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A Ventral Diverterless High Offset S-shaped Inlet at Transonic Speeds 被引量:5
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作者 谢文忠 郭荣伟 《Chinese Journal of Aeronautics》 SCIE EI CAS CSCD 2008年第3期207-214,共8页
An investigation on the ventral diverterless high offset S-shaped inlet is carried out at Mach numbers from 0.600 to 1.534, angles of attack from -4° to 9.4°, and yaw angles from 0° to 8°. Results ... An investigation on the ventral diverterless high offset S-shaped inlet is carried out at Mach numbers from 0.600 to 1.534, angles of attack from -4° to 9.4°, and yaw angles from 0° to 8°. Results indicate: (1) a large region of low total pressure exists at the lower part of the inlet exit caused by the counter-rotating vortices in the S-shaped duct; (2) the performances of the inlet at Mach number 1.000 reach almost the highest, so the propulsion system could work efficiently in terms of aerodynamics; (3) the total pressure recovery increases slowly at first and then remains unvaried as the Mach number rises from 0.6 to 1.0, however, it does in an opposite manner in the conventional diverter-equipped S-shaped inlet; (4) the performances of the inlet are generally insensitive to angles of attack from -4° to 9.4° and yaw angles from 0° to 8° at Mach number 0.850, and angles of attack from -2° to 6° and yaw angles from 0° to 5° at Mach number 1.534. 展开更多
关键词 aerospace propulsion system diverterless inlet high offset transonic inlet s-shaped inlet experimental investigation
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Numerical Investigation of Electrohydrodynamic (EHD) Flow Control in an S-Shaped Duct 被引量:7
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作者 杨晖 李锋 +1 位作者 宋耀颖 孙佰刚 《Plasma Science and Technology》 SCIE EI CAS CSCD 2012年第10期897-904,共8页
An electrohydrodynamic (EHD) method, which is based on glow discharge plasma, is presented for flow control in an S-shaped duct. The research subject is an expanding channel with a constant width and a rectangular c... An electrohydrodynamic (EHD) method, which is based on glow discharge plasma, is presented for flow control in an S-shaped duct. The research subject is an expanding channel with a constant width and a rectangular cross section. An equivalent divergence angle and basic function are introduced to build the three-dimensional model. Subsequently, the plasma physical models are simplified as the effects of electrical body force and work (done by the force) on the fluid near the wall. With the aid of FLUENT software, the source terms of momentum and energy are added to the Navier-Stokes equation. Finally, the original performance of three models (A, B and C) is studied, in which model A demonstrates better performance. Then EHD control based on model A is discussed. The results show that the EHD method is an effective way of reducing flow loss and improving uniformity at the duct exit. The innovation in this study is the assessment of the EHD control effect on the flow in an S-shaped duct. Both the parametric modeling of the S-shaped duct and the simplified models of plasma provide valuable information for future research on aircraft inlet ducts. 展开更多
关键词 electro hydrodynamic (EHD) s-shaped duct flow control glow discharge plasma total pressure.
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Incorporating S-shaped testing-effort functions into NHPP software reliability model with imperfect debugging 被引量:7
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作者 Qiuying Li Haifeng Li Minyan Lu 《Journal of Systems Engineering and Electronics》 SCIE EI CSCD 2015年第1期190-207,共18页
Testing-effort(TE) and imperfect debugging(ID) in the reliability modeling process may further improve the fitting and prediction results of software reliability growth models(SRGMs). For describing the S-shaped... Testing-effort(TE) and imperfect debugging(ID) in the reliability modeling process may further improve the fitting and prediction results of software reliability growth models(SRGMs). For describing the S-shaped varying trend of TE increasing rate more accurately, first, two S-shaped testing-effort functions(TEFs), i.e.,delayed S-shaped TEF(DS-TEF) and inflected S-shaped TEF(IS-TEF), are proposed. Then these two TEFs are incorporated into various types(exponential-type, delayed S-shaped and inflected S-shaped) of non-homogeneous Poisson process(NHPP)SRGMs with two forms of ID respectively for obtaining a series of new NHPP SRGMs which consider S-shaped TEFs as well as ID. Finally these new SRGMs and several comparison NHPP SRGMs are applied into four real failure data-sets respectively for investigating the fitting and prediction power of these new SRGMs.The experimental results show that:(i) the proposed IS-TEF is more suitable and flexible for describing the consumption of TE than the previous TEFs;(ii) incorporating TEFs into the inflected S-shaped NHPP SRGM may be more effective and appropriate compared with the exponential-type and the delayed S-shaped NHPP SRGMs;(iii) the inflected S-shaped NHPP SRGM considering both IS-TEF and ID yields the most accurate fitting and prediction results than the other comparison NHPP SRGMs. 展开更多
