based on the previous case study in promoting transformative learning of college English teachers,who participated in a three-month online training courses,the article made a further research and concluded four strate...Based on the previous case study in promoting transformative learning of college English teachers,who participated in a three-month online training courses,the article made a further research and concluded four strategies on promoting transformative learning of college English Teachers.展开更多
基金supported by the National Natural Science Foundation of China (42274144,42304122,and 41974155)the Key Research and Development Program of Shaanxi (2023-YBGY-076)+1 种基金the National Key R&D Program of China (2020YFA0713404)the China Uranium Industry and East China University of Technology Joint Innovation Fund (NRE202107)。
文摘Time-frequency analysis is a successfully used tool for analyzing the local features of seismic data.However,it suffers from several inevitable limitations,such as the restricted time-frequency resolution,the difficulty in selecting parameters,and the low computational efficiency.Inspired by deep learning,we suggest a deep learning-based workflow for seismic time-frequency analysis.The sparse S transform network(SSTNet)is first built to map the relationship between synthetic traces and sparse S transform spectra,which can be easily pre-trained by using synthetic traces and training labels.Next,we introduce knowledge distillation(KD)based transfer learning to re-train SSTNet by using a field data set without training labels,which is named the sparse S transform network with knowledge distillation(KD-SSTNet).In this way,we can effectively calculate the sparse time-frequency spectra of field data and avoid the use of field training labels.To test the availability of the suggested KD-SSTNet,we apply it to field data to estimate seismic attenuation for reservoir characterization and make detailed comparisons with the traditional time-frequency analysis methods.
文摘Artificial intelligence is increasingly entering everyday healthcare.Large language model(LLM)systems such as Chat Generative Pre-trained Transformer(ChatGPT)have become potentially accessible to everyone,including patients with inflammatory bowel diseases(IBD).However,significant ethical issues and pitfalls exist in innovative LLM tools.The hype generated by such systems may lead to unweighted patient trust in these systems.Therefore,it is necessary to understand whether LLMs(trendy ones,such as ChatGPT)can produce plausible medical information(MI)for patients.This review examined ChatGPT’s potential to provide MI regarding questions commonly addressed by patients with IBD to their gastroenterologists.From the review of the outputs provided by ChatGPT,this tool showed some attractive potential while having significant limitations in updating and detailing information and providing inaccurate information in some cases.Further studies and refinement of the ChatGPT,possibly aligning the outputs with the leading medical evidence provided by reliable databases,are needed.
文摘为提高非平稳响应信号瞬时频率的识别效果,提出基于滑动窗宽优化的局部最大同步挤压广义S变换(local maximum synchrosqueezing generalized S-transform,LMSSGST)。该方法首先对非平稳响应信号进行广义S变换获得相应的时频系数;其次,利用该响应信号的功率谱密度特征曲线确定局部最大同步挤压算子中滑动窗的宽度;再次,通过局部最大同步挤压算子进行时频重排;最后,采用模极大值改进算法提取瞬时频率曲线。通过两个数值算例、一个滑动窗宽参数分析和一个时变拉索试验验证了所提方法的有效性,研究结果表明:利用功率谱密度特征曲线能够有效确定滑动窗的窗宽和模极大值算法的提取范围。相比局部最大同步挤压变换算法,基于滑动窗宽优化的LMSSGST具有更佳的瞬时频率识别效果。
基金Supported by the Natural Science Foundation of Jiangsu Province,China,No.BK2016157the National Natural Science Foundation of China,No.81673973+1 种基金Phase Ⅱ Project Funded by the Priority Academic Program Development of Jiangsu Higher Education Institutions,No.035062002003Developing Program for Highlevel Academic Talent in Jiangsu Hospital of TCM,No.y2018rc16
文摘AIM To explore the role and mechanism of total flavone of Abelmoschus manihot(TFA) on epithelial-mesenchymal transition(EMT) progress of Crohn's disease(CD) intestinal fibrosis.METHODS First,CCK-8 assay was performed to assess TFA on the viability of intestinal epithelial(IEC-6) cells and select the optimal concentrations of TFA for our further studies.Then cell morphology,wound healing and transwell assays were performed to examine the effect of TFA on morphology,migration and invasion of IEC-6 cells treated with TGF-β1.In addition,immunofluorescence,real-time PCR analysis(q RT-PCR) and western blotting assays were carried out to detect the impact of TFA on EMT progress.Moreover,western blotting assay was performed to evaluate the function of TFA on the Smad and MAPK signaling pathways.Further,the role of co-treatment of TFA and si-Smad or MAPK inhibitors has been examined by q RTPCR,western blotting,morphology,wound healing andtranswell assays.RESULTS In this study,TFA promoted transforming growth factor-β1(TGF-β1)-induced(IEC-6) morphological change,migration and invasion,and increased the expression of epithelial markers and reduced the levels of mesenchymal markers,along with the inactivation of Smad and MAPK signaling pathways.Moreover,we revealed that si-Smad and MAPK inhibitors effectively attenuated TGF-β1-induced EMT in IEC-6 cells.Importantly,co-treatment of TFA and si-Smad or MAPK inhibitors had better inhibitory effects on TGF-β1-induced EMT in IEC-6 cells than either one of them.CONCLUSION These findings could provide new insight into the molecular mechanisms of TFA on TGF-β1-induced EMT in IEC-6 cells and TFA is expected to advance as a new therapy to treat CD intestinal fibrosis.
