This paper explores the influence of Christian nationalism on U.S.foreign policy,examining its historical roots,ideological foundations,and contemporary implications.Christian nationalism,an ideology that links Christ...This paper explores the influence of Christian nationalism on U.S.foreign policy,examining its historical roots,ideological foundations,and contemporary implications.Christian nationalism,an ideology that links Christianity with national identity,has shaped U.S.foreign policy in areas such as religious freedom,Middle East diplomacy,and national security.Through its emphasis on the moral duty to defend Christianity and its promotion of conservative social values,Christian nationalism has affected U.S.relations with countries around the world,particularly in the Middle East and with religious minorities.The paper discusses the complexities and controversies surrounding Christian nationalism,its impact on the U.S.’s global image,and the challenges it poses to religious pluralism.The future of Christian nationalism’s influence on U.S.foreign policy is uncertain,as societal shifts and evolving global dynamics may prompt a reevaluation of its role in shaping America’s international actions.Overall,the paper provides a nuanced analysis of how Christian nationalism has intertwined with U.S.foreign policy and how its influence might evolve in the future.展开更多
Since the eruption of the recent global financial crisis, major countries have been pushing forward structural reforms with science and technology (S&T) innovation at the heart. Since taking office, US President Do...Since the eruption of the recent global financial crisis, major countries have been pushing forward structural reforms with science and technology (S&T) innovation at the heart. Since taking office, US President Donald Trump has adopted an "America First" strategy but has yet to specify a clear S&T innovation policy. However, Trump's current policies have already affected S&T innovation and his planned budget cuts will impact US growth potentials. Compared with the US, China is steadily implementing its innovation-driven development strategy with significant improvement in S& T innovation that increasingly supports economic growth. To spur future economic growth, China should steadfastly follow its S&T innovation strategy, promote the utilization of S&T innovation results, boost its economic growth potentials and make the most of global innovation resources.展开更多
BACKGROUND Alzheimer’s disease(AD)is a serious disease causing human dementia and social problems.The quality of life and prognosis of AD patients have attracted much attention.The role of chronic immune inflammation...BACKGROUND Alzheimer’s disease(AD)is a serious disease causing human dementia and social problems.The quality of life and prognosis of AD patients have attracted much attention.The role of chronic immune inflammation in the pathogenesis of AD is becoming more and more important.AIM To study the relationship among cognitive dysfunction,abnormal cellular immune function,neuroimaging results and poor prognostic factors in patients.METHODS A retrospective analysis of 62 hospitalized patients clinical diagnosed with AD who were admitted to our hospital from November 2015 to November 2020.Collect cognitive dysfunction performance characteristics,laboratory test data and neuroimaging data from medical records within 24 h of admission,including Mini Mental State Examination Scale score,drawing clock test,blood T lymphocyte subsets,and neutrophils and lymphocyte ratio(NLR),disturbance of consciousness,extrapyramidal symptoms,electroencephalogram(EEG)and head nucleus magnetic spectroscopy(MRS)and other data.Multivariate logistic regression analysis was used to determine independent prog-nostic factors.the modified Rankin scale(mRS)was used to determine whether the prognosis was good.The correlation between drug treatment and prognostic mRS score was tested by the rank sum test.RESULTS Univariate analysis showed that abnormal cellular immune function,extrapyramidal symptoms,obvious disturbance of consciousness,abnormal EEG,increased NLR,abnormal MRS,and complicated pneumonia were related to the poor prognosis of AD patients.Multivariate logistic regression analysis showed that the decrease in the proportion of T lym-phocytes in the blood after abnormal cellular immune function(odd ratio:2.078,95%confidence interval:1.156-3.986,P<0.05)was an independent risk factor for predicting the poor prognosis of AD.The number of days of donepezil treatment to improve cognitive function was negatively correlated with mRS score(r=0.578,P<0.05).CONCLUSION The decrease in the proportion of T lymphocytes may have predictive value for the poor prognosis of AD.It is recommended that the proportion of T lymphocytes<55%is used as the cut-off threshold for predicting the poor prog-nosis of AD.The early and continuous drug treatment is associated with a good prognosis.展开更多
Milk fat globule membrane(MFGM),which contains abundant glycoproteins and phospholipids,exerts beneficial effects on intestinal health and immunomodulation.The aim of this study was to evaluate the protective effects ...Milk fat globule membrane(MFGM),which contains abundant glycoproteins and phospholipids,exerts beneficial effects on intestinal health and immunomodulation.The aim of this study was to evaluate the protective effects and possible underlying mechanisms of MFGM on cow’s milk allergy(CMA)in aβ-lactoglobulin(BLG)-induced allergic mice model.MFGM was supplemented to allergic mice induced by BLG at a dose of 400 mg/kg body weight.Results demonstrated that MFGM alleviated food allergy symptoms,decreased serum levels of lipopolysaccharide,pro-inflammatory cytokines,immunoglobulin(Ig)E,Ig G1,and Th2 cytokines including interleukin(IL)-4,while increased serum levels of Th1 cytokines including interferon-γand regulatory T cells(Tregs)cytokines including IL-10 and transforming growth factor-β.MFGM modulated gut microbiota and enhanced intestinal barrier of BLG-allergic mice,as evidenced by decreased relative abundance of Desulfobacterota,Rikenellaceae,Lachnospiraceae,and Desulfovibrionaceae,while increased relative abundance of Bacteroidetes,Lactobacillaceae and Muribaculaceae,and enhanced expressions of tight junction proteins including Occludin,Claudin-1 and zonula occludens-1.Furthermore,MFGM increased fecal short-chain fatty acids(SCFAs)levels,which elevated G protein-coupled receptor(GPR)43 and GPR109A expressions.The increased expressions of GPR43 and GPR109A induced CD103+dendritic cells accumulation and promoted Tregs differentiation in mesenteric lymph node to a certain extent.In summary,MFGM alleviated CMA in a BLG-induced allergic mice model through enhancing intestinal barrier and promoting Tregs differentiation,which may be correlated with SCFAs-mediated activation of GPRs.These findings suggest that MFGM may be useful as a promising functional ingredient against CMA.展开更多
