Interferon regulatory factor 7 plays a crucial role in the innate immune response.However,whether interferon regulatory factor 7-mediated signaling contributes to Parkinson's disease remains unknown.Here we report...Interferon regulatory factor 7 plays a crucial role in the innate immune response.However,whether interferon regulatory factor 7-mediated signaling contributes to Parkinson's disease remains unknown.Here we report that interferon regulatory factor 7 is markedly up-regulated in a 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine-induced mouse model of Parkinson's disease and co-localizes with microglial cells.Both the selective cyclic guanosine monophosphate adenosine monophosphate synthase inhibitor RU.521 and the stimulator of interferon genes inhibitor H151 effectively suppressed interferon regulatory factor 7 activation in BV2 microglia exposed to 1-methyl-4-phenylpyridinium and inhibited transformation of mouse BV2 microglia into the neurotoxic M1 phenotype.In addition,si RNA-mediated knockdown of interferon regulatory factor 7 expression in BV2 microglia reduced the expression of inducible nitric oxide synthase,tumor necrosis factorα,CD16,CD32,and CD86 and increased the expression of the anti-inflammatory markers ARG1 and YM1.Taken together,our findings indicate that the cyclic guanosine monophosphate adenosine monophosphate synthase-stimulator of interferon genes-interferon regulatory factor 7 pathway plays a crucial role in the pathogenesis of Parkinson's disease.展开更多
Engine engineering database system is an oriented C AD applied database management system that has the capability managing distributed data. The paper discusses the security issue of the engine engineering database ma...Engine engineering database system is an oriented C AD applied database management system that has the capability managing distributed data. The paper discusses the security issue of the engine engineering database management system (EDBMS). Through studying and analyzing the database security, to draw a series of securi ty rules, which reach B1, level security standard. Which includes discretionary access control (DAC), mandatory access control (MAC) and audit. The EDBMS implem ents functions of DAC, MAC and multigranularity audit. DAC solves the problems o f role inheritance, right contain, authorization identify and cascade revoke, et c; MAC includes subject and object security setup rule, security modify rule and multilevel relation access operation rule, etc; Audit allows making the sub ject, object or operation type as different audit object to implement flexible a nd multigranularity audit method. The model is designed act as a security agent to access daemon database. At present, the model is implemented which runs on th e Windows 2000 environments.展开更多
In order to gain practical experience and hands-on skills,full-time professional master degree postgraduate in mineral processing engineering should engage in professional practices.Nonetheless,a series of problems,in...In order to gain practical experience and hands-on skills,full-time professional master degree postgraduate in mineral processing engineering should engage in professional practices.Nonetheless,a series of problems,including insufficient time for practice,low management level,inadequate implementation of the double-supervisor system,and poor results of professional practice,has reduced the effectiveness of professional practice.In view of the aforementioned problems and the characteristics of the discipline,this paper proposes several strategies for improving the effectiveness of professional practice for postgraduates in mineral processing engineering.展开更多
The effect of synthesis temperature and reaction time on the visible-light photocatalytic activity of hierarchical network-like SnIn4S8 microspheres was investigated by the low-temperature co-precipitation strategy. T...The effect of synthesis temperature and reaction time on the visible-light photocatalytic activity of hierarchical network-like SnIn4S8 microspheres was investigated by the low-temperature co-precipitation strategy. The preparation temperature and reaction time have great influence on the photocatalytic activity of SnIn4S8, and the optimal preparation temperature and reaction time are 70℃ and 3 h, respectively.The SnIn4S8 shows good reusability and high stability with no observable decrease of photocatalytic activity in five consecutive cycles.展开更多
During the early days of New China, to support the domestic construction of those projects aided by the former Soviet Union, the design institution formed a chemical engineering production installation design team. Du...During the early days of New China, to support the domestic construction of those projects aided by the former Soviet Union, the design institution formed a chemical engineering production installation design team. During the 1950s, this team designed an ammonia synthesis unit with an annual capacity of 75000 tons, set up the Sichuan Chemical Plant and worked out a展开更多
