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Dietary polyphenols reduced the allergenicity ofβ-lactoglobulin via non-covalent interactions:a study on the structure-allergenicity relationship
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作者 Chi Zhang Qiaozhi Zhang +6 位作者 Huatao Li Zhouzhou Cheng Shiyu Fan Hujun Xie Zhongshan Gao Yan Zhang Linglin Fu 《Food Science and Human Wellness》 SCIE CAS CSCD 2024年第5期2617-2628,共12页
Studies showed that complexation of polyphenols with milk allergens reduced their immunogenic potential.However,the relationship between structures of polyphenols and their hypoallergenic effects on milk allergens in ... Studies showed that complexation of polyphenols with milk allergens reduced their immunogenic potential.However,the relationship between structures of polyphenols and their hypoallergenic effects on milk allergens in association with physiological and conformational changes of the complexes remain unclear.In this study,polyphenols from eight botanical sources were extracted to prepare non-covalent complexes withβ-lactoglobulin(β-LG),a major allergen in milk.The dominant phenolic compounds bound toβ-LG with a diminished allergenicity were identified to investigate their respective role on the structural and allergenic properties ofβ-LG.Extracts from Vaccinium fruits and black soybeans were found to have great inhibitory effects on the IgE-and IgG-binding abilities ofβ-LG.Among the fourteen structure-related phenolic compounds,flavonoids and tannins with larger MWs and multi-hydroxyl substituents,notably rutin,EGCG,and ellagitannins were more potent to elicit changes on the conformational structures ofβ-LG to decrease the allergenicity of complexedβ-LG.Correlation analysis further demonstrated that a destabilized secondary structure and protein depolymerization caused by polyphenol-binding were closely related to the allergenicity property of formed complexes.This study provides insights into the understanding of structure-allergenicity relationship ofβ-LG-polyphenol interactions and would benefit the development of polyphenol-fortified matrices with hypoallergenic potential. 展开更多
关键词 Cow’s milk allergy Β-LACTOGLOBULIN Protein-polyphenol interaction ALLERGENICITY Conformational structure
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The DUF579 proteins GhIRX15s regulate cotton fiber development by interacting with proteins involved in xylan synthesis
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作者 Mengyun Li Feng Chen +6 位作者 Jingwen Luo Yanan Gao Jinglong Cai Wei Zeng Monika S.Doblin Gengqing Huang Wenliang Xu 《The Crop Journal》 SCIE CSCD 2024年第4期1112-1125,共14页
Cotton provides the most abundant natural fiber for the textile industry.The mature cotton fiber largely consists of secondary cell walls with the highest proportion of cellulose and a small amount of hemicellulose an... Cotton provides the most abundant natural fiber for the textile industry.The mature cotton fiber largely consists of secondary cell walls with the highest proportion of cellulose and a small amount of hemicellulose and lignin.To dissect the roles of hemicellulosic polysaccharides during fiber development,four IRREGULAR XYLEM 15(IRX15)genes,GhIRX15-1/-2/-3/-4,were functionally characterized in cotton.These genes encode DUF579 domain-containing proteins,which are homologs of AtIRX15 involved in xylan biosynthesis.The four GhIRX15 genes were predominantly expressed during fiber secondary wall thickening,and the encoded proteins were localized to the Golgi apparatus.Each GhIRX15 gene could restore the xylan deficient phenotype in the Arabidopsis irx15irx15l double mutant.Silencing of GhIRX15s in cotton resulted in shorter mature fibers with a thinner cell wall and reduced cellulose content as compared to the wild type.Intriguingly,GhIRX15-2 and GhIRX15-4 formed homodimers and heterodimers.In addition,the GhIRX15s showed physical interaction with glycosyltransferases GhGT43C,GhGT47A and GhGT47B,which are responsible for synthesis of the xylan backbone and reducing end sequence.Moreover,the GhIRX15s can form heterocomplexes with enzymes involved in xylan modification and side chain synthesis,such as GhGUX1/2,GhGXM1/2 and GhTBL1.These findings suggest that GhIRX15s participate in fiber xylan biosynthesis and modulate fiber development via forming large multiprotein complexes. 展开更多