关键词 testing-effort(TE) imperfect debugging(ID) software reliability growth models(SRGMs) s-shaped non-homogeneous Poisson process(NHPP)
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Modeling behaviors of a coal pillar rib using the progressive S-shaped yield criterion 被引量:1
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作者 Sankhaneel Sinha Gabriel Walton 《Journal of Rock Mechanics and Geotechnical Engineering》 SCIE CSCD 2020年第3期484-492,共9页
Spalling of pillar ribs has been a major hazard in the mining industry for decades.In the absence of rib support guidelines,accidents have continued to occur in recent years.Developing effective support guidelines req... Spalling of pillar ribs has been a major hazard in the mining industry for decades.In the absence of rib support guidelines,accidents have continued to occur in recent years.Developing effective support guidelines requires a complete understanding of complex pillar damage mechanisms.Continuum models represent a convenient tool for analyzing this problem,but the behavior of such models is dependent of the choice of the constitutive model.In this study,a recently proposed constitutive model was used to simulate the rib fracturing process in a longwall chain pillar at West Cliff mine.After calibration,the model was able to capture the rib displacement profiles for multiple locations of the longwall face and the stress evolution 4 m into the pillar.The rib bolts in the model were found to be yielding over 60% of their length under the headgate loading condition.The model also predicted a steady damage accumulation in the rib for certain face locations,which is consistent with the description of the rib at the site.Damage was localized along the upper part of the pillar and underscored the role that the dirt band played in controlling rib deterioration at the site.The ability of the numerical model to replicate field measurements provides confidence in the capabilities of the new constitutive model.Finally,the need of using multi-point calibration is highlighted by comparing the results of the calibrated model to an alternative model calibrated to a smaller amount of data. 展开更多
关键词 s-shaped yield criterion Coal pillar BACK-ANALYSIS Numerical modeling
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Analysis and Simulation of S-shaped Waveguide in Silicon-on-insulator 被引量:1
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作者 WANGZhang-tao FANZhong-cao XIAJin-song CHENShao-wu YuJinzhong 《Semiconductor Photonics and Technology》 CAS 2004年第2期78-81,共4页
The simulation and analysis of S-shaped waveguide bend are presented.Bend radius larger than 30 mm assures less than 0.5 dB radiation loss for a 4-μm-wide silicon-on-insulator waveguide bend with 2-μm etch depth.Int... The simulation and analysis of S-shaped waveguide bend are presented.Bend radius larger than 30 mm assures less than 0.5 dB radiation loss for a 4-μm-wide silicon-on-insulator waveguide bend with 2-μm etch depth.Intersection angle greater than 20° provides negligible crosstalk (<-30 dB) and very low insertion loss.Any reduction in bend radius and intersection angle is at the cost of the degradation of characteristics of bent waveguide and intersecting waveguide, respectively. 展开更多
关键词 BPM s-shaped bend SILICON-ON-INSULATOR
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Complication rates after direct anterior vs posterior approach for hip hemiarthroplasty in elderly individuals with femoral neck fractures 被引量:3
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作者 Tatiana Charles Nicolas Bloemers +1 位作者 Bilal Kapanci Marc Jayankura 《World Journal of Orthopedics》 2024年第1期22-29,共8页
BACKGROUND Dislocation rates after hemiarthroplasty reportedly vary from 1%to 17%.This serious complication is associated with increased morbidity and mortality rates.Approaches to this surgery are still debated,with ... BACKGROUND Dislocation rates after hemiarthroplasty reportedly vary from 1%to 17%.This serious complication is associated with increased morbidity and mortality rates.Approaches to this surgery are still debated,with no consensus regarding the superiority of any single approach.AIM To compare early postoperative complications after implementing the direct anterior and posterior approaches(PL)for hip hemiarthroplasty after femoral neck fractures.METHODS This is a comparative,retrospective,single-center cohort study conducted at a university hospital.Between March 2008 and December 2018,273 patients(a total of 280 hips)underwent bipolar hemiarthroplasties(n=280)for displaced femoral neck fractures using either the PL(n=171)or the minimally invasive direct anterior approach(DAA)(n=109).The choice of approach was related to the surgeons’practices;the implant types were similar and unrelated to the approach.Dislocation rates and other complications were reviewed after a minimum followup of 6 mo.RESULTS Both treatment groups had similarly aged patients(mean age:82 years),sex ratios,patient body mass indexes,and patient comorbidities.Surgical