BACKGROUND Gastric cancer is a kind of malignant tumor which is prevalent all over the world.Although some progress has been made in the treatment of gastric cancer,its prognosis is still not optimistic,so it is of gr...BACKGROUND Gastric cancer is a kind of malignant tumor which is prevalent all over the world.Although some progress has been made in the treatment of gastric cancer,its prognosis is still not optimistic,so it is of great significance to find reliable prog-nostic indicators to guide the treatment and management of patients with gastric cancer.AIM To explore the relationship between serum levels of five biomarkers[carcinoem-bryonic antigen(CEA),carbohydrate antigen(CA)19-9,CA72-4,CA24-2,and ferritin]and prognosis in patients with gastric cancer.METHODS This study included 200 patients with gastric adenocarcinoma,and conducted an in-depth analysis of their baseline characteristics,relationship between tumor markers and staging,and prognosis.The study found that CA19-9 has a signi-ficant correlation with tumor stage,the average levels of CA24-2,CEA,CA72-4 and ferritin were slightly increased disregarding the stage of tumor.Survival analysis showed that increases in CEA,CA19-9,CA24-2,and ferritin were all associated with shortened overall survival of patients.Further multivariate ana-lysis revealed that elevated serum CA72-4 levels were an inde-pendent adverse prognostic factor.RESULTS This study reveals that there is a significant correlation between the expression levels of serum tumor markers CEA,CA19-9,CA72-4,CA24-2 and ferritin in patients with gastric cancer and prognosis,and can be used as important indicators for prognostic evaluation of gastric cancer.In particular,markers that appear abnormally elevated initially may help identify gastric cancer patients with poor prognosis.CONCLUSION Serum CEA and CA19-9 play an important role in the prognosis assessment of gastric cancer,and are effective tools to guide clinical practice and optimize individualized treatment strategies for gastric cancer patients.展开更多
文摘BACKGROUND Gastric cancer is a kind of malignant tumor which is prevalent all over the world.Although some progress has been made in the treatment of gastric cancer,its prognosis is still not optimistic,so it is of great significance to find reliable prog-nostic indicators to guide the treatment and management of patients with gastric cancer.AIM To explore the relationship between serum levels of five biomarkers[carcinoem-bryonic antigen(CEA),carbohydrate antigen(CA)19-9,CA72-4,CA24-2,and ferritin]and prognosis in patients with gastric cancer.METHODS This study included 200 patients with gastric adenocarcinoma,and conducted an in-depth analysis of their baseline characteristics,relationship between tumor markers and staging,and prognosis.The study found that CA19-9 has a signi-ficant correlation with tumor stage,the average levels of CA24-2,CEA,CA72-4 and ferritin were slightly increased disregarding the stage of tumor.Survival analysis showed that increases in CEA,CA19-9,CA24-2,and ferritin were all associated with shortened overall survival of patients.Further multivariate ana-lysis revealed that elevated serum CA72-4 levels were an inde-pendent adverse prognostic factor.RESULTS This study reveals that there is a significant correlation between the expression levels of serum tumor markers CEA,CA19-9,CA72-4,CA24-2 and ferritin in patients with gastric cancer and prognosis,and can be used as important indicators for prognostic evaluation of gastric cancer.In particular,markers that appear abnormally elevated initially may help identify gastric cancer patients with poor prognosis.CONCLUSION Serum CEA and CA19-9 play an important role in the prognosis assessment of gastric cancer,and are effective tools to guide clinical practice and optimize individualized treatment strategies for gastric cancer patients.
文摘目的 探讨益肾排毒方治疗老年糖尿病肾病患者疗效及对24 h尿蛋白、β2微球蛋白的影响。方法 将武汉市中医医院2019年1月—2021年4月收治的老年糖尿病肾病患者101例,随机对照表法随机分为对照组53例和观察组48例。对照组采用降糖、降压、控制蛋白、纠正电解质代谢紊乱、肾性贫血及肾性骨病等对症治疗;在此基础上,观察组采用益肾排毒方治疗,两组均治疗12周。比较两组的临床疗效及不良反应状况,测定白细胞介素-6(interleukin-6,IL-6)、C反应蛋白(C-reactive protein, CRP)、血肌酐(serum creatinine, Scr)、尿素氮(urea nitrogen, BUN)及24 h尿蛋白(24 h urine protein quantification, 24 h Upro)、β2-微球蛋白(β2-microglobulin, β2-MG)。结果 观察组治疗后血清IL-6与CRP低于对照组,差异有统计学意义(P<0.05)。观察组治疗后SCR、BUN及24 h Upro、β2-MG水平低于对照组(P<0.05)。对照组有效率79.25%(42/53)与观察组93.75%(45/48)比较,差异有统计学意义(P<0.05)。对照组总不良率18.87%(10/53)与观察组27.08%(13/48)比较,差异无统计学意义(P>0.05)。结论 益肾排毒方对老年糖尿病肾病患者的疗效显著,可降低患者炎症因子水平,降低24 h Upro、β2-MG,改善肾功能和血管内皮功能,值得推广。
