A Blade Altering Toolbox for Automating Rotor Design Optimization

The Blade Altering Toolbox(BAT)described in this paper is a tool designed for fast reconstruction of an altered blade geometry for design optimization purposes.The BAT algorithm is capable of twisting a given rotor’s angle of attack and stretching the chord length along the span of the rotor.Several test cases were run using the BAT’s algorithm.The BAT code’s twisting,stretching,and mesh reconstruction capabilities proved to be able to handle reasonably large geometric alterations to a provided input rotor geometry.The test examples showed that the toolbox’s algorithm could handle any stretching of the blade’s chord as long as the blade remained within the original bounds of the unaltered mesh.The algorithm appears to fail when the net twist angle applied the geometry exceeds approximately 30 degrees,however this limitation is dependent on the initial geometry and other input parameters.Overall,the algorithm is a very powerful tool for automating a design optimization procedure.

Novel cyber-physical collaborative detection and localization method against dynamic load altering attacks in smart energy grids

Owing to the integration of energy digitization and artificial intelligence technology,smart energy grids can realize the stable,efficient and clean operation of power systems.However,the emergence of cyber-physical attacks,such as dynamic load-altering attacks(DLAAs)has introduced great challenges to the security of smart energy grids.Thus,this study developed a novel cyber-physical collaborative security framework for DLAAs in smart energy grids.The proposed framework integrates attack prediction in the cyber layer with the detection and localization of attacks in the physical layer.First,a data-driven method was proposed to predict the DLAA sequence in the cyber layer.By designing a double radial basis function network,the influence of disturbances on attack prediction can be eliminated.Based on the prediction results,an unknown input observer-based detection and localization method was further developed for the physical layer.In addition,an adaptive threshold was designed to replace the traditional precomputed threshold and improve the detection performance of the DLAAs.Consequently,through the collaborative work of the cyber-physics layer,injected DLAAs were effectively detected and located.Compared with existing methodologies,the simulation results on IEEE 14-bus and 118-bus power systems verified the superiority of the proposed cyber-physical collaborative detection and localization against DLAAs.

Sex-dependent alterations in extracellular vesicles linking chronic spinal cord injury to brain neuroinflammation and neurodegeneration

Traumatic spinal cord injury(SCI)is a devastating exogenous injury with long-lasting consequences and a leading cause of death and disability worldwide.Advances in assistive technology,rehabilitative interventions,and the ability to identify and intervene in secondary conditions have significantly increased the long-term survival rate of SCI patients,with some people even living well into their seventh or eighth decade.These survival changes have led neurotrauma researchers to examine how SCI interacts with brain aging.Public health and epidemiological data showed that patients with long-term SCI can have a lower life expectancy and quality of life,along with a higher risk of comorbidities and complications.

AMI患者PCI术后心电图ST-T、Tp-e/QT比值及其与预后的相关性

目的研究急性心肌梗死(AMI)患者经皮冠状动脉介入(PCI)术后心电图ST-T、T波峰末间期(Tp-e)/QT比值及其与预后的相关性。方法回顾性分析2021年2月至2023年4月南阳市第二人民医院收治的120例AMI患者的临床资料,根据PCI术后6个月患者的预后情况分为预后不良组(n=18)和预后良好组(n=102),比较两组患者PCI术后ST-T段回落情况、术前Tp-e/QT比值,采用多因素COX回归分析AMI患者PCI术后预后的影响因素,绘制受试者工作特征(ROC)曲线分析ST-T段回落、术前Tp-e/QT比值对AMI患者预后的预测价值。结果预后不良组患者的ST-T段<50%、术前Tp-e/QT比值分别为77.78%、0.34±0.05,明显高于预后良好组的13.73%、0.27±0.04,差异均有统计学意义(P<0.05);COX回归分析结果显示,ST-T段<50%、术前Tp-e/QT比值均是AMI患者PCI术后预后的危险因素(P<0.05);ROC曲线分析结果显示,ST-T段回落、术前Tp-e/QT比值对AMI患者PCI术后预后预测的曲线下面积(AUC)分别为0.686、0.747,特异度分别为61.50%、81.42%,敏感度分别为80.00%、85.31%。结论AMI患者心电图ST-T段回落不良、Tp-e/QT比值增加是PCI术后预后不良的危险因素,临床应加强对此类患者的干预,以减少心血管不良事件的发生。

Fixed Point Results by Altering Distances in Fuzzy Metric Spaces

We establish fixed point theorems in complete fuzzy metric space by using notion of altering distance, initiated by Khan et al. [Bull. Austral. Math. Soc. 30 (1984), 1-9]. Also, we find an affirmative answer in fuzzy metric space to the problem of Sastry [TamkangJ. Math., 31(3) (2000), 243-250].

Common Fixed Point Results for Quasi-contractions Involving Altering Distance Functions in Ordered Cone Metric Spaces

Some common fixed point results for mappings satisfying a quasi-contractive condition which involves altering distance functions are obtained in partially ordered complete cone metric spaces. A sufficient condition for the uniqueness of common fixed point is proved. Also, an example is given to support our results.

Common Fixed Point Theorems in Metric Space by Altering Distance Function

In the present paper, we prove two theorems. In first theorem, we prove fixed point result for self-maps in the metric space under contractive condition of integral type by altering distance. In second result, we prove a unique common fixed point theorem by considering four sub compatible maps under a contractive condition of integral type.