文摘AIM: To explore different roles of TGF-β (transforming growth factor beta) and bone morphogenetic proteins (BMPs)in hepatic stellate cell proliferation and trans-differentiation.METHODS: Hepatic stellate cells were isolated from male Sprague-Dawley rats. Sub-cultured hepatic stellate cells were employed for cell proliferation assay with WST-1 reagent and Western blot analysis with antibody against smooth muscle alpha actin (SMA).RESULTS: The results indicated that TGF-β1 significantly inhibited cell proliferation at concentration as low as 0.1 ng/ml, but both BMP-2 and BMP-4 did not affect cell proliferation at concentration as high as 10 ng/ml. The effect on hepatic stellate cell trans-differentiation was similar between TGFβ1 and BMPs. However, BMPs was more potent at transdifferentiation of hepatic stellate cells than TGF-β1. In addition, we observed that TGF-β1 transient reduced the abundance of SMA in hepatic stellate cells.CONCLUSION: TGF-β may be more important in regulation of hepatic stellate cell proliferation while BMPs may be the major cytokines regulating hepatic stellate cell transdifferentiation.
基金supported by the National Natural Science Foundation of China(61271398)K.C.Wong Magna Fund in Ningbo University
文摘In this work, the image reconstruction in π-scheme short-scan single-photon emission computed tomography (SPECT) with nonuniform attenuation is derived in its most general form when π-scheme short-scan SPECT entails data acquisition over disjoint angular intervals without conjugate views totaling to π radians. The reconstruction results are based on decomposition of Novikov's inversion operator into three parts bounded in the L2 sense. The first part involves the measured partial data; the second part is a skew-symmetric operator; the third part is a symmetric and compact contribution. It is showed firstly that the operators involved belong to L(L^2(B). Furthermore numerical simulations are conducted to demonstrate the effectiveness of the developed method.
基金financial supported by the Natural Science Foundation of Fujian,China(2021J01633).
文摘When a high impedance fault(HIF)occurs in a distribution network,the detection efficiency of traditional protection devices is strongly limited by the weak fault information.In this study,a method based on S-transform(ST)and average singular entropy(ASE)is proposed to identify HIFs.First,a wavelet packet transform(WPT)was applied to extract the feature frequency band.Thereafter,the ST was investigated in each half cycle.Afterwards,the obtained time-frequency matrix was denoised by singular value decomposition(SVD),followed by the calculation of the ASE index.Finally,an appropriate threshold was selected to detect the HIFs.The advantages of this method are the ability of fine band division,adaptive time-frequency transformation,and quantitative expression of signal complexity.The performance of the proposed method was verified by simulated and field data,and further analysis revealed that it could still achieve good results under different conditions.
基金the financial support from the Universiti Kebangsaan Malaysia under the research grant UKM-DLP-2011-059
文摘An alternative method was introduced for voltage sag source location based on S and TT transformed disturbance powers. It is done to avoid the wrong and inconclusive detection of conventional disturbance power method proposed in the literature. Unlike in the case of the traditional method, the proposed method first transforms the recorded voltage and current during the sag event to some special features before calculating the new version of disturbance powers. The effectiveness of the proposed method has been verified through simulation and actual data from an industrial power system. The results show that the presented method can correctly detect the location of voltage sag source.