Over the last 40 years, it has been shown at the global level that sustainable forestry can be achieved through comprehensive forest management,with the decentralized institutional arrangements of community-managed fo...Over the last 40 years, it has been shown at the global level that sustainable forestry can be achieved through comprehensive forest management,with the decentralized institutional arrangements of community-managed forestry coordinated by effective policy implementation. However, there is still a shortage of evidence regarding whether communitybased forestry is well characterized by forest policies,assessing what action is most needed and how best to address the challenges faced by community-based forestry in halting deforestation and promoting rural livelihoods. The study analyzed experts' assessments of the characteristics and success of communitymanaged forestry in Cambodia and explored three case studies of community-managed forestry practice to identify priorities for addressing forest policy implementation inadequacies in halting deforestation and promoting rural livelihoods. There were two methods of data collection. Firstly, this study used a survey of 27 experts to analyze perceptions about how far forest policy supported community-managed forestry effectively, the major challenges faced by the national community-managed forestry program, and the community-managed forestry contribution to halting deforestation and reducing rural poverty.Secondly, data was collected by content analysis of three case studies to explore the knowledge and practical experience of local experts about community-managed forestry practice at local level.The study employed Kendall's Coefficient of Concordance to analyze the level of concordance of experts on related forest policies(n=15) considering community-managed forestry, the challenges faced by the national community-managed forestry program,and the actions required to enable communitymanaged forestry to support communities. Analysis revealed that experts were in moderate agreement,denoted by Kendall's W=0.152, on how well forest policies articulate and implement the characteristics of community-managed forestry. Ranking of the major challenges faced by the national communitymanaged forestry program yielded Kendall's W of0.104, indicating the confidence in the ranking among experts was fair. There was only low confidence in the ranking of the action needed, with Kendall's W of0.055. Content analysis of the three case studies examining local experts' opinions on the attributes of community-managed forestry concerning the access,local participation and protection of the sustainable forestry revealed that Attribute one ‘Local people have access to the forest land and forest resources', and Attribute three ‘Local people begin by protecting and restoring the forests', received high attention from local experts. Of lesser importance or agreement was attributing two: local participation in decision-making concerning the forest.展开更多
With intensifying global climate change,humanity is confronted with unparalleled environmental challenges and risks.This study employs the staggered difference-in-difference model to examine the relationship between c...With intensifying global climate change,humanity is confronted with unparalleled environmental challenges and risks.This study employs the staggered difference-in-difference model to examine the relationship between climate policy and green innovation in the corporate financialization context.Using Chinese-listed company data from 2008 to 2020,our analysis reveals a favorable correlation between China’s carbon emission trading policy(CCTP)and advancements in green innovation.Furthermore,we find that the level of corporate financialization moderates this correlation,diminishing the driving effect of CCTP on green innovation.Additionally,results of heterogeneity analysis show that this moderating consequence is more evident in non-state owned and low-digitization enterprises compared with state-owned and high-digitization ones.Our findings contribute to the existing literature by clarifying the interaction between CCTP,green innovation,and corporate financialization.Our research provides valuable insights for policymakers and stakeholders seeking to strengthen climate policies and encourages green innovation in different types of businesses.展开更多
文摘This paper explores the influence of Christian nationalism on U.S.foreign policy,examining its historical roots,ideological foundations,and contemporary implications.Christian nationalism,an ideology that links Christianity with national identity,has shaped U.S.foreign policy in areas such as religious freedom,Middle East diplomacy,and national security.Through its emphasis on the moral duty to defend Christianity and its promotion of conservative social values,Christian nationalism has affected U.S.relations with countries around the world,particularly in the Middle East and with religious minorities.The paper discusses the complexities and controversies surrounding Christian nationalism,its impact on the U.S.’s global image,and the challenges it poses to religious pluralism.The future of Christian nationalism’s influence on U.S.foreign policy is uncertain,as societal shifts and evolving global dynamics may prompt a reevaluation of its role in shaping America’s international actions.Overall,the paper provides a nuanced analysis of how Christian nationalism has intertwined with U.S.foreign policy and how its influence might evolve in the future.