关键词 Cotton fiber Xylan biosynthesis GhIRX15s Protein-protein interaction Protein complexes
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AAV mediated carboxyl terminus of Hsp70 interacting protein overexpression mitigates the cognitive and pathological phenotypes of APP/PS1 mice
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作者 Zhengwei Hu Jing Yang +7 位作者 Shuo Zhang Mengjie Li Chunyan Zuo Chengyuan Mao Zhongxian Zhang Mibo Tang Changhe Shi Yuming Xu 《Neural Regeneration Research》 SCIE CAS 2025年第1期253-264,共12页
The E3 ubiquitin ligase,carboxyl terminus of heat shock protein 70(Hsp70)interacting protein(CHIP),also functions as a co-chaperone and plays a crucial role in the protein quality control system.In this study,we aimed... The E3 ubiquitin ligase,carboxyl terminus of heat shock protein 70(Hsp70)interacting protein(CHIP),also functions as a co-chaperone and plays a crucial role in the protein quality control system.In this study,we aimed to investigate the neuroprotective effect of overexpressed CHIP on Alzheimer’s disease.We used an adeno-associated virus vector that can cross the blood-brain barrier to mediate CHIP overexpression in APP/PS1 mouse brain.CHIP overexpression significantly ameliorated the performance of APP/PS1 mice in the Morris water maze and nest building tests,reduced amyloid-βplaques,and decreased the expression of both amyloid-βand phosphorylated tau.CHIP also alleviated the concentration of microglia and astrocytes around plaques.In APP/PS1 mice of a younger age,CHIP overexpression promoted an increase in ADAM10 expression and inhibitedβ-site APP cleaving enzyme 1,insulin degrading enzyme,and neprilysin expression.Levels of HSP70 and HSP40,which have functional relevance to CHIP,were also increased.Single nuclei transcriptome sequencing in the hippocampus of CHIP overexpressed mice showed that the lysosomal pathway and oligodendrocyte-related biological processes were up-regulated,which may also reflect a potential mechanism for the neuroprotective effect of CHIP.Our research shows that CHIP effectively reduces the behavior and pathological manifestations of APP/PS1 mice.Indeed,overexpression of CHIP could be a beneficial approach for the treatment of Alzheimer’s disease. 展开更多
关键词 adeno-associated virus Alzheimer’s disease APP/Ps1 mice carboxyl terminus of Hsp70 interacting protein gene therapy
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Numerical Study on the Duct Acoustic Mode Control of Turbine Interaction Noise with Serrated Configurations
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作者 Kangshen Xiang Weijie Chen +1 位作者 Jianxin Lian Weiyang Qiao 《Journal of Applied Mathematics and Physics》 2023年第8期2491-2502,共12页
Turbine noise would be one of the dominant noise sources especially in future UHBR (Ultra High Bypass-Ratio) aeroengine, but its currently far from being studied enough. Acoustic mode is crucial for duct propagation b... Turbine noise would be one of the dominant noise sources especially in future UHBR (Ultra High Bypass-Ratio) aeroengine, but its currently far from being studied enough. Acoustic mode is crucial for duct propagation but little study about the relation between serration and mode. Thus, taking axial single-turbine test bench NPU-Turb as object, the effect of Stator with Serrated Trailing-edge (Bionic S) and Rotor with Serrated Leading-edge (Bionic R) on duct acoustic modes of turbine turbulence interac-tion noise were studied in detail using DDES/AA hybrid model validated by acoustic experiment of NPU-Turb. Serval conclusions can be made here. First, for broadband noise, the effect of serrations on duct modes (increased or reduced of PWL<sub>mn</sub>) with the increasing frequency is more prominent. Second, the changing trend of ?PWL<sub>mn</sub> is something like Chinese character “人” with circumferential mode m and alternating with radial mode. Such distribution is more obvious at higher frequency. More theoretical and mechanistic research work needs to be carried out in depth in the future. . 展开更多
关键词 Turbine interaction Noise Duct Acoustic Mode NPU-Turb Bionic s Bionic R
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“U-S”合作中高校教师与中小学教师的跨界知识互动探究
