一、系统设计1 .系统设计的背景《智力量表》依据心理学理论而制定,能够对人的智力进行多方面、多结构的分析,风行于美国、西欧等发达国家,有较高的社会效益.其中《瑞文标准推理测验》(Raven’s Standard Progressive Matrices简称SPM)...一、系统设计1 .系统设计的背景《智力量表》依据心理学理论而制定,能够对人的智力进行多方面、多结构的分析,风行于美国、西欧等发达国家,有较高的社会效益.其中《瑞文标准推理测验》(Raven’s Standard Progressive Matrices简称SPM)是英国心理学家瑞文(J.C.Raven)1938年设计的非文字智力测验.自其问世以来,许多国家对它做了修订,直至现在仍在广泛使用,有着重要的理论意义与实用价值.在我国的心理学家的不断努力下,我国已经引进了《智力量表》的许多经典之作.并针对中国自已的情况做了修订.但是,在现实生活中,《智力量表》并未起到其应起的作用.这其中不可忽视的一个原因是:《智力量表》展开更多
Aurein is a cationic antimicrobial peptide, rich in phenylalanine residues. Although the peptide has been extensively studied, its mechanism of action is not fully understood and has not been established. This project...Aurein is a cationic antimicrobial peptide, rich in phenylalanine residues. Although the peptide has been extensively studied, its mechanism of action is not fully understood and has not been established. This project is focused on studying the interactions of aurein with model biological membranes and antimalarials using Fourier Transform Infrared (FTIR), fluorescence, dynamic light scattering (DLS), atomic force microscopy (AFM), thermogravimetric analysis (TGA), and differential scanning calorimetry (DSC) techniques. FTIR data revealed conformational changes to the secondary structure of the peptide in the presence of the model membranes. The strongest interactions of aurein were found with DOPC and lipid raft systems. Fluorescence data revealed some differences in the mechanism of interaction between aurein and lipid rafts. Topographical analysis was performed using atomic force microscopy (AFM). AFM images of the peptide with its lipid rafts showed a change in surface roughness suggesting a different mechanism of interaction. DLS data in agreement with FTIR confirmed that aurein interacts differently with the lipid rafts. The results gathered from this study provided new insights on the interaction of aurein. On the other hand, drug-drug interaction issues continue to present a major dilemma for the clinician caring for complex patients such as those infected with infectious disease. This study has examined the interaction of aurein with quinine, primaquine, and chloroquine. Significant interactions between aurein and antimalarials occured at a higher concentration of antimalarials. Interactions between aurein and anti-malarials reveal a strong interaction between aurein and primaquine. Interactions between aurein and quinine or chloroquine were found to be weak and negligible. FTIR, TGA, and DSC may be used in a complementary way to gain insights into the possible drug-drug interactions involving aurein. These studies are needed to initiate in vivo controlled interaction studies between antibiotics and antimalarials.展开更多
The amount of 3D data stored and transmitted in the Internet of Medical Things(IoMT)is increasing,making protecting these medical data increasingly prominent.However,there are relatively few researches on 3D data wate...The amount of 3D data stored and transmitted in the Internet of Medical Things(IoMT)is increasing,making protecting these medical data increasingly prominent.However,there are relatively few researches on 3D data watermarking.Moreover,due to the particularity of medical data,strict data quality should be considered while protecting data security.To solve the problem,in the field of medical volume data,we proposed a robust watermarking algorithm based on Polar Cosine Transform and 3D-Discrete Cosine Transform(PCT and 3D-DCT).Each slice of the volume data was transformed by PCT to obtain feature row vector,and then the reshaped three-dimensional feature matrix was transformed by 3D-DCT.Based on the contour information of the volume data and the detail information of the inner slice,the visual feature vector was obtained by applying the per-ceptual hash.In addition,the watermark was encrypted by a multi-sensitive initial value Sine and Piecewise linear chaotic Mapping(SPM)system,and embedded as a zero watermark.The key was stored in a third party.Under the same experimental conditions,when the volume data is rotated by 80 degrees,cut 25%along the Z axis,and the JPEG compression quality is 1%,the Normalized Correlation Coefficient(NC)of the extracted watermark is 0.80,0.89,and 1.00 respectively,which are significantly higher than the comparison algorithm.展开更多