data(surgery delay time,operative time,and blood loss volume)did not differ significantly between the groups.The 30 d mortality rate was higher in the PL group(9.9%)than in the DAA group(3.7%),but the difference was not statistically significant(P=0.052).Among the one-month survivors,a significantly higher rate of dislocation was observed in the PL group(14/154;9.1%)than in the DAA group(0/105;0%)(P=0.002).Of the 14 patients with dislocation,8 underwent revision surgery for recurrent instability(posterior group),and one of them had 2 additional procedures due to a deep infection.The rate of other complications(e.g.,perioperative and early postoperative periprosthetic fractures and infection-related complications)did not differ significantly between the groups.CONCLUSION These findings suggest that the DAA to bipolar hemiarthroplasty for patients with femoral neck fractures is associated with a lower dislocation rate(<1%)than the PL. 展开更多
关键词 HEMIARTHROPLASTY Femoral neck fracture Direct anterior approach Posterior approach DISLOCATION MORTALITY
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Summarizing the evidence for robotic-assisted bladder neck reconstruction: Systematic review of patency and incontinence outcomes 被引量:1
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作者 Tenny R.Zhang Ashley Alford Lee C.Zhao 《Asian Journal of Urology》 CSCD 2024年第3期341-347,共7页
Objective:Bladder neck contracture and vesicourethral anastomotic stenosis are difficult to manage endoscopically,and open repair is associated with high rates of incontinence.In recent years,there have been increasin... Objective:Bladder neck contracture and vesicourethral anastomotic stenosis are difficult to manage endoscopically,and open repair is associated with high rates of incontinence.In recent years,there have been increasing reports of robotic-assisted bladder neck reconstruction in the literature.However,existing studies are small,heterogeneous case series.The objective of this study was to perform a systematic review of robotic-assisted bladder neck reconstruction to better evaluate patency and incontinence outcomes.Methods:We performed a systematic review of PubMed from first available date to May 2023 for all studies evaluating robotic-assisted reconstructive surgery of the bladder neck in adult men.Articles in non-English,author replies,editorials,pediatric-based studies,and reviews were excluded.Outcomes of interest were patency and incontinence rates,which were pooled when appropriate.Results:After identifying 158 articles on initial search,we included only ten studies that fit all aforementioned criteria for robotic-assisted bladder neck reconstruction.All were case series published from March 2018 to March 2022 ranging from six to 32 men,with the median follow-up of 5e23 months.A total of 119 patients were included in our analysis.A variety of etiologies and surgical techniques were described.Patency rates ranged from 50%to 100%,and pooled patency was 80%(95/119).De novo incontinence rates ranged from 0%to 33%,and pooled incontinence was 17%(8/47).Our findings were limited by small sample sizes,relatively short follow-ups,and heterogeneity between studies. 展开更多
关键词 Bladder neck CONTINENCE INCONTINENCE PATENCY Posterior urethra Reconstructive surgery Robotic surgery STENOSIS STRICTURE Surgical outcome
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Enhancement of Characteristics of Antenna Arrays Employing S-Shaped Resonators
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作者 Belgacem Aouadi Jamel Belhaj Tahar 《Journal of Electromagnetic Analysis and Applications》 2012年第8期326-332,共7页
This paper illustrates a simple kind of tri-band printed G-shaped monopole antenna for Multiple-Input-Multiple-Output (MIMO) systems. The proposed antenna is used to achieve three operating frequencies, 2.45 GHz, 5.2 ... This paper illustrates a simple kind of tri-band printed G-shaped monopole antenna for Multiple-Input-Multiple-Output (MIMO) systems. The proposed antenna is used to achieve three operating frequencies, 2.45 GHz, 5.2 GHz and 8.2 GHz for wireless communications. To improve the isolation between the two radiating elements, we use left-handed materials composed of only S-shaped resonators to get negative refractive index at the three operating frequencies. When one layer of S-shaped resonators is employed, the antenna correlation, the diversity gain and the bandwidth are also enhanced. The simulated results are presented and evaluated with and without left-handed materials. 展开更多
关键词 G-shaped MONOPOLE ANTENNA MIMO Systems s-shaped Resonators Mutual Coupling ANTENNA Correlation
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Shaping ability of thermomechanically treated files in simulated S-shaped root canals
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作者 Nessrin A. Taha Ghada A. Maghaireh +2 位作者 Dyana El Sadek Rafat Bagheri Mohammad Al-Omari 《Open Journal of Stomatology》 2013年第7期386-391,共6页