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作者 陆超 《现代基础教育研究》 2024年第3期27-31,共5页
对于“U-S”合作情境中高校教师与中小学教师如何进行知识互动这一重要问题,鲜有实证研究涉及。通过对高校与中小学合作的多个案例进行质性研究,发现高校教师与中小学教师的知识互动存在三种不同的模式:一是高校教师主导下的知识迁移模... 对于“U-S”合作情境中高校教师与中小学教师如何进行知识互动这一重要问题,鲜有实证研究涉及。通过对高校与中小学合作的多个案例进行质性研究,发现高校教师与中小学教师的知识互动存在三种不同的模式:一是高校教师主导下的知识迁移模式,二是内化与重构后的知识转化模式,三是基于研究伙伴关系的知识生产模式。基于此,自我定位与地位关系、知识互动的聚焦性和持续性、卷入程度及跨界互动能力,是影响高校教师与中小学教师知识互动效果的重要因素。 展开更多
关键词 “U-s”合作 跨界知识互动 知识生产
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[WS_(3)Cu_(2)]簇基超分子框的组装、结构及其三阶非线性光学响应
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作者 余蕙敏 王志康 +3 位作者 李洁 宋瑛林 杜明浩 郎建平 《无机化学学报》 SCIE CSCD 北大核心 2024年第1期71-78,共8页
将二(4-吡啶)硫烷(L_(1))、4,4'-二(4-吡啶)二苯甲酮(L_(2))分别与(Et_(4)N)(Tp*WS_(3))(A)(Tp*=三(3,5-二甲基吡唑)氢合硼酸根)和[Cu(Me CN)_(4)]PF_(6)进行反应,得到2个W/Cu/S簇基超分子化合物[Tp*WS_(3)Cu_(2)(L_(1))]_(2)(PF_(6... 将二(4-吡啶)硫烷(L_(1))、4,4'-二(4-吡啶)二苯甲酮(L_(2))分别与(Et_(4)N)(Tp*WS_(3))(A)(Tp*=三(3,5-二甲基吡唑)氢合硼酸根)和[Cu(Me CN)_(4)]PF_(6)进行反应,得到2个W/Cu/S簇基超分子化合物[Tp*WS_(3)Cu_(2)(L_(1))]_(2)(PF_(6))_(2)·2Me CN·2CHCl_(3)(1·2Me CN·2CHCl_(3))和[Tp*WS_(3)Cu_(2)(L_(2))(Me CN)]_(2)(PF_(6))_(2)·4Me CN (2·4Me CN)。对配合物1·2Me CN·2CHCl_(3)和2·4Me CN分别进行了单晶X射线衍射、核磁、质谱、红外、紫外可见和元素分析表征。单晶X射线衍射分析表明,它们是由2个L_(1)/L_(2)配体连接2个[Tp*WS_(3)Cu_(2)]~+簇核形成的阳离子型簇基超分子框。核磁氢谱和高分辨电喷雾离子化质谱(HRESI-MS)证明它们在溶液中具有一定的稳定性。并利用Z扫描技术测试了超分子化合物1·2Me CN·2CHCl_(3)和2·4MeCN溶液的三阶非线性光学特性,测试结果表明它们的三阶非线性光学响应强于前驱体A。 展开更多
关键词 W/Cu/s 超分子框 三阶非线性光学性质
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Tuning interface mechanism of FeCo alloy embedded N,S-codoped carbon substrate for rechargeable Zn-air battery 被引量:1
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作者 Hui Chang Lulu Zhao +4 位作者 Shan Zhao Zong-Lin Liu Peng-Fei Wang Ying Xie Ting-Feng Yi 《Journal of Energy Chemistry》 SCIE EI CAS CSCD 2024年第6期400-410,I0010,共12页
The interface mechanism between catalyst and carbon substrate has been the focus of research.In this paper,the FeCo alloy embedded N,S co-doped carbon substrate bifunctional catalyst(FeCo/S-NC)is obtained by a simple ... The interface mechanism between catalyst and carbon substrate has been the focus of research.In this paper,the FeCo alloy embedded N,S co-doped carbon substrate bifunctional catalyst(FeCo/S-NC)is obtained by a simple one-step pyrolysis strategy.The experimental results and density functional theory(DFT)calculation show that the formation of FeCo alloy is conducive to promoting electron transfer,and the introduction of S atom can enhance the interaction between FeCo alloy and carbon substrate,thus inhibiting the migration and agglomeration of particles on the surface of carbon material.The FeCo/SNC catalysts show outstanding performance for oxygen reduction reaction(ORR)and oxygen evolution reaction(OER).FeCo/S-NC shows a high half-wave potential(E_(1/2)=0.8823 V)for ORR and a low overpotential at 10 mA cm^(-2)(E_(j=10)=299 mV)for OER.In addition,compared with Pt/C+RuO_(2) assembled Zn-air battery(ZAB),the FeCo/S-NC assembled ZAB exhibits a larger power density(198.8 mW cm^(-2)),a higher specific capacity(786.1 mA h g_(zn)~(-1)),and ultra-stable cycle performance.These results confirm that the optimized composition and the interfacial interaction between catalyst and carbon substrate synergistically enhance the electrochemical performance. 展开更多
关键词 FeCo alloy N s co-doped carbon DFT calculation Zn-air batteries Interfacial interaction
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宿主因子NPSR调节伪狂犬病病毒感染能力的研究
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作者 罗欣欣 郑虎 +1 位作者 高美娟 杨化强 《华南农业大学学报》 CAS CSCD 北大核心 2024年第4期457-468,共12页
[目的]伪狂犬病病毒(Pseudorabies virus,PRV)属甲型疱疹病毒科,是一种嗜神经性病毒,通过接触传播感染造成神经和呼吸系统疾病。猪是PRV的自然宿主,PRV的感染和流行对养猪业造成巨大经济损失。PRV侵染宿主中枢神经系统后,引发神经肽S(Ne... [目的]伪狂犬病病毒(Pseudorabies virus,PRV)属甲型疱疹病毒科,是一种嗜神经性病毒,通过接触传播感染造成神经和呼吸系统疾病。猪是PRV的自然宿主,PRV的感染和流行对养猪业造成巨大经济损失。PRV侵染宿主中枢神经系统后,引发神经肽S(Neuropeptide S,NPS)系统表达水平的改变。NPS是一种神经肽物质,作为神经内分泌系统的关键成员在中枢神经系统中广泛分布,与慢性疾病相关联,NPS通过神经肽S受体(Neuropeptide S receptor,NPSR)介导多样化的生理功能,在机体内以NPS/NPSR系统形式共同参与神经内分泌-免疫网络调节。本研究探讨了NPS/NPSR系统在PRV感染宿主细胞中的作用,以期待开发新的抗PRV靶点。[方法]通过CRISPR/Cas9构建NPS和NPSR敲除的PK15细胞系,利用qPCR、免疫荧光、Western blot、免疫共沉淀(CO-IP)等方法检测感染PRV病毒后细胞系的抗病毒能力及NPSR与病毒表面糖蛋白的结合能力。[结果]NPSR敲除能减弱PRV对PK15细胞的感染能力,而NPS基因敲除增强了PRV对PK15细胞的感染能力。NPSR敲除细胞在PRV吸附过程中能减少病毒的侵入量,因此NPSR是潜在的PRV入侵受体。CO-IP试验证明,NPSR与病毒包膜蛋白gB和gD存在相互作用。[结论]NPSR通过与病毒表面糖蛋白结合促进PRV感染,NPSR可能是PRV感染神经系统的受体因子之一。NPSR敲除能显著抑制PRV对PK15细胞的感染。NPSR可为开发PRV防控药物和治疗策略提供新的研究靶点。 展开更多