文摘Since the eruption of the recent global financial crisis, major countries have been pushing forward structural reforms with science and technology (S&T) innovation at the heart. Since taking office, US President Donald Trump has adopted an "America First" strategy but has yet to specify a clear S&T innovation policy. However, Trump's current policies have already affected S&T innovation and his planned budget cuts will impact US growth potentials. Compared with the US, China is steadily implementing its innovation-driven development strategy with significant improvement in S& T innovation that increasingly supports economic growth. To spur future economic growth, China should steadfastly follow its S&T innovation strategy, promote the utilization of S&T innovation results, boost its economic growth potentials and make the most of global innovation resources.
基金Supported by the National Natural Science Foundation of China,No.3206080019 and No.32060182Science and Technology Support Plan of Guizhou Province in China,No.[2020]4Y129Qiannan Prefecture Science and Technology Plan Project,No.[2022]01.
文摘BACKGROUND Alzheimer’s disease(AD)is a serious disease causing human dementia and social problems.The quality of life and prognosis of AD patients have attracted much attention.The role of chronic immune inflammation in the pathogenesis of AD is becoming more and more important.AIM To study the relationship among cognitive dysfunction,abnormal cellular immune function,neuroimaging results and poor prognostic factors in patients.METHODS A retrospective analysis of 62 hospitalized patients clinical diagnosed with AD who were admitted to our hospital from November 2015 to November 2020.Collect cognitive dysfunction performance characteristics,laboratory test data and neuroimaging data from medical records within 24 h of admission,including Mini Mental State Examination Scale score,drawing clock test,blood T lymphocyte subsets,and neutrophils and lymphocyte ratio(NLR),disturbance of consciousness,extrapyramidal symptoms,electroencephalogram(EEG)and head nucleus magnetic spectroscopy(MRS)and other data.Multivariate logistic regression analysis was used to determine independent prog-nostic factors.the modified Rankin scale(mRS)was used to determine whether the prognosis was good.The correlation between drug treatment and prognostic mRS score was tested by the rank sum test.RESULTS Univariate analysis showed that abnormal cellular immune function,extrapyramidal symptoms,obvious disturbance of consciousness,abnormal EEG,increased NLR,abnormal MRS,and complicated pneumonia were related to the poor prognosis of AD patients.Multivariate logistic regression analysis showed that the decrease in the proportion of T lym-phocytes in the blood after abnormal cellular immune function(odd ratio:2.078,95%confidence interval:1.156-3.986,P<0.05)was an independent risk factor for predicting the poor prognosis of AD.The number of days of donepezil treatment to improve cognitive function was negatively correlated with mRS score(r=0.578,P<0.05).CONCLUSION The decrease in the proportion of T lymphocytes may have predictive value for the poor prognosis of AD.It is recommended that the proportion of T lymphocytes<55%is used as the cut-off threshold for predicting the poor prog-nosis of AD.The early and continuous drug treatment is associated with a good prognosis.