The interaction of cetyl trimethylammonium bromide (CTAB)and an anionic copolymer derived from 3\|sulfopropylmethacrylate, potassium salt (SPMS) and styrene (St) in aqueous solutions has been studied. It was found tha...The interaction of cetyl trimethylammonium bromide (CTAB)and an anionic copolymer derived from 3\|sulfopropylmethacrylate, potassium salt (SPMS) and styrene (St) in aqueous solutions has been studied. It was found that the viscosity of the anionic copolymer\|CTAB solution rises suddenly in a specific molar ratio of CTAB/anion. For instance, the viscosity of polymer (No.1) solutions increases to about 20 times at CTAB/\|SO\-3K=1.0～1 05, and increases to about 100 times at CTAB/\|SO 3K=1.4～1 5. In the case of polymer samples No.2 and No.3, the changes of solution viscosity are similar to that of sample No.1, but the gelation takes place at CTAB/\|SO\-3K=1.4～1 5 region because of the lower negative charge density on No.2 and No.3 polymer chains. It is proposed that the dramatical change of the P(SPMS-co-St)/CTAB aqueous solution is ascribed to the aggregation behavior of CTAB, then the P(SPMS-co-St) aggregates. This consideration was verified by fluorescence determination and laser light scattering experiments. Using DMAF as fluoresscent probe, the hydrophobic microdomain existed in P(SPMS-co-St)/CTAB aqueous solutions in the viscosity rising region has been confirmed and it is in agreement well with the results obtained by laser light scattering determination.展开更多
Mesaieed(梅赛伊德)港是一个集油类产品、液化石油气、石油化工、化肥、散杂货为一体的综合性货物操作港口,坐落于卡塔尔东南岸,距离首都多哈约45km。该港拥有3艘速度可达27节的引水艇,8艘拖轮(80吨2艘,55吨4艘,35吨2艘),以及4条系缆艇...Mesaieed(梅赛伊德)港是一个集油类产品、液化石油气、石油化工、化肥、散杂货为一体的综合性货物操作港口,坐落于卡塔尔东南岸,距离首都多哈约45km。该港拥有3艘速度可达27节的引水艇,8艘拖轮(80吨2艘,55吨4艘,35吨2艘),以及4条系缆艇。对于VLCC,该港仅有SPM(24°53.72'N051°34.96'E)和MPB(24°53.80 N 051°33.25E)两个泊位可以靠泊。其中,SPM系泊期间船尾会有一艘拖轮拖带。展开更多
文摘一、系统设计1 .系统设计的背景《智力量表》依据心理学理论而制定,能够对人的智力进行多方面、多结构的分析,风行于美国、西欧等发达国家,有较高的社会效益.其中《瑞文标准推理测验》(Raven’s Standard Progressive Matrices简称SPM)是英国心理学家瑞文(J.C.Raven)1938年设计的非文字智力测验.自其问世以来,许多国家对它做了修订,直至现在仍在广泛使用,有着重要的理论意义与实用价值.在我国的心理学家的不断努力下,我国已经引进了《智力量表》的许多经典之作.并针对中国自已的情况做了修订.但是,在现实生活中,《智力量表》并未起到其应起的作用.这其中不可忽视的一个原因是:《智力量表》
文摘Aurein is a cationic antimicrobial peptide, rich in phenylalanine residues. Although the peptide has been extensively studied, its mechanism of action is not fully understood and has not been established. This project is focused on studying the interactions of aurein with model biological membranes and antimalarials using Fourier Transform Infrared (FTIR), fluorescence, dynamic light scattering (DLS), atomic force microscopy (AFM), thermogravimetric analysis (TGA), and differential scanning calorimetry (DSC) techniques. FTIR data revealed conformational changes to the secondary structure of the peptide in the presence of the model membranes. The strongest interactions of aurein were found with DOPC and lipid raft systems. Fluorescence data revealed some differences in the mechanism of interaction between aurein and lipid rafts. Topographical analysis was performed using atomic force microscopy (AFM). AFM images of the peptide with its lipid rafts showed a change in surface roughness suggesting a different mechanism of interaction. DLS data in agreement with FTIR confirmed that aurein interacts differently with the lipid rafts. The results gathered from this study provided new insights on the interaction of aurein. On the other hand, drug-drug interaction issues continue to present a major dilemma for the clinician caring for complex patients such as those infected with infectious disease. This study has examined the interaction of aurein with quinine, primaquine, and chloroquine. Significant interactions between aurein and antimalarials occured at a higher concentration of antimalarials. Interactions between aurein and anti-malarials reveal a strong interaction between aurein and primaquine. Interactions between aurein and quinine or chloroquine were found to be weak and negligible. FTIR, TGA, and DSC may be used in a complementary way to gain insights into the possible drug-drug interactions involving aurein. These studies are needed to initiate in vivo controlled interaction studies between antibiotics and antimalarials.