关键词 神经肽s受体 伪狂犬病病毒 病毒受体 宿主病毒相互作用
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SARS-CoV-2 S蛋白与宿主细胞相互作用的相关受体研究进展
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作者 方晓敏 刘兴健 张锐钢 《中国感染控制杂志》 CAS CSCD 北大核心 2024年第10期1326-1332,共7页
自2019年底新型冠状病毒(SARS-CoV-2)感染暴发以来,对其的研究成为热点。冠状病毒感染趋向性主要取决于刺突蛋白(spike protein,S蛋白)与细胞表面受体结合的能力,而S蛋白及其受体结合域(S-RBD)不仅在病毒与宿主细胞结合及病毒进入细胞... 自2019年底新型冠状病毒(SARS-CoV-2)感染暴发以来,对其的研究成为热点。冠状病毒感染趋向性主要取决于刺突蛋白(spike protein,S蛋白)与细胞表面受体结合的能力,而S蛋白及其受体结合域(S-RBD)不仅在病毒与宿主细胞结合及病毒进入细胞中起着关键作用,还可以与宿主细胞表面受体如血管紧张素转化酶2(ACE2)、Toll样受体(TLRs)、分化集群(CD)147、神经纤毛蛋白-1(NRP-1)等结合并激活不同的信号通路,从而促进病毒入侵宿主细胞及引发炎症等一系列致病进程。因此,研究S蛋白与宿主细胞相互作用的相关受体具有重要意义。本文综述S蛋白与宿主细胞相互作用的相关受体,以期为新型冠状病毒感染的防治提供理论依据。 展开更多
关键词 新冠病毒 s蛋白 受体 相互作用 sARs-CoV-2
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Design of a Landscape Device for Children from the Perspective of Embodied Cognition in the New Era
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作者 HU Bingbing 《Journal of Landscape Research》 2024年第5期5-9,共5页
In recent years,embodied cognition has ushered in a new research upsurge in the academic field,and has become a hot topic in the field of cognitive psychology.In this paper,from the perspective of embodied cognition,t... In recent years,embodied cognition has ushered in a new research upsurge in the academic field,and has become a hot topic in the field of cognitive psychology.In this paper,from the perspective of embodied cognition,the interaction ways of a landscape device for children were discussed to achieve a more real and harmonious interaction between children and scenes.The research data of embodied cognition used by children was analyzed,and the drawbacks and breakthrough points of current landscape devices for children were discussed.The core characteristics of children’s growth period were extracted to establish children’s interaction model and summarize the interactive design methods of landscape devices for children.Embodied cognition has become the most intuitive way for children to know and understand the environment,and plays a pivotal role in children’s growth.Based on embodied cognition principle and interactive behavior mode,the interactive design of a landscape device for children was studied,and three interactive design modes,including simple and convenient interaction mode,multi-sensory interaction mode and game natural interaction mode were summarized.On the basis of this research,relevant design practice and research were carried out to bring a new vision to the design of children’s landscape. 展开更多
关键词 Embodied cognition Children’s landscape Device design interactive behavior pattern
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Evaluation of Technical Education by Using a Modern Structured MOODLE Laboratory Course, in Relation to Recent Data
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作者 Gerasimos Vlassopoulos George Albert Karikas +4 位作者 Efstathia Papageorgiou Ioannis Psaromiligkos Niki Giannouli Pigi Vlassopoulou Petros Karkalousos 《Journal of Intelligent Learning Systems and Applications》 2024年第3期316-339,共24页
E-learning platforms support education systems worldwide, transferring theoretical knowledge as well as soft skills. In the present study high-school pupils’, and adult students’ opinions were evaluated through a mo... E-learning platforms support education systems worldwide, transferring theoretical knowledge as well as soft skills. In the present study high-school pupils’, and adult students’ opinions were evaluated through a modern structured MOODLE interactive course, designed for the needs of the laboratory course “Automotive Systems”. The study concerns Greek secondary vocational education pupils aged 18 and vocational training adult students aged 20 to 50 years. The multistage, equal size simple random cluster sample was used as a sampling method. Pupils and adult students of each cluster completed structured 10-question questionnaires both before and after attending the course. A total of 120 questionnaires were collected. In general, our findings disclosed that the majority of pupils and adult students had significantly improved their knowledge and skills from using MOODLE. They reported strengthening conventional teaching, using the new MOODLE technology. The satisfaction indices improved quite, with the differences in their mean values being statistically significant. 展开更多