Aim: the aim of this study was to investigate the shaping ability of thermomechanically treated files manufactured by twisting(Twisted files)and compare it to conventional rotary system (K3, Sybron Endo, Orange, CA) i... Aim: the aim of this study was to investigate the shaping ability of thermomechanically treated files manufactured by twisting(Twisted files)and compare it to conventional rotary system (K3, Sybron Endo, Orange, CA) in S-shaped canals, including formation of ledges, zipping, elbow, outer widening, danger zone, perforation and file deformation. Materials & Methods: Forty S-Shaped canals in resin blocks were randomly divided into 2 groups of 20 each. Pre-instrumentation images of the canals were taken via a digital camera and superimposed on images taken after preparation with TF and K3 systems to apical size of 25/06 and 30/06. Canal aberrations were measured from the superimposed image at five levels using AutoCAD system. Fisher exact test and Mann Whitney test were used for analysis of the data. Results: the incidence of zipping, elbow and apical transportation was significantly lower in the TF group (P = 0.04). Generally the incidence of aberration increased when the apical size increased to 30/0.06 regardless of the file system. Significant file deformation was evident in the TF after single use (P ? 0.001). Conclusion: Under the conditions of this study, TF manufactured by new technique performed better than K3 systems when used up to size 25/06 in simulated S-shaped canals. Clinical significance: The flexibility of thermomechanically treated files is beneficial in canals with multiple curvatures;however, attention should be paid to the instrument taper and final apical size of the preparation. 展开更多
关键词 Keywords: s-shaped CANAL TWISTED FILES K3 CANAL ABERRATION
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Analysis of the generation mechanism of the S-shaped J–V curves of MoS_(2)/Si-based solar cells
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作者 He-Ju Xu Li-Tao Xin +2 位作者 Dong-Qiang Chen Ri-Dong Cong Wei Yu 《Chinese Physics B》 SCIE EI CAS CSCD 2022年第3期608-612,共5页
Amorphous–microcrystalline MoS_(2)thin films are fabricated using the sol-gel method to produce MoS_(2)/Si-based solar cells. The generation mechanisms of the S-shaped current density–voltage(J–V) curves of the sol... Amorphous–microcrystalline MoS_(2)thin films are fabricated using the sol-gel method to produce MoS_(2)/Si-based solar cells. The generation mechanisms of the S-shaped current density–voltage(J–V) curves of the solar cells are analyzed. To improve the performance of the solar cells and address the problem of the S-shaped J–V curve, a MoS_(2)film and a p^(+) layer are introduced into the front and back interfaces of the solar cell, respectively, which leads to the formation of a p–n junction between the p-Si and the MoS_(2)film as well as ohmic contacts between the MoS_(2)film and the ITO, improving the S-shaped J–V curve. As a result of the high doping characteristics and the high work function of the p^(+) layer, a high–low junction is formed between the p;and p layers along with ohmic contacts between the p;layer and the Ag electrode. Consequently,the S-shaped J–V curve is eliminated, and a significantly higher current density is achieved at a high voltage. The device exhibits ideal p–n junction rectification characteristics and achieves a high power-conversion efficiency(CE) of 7.55%. The findings of this study may improve the application of MoS_(2)thin films in silicon-based solar cells, which are expected to be widely used in various silicon-based electronic and optical devices. 展开更多
关键词 MoS_(2)/Si-based solar cell s-shaped J–V curve power conversion efficiency p^(+)layer
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Engineering The Neck Hinge Reshapes The Processive Movement of Kinesin-3
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作者 LI Dong REN Jin-Qi +2 位作者 SONG Yin-Long LIANG Xin FENG Wei 《生物化学与生物物理进展》 SCIE CAS CSCD 北大核心 2024年第10期2730-2740,共11页
Objective In kinesin-3,the neck coil correlates with the following segments to form an extended neck that contains a characteristic hinge diverse from a proline in KIF13B to a long flexible linker in KIF1A.The functio... Objective In kinesin-3,the neck coil correlates with the following segments to form an extended neck that contains a characteristic hinge diverse from a proline in KIF13B to a long flexible linker in KIF1A.The function of this neck hinge for controlling processive movement,however,remains unclear.Methods We made a series of modifications to the neck hinges of KIF13B and KIF1A and tested their movement using a single-molecule motility assay.Results In KIF13B,the insertion of flexible residues before or after the proline differentially impacts the processivity or velocity,while the removal of this proline increases the both.In KIF1A,the deletion of entire flexible neck hinge merely enhances the processivity.The engineering of these hinge-truncated necks of kinesin-3 into kinesin-1 similarly boosts the processive movement of kinesin-1.Conclusion The neck hinge in kinesin-3 controls its processive movement and proper modifications tune the motor motility,which provides a novel strategy to reshape the processive movement of kinesin motors. 展开更多