基金supported by the Australian Centre for International Agricultural Research(ACIAR,ADP/2017/024)。
文摘Rural transformation can improve poverty reduction,living standards,and health outcomes in developing countries.However,impacts associated with rural transformation vary by region,household,and individual trait(including gender).While research on rural transformation has been increasing over the last decade,there has been no comprehensive review conducted on the relationships between gender and rural transformation.Here,we conduct a systematic literature review to investigate the impacts of rural transformation on gender and the influence of gender inclusiveness on rural transformation.We reviewed 82 studies from 1960-2021 that explore the relationships between rural transformation and gender.We then developed a framework that captures incidences and flow directions between indicators.Results show that most studies examined the impacts of rural transformation on women and between gender indicators.Few investigated the role of women and the influence of gender inclusiveness on rural transformation.Overall,studies showed that rural transformation typically leads to positive outcomes for women regarding employment,income,and empowerment.However,negative impacts on women’s control over income,stability of new income sources,and access to healthy food are also common.Tailoring future development policies and programs to explicitly account for gender inclusiveness can lead to more successful rural transformation.
基金Supported by National Nature Science Foundation of China,No.82060450,No.82360517,No.81460374,and No.31460304Nature Science Foundation of Jiangxi Province of China,No.20232BAB206086,No.20192BAB205072,No.20203BBGL73206,No.2017BCB23086,No.2017BAB205062,and No.20181BAB205050.
文摘BACKGROUND The TGF-β/SMAD3 and VEGFR-1 signaling pathways play important roles in gastric cancer metastasis.SMAD3 phosphorylation is a crucial prognostic marker in gastric cancer.AIM To determine the prognostic value and relationship of SMAD3 phospho-isoforms and VEGFR-1 in gastric cancer.METHODS This was a single-center observational study which enrolled 98 gastric cancer patients and 82 adjacent normal gastric tissues from patients aged 32-84 years(median age 65)between July 2006 and April 2007.Patients were followed up until death or the study ended(median follow-up duration of 28.5 mo).The samples were used to generate tissue microarrays(TMAs)for immunohistochemical(IHC)staining.The expressions of TGF-β1,pSMAD3C(S423/425),pSMAD3L(S204),and VEGFR-1 in gastric cancer(GC)tumor tissue and normal tissue were measured by IHC staining using TMAs obtained from 98 GC patients.Prognosis and survival information of the patients was recorded by Outdo Biotech from May 2007 to July 2015.The relationship between TGF-β1,pSMAD3C(S423/425),pSMAD3L(S204),and VEGFR-1 protein expression levels was analyzed using Pearson's correlation coefficient.The relationship between protein expression levels and clinicopathological parameters was analyzed using the Chi-squared test.A survival curve was generated using the Kaplan-Meier survival analysis.RESULTS TGFβ-1 and VEGFR-1 expression was significantly upregulated in gastric cancer tissue compared to adjacent noncancerous tissue.The positive expression of phosphorylated isoforms of Smad3 varied depending on the phosphorylation site[pSMAD3C(S423/425):51.0%and pSMAD3L(S204):31.6%].High expression of pSMAD-3L(S204)was significantly correlated with larger tumors(P=0.038)and later N stages(P=0.035).Additionally,high expression of VEGFR-1 was closely correlated with tumor size(P=0.015)and pathological grading(P=0.013).High expression of both pSMAD3L(S204)and VEGFR-1 was associated with unfavorable outcomes in terms of overall survival(OS).Multivariate analysis indicated that high expression of pSMAD3L(S204)and VEGFR-1 were independent risk factors for prognosis in GC patients.VEGFR-1 protein expression was correlated with TGF-β1(r=0.220,P=0.029),pSMAD3C(S423/425)(r=0.302,P=0.002),and pSMAD3L(S204)(r=0.201,P=0.047),respectively.Simultaneous overexpression of pSMAD3L(S204)and VEGFR-1 was associated with poor OS in gastric cancer patients.CONCLUSION Co-upregulation of pSMAD3L(S204)and VEGFR-1 can serve as a predictive marker for poor gastric cancer prognosis,and pSMAD3L(204)may be involved in enhanced gastric cancer metastasis in a VEGFR-1-dependent manner.