关键词 Information and Communication Technologies (ICT) Distance Learning E-Learning students Opinions Education in Greece I.C.T. in Greece sTUDENTs Pupils Adults Adult students MOODLE MOOC (V.H.s.) Vocational High schools (s.H.V.T.) schools of Higher Vocational Training VOCATIONAL Profession interactive Lessons Courses Training Laboratory Course secondary Education Automotive systems Car systems
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Interactions of Sn and S and their effects on the magnetic properties of non-oriented silicon steel sheets 被引量:8
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作者 ZHANG Feng WANG Bo +1 位作者 LV Xuejun CHEN Lingyun 《Baosteel Technical Research》 CAS 2013年第2期12-16,共5页
The interactions of Sn and S and their effects on the magnetic properties of non-oriented silicon steel sheets were discussed in reference to industrial production. Results show that minor amounts of Sn can improve ma... The interactions of Sn and S and their effects on the magnetic properties of non-oriented silicon steel sheets were discussed in reference to industrial production. Results show that minor amounts of Sn can improve magnetic induction sharply but have little effect on core loss when the S content is below 10 × 10 ^-4%. The precipitation of AlN can be restrained effectively by Sn. Sn, as the nucleus, can remove some of the inclusions with a size of 0.5μm or larger, but has little effect on inclusions smaller than 0.5 μm,which is the key factor affecting core loss. Sn improves the magnetic induction of finished steel sheets mainly through the change of the steel texture. The relationship between the magnetic induction and Sn and S content can be regressed as B50 = 1.69 -4.37 ws +0.30 Ws,. From the regression formulation,the magnetic induction can be improved by 0.03 T when 0.01% Sn is added under relatively low S content conditions. 展开更多
关键词 silicon steel sN s interaction magnetic property
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Groundwater monitoring of an open-pit limestone quarry:Water-rock interaction and mixing estimation within the rock layers by geochemical and statistical analyses 被引量:9
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作者 Khy Eam Eang Toshifumi Igarashi +3 位作者 Megumi Kondo Tsurugi Nakatani Carlito Baltazar Tabelin Ryota Fujinaga 《International Journal of Mining Science and Technology》 SCIE EI CSCD 2018年第6期849-857,共9页
Water-rock interaction and groundwater mixing are important phenomena in understanding hydrogeological systems and the stability of rock slopes especially those consisting largely of moderately watersoluble minerals l... Water-rock interaction and groundwater mixing are important phenomena in understanding hydrogeological systems and the stability of rock slopes especially those consisting largely of moderately watersoluble minerals like calcite. In this study, the hydrogeological and geochemical evolutions of groundwater in a limestone quarry composed of three strata: limestone layer(covering), interbedded layer under the covering layer, and slaty greenstone layer(basement) were investigated. Water-rock interaction in the open-pit limestone quarry was evaluated using PHREEQC, while hierarchical cluster analysis(HCA)and principal component analysis(PCA) were used to classify and identify water sources responsible for possible groundwater mixing within rock layers. In addition, Geochemist's Workbench was applied to estimate the mixing fractions to clarify sensitive zones that may affect rock slope stability. The results showed that the changes in Ca2+and HCO3àconcentrations of several groundwater samples along the interbedded layer could be attributed to mixing groundwater from the limestone layer and that from slaty greenstone layer. Based on the HCA and PCA results, groundwaters were classified into several types depending on their origin:(1) groundwater from the limestone layer(LO),(2) mixed groundwater flowing along the interbedded layer(e.g., groundwater samples L-7, L-11, S-3 