关键词 intracellular transport molecular motor kinesin-3 neck hinge processive movement
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Consolidation of a Femoral Neck Fracture in Sickle Cell Disease Patient after Surgical Abstention: A Beneficial and Favorable Outcome
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作者 Marc Leroy Guifo Albert Desiré Atangana Fouda +4 位作者 Faustin Atemkeng Tsatedem Emini Ngono Mengale Ntang Ulrich Bisay Souhe Ginette Kalla 《Surgical Science》 2024年第7期438-443,共6页
Femoral neck fracture is classically a traumatic pathology in the elderly but it can also occur in young people during a road traffic accident or occasionally when the femoral neck has been weakened by a pathological ... Femoral neck fracture is classically a traumatic pathology in the elderly but it can also occur in young people during a road traffic accident or occasionally when the femoral neck has been weakened by a pathological process. In sickle cell patients, the hip is often subjected to aseptic necrosis. The authors report the case of the child NL, aged 5 years and 4 months in whom a fracture of the femoral neck classified Delbet 3 was found as well as his sickle cell status discovered and in whom treatment by surgical abstention was carried out with a favorable evolution. This association of factors of the femoral head necrosis or nonunion is unusual and confirms the osteogenetic potential of a child. However, monitoring is necessary because other anomalies may reveal themselves. 展开更多
关键词 Sickle Cell Disease Fracture Femoral neck OSTEOMYELITIS
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Deep neck infections mortal complications:Intrathoracic complications and necrotising fasciitis
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作者 Kemal Koray Bal Can Aslan +3 位作者 Harun Gür Seda Turk Bal Recep Okan Ustun Murat Unal 《World Journal of Clinical Cases》 SCIE 2024年第30期6383-6390,共8页
BACKGROUND We planned this study considering that complications of deep neck infections can be seriously life threatening.AIM To raise awareness that introthoracic complications and necrotizing fasciitis are causes of... BACKGROUND We planned this study considering that complications of deep neck infections can be seriously life threatening.AIM To raise awareness that introthoracic complications and necrotizing fasciitis are causes of serious mortality and morbidity.METHODS This study was carried out with the participation of 188 patients who were treated at Mersin University Department of Otorhinolaryngology and Head and Neck Surgery at January 1,2024.When the patient files were retrospectively examined,16 of 188 patients(8.5%)were included in the study because they were observed to have necrotizing fasciitis and/or intrathoracic complications.RESULTS There were a total of 16 patients in this study,9 males(56.25%)and 7 females(43.75%).All patients were adults(>18 years)and the mean age was 50.37 years±15.37 years.Female patients had a mean age of 40.42 years±13.38 years,whereas for male patients was 58.11 years±12.44 years.CONCLUSION Patients with necrotizing fasciitis and/or intrathoracic complications require more complicated and serious surgeries,intensive care unit monitoring,and mechanical ventilator support.Higher rates of morbidity and mortality should be expected in Bal KK et al.Deep neck infections mortal complications WJCC https://www.wjgnet.com 6384 October 26,2024 Volume 12 Issue 30 these patients who are hospitalized for longer periods of time. 展开更多
关键词 Deep neck infection Necrotising fasciitis MEDIASTINITIS COMPLICATIONS MORTALITY
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Lateral femoral neck stress fractures: A case report
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作者 Christiaan AJ Oudmaijer Nuno R Paulino Pereira +3 位作者 David Visser Alexander M Wakker Wout S Veltman Robbart van Linschoten 《World Journal of Orthopedics》 2024年第9期891-901,共11页
BACKGROUND Sport-induced injuries particularly affect young,healthy,and active individuals.Running,a popular and accessible sport,can cause a wide range of injuries,including stress fractures.Stress fractures can occu... BACKGROUND Sport-induced injuries particularly affect young,healthy,and active individuals.Running,a popular and accessible sport,can cause a wide range of injuries,including stress fractures.Stress fractures can occur during high-intensity training or competitions,especially among well-trained amateurs and professional athletes.Adequate diagnosis can be complicated by the typically young age,unremarkable medical history,and vital condition of the patient.Stress fractures present insidiously,and this is specifically the case with stress fractures of the femoral neck.Timely intervention is crucial to prevent progressive displacement,as this can damage the blood supply to the femoral head.CASE SUMMARY A 30-year-old male runner presented to our outpatient clinic with persistent pain 3 weeks after running a marathon.X-ray showed a complete lateral fracture of the left femoral neck,which was treated surgically with a dynamic hip screw.CONCLUSION It is essential for healthcare providers to be vigilant for the subtle symptoms of stress fractures to ensure timely treatment.Early recognition prevents com-plication and leads to a better prognosis. 展开更多
