The emerging virtual coupling technology aims to operate multiple train units in a Virtually Coupled Train Set(VCTS)at a minimal but safe distance.To guarantee collision avoidance,the safety distance should be calcula...The emerging virtual coupling technology aims to operate multiple train units in a Virtually Coupled Train Set(VCTS)at a minimal but safe distance.To guarantee collision avoidance,the safety distance should be calculated using the state-of-the-art space-time separation principle that separates the Emergency Braking(EB)trajectories of two successive units during the whole EB process.In this case,the minimal safety distance is usually numerically calculated without an analytic formulation.Thus,the constrained VCTS control problem is hard to address with space-time separation,which is still a gap in the existing literature.To solve this problem,we propose a Distributed Economic Model Predictive Control(DEMPC)approach with computation efficiency and theoretical guarantee.Specifically,to alleviate the computation burden,we transform implicit safety constraints into explicitly linear ones,such that the optimal control problem in DEMPC is a quadratic programming problem that can be solved efficiently.For theoretical analysis,sufficient conditions are derived to guarantee the recursive feasibility and stability of DEMPC,employing compatibility constraints,tube techniques and terminal ingredient tuning.Moreover,we extend our approach with globally optimal and distributed online EB configuration methods to shorten the minimal distance among VCTS.Finally,experimental results demonstrate the performance and advantages of the proposed approaches.展开更多
目的:对比三维多回波恢复梯度回波(3D MERGE)、三维可变反转角快速自旋回波(3D SPACE STIR)序列在腰椎间盘突出症(LDH)检查中的应用效果。方法:选择2020年1月~2022年11月收治的135例LDH患者,回顾性分析患者临床和磁共振成像(MRI)资料,...目的:对比三维多回波恢复梯度回波(3D MERGE)、三维可变反转角快速自旋回波(3D SPACE STIR)序列在腰椎间盘突出症(LDH)检查中的应用效果。方法:选择2020年1月~2022年11月收治的135例LDH患者,回顾性分析患者临床和磁共振成像(MRI)资料,所有患者均接受常规MRI扫描及3D MERGE、3D SPACE STIR序列扫描,对比3D MERGE、3D SPACE STIR序列测量神经根直径的一致性,评价两种序列的图像质量参数[信噪比(SNR)、对比噪声比(CNR)]、图像清晰度评分。结果:3D MERGE和3D SPACE STIR序列测量的L3~S1神经根直径比较差异无统计学意义(P>0.05),且两组序列测量的L3、L4、L5和S1直径均显示出较高相关性(r=0.957,0.986,0.975,0.972,P<0.05);3D MERGE序列的SNR及CNR均高于3D SPACE STIR序列,神经根显示分级、图像清晰度评分优于3D SPACE STIR序列,差异有统计学意义(P<0.05)。结论:3D MERGE、3D SPACE STIR序列在LDH神经根直径测量中具有极高一致性,3D MERGE序列较3D SPACE STIR序列能够更清晰显示神经跟的解剖形态,图像质量更好。展开更多
在循证医学时代下,依托规范的技术方法和标准化的操作规程发掘中医药独特优势,是实现中医药现代化、国际化发展并惠泽人类的必由之路。中医理论、人用经验和研究证据三结合证据体系的提出标志着中医药特色评价体系思维方法取得了重要进...在循证医学时代下,依托规范的技术方法和标准化的操作规程发掘中医药独特优势,是实现中医药现代化、国际化发展并惠泽人类的必由之路。中医理论、人用经验和研究证据三结合证据体系的提出标志着中医药特色评价体系思维方法取得了重要进步,经过恰当方法整合后的多元证据体是中医药临床指南推荐意见和循证卫生决策的有力支撑。本文基于当前国际证据合成与分级方法学前沿进展,初步提出中医药多元证据整合的方法学框架——MERGE(Merge Evidence-based Research and artificial intelliGence to support smart dEcision)框架,以期为中医药循证医学方法学体系的完善和发展提供借鉴和参考。展开更多
Understanding the ocean's role in the global carbon cycle and its response to environmental change requires a high spatio-temporal resolution of observation.Merging ocean color data from multiple sources is an effect...Understanding the ocean's role in the global carbon cycle and its response to environmental change requires a high spatio-temporal resolution of observation.Merging ocean color data from multiple sources is an effective way to alleviate the limitation of individual ocean color sensors(e.g.,swath width and gaps,cloudy or rainy weather,and sun glint) and to improve the temporal and spatial coverage.Since the missions of Sea-Viewing Wide Field-of-View Sensor(Sea Wi FS) and Medium-spectral Resolution Imaging Spectrometer(MERIS) ended on December 11,2010 and May 9,2012,respectively,the number of available ocean color sensors has declined,reducing the benefits of the merged ocean color data with respect to the spatial and temporal coverage.In present work,Medium Resolution Spectral Imager(MERSI)/FY-3 of China is added in merged processing and a new dataset of global ocean chlorophyll a(Chl a) concentration(2000–2015) is generated from the remote sensing reflectance(Rrs(λ)) observations of MERIS,Moderate-resolution imaging spectra-radiometer(MODIS)-AQUA,Visible infrared Imaging Radiometer(VIIRS) and MERSI.These data resources are first merged into unified remote sensing reflectance data,and then Chl a concentration data are inversed using the combined Chl a algorithm of color index-based algorithm(CIA) and OC3.The merged data products show major improvements in spatial and temporal coverage from the addition of MERSI.The average daily coverage of merged products is approximately 24% of the global ocean and increases by approximately 9% when MERSI data are added in the merging process.Sampling frequency(temporal coverage) is greatly improved by combining MERSI data,with the median sampling frequency increasing from 15.6%(57 d/a) to 29.9%(109 d/a).The merged Chl a products herein were validated by in situ measurements and comparing them with the merged products using the same approach except for omitting MERSI and Glob Colour and MEa SUREs merged data.Correlation and relative error between the new merged Chl a products and in situ observation are stable relative to the results of the merged products without the addition of MERSI.Time series of the Chl a concentration anomalies are similar to the merged products without adding MERSI and single sensors.The new merged products agree within approximately 10% of the merged Chl a product from Glob Colour and MEa SUREs.展开更多