and S-4), and(3) groundwater originating from the slaty greenstone layer(SO). The mixing fractions of 41% LO: 59% SO, 64% LO: 36% SO, 43%LO: 57% SOand 25% LO: 75% SOon the normal days corresponded to groundwaters L-7, L-11, S-3 and S-4,respectively, while the mixing fractions of groundwaters L-7 and L-11(61% LO: 39% SOand 93% LO: 7% SO,respectively) on rainy days became the majority of groundwater originating from the limestone layer.These indicate that groundwater along the interbedded layer significantly affected the stability of rock slopes by enlarging multi-breaking zones in the layer through calcite dissolution and inducing high water pressure, tension cracks and potential sliding plane along this layer particularly during intense rainfall episodes. 展开更多
关键词 Water-rock interaction GROUNDWATER MIXING Interbedded layer Geochemist’s WORKBENCH ROCK sLOPE stability
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Soliton solution and interaction property for a coupled modified Korteweg-de Vries (mKdV) system 被引量:5
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作者 杨建荣 毛杰健 《Chinese Physics B》 SCIE EI CAS CSCD 2008年第12期4337-4343,共7页
Hirota's bilinear direct method is applied to constructing soliton solutions to a special coupled modified Korteweg- de Vries (mKdV) system. Some physical properties such as the spatiotemporal evolution, waveform s... Hirota's bilinear direct method is applied to constructing soliton solutions to a special coupled modified Korteweg- de Vries (mKdV) system. Some physical properties such as the spatiotemporal evolution, waveform structure, interactive phenomena of solitons are discussed, especially in the two-soliton case. It is found that different interactive behaviours of solitary waves take place under different parameter conditions of overtaking collision in this system. It is verified that the elastic interaction phenomena exist in this (1+1)-dimensional integrable coupled model. 展开更多
关键词 coupled mKdV system Hirota's bilinear method soliton solution elastic interaction
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Study on soil-pile-structure-TMD interaction system by shaking table model test 被引量:3
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作者 楼梦麟 王文剑 《Earthquake Engineering and Engineering Vibration》 SCIE EI CSCD 2004年第1期127-137,共11页
The success of the tuned mass damper (TMD) in reducing wind-induced structural vibrations has been well established. However, from most of the recent numerical studies, it appears that for a structure situated on very... The success of the tuned mass damper (TMD) in reducing wind-induced structural vibrations has been well established. However, from most of the recent numerical studies, it appears that for a structure situated on very soft soil, soil-structure interaction (SSI) could render a damper on the structure totally ineffective. In order to experimentally verify the SSI effect on the seismic performance of TMD, a series of shaking table model tests have been conducted and the results are presented in this paper. It has been shown that the TMD is not as effective in controlling the seismic responses of structures built on soft soil sites due to the SSI effect. Some test results also show that a TMD device might have a negative impact if the SSI effect is neglected and the structure is built on a soft soil site. For structures constructed on a soil foundation, this research verifies that the SSI effect must be carefully understood before a TMD control system is designed to determine if the control is necessary and if the SSI effect must be considered when choosing the optimal parameters of the TMD device. 展开更多
关键词 soil-pile-structure interaction TMD’s performance structural control shaking table model test
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An Analysis of Michael Long’s Interaction Hypothesis in Second Language Acquisition 被引量:5
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作者 单映 《科技信息》 2009年第29期227-229,共3页
