Deregulated c-Myc expression is a hallmark of many human cancers. We have recently identified a role of mammalian homolog of yeast SPT-ADA-GCN5-acetyltransferas(SAGA) complex component, SAGAassociated factor 29(SGF29)...Deregulated c-Myc expression is a hallmark of many human cancers. We have recently identified a role of mammalian homolog of yeast SPT-ADA-GCN5-acetyltransferas(SAGA) complex component, SAGAassociated factor 29(SGF29), in regulating the c-Myc overexpression. Here, we discuss the molecular nature of SFG29 in SPT3-TAF9-GCN5-acetyltransferase complex, a counterpart of yeast SAGA complex, and the mechanism through which the elevated SGF29 expression contribute to oncogenic potential of c-Myc in hepatocellularcarcinoma(HCC). We propose that the upstream regulation of SGF29 elicited by sexdetermining region Y(Sry) is also augmented in HCC. We hypothesize that c-Myc elevation driven by the deregulated Sry and SGF29 pathway is implicated in the male specific acquisition of human HCCs.展开更多
Lead strontium titanate(Sr_(1-x)Pbx)TiO_(3)(0.20≤x≤0.45,step=0.05)ceramics were prepared by conventional mixed oxide method.The X-ray diffraction patterns indicate that the prepared samples have perovskite-type stru...Lead strontium titanate(Sr_(1-x)Pbx)TiO_(3)(0.20≤x≤0.45,step=0.05)ceramics were prepared by conventional mixed oxide method.The X-ray diffraction patterns indicate that the prepared samples have perovskite-type structure.With the increase of Pb content,there is a tendency from the cubic to tetragonal structure.The scanning electron microscopy micrographs reveal that the addition of Pb can affect microstructure.The dependent temperature dielectric permittivity and dielectric loss were investigated in the frequency range from 100 Hz to 1MHz.The maximum peak of the dielectric permittivity versus temperature curve was broadened and a frequency dispersion of the dielectric permittivity was observed for the(Sr_(0.8)Pb_(0.2))TiO_(3)ceramics.The results obtained at the frequency of 10 kHz reveal the Curie temperature linearly increased with the lead content.Thefitted curves of temperature versus inverse dielectric permittivity at 10 kHz for(Sr_(1-x)Pbx)TiO_(3)ceramics are consistent with Curie-Weiss law.The Pyroelectric properties were also investigated.The high pyroelectric coe±cients andfigure of merits indicate that the SPT ceramics are potential materials for pyroelectric sensors.展开更多
基金Supported by The "Academic Frontier" project for Private University:a matching fund subsidy from MEXT(Ministry of Education,Culture,Sports,Science and Technology),2006-2010(to Tashiro F)
文摘Deregulated c-Myc expression is a hallmark of many human cancers. We have recently identified a role of mammalian homolog of yeast SPT-ADA-GCN5-acetyltransferas(SAGA) complex component, SAGAassociated factor 29(SGF29), in regulating the c-Myc overexpression. Here, we discuss the molecular nature of SFG29 in SPT3-TAF9-GCN5-acetyltransferase complex, a counterpart of yeast SAGA complex, and the mechanism through which the elevated SGF29 expression contribute to oncogenic potential of c-Myc in hepatocellularcarcinoma(HCC). We propose that the upstream regulation of SGF29 elicited by sexdetermining region Y(Sry) is also augmented in HCC. We hypothesize that c-Myc elevation driven by the deregulated Sry and SGF29 pathway is implicated in the male specific acquisition of human HCCs.
基金supported by the Major Program of the National Natural Science Foundation of China(Grant No.1103201)Natural Science Foundation of Hunan Province for innovation group(Grant No.09JJ7004)the Opening Project Program of Key Laboratory of Low Dimensional Materials and Ap-plication Technology(Xiangtan University),Min-istry of Education,China(Grant No.DWKF0804).
文摘Lead strontium titanate(Sr_(1-x)Pbx)TiO_(3)(0.20≤x≤0.45,step=0.05)ceramics were prepared by conventional mixed oxide method.The X-ray diffraction patterns indicate that the prepared samples have perovskite-type structure.With the increase of Pb content,there is a tendency from the cubic to tetragonal structure.The scanning electron microscopy micrographs reveal that the addition of Pb can affect microstructure.The dependent temperature dielectric permittivity and dielectric loss were investigated in the frequency range from 100 Hz to 1MHz.The maximum peak of the dielectric permittivity versus temperature curve was broadened and a frequency dispersion of the dielectric permittivity was observed for the(Sr_(0.8)Pb_(0.2))TiO_(3)ceramics.The results obtained at the frequency of 10 kHz reveal the Curie temperature linearly increased with the lead content.Thefitted curves of temperature versus inverse dielectric permittivity at 10 kHz for(Sr_(1-x)Pbx)TiO_(3)ceramics are consistent with Curie-Weiss law.The Pyroelectric properties were also investigated.The high pyroelectric coe±cients andfigure of merits indicate that the SPT ceramics are potential materials for pyroelectric sensors.