Due to the considerable uncertainties inherent in the datasets describing the spatiotemporal distributions of precipitation in the drylands of China,this study presents a new merged monthly precipitation product with ...Due to the considerable uncertainties inherent in the datasets describing the spatiotemporal distributions of precipitation in the drylands of China,this study presents a new merged monthly precipitation product with a spatial resolution of approximately 0.2°×0.2°during 1980–2019.The newly developed precipitation product was validated at different temporal scales(e.g.,monthly,seasonally,and annually).The results show that the new product consistently aligns with the spatiotemporal distributions reported by the Chinese Meteorological Administration Land Data Assimilation System(CLDAS)product and Multi-Source Weighted Ensemble Precipitation(MSWEP).The merged product exhibits exceptional quality in describing the drylands of China,with a bias of–2.19 mm month^(–1)relative to MSWEP.In addition,the annual trend of the merged product(0.09 mm month^(–1)yr^(−1))also closely aligns with that of the MSWEP(0.11 mm month^(–1)yr^(−1))during 1980–2019.The increasing trend indicates that the water cycle and wetting process intensified in the drylands of China during this period.In particular,there was an increase in wetting during the period from 2001–2019.Generally,the merged product exhibits potential value for improving our understanding of the climate and water cycle in the drylands of China.展开更多
In order to solve the problems of excess ovality and cross-section distortion of longitudinally submerged arc welding pipes after forming,a new three-roller continuous setting round process was proposed.This process c...In order to solve the problems of excess ovality and cross-section distortion of longitudinally submerged arc welding pipes after forming,a new three-roller continuous setting round process was proposed.This process can be divided into three stages:loading stage,roll bending stage and unloading stage.Based on the discretization idea,the mechanical model of the primary statically indeterminate problem of the longitudinally submerged arc welding pipes at the roll bending stage was established,and the deformation response was obtained.The simulation and theoretical results show that there are three positive bending regions and three reverse bending regions along the circumference of the pipe.The loading force of each roller shows growth,stability and downward trend with time.The error between the theoretical fitting curve and the simulated data point is very small,and the simulation results verify the reliability of the theoretical calculation.The experimental results show that the residual ovality decreases with the increase of the reduction,and the reduction of the turning point is the optimum reduction.In addition,the residual ovality of the pipe is less than 0.7%without cross-section distortion,which verifies the feasibility of this process.展开更多
A new structure of 4H-silicon carbide (SIC) merged PiN-Schottky (MPS) diodes with offset field-plate (FP) as edge termination is developed. To understand the influences of 4H-SiC MPS diodes with offset FP on the...A new structure of 4H-silicon carbide (SIC) merged PiN-Schottky (MPS) diodes with offset field-plate (FP) as edge termination is developed. To understand the influences of 4H-SiC MPS diodes with offset FP on the characteristics, simulations have been done by using ISE TCAD. Related factors of offset FP have been studied as well to optimise the reverse characteristics of 4H SiC MPS diodes. The simulation results show that the device using offset FP can create a higher blocking voltage under reverse bias as compared with that using field guard rings. Besides, the offset FP does not cause any extra steps in the manufacture of MPS diodes.展开更多