The Interaction Hypothesis,which was first advanced by Michael Long,is considered as a further supplement or extension of the Input Hypothesis in the field of second language acquisition. This paper explains the main ... The Interaction Hypothesis,which was first advanced by Michael Long,is considered as a further supplement or extension of the Input Hypothesis in the field of second language acquisition. This paper explains the main claims of Michael Long's Interaction Hypothesis,the three steps to study how input and interaction affect the acquisition of a second language,and the importance of the interactional modifications applied by both participants of the interaction. Emphasis is placed on the evaluation of the theory as well as its relation to second language teaching,with many researchers' findings and arguments discussed as supporting evidence. It aims to help the effective application of this theory in second language teaching. 展开更多
关键词 第二语言 语法 学习方法 教学方法
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Interaction of the major inflammatory bowel disease susceptibility alleles in Crohn’s disease patients 被引量:2
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作者 Veronika Csngei Luca Járomi +9 位作者 EnikSáfrány Csilla Sipeky Lili Magyari Bernadett Faragó Judit Bene Noémi Polgár Lilla Lakner Patrícia Sarlós Márta Varga Béla Melegh 《World Journal of Gastroenterology》 SCIE CAS CSCD 2010年第2期176-183,共8页
AIM:To investigate the interaction of interleukin-23 receptor(IL23R)(rs1004819 and rs2201841),autophagy-related 16-like 1(ATG16L1)(rs2241880), caspase recruitment domain-containing protein 15 (CARD15)genes,and IBD5 lo... AIM:To investigate the interaction of interleukin-23 receptor(IL23R)(rs1004819 and rs2201841),autophagy-related 16-like 1(ATG16L1)(rs2241880), caspase recruitment domain-containing protein 15 (CARD15)genes,and IBD5 locus in Crohn's disease(CD) patients. METHODS:A total of 315 unrelated subjects with CD and 314 healthy controls were genotyped.Interactions and specific genotype combinations of a total of eight variants were tested.The variants of IBD5locus(IGR2198a_1 rs11739135 and IGR2096a_1 rs12521868),CARD15(R702W rs2066845 and L1007fs rs2066847),ATG16L1(rs2241880)and IL23R (rs1004819,rs2201841)genes were genotyped by PCR-RFLP,the G908R(rs2066844)in CARD15 was determined by direct sequencing. RESULTS:The association of ATG16L1 T300A with CD was confirmed[P=0.004,odds ratio(OR)=1.69, 95%CI:1.19-2.41],and both IL23R variants were found to represent significant risk for the disease(P= 0.008,OR=2.05,95%CI:1.20-3.50 for rs1004819 AA;P<0.001,OR=2.97,95%CI:1.65-5.33 for rs2201841 CC).Logistic regression analysis of pairwise interaction of the inflammatory bowel disease (IBD)loci indicated that IL23R,ATG16L1,CARD15 and IBD5(IGR2198a_1)contribute independently to disease risk.We also analysed the specific combina- tions by pair of individual ATG16L1,IL23R rs1004819, rs2201841,IGR2198a_1,IGR2096a_1 and CARD15 genotypes for disease risk influence.In almost all cases,the combined risk of susceptibility pairs was higher in patients carrying two different risk-associated gene variants together than individuals with just one polymorphism.The highest OR was found for IL23R rs2201841 homozygous genotype with combination of positive CARD15 status(P<0.001,OR=9.15,95% CI:2.05-40.74). CONCLUSION:The present study suggests a cumulative effect of individual IBD susceptibility loci. 展开更多
关键词 Gene interaction Interleukin-23 receptor Autophagy-related 16-like 1 IBD5 Caspase recruitment domain-containing protein 15 Crohn’s disease Inflammatory bowel disease
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Vaccine by Chicken Line Interaction Alters the Protective Efficacy against Challenge with a Very Virulent plus Strain of Marek’s Disease Virus in White Leghorn Chickens 被引量:1
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作者 Shuang Chang John R. Dunn +4 位作者 Mohammad Heidari Lucy F. Lee Catherine W. Ernst Jiuzhou Song Huanmin Zhang 《World Journal of Vaccines》 2012年第1期1-11,共11页
