Design of an Analog Front End for Passive UHF RFID Transponder IC

This paper introduces a high-performance analog front end for a passive UHF RFID transponder IC, which is compatible with the ISO/IEC 18000-6B standard,operating at the 915MHz ISM band with a total supply current consumption less than 8μA. There are no external components, except for the antenna. The passive IC＇s power supply is taken from the energy of the received RF electromagnetic field with the help of a Schottky diode rectifier. The RFID analog front end includes a local oscillator, clock generator, power on reset circuit, matching network and backscatter,rectifier,regulator, and AM demodulator. The IC, whose reading distance is more than 3m,is fabricated with a Chartered 0.35μm two-poly four-metal CMOS process with Schottky diodes and is EEPROM supported. The core size is 300μm × 720μm.

SYSTEMATIC METHOD TO GENERATE NEW IDEAS IN FUZZY FRONT END USING TRIZ

The obstacle for idea generation in fuzzy front end （FFE） is difficult to apply knowledge in different fields for designers. Theory of inventive problem solving TRIZ and computer-aided innovation systems （CAIs） which are TRIZ-base software systems with a knowledge base provide a framework for knowledge application in different fields. The major methods in TRIZ are selected, which have four types. The problems to be solved for each method are summarized and mapping from the problems to the methods is given. Systematic method with eight paths to integrate the methods and problems is formed. A case study shows the idea generation in FFE using the integrated method step by step.

基于硅工艺的12GHz单片接收RF Front-End设计

提出了一种基于硅材料的、工作在12 GHz频率的用于接收卫星数字图像广播的单片射频前端系统,该系统含有低噪声放大器、混频器和第二级放大器,所有的电路都集成在硅材料工艺中,可以用于频率在12GHz的卫星通信频段信号的接收。

RF front-end for digital beam position monitor signal processor

RF circuit board has a significant impact on performance of the Digital Beam Position Monitor (DBPM) in storage ring of a synchrotron radiation facility.In this paper,a front-end RF board is designed for DBPM,and schematics of the RF board and the test results are given.In view of the inevitable inconsistency in the multi-channel circuit,a calibration circuit is designed to reduce such an influence.The test results show that the calibration method is useful for beam current dependence which is sensitive to channels inconsistency.

Multi-frequency point supported LLRF front-end for CiADS wide-bandwidth application

The China initiative Accelerator Driven System,CiADS,physics design adopts 162.5 MHz,325 MHz,and 650 MHz cavities,which are driven by the corresponding radio frequency(RF)power system,requiring frequency translation front-end for the RF station.For that application,a general-purpose design front-end prototype has been developed to evaluate the multi-frequency point supported design feasibility.The difficult parts to achieve the requirements of the general-purpose design are reasonable device selection and balanced design.With a carefully selected low-noise wide-band RF mixer and amplifier to balance the performance of multi-frequency supported down-conversion,specially designed LO distribution net to increase isolation between adjacent channels,and external band-pass filter to realize expected up-conversion frequencies,high maintenance and modular front-end generalpurpose design has been implemented.Results of standard parameters show an R2 value of at least 99.991%in the range of-60-10 dBm for linearity,up to 18 dBm for P1dB,and up to 89 dBc for cross talk between adjacent channels.The phase noise spectrum is lower than 80 dBc in the range of 0-1 MHz;cumulative phase noise is 0.006°;and amplitude and phase stability are 0.022%and 0.034°,respectively.

An Analog Front End for Recording Neuronal Activity in Freely Behaving Small Animals

Extracting characteristic brain signals and simultaneous recording animals behaving could help us to understand the complex behavior of neuronal ensembles. Here, a system was established to record local field potentials (LFP) and extracellular signal or multiple-unit discharge and behavior synchronously by utilizing electrophysiology and integrated circuit technique. It comprised microelectrodes and micro-driver assembly, analog front end (AFE),while a computer (Pentium III ) was used as the platform for the graphic user interface, which was developed using the LabVIEW programming language. It was designed as a part of ongoing research to develop a portable wireless neural signal recording system. We believe that this information will be useful for the research of brain-computer interface.