Probabilistic linguistic term sets(PLTSs)are an effective tool for expressing subjective human cognition that offer advantages in the field ofmulti-attribute decision-making(MADM).However,studies have found that PLTSs...Probabilistic linguistic term sets(PLTSs)are an effective tool for expressing subjective human cognition that offer advantages in the field ofmulti-attribute decision-making(MADM).However,studies have found that PLTSs have lost their ability to accurately capture the views of decision-makers(DMs)in certain circumstances,such as when the DM hesitates between multiple linguistic terms or the decision information is incomplete,thus affecting their role in the decision-making process.Belief function theory is a leading streamof thought in uncertainty processing that is suitable for dealing with the limitations of PLTS.Therefore,the purpose of this study is to extend PLTS to incorporate belief function theory.First,we provide the basic concepts of the extended PLTS(i.e.,belief-based PLTS)through case analyses.Second,the aggregation operator of belief-based PLTS is defined with the ordered weighted average(OWA)-based soft likelihood function,which is improved by considering the reliability of the information source.Third,to measure the magnitude of different belief-based PLTSs,the belief interval of singleton is calculated,and the comparison method of belief-based PLTS is constructed based on probabilities.On the basis of the preceding discussion,we further develop an emergency decision framework that includes several novel techniques,such as attribute weight determination and decision information aggregation.Finally,the usefulness of the framework is demonstrated through a case study,and its effectiveness is illustrated through a series of comparisons.展开更多
Pharmacophore is a commonly used method for molecular simulation, including ligand-based pharmacophore (LBP) and structure-based pharmacophore (SBP). LBP can be utilized to identify active compounds usual with low...Pharmacophore is a commonly used method for molecular simulation, including ligand-based pharmacophore (LBP) and structure-based pharmacophore (SBP). LBP can be utilized to identify active compounds usual with lower accuracy, and SBP is able to use for distin- guishing active compounds from inactive compounds with frequently higher missing rates. Merged pharmacophore (MP) is presented to integrate advantages and avoid shortcomings of LBP and SBP. In this work, LBP and SBP models were constructed for the study of per- oxisome proliferator receptor-alpha (PPARα) agonists. According to the comparison of the two types of pharmacophore models, mainly and secondarily pharmacological features were identified. The weight and tolerance values of these pharmacological features were adjusted to construct MP models by single-factor explorations and orthogonal experimental design based on SBP model. Then, the reliability and screening efficiency of the best MP model were validated by three databases. The best MP model was utilized to compute PPARα activity of compounds from traditional Chinese medicine. The screening efficiency of MP model outperformed individual LBP or SBP model for PPARα agonists, and was similar to combinatorial screening of LBP and SBP. However, MP model might have an advantage over the combination of LBP and SBP in evaluating the activity of compounds and avoiding the inconsistent prediction of LBP and SBP, which would be beneficial to guide drug design and optimization.展开更多
In this study, we investigated wave transformation and wave set-up between a submerged permeable breakwater and a seawall. Modified time-dependent mild-slope equations, which involve parameters of the porous medium, w...In this study, we investigated wave transformation and wave set-up between a submerged permeable breakwater and a seawall. Modified time-dependent mild-slope equations, which involve parameters of the porous medium, were used to calculate the wave height transformation and the mean water level change around a submerged breakwater. The numerical solution is verified with experimental data. The simulated results show that modulations of the wave profile and wave set-up are clearly observed between the submerged breakwater and the seawall. In contrast to cases without a seawall, the node or pseudo-node of wave height evolution can be found between the submerged breakwater and the seawall. Higher wave set-up occurs if the nodal or pseudo-nodal point appears near the submerged breakwater. We also examined the influence of the porosity and friction factor of the submerged permeable breakwater on wave transformation and set-up.展开更多
基金supported by the National Natural Science Foundation of China(52372310)the State Key Laboratory of Advanced Rail Autonomous Operation(RAO2023ZZ001)+1 种基金the Fundamental Research Funds for the Central Universities(2022JBQY001)Beijing Laboratory of Urban Rail Transit.