Marek’s disease (MD) is a lymphoproliferative disease of domestic chickens caused by Marek’s disease virus (MDV), an oncogenic and highly contagious α-herpesvirus. MD has been controlled by vaccination but sporadic... Marek’s disease (MD) is a lymphoproliferative disease of domestic chickens caused by Marek’s disease virus (MDV), an oncogenic and highly contagious α-herpesvirus. MD has been controlled by vaccination but sporadic outbreaks of MD still occur in some parts of the world. Efforts to improve vaccine efficacy have continued in both research communities and vaccine industries. We reported the host genetic variation affecting Marek’s disease vaccine-induced immunity in chickens earlier. In this study, we evaluated chicken lines, vaccines, and line by vaccine interaction on the protective efficacy of vaccination against MD. Specific pathogen free chickens from the relatively resistant line 63 and the highly susceptible line 72 were primarily used to evaluate the protection by three kinds of vaccines (rMd5ΔMeq, CVI988/Rispens, and HVT) upon challenge with a very virulent plus strain of MDV, vv+648A. Our data confirmed that both the chicken line and the vaccine significantly affected the protective efficacy of vaccination and showed that a chicken line by vaccine interaction, in most of the trials, also altered vaccine protective efficacy. More interestingly, although the protective index of all vaccine strains was higher in resistant than in susceptible line of chickens, the difference for HVT protection was striking and warrants further study. The findings may have important implications for vaccine development as well as for selective use of particular vaccines in specific lines of chickens to achieve maximum protection at minimized costs. 展开更多
关键词 Marek’s Disease VACCINE VACCINE Efficacy Host Genetics VACCINE by CHICKEN LINE interaction
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An overview of a unified theory of dynamics of vehicle–pavement interaction under moving and stochastic load 被引量:2
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作者 Lu Sun 《Journal of Modern Transportation》 2013年第3期135-162,共28页
This article lays out a unified theory for dynamics of vehicle-pavement interaction under moving and stochastic loads. It covers three major aspects of the subject: pavement surface, tire-pavement contact forces, and... This article lays out a unified theory for dynamics of vehicle-pavement interaction under moving and stochastic loads. It covers three major aspects of the subject: pavement surface, tire-pavement contact forces, and response of continuum media under moving and stochastic vehicular loads. Under the subject of pavement surface, the spectrum of thermal joints is analyzed using Fourier analysis of periodic function. One-dimensional and two-dimensional random field models of pavement surface are discussed given three different assumptions. Under the subject of tire-pavement contact forces, a vehicle is modeled as a linear system. At a constant speed of travel, random field of pavement surface serves as a stationary stochastic process exciting vehicle vibration, which, in turn, generates contact force at the interface of tire and pavement. The contact forces are analyzed in the time domain and the frequency domains using random vibration theory. It is shown that the contact force can be treated as a nonzero mean stationary process with a normal distribution. Power spectral density of the contact force of a vehicle with walking-beam suspension is simulated as an illustration. Under the subject of response of continuum media under moving and stochastic vehicular loads, both time-domain and frequency-domain analyses are presented for analytic treatment of moving load problem. It is shown that stochastic response of linear continuum media subject to a moving stationary load is a nonstationary process. Such a nonstationary stochastic process can be converted to a stationary stochastic process in a follow-up moving coordinate. 展开更多
关键词 Vehicle-pavement interaction - Random field.Continuum medium - spectral analysis ~ Green's function.Linear system
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KINETICS OF INTERACTION BETWEEN Cu_2S AND Cu_2O IN SOLID STATE UNDER NONISOTHERMAL CONDITION
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作者 Song, Ning Liu, Chunpeng 《中国有色金属学会会刊:英文版》 EI CSCD 1997年第1期39-42,51,共5页
KINETICSOFINTERACTIONBETWEENCu2SANDCu2OINSOLIDSTATEUNDERNONISOTHERMALCONDITION①SongNing,LiuChunpengDepartmen... KINETICSOFINTERACTIONBETWEENCu2SANDCu2OINSOLIDSTATEUNDERNONISOTHERMALCONDITION①SongNing,LiuChunpengDepartmentofMetalurgy,Kunm... 展开更多
关键词 KINETICs of interaction NONIsOTHERMAL process CU 2s CU 2O
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