Objective:To analyze the safety and effectiveness of the ethylene-vinyl alcohol copolymer(EVOH)liquid embolic agent Squid(Emboflu,Switzerland)for the treatment of brain arteriovenous malformations.Materials and proced...Objective:To analyze the safety and effectiveness of the ethylene-vinyl alcohol copolymer(EVOH)liquid embolic agent Squid(Emboflu,Switzerland)for the treatment of brain arteriovenous malformations.Materials and procedures:Between April 2015 and July 2017,46 embolization treatments for brain arteriovenous malformations(BAVM)were performed in 25 patients using two Squid formulations(18 and 12).Six female and 19 male patients with a mean age of 34 years(range,9–62 years)were included.A total of 46 procedures were performed.The BAVMs were classified as Spetzler-Martin gradeⅡin 4 procedures,Ⅲin 27 procedures,and 1V in 15 procedures.Among the 25 patients,15 presented with hemorrhage,5 with seizures,and 5 with headache and neurology.The BAVMs were located in the temporal lobe in 5 patients,parietal lobe in 7 patients,frontal lobe in 3 patients,posterior fossa in 6 patients,basal ganglia in 3 patients,and parasagittal lobe in 1 patient.Results:The obliteration rate of the BAVMs ranged from 10%to 100%,with a mean of 33%.Most patients underwent their first or second embolization procedure.Four patients(8%)developed intracranial bleeding post procedure,with one death(2%).One patient(2%)experienced a seizure during the procedure;however,no intracranial bleeding was observed.Seven patients(15%)experienced perforations during catheter manipulation.One case(2%)of fractured catheter was recorded,but no significant complications were observed.The average volume of copolymer injected was 0.6 ml per nidus.Thirteen procedures used the Squid-12 formulation,29 procedures used the Squid-18 formulation,and 3 procedures used a combination of Squid-12 and-18 formulations.Conclusion:Squid is a safe and effective embolic agent for treating BAVMs.展开更多
Superconducting quantum interference devices(SQUIDs) are low-noise amplifiers that are essential for the readouts of translation edge sensors(TESs). The linear flux range is an important parameter for SQUID amplifiers...Superconducting quantum interference devices(SQUIDs) are low-noise amplifiers that are essential for the readouts of translation edge sensors(TESs). The linear flux range is an important parameter for SQUID amplifiers, especially those controlled by high-bandwidth digital flux-locked-loop circuits. A large linear flux range conduces to accurately measuring the input signal and also increasing the multiplexing factor in the time-division multiplexed(TDM) readout scheme of the TES array. In this work, we report that the linear flux range of an SQUID can be improved by using self-feedback effect. When the SQUID loop is designed to be asymmetric, a voltage-biased SQUID shows an asymmetric current–flux(I–Φ) response curve. The linear flux range is improved along the I–Φ curve with a shallow slope. The experimental results accord well with the numerical simulations. The asymmetric SQUID will be able to serve as a building block in the development of the TDM readout systems for large TES arrays.展开更多
金属磁微量能计(Metallic Magnetic Calorimeter,MMC)是一种具有极高能量分辨率的低温光子探测器。它通过顺磁材料磁化率在低温下随温度急剧变化的特性来实现对光子能量的精确测量。金属磁微量能计通常使用超导量子干涉器进行信号读出...金属磁微量能计(Metallic Magnetic Calorimeter,MMC)是一种具有极高能量分辨率的低温光子探测器。它通过顺磁材料磁化率在低温下随温度急剧变化的特性来实现对光子能量的精确测量。金属磁微量能计通常使用超导量子干涉器进行信号读出。研究介绍了一种用于金属磁微量能计信号读出的两级超导量子干涉器电路。初级放大器的设计采用了二阶梯度计构型,测试结果显示该设计方案有效的抑制了环境噪声的干扰。在液氦温度下,两级放大电路在磁通锁定环模式下实现了27400 V/A的跨阻增益,白噪声水平达到11.5 pA/Hz^(1/2)。展开更多
文摘Objective:To analyze the safety and effectiveness of the ethylene-vinyl alcohol copolymer(EVOH)liquid embolic agent Squid(Emboflu,Switzerland)for the treatment of brain arteriovenous malformations.Materials and procedures:Between April 2015 and July 2017,46 embolization treatments for brain arteriovenous malformations(BAVM)were performed in 25 patients using two Squid formulations(18 and 12).Six female and 19 male patients with a mean age of 34 years(range,9–62 years)were included.A total of 46 procedures were performed.The BAVMs were classified as Spetzler-Martin gradeⅡin 4 procedures,Ⅲin 27 procedures,and 1V in 15 procedures.Among the 25 patients,15 presented with hemorrhage,5 with seizures,and 5 with headache and neurology.The BAVMs were located in the temporal lobe in 5 patients,parietal lobe in 7 patients,frontal lobe in 3 patients,posterior fossa in 6 patients,basal ganglia in 3 patients,and parasagittal lobe in 1 patient.Results:The obliteration rate of the BAVMs ranged from 10%to 100%,with a mean of 33%.Most patients underwent their first or second embolization procedure.Four patients(8%)developed intracranial bleeding post procedure,with one death(2%).One patient(2%)experienced a seizure during the procedure;however,no intracranial bleeding was observed.Seven patients(15%)experienced perforations during catheter manipulation.One case(2%)of fractured catheter was recorded,but no significant complications were observed.The average volume of copolymer injected was 0.6 ml per nidus.Thirteen procedures used the Squid-12 formulation,29 procedures used the Squid-18 formulation,and 3 procedures used a combination of Squid-12 and-18 formulations.Conclusion:Squid is a safe and effective embolic agent for treating BAVMs.
基金Project supported by the Fund from China National Space Administration (CNSA) (Grant No. D050104)the Fund for Low Energy Gamma Ray Detection Research Based on SQUID Techniquethe Superconducting Electronics Facility (SELF) of Shanghai Institute of Microsystem and Information Technology, Chinese Academy of Sciences。
文摘Superconducting quantum interference devices(SQUIDs) are low-noise amplifiers that are essential for the readouts of translation edge sensors(TESs). The linear flux range is an important parameter for SQUID amplifiers, especially those controlled by high-bandwidth digital flux-locked-loop circuits. A large linear flux range conduces to accurately measuring the input signal and also increasing the multiplexing factor in the time-division multiplexed(TDM) readout scheme of the TES array. In this work, we report that the linear flux range of an SQUID can be improved by using self-feedback effect. When the SQUID loop is designed to be asymmetric, a voltage-biased SQUID shows an asymmetric current–flux(I–Φ) response curve. The linear flux range is improved along the I–Φ curve with a shallow slope. The experimental results accord well with the numerical simulations. The asymmetric SQUID will be able to serve as a building block in the development of the TDM readout systems for large TES arrays.
文摘金属磁微量能计(Metallic Magnetic Calorimeter,MMC)是一种具有极高能量分辨率的低温光子探测器。它通过顺磁材料磁化率在低温下随温度急剧变化的特性来实现对光子能量的精确测量。金属磁微量能计通常使用超导量子干涉器进行信号读出。研究介绍了一种用于金属磁微量能计信号读出的两级超导量子干涉器电路。初级放大器的设计采用了二阶梯度计构型,测试结果显示该设计方案有效的抑制了环境噪声的干扰。在液氦温度下,两级放大电路在磁通锁定环模式下实现了27400 V/A的跨阻增益,白噪声水平达到11.5 pA/Hz^(1/2)。