关键词 Stress fractures ATYPICAL Femoral neck MARATHON DIAGNOSIS Case report
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New perspectives on biology,disease progression,and therapy response of head and neck cancer gained from single cell RNA sequencing and spatial transcriptomics
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作者 GERWIN HELLER THORSTEN FUEREDER +1 位作者 ALEXANDER MICHAEL GRANDITS ROTRAUD WIESER 《Oncology Research》 SCIE 2024年第1期1-17,共17页
Head and neck squamous cell carcinoma(HNSCC)is one of the most frequent cancers worldwide.The main risk factors are consumption of tobacco products and alcohol,as well as infection with human papilloma virus.Approved ... Head and neck squamous cell carcinoma(HNSCC)is one of the most frequent cancers worldwide.The main risk factors are consumption of tobacco products and alcohol,as well as infection with human papilloma virus.Approved therapeutic options comprise surgery,radiation,chemotherapy,targeted therapy through epidermal growth factor receptor inhibition,and immunotherapy,but outcome has remained unsatisfactory due to recurrence rates of~50%and the frequent occurrence of second primaries.The availability of the human genome sequence at the beginning of the millennium heralded the omics era,in which rapid technological progress has advanced our knowledge of the molecular biology of malignant diseases,including HNSCC,at an unprecedented pace.Initially,microarray-based methods,followed by approaches based on next-generation sequencing,were applied to study the genetics,epigenetics,and gene expression patterns of bulk tumors.More recently,the advent of single-cell RNA sequencing(scRNAseq)and spatial transcriptomics methods has facilitated the investigation of the heterogeneity between and within different cell populations in the tumor microenvironment(e.g.,cancer cells,fibroblasts,immune cells,endothelial cells),led to the discovery of novel cell types,and advanced the discovery of cell-cell communication within tumors.This review provides an overview of scRNAseq,spatial transcriptomics,and the associated bioinformatics methods,and summarizes how their application has promoted our understanding of the emergence,composition,progression,and therapy responsiveness of,and intercellular signaling within,HNSCC. 展开更多
关键词 Head and neck squamous cell carcinoma Tumor microenvironment IMMUNOTHERAPY Gene expression OMICS
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Fibroblast activation protein (FAP) as a prognostic biomarker in multiple tumors and its therapeutic potential in head and neck squamous cell carcinoma
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作者 RUIFANG LI XINRONG NAN +1 位作者 MING LI OMAR RAHHAL 《Oncology Research》 SCIE 2024年第8期1323-1334,共12页
Background:Fibroblast activation protein(FAP),a cell surface serine protease,plays roles in tumor invasion and immune regulation.However,there is currently no pan-cancer analysis of FAP.Objective:We aimed to assess th... Background:Fibroblast activation protein(FAP),a cell surface serine protease,plays roles in tumor invasion and immune regulation.However,there is currently no pan-cancer analysis of FAP.Objective:We aimed to assess the pan-cancer expression profile of FAP,its molecular function,and its potential role in head and neck squamous cell carcinoma(HNSC).Methods:We analyzed gene expression,survival status,immune infiltration,and molecular functional pathways of FAP in The Cancer Genome Atlas(TCGA)and Genotype Tissue Expression(GTEx)tumors.Furthermore,to elucidate the role of FAP in HNSC,we performed proliferation,migration,and invasion assays post-FAP overexpression or knock-down.Results:FAP expression was elevated in nine tumor types and was associated with poor survival in eight of them.In the context of immune infiltration,FAP expression negatively correlated with CD8+T-cell infiltration infive tumor types and positively with regulatory T-cell infiltration in four tumor types.Our enrichment analysis highlighted FAP’s involvement in the PI3K-Akt signaling pathway.In HNSC cells,FAP overexpression activated the PI3K-Akt pathway,promoting tumor proliferation,migration,and invasion.Conversely,FAP knockdown showed inhibitory effects.Conclusion:Our study unveils the association of FAP with poor tumor prognosis across multiple cancers and highlights its potential as a therapeutic target in HNSC. 展开更多
关键词 FAP Head and neck squamous cell carcinoma CANCER PROGNOSIS Tumor microenvironment Molecular function
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PPP1R14A is Associated with Immunotherapy Resistance in Head and Neck Squamous Cell Carcinoma Identified by Single-Cell and Bulk RNA-Sequencing
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作者 Jun-Jie Ma Lei Zhang +1 位作者 Jin Lu Hao-Xuan Zhang 《Chinese Medical Sciences Journal》 CAS CSCD 2024年第2期111-121,共11页