Software product lines have recently been presented as one of the best promis-ing improvements for the efficient software development. Different research works contribute supportive parameters and negotiations regardi...Software product lines have recently been presented as one of the best promis-ing improvements for the efficient software development. Different research works contribute supportive parameters and negotiations regarding the prob-lems of producing a perfect software scheme. Traditional approaches or recy-cling software are not effective to solve the problems concerning software competence. Since fast developments with software engineering in the past few years, studies show that some approaches are getting extensive attention in both industries and universities. This method is categorized as the software product line improvement;that supports reusing of software in big organizations. Different industries are adopting product lines to enhance efficiency and reduce operational expenses by way of emerging product developments. This research paper is formed to offer in-depth study regarding the software engineering issues such as complexity, conformity, changeability, invisibility, time constraints, budget constraints, and security. We have conducted various research surveys by visiting different professional software development organizations and took feedback from the professional software engineers to analyze the real-time problems that they are facing during the development process of software systems. Survey results proved that complexity is a most occurring issue that most software developers face while developing software applications. Moreover, invisibility is the problem that rarely happens according to the survey.展开更多
The origin,formation and evolution of the systems engineering theory accompanied QIAN Xuesen's whole life.The systems engineering theory is the concentrated reflection of QIAN's achievements and theory in all ...The origin,formation and evolution of the systems engineering theory accompanied QIAN Xuesen's whole life.The systems engineering theory is the concentrated reflection of QIAN's achievements and theory in all aspects.From returning to China to pioneer China's space industry,creating a new management mode of "one overall design department,two command lines",publishing Organization and Management Technology:Systems Engineering,to proposing the theory of Open Complex Giant System(OCGS) and the theory of Metasynthetic Wisdom,all these mark the formation of the Chinese school of systems engineering.Guided by QIAN's academic ideas,various major Chinese space programs have been implemented successfully which verified the fact that the systems engineering is scientific.The systems engineering has been applied to different fields of the national economy and has a development process with the distinguished characteristics of Chinese systems science.On one hand,the systems engineering is put forward deeply along the traditional systems engineering thought and theory;on the other hand,a batch of innovations that break the traditional shackles have occurred,making the Chinese systems engineering unique and outstanding compared with foreign counterparts.展开更多
ECO-88D Double Rope High Speed Dyeing Machine ECO-88D Double Rope High Speed Dyeing Machine is suitable for the processing of light to medium weight fabric made from synthetic ber. Fabric structure suitable for the dy...ECO-88D Double Rope High Speed Dyeing Machine ECO-88D Double Rope High Speed Dyeing Machine is suitable for the processing of light to medium weight fabric made from synthetic ber. Fabric structure suitable for the dyeing process inside the ECO-88D includes woven,展开更多
This article expounds that China’s higher engineering education is facing both challenges and opportunities. Some special difficulties and problems rise in the course of economic transition, and exhort us that it has...This article expounds that China’s higher engineering education is facing both challenges and opportunities. Some special difficulties and problems rise in the course of economic transition, and exhort us that it has been of great urgency to carry out a reform of higher engineering education. Here are put forward six measures: to explore training patterns of such an education suited to China’s national conditions; to improve university system: to transform educational ideology, and reform educational contents and methods; to establish a system of cooperation of engineering universities and colleges with industries; to strengthen construction of teacher contingent in engineering universities and colleges; and to carry out testing work of continuing engineering education and training education.展开更多