Polyphase Filter Banks for Embedded Sample Rate Changes in Digital Radio Front-Ends

This paper presents efficient processing engines for software-defined radio （SDR） front-ends. These engines, based on a polyphase channelizer, perform arbitrary sample-rate changes, frequency selection, and bandwidth control. This paper presents an M-path polyphase filter bank based on a modified N-path polyphase filter. Such a system allows resampling by arbitrary ratios while performing baseband aliasing from center frequencies at Nyquist zones that are not multiples of the output sample rate. This resampling technique is based on sliding cyclic data load interacting with cyclic-shifted coefficients. A non-maximally-decimated polyphase filterbank （where the number of data loads is not equal to the number of M subfilters） processes M subfilters in a time period that is less than or greater than the M data loads. A polyphase filter bank with five different resampling modes is used as a case study for embedded resamp/ing in SDR front-ends. These modes are （i） maximally decimated, （ii） Under-decimated, （iii） over-decimated, and combined up- and down-sampling with （iv） single stride length, and （v） multiple stride lengths. These modes can be used to obtain any required rational sampling rate change in an SDR front-end based on a polyphase channelizer. They can also be used for translation to and from arbitrary center frequencies that are unrelated to the output sample rates.

A Study on the Activities During the Fuzzy Front End in New Product Development Projects of Korean ICT Firms

Although previous studies on Korean manufacturing firms have empirically analyzed the causal relationship between activities during the FFE(Fuzzy Front End)and success of NPD(New Product Development)of Korean manufacturing firms,no study has concretely focused on Korean ICT(Information and Communications Technology)firms and their FFE activities.The main aim of this study is to identify the activities of these firms during their FFE and provide managerial insights into the other ICT firms.The authors conducted a survey(106 valid responses)that their FFE activities on new product development project managers in Korean ICT firms.The results showed that even though new product development managers of Korean ICT firms did not search for ideas systemically,they communicated with those departments/divisions that had frequent interaction with customers for idea assessment,with the active involvement of middle-or higher-level managers.They thoroughly established initial plans in the pre-development stages and seriously analyzed competitors’products and direct and indirect customer interactions in their market survey activities.

Design of a Low-Noise Front-End Readout CSP-Shaper System for CZT Detectors

This paper describes a low-noise front-end readout circuit for CZT detectors based on TSMC 0.35 um mixed-single CMOS technology;mainly analyzes the noise model of the detector-preamplifier and presents the low-noise circuit schematic of charge sensitive preamplifier and shaper. Considering the parasitical influences, the circuit and layout-design are optimized to reduce noise. The preliminary simulation results show that, the equivalent noise charge (ENC) is 74 e﹣ (rms), noise slope is 9 e﹣/pF, power consumption is 2 mW, and non-linearity

High glucose reduces Nrf2-dependent cRAGE release and enhances inflammasome-dependent IL-1βproduction in monocytes:the modulatory effects of EGCG

Soluble receptor for advanced glycation end products(sRAGE)acts as a decoy sequestering of RAGE ligands,thus preventing the activation of the ligand-RAGE axis linking human diseases.However,the molecular mechanisms underlying sRAGE remain unclear.In this study,THP-1 monocytes were cultured in normal glucose(NG,5.5 mmol/L)and high glucose(HG,15 mmol/L)to investigate the effects of diabetesrelevant glucose concentrations on sRAGE and interleukin-1β(IL-1β)secretion.The modulatory effects of epigallocatechin gallate(EGCG)in response to HG challenge were also evaluated.HG enhanced intracellular reactive oxygen species(ROS)generation and RAGE expression.The secretion of sRAGE,including esRAGE and cRAGE,was reduced under HG conditions,together with the downregulation of a disintegrin and metallopeptidase 10(ADAM10)and nuclear factor erythroid 2-related factor 2(Nrf2)nuclear translocation.Mechanistically,the HG effects were counteracted by siRAGE and exacerbated by siNrf2.Chromatin immunoprecipitation results showed that Nrf2 binding to the ADAM10 promoter and HG interfered with this binding.Our data reinforce the notion that RAGE and Nrf2 might be sRAGE-regulating factors.Under HG conditions,the treatment of EGCG reduced ROS generation and RAGE activation.EGCG-stimulated cRAGE release was likely caused by the upregulation of the Nrf2-ADAM10 pathway.EGCG inhibited HG-mediated NLRP3 inflammasome activation at least partly by stimulating sRAGE,thereby reducing IL-1βrelease.