Objective To identify nivolumab resistance-related genes in patients with head and neck squamous cell carcinoma(HNSCC)using single-cell and bulk RNA-sequencing data.Methods The single-cell and bulk RNA-sequencing data... Objective To identify nivolumab resistance-related genes in patients with head and neck squamous cell carcinoma(HNSCC)using single-cell and bulk RNA-sequencing data.Methods The single-cell and bulk RNA-sequencing data downloaded from the Gene Expression Omnibus database were analyzed to screen out differentially expressed genes(DEGs)between nivolumab resistant and nivolumab sensitive patients using R software.The Least Absolute Shrinkage Selection Operator(LASSO)regression and Recursive Feature Elimination(RFE)algorithm were performed to identify key genes associated with nivolumab resistance.Functional enrichment of DEGs was analyzed with Gene Ontology and Kyoto Encyclopedia of Genes and Genomes analyses.The relationships of key genes with immune cell infiltration,differentation trajectory,dynamic gene expression profiles,and ligand-receptor interaction were explored.Results We found 83 DEGs.They were mainly enriched in T-cell differentiation,PD-1 and PD-L1 checkpoint,and T-cell receptor pathways.Among six key genes identified using machine learning algorithms,only PPP1R14A gene was differentially expressed between the nivolumab resistant and nivolumab sensitive groups both before and after immunotherapy(P<0.05).The high PPP1R14A gene expression group had lower immune score(P<0.01),higher expression of immunosuppressive factors(such as PDCD1,CTLA4,and PDCD1LG2)(r>0,P<0.05),lower differentiation of infiltrated immune cells(P<0.05),and a higher degree of interaction between HLA and CD4(P<0.05).Conclusions PPP1R14A gene is closely associated with resistance to nivolumab in HNSCC patients.Therefore,PPP1R14A may be a target to ameliorate nivolumab resistance of HNSCC patients. 展开更多
关键词 PPP1R14A head and neck squamous cell carcinoma IMMUNOTHERAPY drug resistance
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Bipolar hip arthroplasty using conjoined tendon preserving posterior lateral approach in treatment of displaced femoral neck fractures
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作者 Ting-Xin Yan Sheng-Jie Dong +1 位作者 Bo Ning Yu-Chi Zhao 《World Journal of Clinical Cases》 SCIE 2024年第6期1076-1083,共8页
BACKGROUND Hip fractures account for 23.8%of all fractures in patients over the age of 75 years.More than half of these patients are older than 80 years.Bipolar hemiarthroplasty(BHA)was established as an effective man... BACKGROUND Hip fractures account for 23.8%of all fractures in patients over the age of 75 years.More than half of these patients are older than 80 years.Bipolar hemiarthroplasty(BHA)was established as an effective management option for these patients.Various approaches can be used for the BHA procedure.However,there is a high risk of postoperative dislocation.The conjoined tendon-preserving posterior(CPP)lateral approach was introduced to reduce postoperative dislocation rates.AIM To evaluate the effectiveness and safety of the CPP lateral approach for BHA in elderly patients.METHODS We retrospectively analyzed medical data from 80 patients with displaced femoral neck fractures who underwent BHA.The patients were followed up for at least 1 year.Among the 80 patients,57(71.3%)were female.The time to operation averaged 2.3 d(range:1-5 d).The mean age was 80.5 years(range:67-90 years),and the mean body mass index was 24.9 kg/m^(2)(range:17-36 kg/m^(2)).According to the Garden classification,42.5%of patients were typeⅢand 57.5%of patients were typeⅣ.Uncemented bipolar hip prostheses were used for all patients.Torn conjoined tendons,dislocations,and adverse complications during and after surgery were recorded.RESULTS The mean postoperative follow-up time was 15.3 months(range:12-18 months).The average surgery time was 52 min(range:40-70 min)with an average blood loss of 120 mL(range:80-320 mL).The transfusion rate was 10%(8 of 80 patients).The gemellus inferior was torn in 4 patients(5%),while it was difficult to identify in 2 patients(2.5%)during surgery.The posterior capsule was punctured by the fractured femoral neck in 3 patients,but the conjoined tendon and the piriformis tendon remained intact.No patients had stem varus greater than 3 degrees or femoral fracture.There were no patients with stem subsidence more than 5 mm at the last follow-up.No postoperative dislocations were observed throughout the follow-up period.No significance was found between preoperative and postoperative mean Health Service System scores(87.30±2.98 vs 86.10±6.10,t=1.89,P=0.063).CONCLUSION The CPP lateral approach can effectively reduce the incidence of postoperative dislocation without increasing perioperative complications.For surgeons familiar with the posterior lateral approach,there is no need for additional surgical instruments,and it does not increase surgical difficulty. 展开更多
关键词 Conjoined tendon preserving Bipolar hip arthroplasty Femoral neck fractures Postoperative dislocation Posterolateral approach