基金supported in part by the Natural Science Foundation of China under Grants 62063004the Key Research Project of Hainan Province under Grant ZDYF2021SHFZ093+1 种基金the Hainan Provincial Natural Science Foundation of China under Grants 2019RC018 and 619QN246the postdoctor research from Zhejiang Province under Grant ZJ2021028.
文摘The amount of 3D data stored and transmitted in the Internet of Medical Things(IoMT)is increasing,making protecting these medical data increasingly prominent.However,there are relatively few researches on 3D data watermarking.Moreover,due to the particularity of medical data,strict data quality should be considered while protecting data security.To solve the problem,in the field of medical volume data,we proposed a robust watermarking algorithm based on Polar Cosine Transform and 3D-Discrete Cosine Transform(PCT and 3D-DCT).Each slice of the volume data was transformed by PCT to obtain feature row vector,and then the reshaped three-dimensional feature matrix was transformed by 3D-DCT.Based on the contour information of the volume data and the detail information of the inner slice,the visual feature vector was obtained by applying the per-ceptual hash.In addition,the watermark was encrypted by a multi-sensitive initial value Sine and Piecewise linear chaotic Mapping(SPM)system,and embedded as a zero watermark.The key was stored in a third party.Under the same experimental conditions,when the volume data is rotated by 80 degrees,cut 25%along the Z axis,and the JPEG compression quality is 1%,the Normalized Correlation Coefficient(NC)of the extracted watermark is 0.80,0.89,and 1.00 respectively,which are significantly higher than the comparison algorithm.
文摘The interaction of cetyl trimethylammonium bromide (CTAB)and an anionic copolymer derived from 3\|sulfopropylmethacrylate, potassium salt (SPMS) and styrene (St) in aqueous solutions has been studied. It was found that the viscosity of the anionic copolymer\|CTAB solution rises suddenly in a specific molar ratio of CTAB/anion. For instance, the viscosity of polymer (No.1) solutions increases to about 20 times at CTAB/\|SO\-3K=1.0～1 05, and increases to about 100 times at CTAB/\|SO 3K=1.4～1 5. In the case of polymer samples No.2 and No.3, the changes of solution viscosity are similar to that of sample No.1, but the gelation takes place at CTAB/\|SO\-3K=1.4～1 5 region because of the lower negative charge density on No.2 and No.3 polymer chains. It is proposed that the dramatical change of the P(SPMS-co-St)/CTAB aqueous solution is ascribed to the aggregation behavior of CTAB, then the P(SPMS-co-St) aggregates. This consideration was verified by fluorescence determination and laser light scattering experiments. Using DMAF as fluoresscent probe, the hydrophobic microdomain existed in P(SPMS-co-St)/CTAB aqueous solutions in the viscosity rising region has been confirmed and it is in agreement well with the results obtained by laser light scattering determination.
文摘Mesaieed(梅赛伊德)港是一个集油类产品、液化石油气、石油化工、化肥、散杂货为一体的综合性货物操作港口,坐落于卡塔尔东南岸,距离首都多哈约45km。该港拥有3艘速度可达27节的引水艇,8艘拖轮(80吨2艘,55吨4艘,35吨2艘),以及4条系缆艇。对于VLCC,该港仅有SPM(24°53.72'N051°34.96'E)和MPB(24°53.80 N 051°33.25E)两个泊位可以靠泊。其中,SPM系泊期间船尾会有一艘拖轮拖带。