基金supported by the National Key Research and Development Program of China(Grant No.2019YFC1605000)National Natural Science Foundation of China(Grant No.31871806)the Beijing Livestock Industry Innovation Team(BAIC05-2023)。
文摘Milk fat globule membrane(MFGM),which contains abundant glycoproteins and phospholipids,exerts beneficial effects on intestinal health and immunomodulation.The aim of this study was to evaluate the protective effects and possible underlying mechanisms of MFGM on cow’s milk allergy(CMA)in aβ-lactoglobulin(BLG)-induced allergic mice model.MFGM was supplemented to allergic mice induced by BLG at a dose of 400 mg/kg body weight.Results demonstrated that MFGM alleviated food allergy symptoms,decreased serum levels of lipopolysaccharide,pro-inflammatory cytokines,immunoglobulin(Ig)E,Ig G1,and Th2 cytokines including interleukin(IL)-4,while increased serum levels of Th1 cytokines including interferon-γand regulatory T cells(Tregs)cytokines including IL-10 and transforming growth factor-β.MFGM modulated gut microbiota and enhanced intestinal barrier of BLG-allergic mice,as evidenced by decreased relative abundance of Desulfobacterota,Rikenellaceae,Lachnospiraceae,and Desulfovibrionaceae,while increased relative abundance of Bacteroidetes,Lactobacillaceae and Muribaculaceae,and enhanced expressions of tight junction proteins including Occludin,Claudin-1 and zonula occludens-1.Furthermore,MFGM increased fecal short-chain fatty acids(SCFAs)levels,which elevated G protein-coupled receptor(GPR)43 and GPR109A expressions.The increased expressions of GPR43 and GPR109A induced CD103+dendritic cells accumulation and promoted Tregs differentiation in mesenteric lymph node to a certain extent.In summary,MFGM alleviated CMA in a BLG-induced allergic mice model through enhancing intestinal barrier and promoting Tregs differentiation,which may be correlated with SCFAs-mediated activation of GPRs.These findings suggest that MFGM may be useful as a promising functional ingredient against CMA.
基金the support of R&D Program for Forest Science Technology (Project No. 2014068E101819AA03) provided by Korea Forest Service (Korea Forestry Promotion Institute)
文摘Over the last 40 years, it has been shown at the global level that sustainable forestry can be achieved through comprehensive forest management,with the decentralized institutional arrangements of community-managed forestry coordinated by effective policy implementation. However, there is still a shortage of evidence regarding whether communitybased forestry is well characterized by forest policies,assessing what action is most needed and how best to address the challenges faced by community-based forestry in halting deforestation and promoting rural livelihoods. The study analyzed experts' assessments of the characteristics and success of communitymanaged forestry in Cambodia and explored three case studies of community-managed forestry practice to identify priorities for addressing forest policy implementation inadequacies in halting deforestation and promoting rural livelihoods. There were two methods of data collection. Firstly, this study used a survey of 27 experts to analyze perceptions about how far forest policy supported community-managed forestry effectively, the major challenges faced by the national community-managed forestry program, and the community-managed forestry contribution to halting deforestation and reducing rural poverty.Secondly, data was collected by content analysis of three case studies to explore the knowledge and practical experience of local experts about community-managed forestry practice at local level.The study employed Kendall's Coefficient of Concordance to analyze the level of concordance of experts on related forest policies(n=15) considering community-managed forestry, the challenges faced by the national community-managed forestry program,and the actions required to enable communitymanaged forestry to support communities. Analysis revealed that experts were in moderate agreement,denoted by Kendall's W=0.152, on how well forest policies articulate and implement the characteristics of community-managed forestry. Ranking of the major challenges faced by the national communitymanaged forestry program yielded Kendall's W of0.104, indicating the confidence in the ranking among experts was fair. There was only low confidence in the ranking of the action needed, with Kendall's W of0.055. Content analysis of the three case studies examining local experts' opinions on the attributes of community-managed forestry concerning the access,local participation and protection of the sustainable forestry revealed that Attribute one ‘Local people have access to the forest land and forest resources', and Attribute three ‘Local people begin by protecting and restoring the forests', received high attention from local experts. Of lesser importance or agreement was attributing two: local participation in decision-making concerning the forest.
基金support was obtained from the Fundamental Research Funds for the Central Universities[Grant No.JBK2307090].
文摘With intensifying global climate change,humanity is confronted with unparalleled environmental challenges and risks.This study employs the staggered difference-in-difference model to examine the relationship between climate policy and green innovation in the corporate financialization context.Using Chinese-listed company data from 2008 to 2020,our analysis reveals a favorable correlation between China’s carbon emission trading policy(CCTP)and advancements in green innovation.Furthermore,we find that the level of corporate financialization moderates this correlation,diminishing the driving effect of CCTP on green innovation.Additionally,results of heterogeneity analysis show that this moderating consequence is more evident in non-state owned and low-digitization enterprises compared with state-owned and high-digitization ones.Our findings contribute to the existing literature by clarifying the interaction between CCTP,green innovation,and corporate financialization.Our research provides valuable insights for policymakers and stakeholders seeking to strengthen climate policies and encourages green innovation in different types of businesses.