Effect of Bogie Cavity End Wall Inclination on Flow Field and Aerodynamic Noise in the Bogie Region of High-Speed Trains

Combining the detached eddy simulation(DES)method and Ffowcs Williams-Hawkings(FW-H)equation,the effect of bogie cavity end wall inclination on the flow field and aerodynamic noise in the bogie region is numerically studied.First,the simulation is conducted based on a simplified cavity-bogie model,including five cases with different inclination angles of the front and rear walls of the cavity.By comparing and analyzing the flow field and acoustic results of the five cases,the influence of the regularity and mechanism of the bogie cavity end wall inclination on the flow field and the aerodynamic noise of the bogie region are revealed.Then,the noise reduction strategy determined by the results of the simplified cavity-bogie model is applied to a three-car marshaling train model to verify its effectiveness when applied to the real train.The results reveal that the forward inclination of the cavity front wall enlarges the influence area of shear vortex structures formed at the leading edge of the cavity and intensifies the interaction between the vortex structures and the front wheelset,frontmotor,and front gearbox,resulting in the increase of the aerodynamic noise generated by the bogie itself.The backward inclination of the cavity rear wall is conducive to guiding the vortex structures flow out of the cavity and weakening the interaction between the shear vortex structures and the cavity rear wall,leading to the reduction of the aerodynamic noise generated by the bogie cavity.Inclining the rear end wall of the foremost bogie cavity of the head car is a feasible aerodynamic noise reduction measure for high-speed trains.

End-group modulation of phenazine based non-fullerene acceptors for efficient organic solar cells with high open-circuit voltage

Phenazine-based non-fullerene acceptors(NFAs)have demonstrated great potential in improving the power conversion efficiency(PCE)of organic solar cells(OSCs).Halogenation is known to be an effective strategy for increasing optical absorption,refining energy levels,and improving molecular packing in organic semiconductors.Herein,a series of NFAs(Pz IC-4H,Pz IC-4F,Pz IC-4Cl,Pz IC-2Br)with phenazine as the central core and with/without halogen-substituted(dicyanomethylidene)-indan-1-one(IC)as the electron-accepting end group were synthesized,and the effect of end group matched phenazine central unit on the photovoltaic performance was systematically studied.Synergetic photophysical and morphological analyses revealed that the PM6:Pz IC-4F blend involves efficient exciton dissociation,higher charge collection and transfer rates,better crystallinity,and optimal phase separation.Therefore,OSCs based on PM6:Pz IC-4F as the active layer exhibited a PCE of 16.48%with an open circuit voltage(Voc)and energy loss of 0.880 V and 0.53 e V,respectively.Accordingly,this work demonstrated a promising approach by designing phenazine-based NFAs for achieving high-performance OSCs.

Front-end signal analysis of the transverse feedback system for SSRF

Multi-bunch instabilities degrade beam quality through increased beam emittance,energy spread and even cause beam loss.A feedback system is used to suppress multi-bunch instabilities associated with resistive wall of the beam ducts,cavity-like structures,and trapped ions.A digital TFS (Transverse Feedback System) is in construction at the SSRF (Shanghai Synchrotron Radiation Facility),which is based on the latest generation of FPGA (Field Programmable Gate Array) processor.Before we get such FPGA disital board,investigation and simulation of the front-end were done in the first place.The signal flow was analyzed by SystemView.Construction and optimization of the entire system is our next goal.

Molecular packing tuning via chlorinated end group enables efficient binary organic solar cells over 18.5%

