Objective: To understand the application of echocardiography combined with blood SAA, IL-6, PCT, and CRP detection in the diagnosis and treatment of Kawasaki disease in children. Methods: 56 children with Kawasaki dis...Objective: To understand the application of echocardiography combined with blood SAA, IL-6, PCT, and CRP detection in the diagnosis and treatment of Kawasaki disease in children. Methods: 56 children with Kawasaki disease were selected as the study subjects as the treatment group, and 54 children with other diseases during the same period were selected as the control group. Echocardiography, blood SAA, IL-6, PCT and CRP were detected before and after treatment to observe the results of the two groups. A database was established to compare the changes of various indicators between the two groups, as well as the application value of each indicator in the clinical diagnosis and treatment of Kawasaki disease, and the pros and cons of the application of each indicator in the diagnosis and treatment of children with Kawasaki disease were analyzed, so as to provide a clearer early warning mechanism for the clinical diagnosis and treatment of children with Kawasaki disease. Results: There was no significant difference in the results of related imaging indexes in the control group before and after treatment (P > 0.05). There was no significant difference in the results of relevant imaging indicators in the treatment group before and after treatment (P > 0.05), except for LMCA (P < 0.05). The comparison of imaging related indicators before and after treatment between the two groups showed that except for no statistically significant difference in LMCA and RMCA before treatment (P > 0.05), all other indicators had statistical significance (P < 0.05). The results of relevant laboratory indexes in control group before and after treatment were statistically significant (P < 0.05). The results of relevant laboratory indexes before and after treatment in the treatment group were statistically significant (P < 0.05). The results of relevant laboratory indicators were compared between the two groups, except for the results of SAA, IL-6 and PCT before treatment, which were not statistically significant (P > 0.05), the differences in all other indicators were statistically significant (P Conclusion: The combination of echocardiography with blood SAA, IL-6, PCT, and CRP detection can establish the optimal evaluation plan for accurate and effective diagnosis, treatment, and prognosis of Kawasaki disease in children, providing more accurate and reliable diagnostic and treatment methods and laboratory data for clinical practice, and thus providing strong protection for children’s health.展开更多
冠心病(Coronary Heart Disease, CHD)作为一类高发性心血管疾病,有着较高概率造成患者出现心肌梗死的症状。因此,对CHD的早期筛查,对于挽救患者生命健康而言具有十分重要的意义。本研究基于血清淀粉样蛋白A(Serum Amyloid A, SAA)在急...冠心病(Coronary Heart Disease, CHD)作为一类高发性心血管疾病,有着较高概率造成患者出现心肌梗死的症状。因此,对CHD的早期筛查,对于挽救患者生命健康而言具有十分重要的意义。本研究基于血清淀粉样蛋白A(Serum Amyloid A, SAA)在急性期内与高密度脂蛋白(high density lipoprotein,HDL)大量结合的特点,将SAA作为心血管疾病标志物,与临床常用心血管疾病标志物肌红蛋白进行联合检验。观察其在CHD组和对照组之间的表达水平差异,并对比其单项检验与联合检验的灵敏度、特异度差异。以分析该联合检验在CHD早期筛查中的应用价值。展开更多
文摘Objective: To understand the application of echocardiography combined with blood SAA, IL-6, PCT, and CRP detection in the diagnosis and treatment of Kawasaki disease in children. Methods: 56 children with Kawasaki disease were selected as the study subjects as the treatment group, and 54 children with other diseases during the same period were selected as the control group. Echocardiography, blood SAA, IL-6, PCT and CRP were detected before and after treatment to observe the results of the two groups. A database was established to compare the changes of various indicators between the two groups, as well as the application value of each indicator in the clinical diagnosis and treatment of Kawasaki disease, and the pros and cons of the application of each indicator in the diagnosis and treatment of children with Kawasaki disease were analyzed, so as to provide a clearer early warning mechanism for the clinical diagnosis and treatment of children with Kawasaki disease. Results: There was no significant difference in the results of related imaging indexes in the control group before and after treatment (P > 0.05). There was no significant difference in the results of relevant imaging indicators in the treatment group before and after treatment (P > 0.05), except for LMCA (P < 0.05). The comparison of imaging related indicators before and after treatment between the two groups showed that except for no statistically significant difference in LMCA and RMCA before treatment (P > 0.05), all other indicators had statistical significance (P < 0.05). The results of relevant laboratory indexes in control group before and after treatment were statistically significant (P < 0.05). The results of relevant laboratory indexes before and after treatment in the treatment group were statistically significant (P < 0.05). The results of relevant laboratory indicators were compared between the two groups, except for the results of SAA, IL-6 and PCT before treatment, which were not statistically significant (P > 0.05), the differences in all other indicators were statistically significant (P Conclusion: The combination of echocardiography with blood SAA, IL-6, PCT, and CRP detection can establish the optimal evaluation plan for accurate and effective diagnosis, treatment, and prognosis of Kawasaki disease in children, providing more accurate and reliable diagnostic and treatment methods and laboratory data for clinical practice, and thus providing strong protection for children’s health.
文摘冠心病(Coronary Heart Disease, CHD)作为一类高发性心血管疾病,有着较高概率造成患者出现心肌梗死的症状。因此,对CHD的早期筛查,对于挽救患者生命健康而言具有十分重要的意义。本研究基于血清淀粉样蛋白A(Serum Amyloid A, SAA)在急性期内与高密度脂蛋白(high density lipoprotein,HDL)大量结合的特点,将SAA作为心血管疾病标志物,与临床常用心血管疾病标志物肌红蛋白进行联合检验。观察其在CHD组和对照组之间的表达水平差异,并对比其单项检验与联合检验的灵敏度、特异度差异。以分析该联合检验在CHD早期筛查中的应用价值。