文摘The emerging virtual coupling technology aims to operate multiple train units in a Virtually Coupled Train Set(VCTS)at a minimal but safe distance.To guarantee collision avoidance,the safety distance should be calculated using the state-of-the-art space-time separation principle that separates the Emergency Braking(EB)trajectories of two successive units during the whole EB process.In this case,the minimal safety distance is usually numerically calculated without an analytic formulation.Thus,the constrained VCTS control problem is hard to address with space-time separation,which is still a gap in the existing literature.To solve this problem,we propose a Distributed Economic Model Predictive Control(DEMPC)approach with computation efficiency and theoretical guarantee.Specifically,to alleviate the computation burden,we transform implicit safety constraints into explicitly linear ones,such that the optimal control problem in DEMPC is a quadratic programming problem that can be solved efficiently.For theoretical analysis,sufficient conditions are derived to guarantee the recursive feasibility and stability of DEMPC,employing compatibility constraints,tube techniques and terminal ingredient tuning.Moreover,we extend our approach with globally optimal and distributed online EB configuration methods to shorten the minimal distance among VCTS.Finally,experimental results demonstrate the performance and advantages of the proposed approaches.
文摘目的:对比三维多回波恢复梯度回波(3D MERGE)、三维可变反转角快速自旋回波(3D SPACE STIR)序列在腰椎间盘突出症(LDH)检查中的应用效果。方法:选择2020年1月~2022年11月收治的135例LDH患者,回顾性分析患者临床和磁共振成像(MRI)资料,所有患者均接受常规MRI扫描及3D MERGE、3D SPACE STIR序列扫描,对比3D MERGE、3D SPACE STIR序列测量神经根直径的一致性,评价两种序列的图像质量参数[信噪比(SNR)、对比噪声比(CNR)]、图像清晰度评分。结果:3D MERGE和3D SPACE STIR序列测量的L3~S1神经根直径比较差异无统计学意义(P>0.05),且两组序列测量的L3、L4、L5和S1直径均显示出较高相关性(r=0.957,0.986,0.975,0.972,P<0.05);3D MERGE序列的SNR及CNR均高于3D SPACE STIR序列,神经根显示分级、图像清晰度评分优于3D SPACE STIR序列,差异有统计学意义(P<0.05)。结论:3D MERGE、3D SPACE STIR序列在LDH神经根直径测量中具有极高一致性,3D MERGE序列较3D SPACE STIR序列能够更清晰显示神经跟的解剖形态,图像质量更好。
文摘在循证医学时代下,依托规范的技术方法和标准化的操作规程发掘中医药独特优势,是实现中医药现代化、国际化发展并惠泽人类的必由之路。中医理论、人用经验和研究证据三结合证据体系的提出标志着中医药特色评价体系思维方法取得了重要进步,经过恰当方法整合后的多元证据体是中医药临床指南推荐意见和循证卫生决策的有力支撑。本文基于当前国际证据合成与分级方法学前沿进展,初步提出中医药多元证据整合的方法学框架——MERGE(Merge Evidence-based Research and artificial intelliGence to support smart dEcision)框架,以期为中医药循证医学方法学体系的完善和发展提供借鉴和参考。
基金The National Key R&D Program of China under contract No.2016YFA0600102the National Natural Science Foundation of China under contract Nos 41506203,41476159,41506204,41606197,41471303 and 41706209the Cooperation Project of FIO and KOIST under contract No.PI-2017-03
文摘Understanding the ocean's role in the global carbon cycle and its response to environmental change requires a high spatio-temporal resolution of observation.Merging ocean color data from multiple sources is an effective way to alleviate the limitation of individual ocean color sensors(e.g.,swath width and gaps,cloudy or rainy weather,and sun glint) and to improve the temporal and spatial coverage.Since the missions of Sea-Viewing Wide Field-of-View Sensor(Sea Wi FS) and Medium-spectral Resolution Imaging Spectrometer(MERIS) ended on December 11,2010 and May 9,2012,respectively,the number of available ocean color sensors has declined,reducing the benefits of the merged ocean color data with respect to the spatial and temporal coverage.In present work,Medium Resolution Spectral Imager(MERSI)/FY-3 of China is added in merged processing and a new dataset of global ocean chlorophyll a(Chl a) concentration(2000–2015) is generated from the remote sensing reflectance(Rrs(λ)) observations of MERIS,Moderate-resolution imaging spectra-radiometer(MODIS)-AQUA,Visible infrared Imaging Radiometer(VIIRS) and MERSI.These data resources are first merged into unified remote sensing reflectance data,and then Chl a concentration data are inversed using the combined Chl a algorithm of color index-based algorithm(CIA) and OC3.The merged data products show major improvements in spatial and temporal coverage