Designing novel nonfullerene acceptors(NFAs)is of vital importance for the development of organic solar cells(OSC).Modification on the side chain and end group are two powerful tools to construct efficient NFAs.Here,based on the high-performance L8BO,we selected 3-ethylheptyl to substitute the inner chain of 2-ethylhexyl,obtaining the backbone of BON3.Then we introduced different halogen atoms of fluorine and chlorine on 2-(3-oxo-2,3-dihydro-1Hinden-1-ylidene)malononitrile end group(EG)to construct efficient NFAs named BON3-F and BON3-Cl,respectively.Polymer donor D18 was chosen to combine with two novel NFAs to construct OSC devices.Impressively,D18:BON3-Cl-based device shows a remarkable power conversion efficiency(PCE)of 18.57%,with a high open-circuit voltage(V_(OC))of 0.907 V and an excellent fill factor(FF)of 80.44%,which is one of the highest binary PCE of devices based on D18 as the donor.However,BON3-F-based device shows a relatively lower PCE of 17.79%with a decreased FF of 79.05%.The better photovoltaic performance is mainly attributed to the red-shifted absorption,higher electron and hole mobilities,reduced charge recombination,and enhanced molecular packing in the D18:BON3-Cl films.Also,we performed stability tests on two binary systems;the D18:BON3-Cl and D18:BON3-F devices maintain 88.1%and 85.5%of their initial efficiencies after 169 h of storage at 85°C in an N2-filled glove box,respectively.Our work demonstrates the importance of selecting halogen atoms on EG and provides an efficient binary system of D18:BON3-Cl for further improvement of PCE.

MGMT activated by Wnt pathway promotes cisplatin tolerance through inducing slow-cycling cells and nonhomologous end joining in colorectal cancer

Chemotherapy resistance plays a pivotal role in the prognosis and therapeutic failure of patients with colorectal cancer(CRC).Cisplatin(DDP)-resistant cells exhibit an inherent ability to evade the toxic chemotherapeutic drug effects which are characterized by the activation of slow-cycle programs and DNA repair.Among the elements that lead to DDP resistance,O^(6)-methylguanine(O^(6)-MG)-DNA-methyltransferase(MGMT),a DNA-repair enzyme,performs a quintessential role.In this study,we clarify the significant involvement of MGMT in conferring DDP resistance in CRC,elucidating the underlying mechanism of the regulatory actions of MGMT.A notable upregulation of MGMT in DDP-resistant cancer cells was found in our study,and MGMT repression amplifies the sensitivity of these cells to DDP treatment in vitro and in vivo.Conversely,in cancer cells,MGMT overexpression abolishes their sensitivity to DDP treatment.Mechanistically,the interaction between MGMT and cyclin dependent kinase 1(CDK1)inducing slow-cycling cells is attainted via the promotion of ubiquitination degradation of CDK1.Meanwhile,to achieve nonhomologous end joining,MGMT interacts with XRCC6 to resist chemotherapy drugs.Our transcriptome data from samples of 88 patients with CRC suggest that MGMT expression is co-related with the Wnt signaling pathway activation,and several Wnt inhibitors can repress drug-resistant cells.In summary,our results point out that MGMT is a potential therapeutic target and predictive marker of chemoresistance in CRC.

融合BlendMask的机械手臂抓取位姿估计模型

针对复杂场景抓取位姿估计速度慢、精度低的问题,基于BlendMask实例分割网络,结合实例分割与抓取位姿估计,设计了一种端到端的机械手臂抓取位姿估计深度模型GPNet。该模型首先依据图像2D信息,在BlendMask网络中增加抓取中心、抓取主方向估计分支,提升抓取位姿估计速度;其次采用霍夫投票获取抓取中心及主方向,提高了2D抓取位姿估计的精度与鲁棒性;然后采用椭圆筛选机制,有效地解决了由圆形物体任意性对抓取主方向估计的干扰;最后依据新的损失函数训练GPNet,并结合图像深度信息获得最终抓取位姿信息。以中国信息通信研究院工业互联网平台、工业和信息化部重点实验室抓取实验场景为对象进行抓取速度与精度验证,以9种物体为抓取目标,结果表明在平均每个场景6种抓取目标实例且有干扰物体遮挡的复杂场景下,所提模型位姿估计平均速度达到0.057 s,平均抓取成功率达到90.2%。

End-of-Pregnancy Monitoring at CHUMEFJE through the Functional Investigation Centre (FIC) in 2022