The author puts forward a proposal for developing chemistry and chemical engineering of China’s salt lakes on the basis of an investigation into exploitation and utilization of salt lake resources all over the world....The author puts forward a proposal for developing chemistry and chemical engineering of China’s salt lakes on the basis of an investigation into exploitation and utilization of salt lake resources all over the world. It contains the subjects of setting up an engineering research center, mainly developing leading products, giving priority to the development of a chemical industry by using Qinghai salt lake resources, actively popularizing results, stressing basic research and systematic management.展开更多
Alzheimer s disease,among the most common neurodegenerative disorders,is chara cterized by progressive cognitive impairment.At present,the Alzheimer’s disease main risk remains genetic ris ks,but major environmental ...Alzheimer s disease,among the most common neurodegenerative disorders,is chara cterized by progressive cognitive impairment.At present,the Alzheimer’s disease main risk remains genetic ris ks,but major environmental fa ctors are increasingly shown to impact Alzheimer’s disease development and progression.Microglia,the most important brain immune cells,play a central role in Alzheimer’s disease pathogenesis and are considered environmental and lifestyle"sensors."Factors like environmental pollution and modern lifestyles(e.g.,chronic stress,poor dietary habits,sleep,and circadian rhythm disorde rs)can cause neuroinflammato ry responses that lead to cognitive impairment via microglial functioning and phenotypic regulation.However,the specific mechanisms underlying interactions among these facto rs and microglia in Alzheimer’s disease are unclear.Herein,we:discuss the biological effects of air pollution,chronic stress,gut micro biota,sleep patterns,physical exercise,cigarette smoking,and caffeine consumption on microglia;consider how unhealthy lifestyle factors influence individual susceptibility to Alzheimer’s disease;and present the neuroprotective effects of a healthy lifestyle.Toward intervening and controlling these environmental risk fa ctors at an early Alzheimer’s disease stage,understanding the role of microglia in Alzheimer’s disease development,and to rgeting strategies to to rget microglia,co uld be essential to future Alzheimer’s disease treatments.展开更多
Xinqiao Gully is located in the area of the 2008 Wenchuan M_(s)8.0 earthquake in Sichuan province,China.Based on the investigation of the 2023"6-26"Xinqiao Gully debris flow event,this study assessed the eff...Xinqiao Gully is located in the area of the 2008 Wenchuan M_(s)8.0 earthquake in Sichuan province,China.Based on the investigation of the 2023"6-26"Xinqiao Gully debris flow event,this study assessed the effectiveness of the debris flow control project and evaluated the debris flow hazards.Through field investigation and numerical simulation methods,the indicators of flow intensity reduction rate and storage capacity fullness were proposed to quantify the effectiveness of the engineering measures in the debris flow event.The simulation results show that the debris flow control project reduced the flow intensity by41.05%to 64.61%.The storage capacity of the dam decreases gradually from upstream to the mouth of the gully,thus effectively intercepting and controlling the debris flow.By evaluating the debris flow of different recurrence intervals,further measures are recommended for managing debris flow events.展开更多
基金supported by the National Natural Science Foundation of China,Nos.82171429,81771384a grant from Wuxi Municipal Health Commission,No.1286010241190480(all to YS)。
文摘Interferon regulatory factor 7 plays a crucial role in the innate immune response.However,whether interferon regulatory factor 7-mediated signaling contributes to Parkinson's disease remains unknown.Here we report that interferon regulatory factor 7 is markedly up-regulated in a 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine-induced mouse model of Parkinson's disease and co-localizes with microglial cells.Both the selective cyclic guanosine monophosphate adenosine monophosphate synthase inhibitor RU.521 and the stimulator of interferon genes inhibitor H151 effectively suppressed interferon regulatory factor 7 activation in BV2 microglia exposed to 1-methyl-4-phenylpyridinium and inhibited transformation of mouse BV2 microglia into the neurotoxic M1 phenotype.In addition,si RNA-mediated knockdown of interferon regulatory factor 7 expression in BV2 microglia reduced the expression of inducible nitric oxide synthase,tumor necrosis factorα,CD16,CD32,and CD86 and increased the expression of the anti-inflammatory markers ARG1 and YM1.Taken together,our findings indicate that the cyclic guanosine monophosphate adenosine monophosphate synthase-stimulator of interferon genes-interferon regulatory factor 7 pathway plays a crucial role in the pathogenesis of Parkinson's disease.