from the addition of MERSI.The average daily coverage of merged products is approximately 24% of the global ocean and increases by approximately 9% when MERSI data are added in the merging process.Sampling frequency(temporal coverage) is greatly improved by combining MERSI data,with the median sampling frequency increasing from 15.6%(57 d/a) to 29.9%(109 d/a).The merged Chl a products herein were validated by in situ measurements and comparing them with the merged products using the same approach except for omitting MERSI and Glob Colour and MEa SUREs merged data.Correlation and relative error between the new merged Chl a products and in situ observation are stable relative to the results of the merged products without the addition of MERSI.Time series of the Chl a concentration anomalies are similar to the merged products without adding MERSI and single sensors.The new merged products agree within approximately 10% of the merged Chl a product from Glob Colour and MEa SUREs.
基金supported by the National Natural Science Foundation of China the National Natural Science Foundation of China(Grant No.41991231)the Fundamental Research Funds for the Central Universities(lzujbky-2022-kb11).
文摘Due to the considerable uncertainties inherent in the datasets describing the spatiotemporal distributions of precipitation in the drylands of China,this study presents a new merged monthly precipitation product with a spatial resolution of approximately 0.2°×0.2°during 1980–2019.The newly developed precipitation product was validated at different temporal scales(e.g.,monthly,seasonally,and annually).The results show that the new product consistently aligns with the spatiotemporal distributions reported by the Chinese Meteorological Administration Land Data Assimilation System(CLDAS)product and Multi-Source Weighted Ensemble Precipitation(MSWEP).The merged product exhibits exceptional quality in describing the drylands of China,with a bias of–2.19 mm month^(–1)relative to MSWEP.In addition,the annual trend of the merged product(0.09 mm month^(–1)yr^(−1))also closely aligns with that of the MSWEP(0.11 mm month^(–1)yr^(−1))during 1980–2019.The increasing trend indicates that the water cycle and wetting process intensified in the drylands of China during this period.In particular,there was an increase in wetting during the period from 2001–2019.Generally,the merged product exhibits potential value for improving our understanding of the climate and water cycle in the drylands of China.
基金supported by the National Natural Science Foundation of China (Nos. 52005431, 51705449 and 51975509)the Natural Science Foundation of Hebei Province of China (No. E2020203086)the National Major Science and Technology Projects of China (No. 2018ZX04007002)
文摘In order to solve the problems of excess ovality and cross-section distortion of longitudinally submerged arc welding pipes after forming,a new three-roller continuous setting round process was proposed.This process can be divided into three stages:loading stage,roll bending stage and unloading stage.Based on the discretization idea,the mechanical model of the primary statically indeterminate problem of the longitudinally submerged arc welding pipes at the roll bending stage was established,and the deformation response was obtained.The simulation and theoretical results show that there are three positive bending regions and three reverse bending regions along the circumference of the pipe.The loading force of each roller shows growth,stability and downward trend with time.The error between the theoretical fitting curve and the simulated data point is very small,and the simulation results verify the reliability of the theoretical calculation.The experimental results show that the residual ovality decreases with the increase of the reduction,and the reduction of the turning point is the optimum reduction.In addition,the residual ovality of the pipe is less than 0.7%without cross-section distortion,which verifies the feasibility of this process.