Introduction: The end of pregnancy is a high-risk period for both mother and foetus. Rigorous monitoring can prevent complications before delivery. Materials and Method: We conducted a descriptive cross-sectional observational study. It took place in the delivery room of the Teacher hospital Mother and Child of Jeanne Ebori Fondation from the 01 October 2020 to 01 October 2021. All patients followed at the Functional Investigation Centre (FIC) of the CHUMEFJE and who gave birth in that same hospital were included. Data were collected on the basis of pregnancy diaries, the fic register and delivery room registers. They were analysed using SPSS Statistical Software. Results: During the period of our study, 4086 parturients arrived in the delivery room. Of these, 150 were followed up at the FIC, giving a prevalence of 3.7%. The majority of parturients (48%) had only one prenatal contact. 6 (4%) patients underwent pelvic scans, and 4 (2.6%) presented with a narrowed pelvis. A vaginal delivery was performed in 80% of cases, and of the caesarean sections, 9 (30%) could be scheduled. The maternal prognosis was marred by one post-partum complication of hypertension, and newborns with poor adaptation to life outside the womb accounted for 3.3% of cases. Conclusion: The Functional Investigation Centre makes it possible to detect anomalies at the end of pregnancy with a view to better planning of delivery.

Diet with high content of advanced glycation end products induces oxidative stress damage and systemic inflammation in experimental mice: protective effect of peanut skin procyanidins

Non-enzymatic glycation reaction in food can produce diet-derived advanced glycation end products(dAGEs),which have potential health risks.Thus,it is of great significance to find efficient substances to improve the negative effects induced by dAGEs on human health.This study investigated the intervening effects of peanut skin procyanidins(PSP)on the dAGEs-induced oxidative stress and systemic inflammation in experimental mice model.Results showed that the accumulation of AGEs in serum,liver,and kidney was significantly increased after mice were fed dAGEs(P<0.05).The expression of advanced glycation product receptor(RAGE)was also significantly increased in liver and kidney(P<0.05).PSP could not only effectively reduce the accumulation of AGEs in serum,liver and kidney of mice,but also reduce the expression of RAGE in liver and kidney of mice.And the levels of pro-inflammatory cytokines interleukin-6(IL-6),tumor necrosis factor(TNF-α),and IL-1βin serum of mice were significantly decreased(P<0.05),while the levels of antiinflammatory factor IL-10 were increased,and the inflammatory injury in mice was improved.In addition,the levels of superoxide dismutase(SOD),glutathione(GSH),catalase(CAT)in liver and kidney of mice were increased(P<0.05),and the level of malondialdehyde(MDA)was decreased(P<0.05),which enhanced the antioxidant capacity of mice in vivo,and improved the oxidative damage of liver and kidney.Molecular docking technique was used to confirm that the parent compound of procyanidins and its main metabolites,such as 3-hydroxyphenylacetic acid,could interact with RAGE,which might inhibit the activation of nuclear transcription factor(NF-κB),and ultimately reduce oxidative stress and inflammation in mice.

The front-end electronics design of dose monitors for beam delivery system of Shanghai Advanced Proton Therapy Facility

A front-end electronics of dose monitor has been developed for measuring irradiation dose to the patient in Shanghai Advanced Proton Therapy Facility.The parallel plate ionization chamber is used for the dose monitoring.Unlike the traditional method of recycling capacitor integration and voltage-to-frequency conversion,this dose monitor electronics uses the trans-impedance amplifier and analog-to-digital conversion method.It performs satisfactorily,with the integral nonlinearity of less than ±0.04 nA in the range of-400 to 50 nA and the resolution of about±0.6 nA.

Advanced glycation end products in gastric cancer:A promising future

In this editorial,we delve into the article and offer valuable insights into a crucial aspect of gastric cancer aetiology.Gastric cancer is a malignancy emanating from the epithelial lining of the gastric mucosa and one of the most prevalent forms of cancer worldwide.The development of gastric cancer is associated with multiple risk factors,including Helicobacter pylori infection,advanced age,a diet rich in salt,and suboptimal eating patterns.Despite notable reductions in morbidity and mortality rates,gastric cancer remains a formidable public health concern,impacting patients’lives.Advanced glycation end products(AGEs)are complex compounds arising from nonenzymatic reactions within living organisms,the accumulation of which is implicated in cellular and tissue damage;thus,the levels are AGEs are correlated with the risk of diverse diseases.The investigation of AGEs is of paramount importance for the treatment of gastric cancer and can provide pivotal insights into disease pathogenesis and preventive and therapeutic strategies.The reduction of AGEs levels and suppression of their accumulation are promising avenues for mitigating the risk of gastric cancer.This approach underscores the need for further research aimed at identifying innovative interventions that can effectively lower the incidence and mortality rates of this malignancy.