基金supported by Thailand Science Research and Innovation Fund Chulalongkorn University,Thailand(IND66210014)。
文摘Hydrogen sulfide(H_(2)S) not only presents significant environmental concerns but also induces severe corrosion in industrial equipment,even at low concentrations.Among various technologies,the selective oxidation of hydrogen sulfide(SOH_(2)S) to elemental sulfur(S) has emerged as a sustainable and environmentally friendly solution.Due to its unique properties,iron oxide has been extensively investigated as a catalyst for SOH_(2)S;however,rapid deactivation has remained a significant drawback.The causes of iron oxide-based catalysts deactivation mechanisms in SOH_(2)S,including sulfur or sulfate deposition,the transformation of iron species,sintering and excessive oxygen vacancy formation,and active site loss,are thoroughly examined in this review.By focusing on the deactivation mechanisms,this review aims to provide valuable insights into enhancing the stability and efficiency of iron-based catalysts for SOH_(2)S.
基金This work is supported by the National Natural Science Foundation of China(Nos.11672069,11702059,11232003,11672062)The Ph.D.Programs Foundation of Ministry of Education of China(No.20130041110050)+3 种基金the Research Startup Project Plan for Liaoning Doctors(No.20141119)the Fundamental Research Funds for the Central Universities(20000101)the Natural Science Foundation of Liaoning Province(No.20170540199)111 Project(B08014).
文摘In this paper,a nonlinear wave equation with variable coefficients is studied,interestingly,this equation can be used to describe the travelling waves propagating along the circular rod composed of a general compressible hyperelastic material with variable cross-sections and variable material densities.With the aid of Lou’s direct method1,the nonlinear wave equation with variable coefficients is reduced and two sets of symmetry transformations and exact solutions of the nonlinear wave equation are obtained.The corresponding numerical examples of exact solutions are presented by using different coefficients.Particularly,while the variable coefficients are taken as some special constants,the nonlinear wave equation with variable coefficients reduces to the one with constant coefficients,which can be used to describe the propagation of the travelling waves in general cylindrical rods composed of generally hyperelastic materials.Using the same method to solve the nonlinear wave equation,the validity and rationality of this method are verified.
基金Italian Civil Protection within the Projects DPC-RELUIS 2010-2013(Task 3.1)DPC-RELUIS 2014(Special Project"Monitoraggio")
文摘The key parameters for damage detection and localization are eigenfrequencies, related equivalent viscous damping factors and mode shapes. The classical approach is based on the evaluation of these structural parameters before and after a seismic event, but by using a modern approach based on time-frequency transformations it is possible to quantify these parameters throughout the ground shaking phase. In particular with the use of the S-Transform, it is possible to follow the temporal evolution of the structural dynamics parameters before, during and after an earthquake. In this paper, a methodology for damage localization on framed structures subjected to strong motion earthquakes is proposed based on monitoring the modal curvature variation in the natural frequency of a structure. Two examples of application are described to illustrate the technique: Computer simulation of the nonlinear response of a model, and several laboratory(shaking table) tests performed at the University of Basilicata(Italy). Damage detected using the proposed approach and damage revealed via visual inspections in the tests are compared.
基金The paper was support by a grant from the Ministry Youth Research of China,No.98-1-269
文摘AIM: To study persistence and replication of hepatitis C virus (HCV) in patients' peripheral blood mononuclear cells (PBMC) cultured in vitro. METHODS: Epstein Barr virus (EBV) was used to transform the hepatitis C virus from a HCV positive patient to permanent lymphoblastoid cell lines (LCL). Positive and negative HCV RNA strands of the cultured cells and growth media were detected by reverse transcriptase-polymerase chain reaction (RT-PCR) each month. Core and NS5 proteins of HCV were further tested using immunohistochemical SP method and in situ RT-PCR. RESULTS: HCV RNA positive strands were consistently detected the cultured cells for one year. The negative-strand RNA in LCL cells and the positive-strand RNA in supernatants were observed intermittently. Immunohistochemical results medicated expression of HCV NS3 and C proteins in LCL cytoplasm mostly. The positive signal of PCR product was dark blue and mainly localized to the LCL cytoplasm. The RT-PCR signal was eliminated by overnight RNase digestion but not DNase digestion. CONCLUSION: HCV may exist and remain functional in a cultured cell line for a long period.
基金supported by Educational Commission of Jilin Province of China(Grant No.JJKH20190782SK)supported by the Jilin Vocational and Technical Education Association(Grant No.2018XHY115).
文摘Based on the previous case study in promoting transformative learning of college English teachers,who participated in a three-month online training courses,the article made a further research and concluded four strategies on promoting transformative learning of college English Teachers.