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Effect of Mouth Opening Training Stick Combined with Oral Massage on Mouth Opening Difficulty in Head and Neck Cancer Patients after Treatment
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作者 Jinhua Liu Qiong Wen 《Journal of Biosciences and Medicines》 2024年第6期43-51,共9页
Objective: To study the application effect of mouth-opening training sticks combined with oral massage on patients with mouth-opening difficulty after treatment for head and neck cancer. Methods: Using convenient samp... Objective: To study the application effect of mouth-opening training sticks combined with oral massage on patients with mouth-opening difficulty after treatment for head and neck cancer. Methods: Using convenient sampling, 60 patients with mouth-opening difficulty after treatment for head and neck cancer admitted to the Oncology Department from February 2022 to October 2023 were selected for a 2-week exercise and nursing program. The patients were divided into a control group (February 1, 2022 to November 30, 2022) and an observation group (December 1, 2022 to October 31, 2023), with 30 patients in each group. The control group underwent routine mouth-opening functional exercises combined with cork for oral support training, while the observation group underwent routine mouth-opening functional exercises combined with oral massage and mouth-opening training sticks for oral support training. The mouth-opening degree, mouth-opening difficulty level, comfort level, compliance, and quality of life were observed in both groups. Results: Before the intervention, there were no statistically significant differences in mouth-opening degree and mouth-opening difficulty level between the two groups (P > 0.05). After the intervention, the mouth-opening degree, mouth-opening difficulty level, oral comfort level, compliance, and QLICP-HN scores in the observation group were all better than those in the control group, with statistically significant differences (P < 0.05). Conclusion: The combination of mouth-opening training sticks and oral massage with mouth-opening functional exercises can effectively improve the degree of mouth-opening difficulty, enhance oral comfort, increase compliance with mouth-opening exercises, and improve quality of life. 展开更多
关键词 Head and neck Cancer Difficulty in Opening the Mouth Open Mouth Training Stick Oral Massage Rehabilitation Effect
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Relationship between preoperative psychological stress and shortterm prognosis in elderly patients with femoral neck fracture
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作者 Wen-Hui Fu Zhi-Long Hu +6 位作者 Yuan-Jun Liao Ri-Jiang Chen Jian-Bin Qiu Wu-Tang Que Wan-Tao Wang Wei-Hua Li Wei-Bin Lan 《World Journal of Psychiatry》 SCIE 2024年第6期838-847,共10页
BACKGROUND Older adults are at high risk of femoral neck fractures(FNFs).Elderly patients face and adapt to significant psychological burdens,resulting in different degrees of psychological stress response.Total hip r... BACKGROUND Older adults are at high risk of femoral neck fractures(FNFs).Elderly patients face and adapt to significant psychological burdens,resulting in different degrees of psychological stress response.Total hip replacement is the preferred treatment for FNF in elderly patients;however,some patients have poor postoperative prognoses,and the underlying mechanism is unknown.We speculated that the postoperative prognosis of elderly patients with FNF may be related to preoperative psychological stress.AIM To explore the relationship between preoperative psychological stress and the short-term prognosis of elderly patients with FNF.METHODS In this retrospective analysis,the baseline data,preoperative 90-item Symptom Checklist score,and Harris score within 6 months of surgery of 120 elderly patients with FNF who underwent total hip arthroplasty were collected.We analyzed the indicators of poor short-term postoperative prognosis and the ability of the indicators to predict poor prognosis and compared the correlation between the indicators and the Harris score.RESULTS Anxiety,depression,garden classification of FNF,cause of fracture,FNF reduction quality,and length of hospital stay were independent influencing factors for poor short-term postoperative prognoses in elderly patients with FNF(P<0.05).The areas under the curve for anxiety,depression,and length of hospital stay were 0.742,0.854,and 0.749,respectively.The sensitivities of anxiety,depression,garden classification of FNF,and prediction of the cause of fracture were 0.857,0.786,0.821,and 0.821,respectively.The specificities of depression,FNF quality reduction,and length of hospital stay were the highest at 0.880,0.783,and 0.761,respectively.Anxiety,depression,and somatization scores correlated moderately with Harris scores(r=-0.523,-0.625,and-0.554;all P<0.001).CONCLUSION Preoperative anxiety,depression,and somatization are correlated with poor short-term prognosis in elderly patients with FNF and warrant consideration. 展开更多
关键词 Psychological stress Old age Femoral neck fracture Hip replacement Short-term prognosis CORRELATION
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