基金Project supported by Applied Materials Innovation Fund (Grant No. XA-AM-200702)the 13115 Innovation Engineering of Shaanxi Province,China (Grant No. 2008ZDKG-30)
文摘A new structure of 4H-silicon carbide (SIC) merged PiN-Schottky (MPS) diodes with offset field-plate (FP) as edge termination is developed. To understand the influences of 4H-SiC MPS diodes with offset FP on the characteristics, simulations have been done by using ISE TCAD. Related factors of offset FP have been studied as well to optimise the reverse characteristics of 4H SiC MPS diodes. The simulation results show that the device using offset FP can create a higher blocking voltage under reverse bias as compared with that using field guard rings. Besides, the offset FP does not cause any extra steps in the manufacture of MPS diodes.
基金supported by National Social Science Foundation of China (Grant No.17ZDA030).
文摘Probabilistic linguistic term sets(PLTSs)are an effective tool for expressing subjective human cognition that offer advantages in the field ofmulti-attribute decision-making(MADM).However,studies have found that PLTSs have lost their ability to accurately capture the views of decision-makers(DMs)in certain circumstances,such as when the DM hesitates between multiple linguistic terms or the decision information is incomplete,thus affecting their role in the decision-making process.Belief function theory is a leading streamof thought in uncertainty processing that is suitable for dealing with the limitations of PLTS.Therefore,the purpose of this study is to extend PLTS to incorporate belief function theory.First,we provide the basic concepts of the extended PLTS(i.e.,belief-based PLTS)through case analyses.Second,the aggregation operator of belief-based PLTS is defined with the ordered weighted average(OWA)-based soft likelihood function,which is improved by considering the reliability of the information source.Third,to measure the magnitude of different belief-based PLTSs,the belief interval of singleton is calculated,and the comparison method of belief-based PLTS is constructed based on probabilities.On the basis of the preceding discussion,we further develop an emergency decision framework that includes several novel techniques,such as attribute weight determination and decision information aggregation.Finally,the usefulness of the framework is demonstrated through a case study,and its effectiveness is illustrated through a series of comparisons.
文摘Pharmacophore is a commonly used method for molecular simulation, including ligand-based pharmacophore (LBP) and structure-based pharmacophore (SBP). LBP can be utilized to identify active compounds usual with lower accuracy, and SBP is able to use for distin- guishing active compounds from inactive compounds with frequently higher missing rates. Merged pharmacophore (MP) is presented to integrate advantages and avoid shortcomings of LBP and SBP. In this work, LBP and SBP models were constructed for the study of per- oxisome proliferator receptor-alpha (PPARα) agonists. According to the comparison of the two types of pharmacophore models, mainly and secondarily pharmacological features were identified. The weight and tolerance values of these pharmacological features were adjusted to construct MP models by single-factor explorations and orthogonal experimental design based on SBP model. Then, the reliability and screening efficiency of the best MP model were validated by three databases. The best MP model was utilized to compute PPARα activity of compounds from traditional Chinese medicine. The screening efficiency of MP model outperformed individual LBP or SBP model for PPARα agonists, and was similar to combinatorial screening of LBP and SBP. However, MP model might have an advantage over the combination of LBP and SBP in evaluating the activity of compounds and avoiding the inconsistent prediction of LBP and SBP, which would be beneficial to guide drug design and optimization.
基金supported by The Science Council of Taiwan under Grant No. 95-2221-E-005-154
文摘In this study, we investigated wave transformation and wave set-up between a submerged permeable breakwater and a seawall. Modified time-dependent mild-slope equations, which involve parameters of the porous medium, were used to calculate the wave height transformation and the mean water level change around a submerged breakwater. The numerical solution is verified with experimental data. The simulated results show that modulations of the wave profile and wave set-up are clearly observed between the submerged breakwater and the seawall. In contrast to cases without a seawall, the node or pseudo-node of wave height evolution can be found between the submerged breakwater and the seawall. Higher wave set-up occurs if the nodal or pseudo-nodal point appears near the submerged breakwater. We also examined the influence of the porosity and friction factor of the submerged permeable breakwater on wave transformation and set-up.