文摘Engine engineering database system is an oriented C AD applied database management system that has the capability managing distributed data. The paper discusses the security issue of the engine engineering database management system (EDBMS). Through studying and analyzing the database security, to draw a series of securi ty rules, which reach B1, level security standard. Which includes discretionary access control (DAC), mandatory access control (MAC) and audit. The EDBMS implem ents functions of DAC, MAC and multigranularity audit. DAC solves the problems o f role inheritance, right contain, authorization identify and cascade revoke, et c; MAC includes subject and object security setup rule, security modify rule and multilevel relation access operation rule, etc; Audit allows making the sub ject, object or operation type as different audit object to implement flexible a nd multigranularity audit method. The model is designed act as a security agent to access daemon database. At present, the model is implemented which runs on th e Windows 2000 environments.
基金This work was supported by The Graduate Education and Teaching Reform Project of CUMTB(YJG202200301)The Yueqi Outstanding Scholar Award of CUMTB and Science and Technology Major Project of Ordos City-Iconic Innovation Team(202204).
文摘In order to gain practical experience and hands-on skills,full-time professional master degree postgraduate in mineral processing engineering should engage in professional practices.Nonetheless,a series of problems,including insufficient time for practice,low management level,inadequate implementation of the double-supervisor system,and poor results of professional practice,has reduced the effectiveness of professional practice.In view of the aforementioned problems and the characteristics of the discipline,this paper proposes several strategies for improving the effectiveness of professional practice for postgraduates in mineral processing engineering.
基金supported by Natural Science Foundation of China (51741806, 51238002, 51720105001)Science Fund for Excellent Young Scholars of Jiangxi Province (20162BCB23038)Natural Science Foundation of Jiangxi Province (20161BAB206117)
文摘The effect of synthesis temperature and reaction time on the visible-light photocatalytic activity of hierarchical network-like SnIn4S8 microspheres was investigated by the low-temperature co-precipitation strategy. The preparation temperature and reaction time have great influence on the photocatalytic activity of SnIn4S8, and the optimal preparation temperature and reaction time are 70℃ and 3 h, respectively.The SnIn4S8 shows good reusability and high stability with no observable decrease of photocatalytic activity in five consecutive cycles.
文摘During the early days of New China, to support the domestic construction of those projects aided by the former Soviet Union, the design institution formed a chemical engineering production installation design team. During the 1950s, this team designed an ammonia synthesis unit with an annual capacity of 75000 tons, set up the Sichuan Chemical Plant and worked out a
文摘Software product lines have recently been presented as one of the best promis-ing improvements for the efficient software development. Different research works contribute supportive parameters and negotiations regarding the prob-lems of producing a perfect software scheme. Traditional approaches or recy-cling software are not effective to solve the problems concerning software competence. Since fast developments with software engineering in the past few years, studies show that some approaches are getting extensive attention in both industries and universities. This method is categorized as the software product line improvement;that supports reusing of software in big organizations. Different industries are adopting product lines to enhance efficiency and reduce operational expenses by way of emerging product developments. This research paper is formed to offer in-depth study regarding the software engineering issues such as complexity, conformity, changeability, invisibility, time constraints, budget constraints, and security. We have conducted various research surveys by visiting different professional software development organizations and took feedback from the professional software engineers to analyze the real-time problems that they are facing during the development process of software systems. Survey results proved that complexity is a most occurring issue that most software developers face while developing software applications. Moreover, invisibility is the problem that rarely happens according to the survey.
文摘The origin,formation and evolution of the systems engineering theory accompanied QIAN Xuesen's whole life.The systems engineering theory is the concentrated reflection of QIAN's achievements and theory in all aspects.From returning to China to pioneer China's space industry,creating a new management mode of "one overall design department,two command lines",publishing Organization and Management Technology:Systems Engineering,to proposing the theory of Open Complex Giant System(OCGS) and the theory of Metasynthetic Wisdom,all these mark the formation of the Chinese school of systems engineering.Guided by QIAN's academic ideas,various major Chinese space programs have been implemented successfully which verified the fact that the systems engineering is scientific.The systems engineering has been applied to different fields of the national economy and has a development process with the distinguished characteristics of Chinese systems science.On one hand,the systems engineering is put forward deeply along the traditional systems engineering thought and theory;on the other hand,a batch of innovations that break the traditional shackles have occurred,making the Chinese systems engineering unique and outstanding compared with foreign counterparts.
文摘ECO-88D Double Rope High Speed Dyeing Machine ECO-88D Double Rope High Speed Dyeing Machine is suitable for the processing of light to medium weight fabric made from synthetic ber. Fabric structure suitable for the dyeing process inside the ECO-88D includes woven,
文摘This article expounds that China’s higher engineering education is facing both challenges and opportunities. Some special difficulties and problems rise in the course of economic transition, and exhort us that it has been of great urgency to carry out a reform of higher engineering education. Here are put forward six measures: to explore training patterns of such an education suited to China’s national conditions; to improve university system: to transform educational ideology, and reform educational contents and methods; to establish a system of cooperation of engineering universities and colleges with industries; to strengthen construction of teacher contingent in engineering universities and colleges; and to carry out testing work of continuing engineering education and training education.
文摘The author puts forward a proposal for developing chemistry and chemical engineering of China’s salt lakes on the basis of an investigation into exploitation and utilization of salt lake resources all over the world. It contains the subjects of setting up an engineering research center, mainly developing leading products, giving priority to the development of a chemical industry by using Qinghai salt lake resources, actively popularizing results, stressing basic research and systematic management.
基金supported by the National Natural Science Foundation of China,Nos.82071190 and 82371438(to LC)Innovative Strong School Project of Guangdong Medical University,No.4SG21230G(to LC)Scientific Research Foundation of Guangdong Medical University,No.GDMUM2020017(to CL)。
文摘Alzheimer s disease,among the most common neurodegenerative disorders,is chara cterized by progressive cognitive impairment.At present,the Alzheimer’s disease main risk remains genetic ris ks,but major environmental fa ctors are increasingly shown to impact Alzheimer’s disease development and progression.Microglia,the most important brain immune cells,play a central role in Alzheimer’s disease pathogenesis and are considered environmental and lifestyle"sensors."Factors like environmental pollution and modern lifestyles(e.g.,chronic stress,poor dietary habits,sleep,and circadian rhythm disorde rs)can cause neuroinflammato ry responses that lead to cognitive impairment via microglial functioning and phenotypic regulation.However,the specific mechanisms underlying interactions among these facto rs and microglia in Alzheimer’s disease are unclear.Herein,we:discuss the biological effects of air pollution,chronic stress,gut micro biota,sleep patterns,physical exercise,cigarette smoking,and caffeine consumption on microglia;consider how unhealthy lifestyle factors influence individual susceptibility to Alzheimer’s disease;and present the neuroprotective effects of a healthy lifestyle.Toward intervening and controlling these environmental risk fa ctors at an early Alzheimer’s disease stage,understanding the role of microglia in Alzheimer’s disease development,and to rgeting strategies to to rget microglia,co uld be essential to future Alzheimer’s disease treatments.
基金supported by the project of the China Geological Survey(No.DD20221746)the National Natural Science Foundation of China(Grant Nos.41101086)。
文摘Xinqiao Gully is located in the area of the 2008 Wenchuan M_(s)8.0 earthquake in Sichuan province,China.Based on the investigation of the 2023"6-26"Xinqiao Gully debris flow event,this study assessed the effectiveness of the debris flow control project and evaluated the debris flow hazards.Through field investigation and numerical simulation methods,the indicators of flow intensity reduction rate and storage capacity fullness were proposed to quantify the effectiveness of the engineering measures in the debris flow event.The simulation results show that the debris flow control project reduced the flow intensity by41.05%to 64.61%.The storage capacity of the dam decreases gradually from upstream to the mouth of the gully,thus effectively intercepting and controlling the debris flow.By evaluating the debris flow of different recurrence intervals,further measures are recommended for managing debris flow events.