ST-T段改变患者心电瀑布图形态特征及其对心血管疾病的预测价值

目的探讨究ST-T段改变患者心电瀑布图形态特征及其对心血管疾病的预测价值。方法选择2020年6月1日至2022年6月1日在该院进行心电瀑布图及传统心电图检查的疑似心脏病患者970例作为研究对象,根据24 h动态心电图分为ST-T段改变216例及正常心电图754例。分析心电图ST段下降、ST段抬高、T波低平、T波负向、T波正向、T波双向波长中心电瀑布图形态特征;采用一致性检验法检测心电瀑布图、常规心电图与24 h动态心电图诊断ST-T段改变的一致性;采用四格表法检测心电瀑布图、常规心电图诊断ST-T段改变的灵敏度、特异度。结果正常心电图受检者心电图波及波群TP带、P峰带、PR峰、QPS带、ST带、T峰带、TP带心电瀑布图特征主要表现浅蓝色、亮蓝色、蓝色、红色/黄色/橙色、蓝色、蓝色/亮蓝色、浅蓝色。216例ST-T段改变患者中,156例患者心电图显示为ST段下降,其中68例患者为T波负向,心电瀑布图表现为深蓝色62例(91.18%)、蓝黑色6例(8.82%);73例患者为T波正向,心电瀑布图表现为蓝黑色66例(90.41%)、深蓝色7例(9.59%)。60例患者心电图显示为ST段抬高,其中51例患者为T波正向,心电瀑布图表现为亮蓝色43例(84.31%)、深蓝色6例(11.76%)、淡黄色2例(3.92%)。74例患者存在T波负向,心电瀑布图表现为蓝黑色;124例患者存在T波正向,心电瀑布图随T波幅度呈浅蓝-亮蓝-黄-红改变;12例存在T波低平,心电瀑布图上方随T波幅度呈浅蓝-亮蓝-黄-红改变,下方主要表现为蓝黑色。心电瀑布图诊断ST-T段改变的灵敏度、特异度、准确度分别为96.30%、88.73%、90.41%,常规心电图诊断ST-T段改变的灵敏度、特异度、准确度分别为83.33%、72.68%、75.05%。一致性检验结果显示,心电瀑布图与24 h动态心电图诊断ST-T段改变的一致性极强,常规心电图与24 h动态心电图诊断ST-T段改变的一致性较好。结论ST-T改变患者心电瀑布图具有明显特征性改变,其在诊断心血管疾病方面的价值优于常规心电图,可推广应用。

Risk stratification for radioactive iodine refractoriness using molecular alterations in distant metastatic differentiated thyroid cancer

Objective: Patients with radioactive iodine-refractory differentiated thyroid cancer(RAIR-DTC) are often diagnosed with delay and constrained to limited treatment options. The correlation between RAI refractoriness and the underlying genetic characteristics has not been extensively studied.Methods: Adult patients with distant metastatic DTC were enrolled and assigned to undergo next-generation sequencing of a customized 26-gene panel(Thyro Lead). Patients were classified into RAIR-DTC or non-RAIR groups to determine the differences in clinicopathological and molecular characteristics. Molecular risk stratification(MRS) was constructed based on the association between molecular alterations identified and RAI refractoriness, and the results were classified as high, intermediate or low MRS.Results: A total of 220 patients with distant metastases were included, 63.2% of whom were identified as RAIRDTC. Genetic alterations were identified in 90% of all the patients, with BRAF(59.7% vs. 17.3%), TERT promoter(43.9% vs. 7.4%), and TP53 mutations(11.5% vs. 3.7%) being more prevalent in the RAIR-DTC group than in the non-RAIR group, except for RET fusions(15.8% vs. 39.5%), which had the opposite pattern. BRAF and TERT promoter are independent predictors of RAIR-DTC, accounting for 67.6% of patients with RAIR-DTC. MRS was strongly associated with RAI refractoriness(P<0.001), with an odds ratio(OR) of high to low MRS of 7.52 [95%confidence interval(95% CI), 3.96-14.28;P<0.001] and an OR of intermediate to low MRS of 3.20(95% CI,1.01-10.14;P=0.041).Conclusions: Molecular alterations were associated with RAI refractoriness, with BRAF and TERT promoter mutations being the predominant contributors, followed by TP53 and DICER1 mutations. MRS might serve as a valuable tool for both prognosticating clinical outcomes and directing precision-based therapeutic interventions.

Using Genomic Information for Altering Bolting and Flowering Behaviour of Crop Plants

Altering the phenological development of a plant is a major target of many plant breeding programs and can be exploited to achieve different outcomes. For example, in seed crops, the transition from the vegetative to

心电图ST-T段异常对缺血性脑卒中的预测效能

目的 探讨心电图ST-T段异常(STA)对缺血性脑卒中的预测价值。方法 采用前瞻性研究方法,对3 027名体检人员(受试者)进行心电图检查,并随访60个月~120个月(随访截止2022年6月,或研究对象发生缺血性脑卒中则停止随访)。根据随访结果进行分组,将发生缺血性脑卒中的94例受试者设为研究组,将其余2 933例受试者设为对照组,统计STA发生情况。对缺血性脑卒中的影响因素采用单因素分析及多因素非条件Logistic回归分析,绘制受试者工作特征(ROC)曲线分析STA对缺血性脑卒中的预测价值。结果 两组受试者性别、年龄、STA占比、左心室肥厚、脑卒中家族史比较,差异有统计学意义(P<0.01)。多因素非条件Logistic回归分析显示,年龄、STA、高血压、高血脂症、饮酒均是缺血性脑卒中的危险因素(P<0.05或0.01)。ROC曲线显示,STA预测缺血性脑卒中的曲线下面积为0.859,灵敏度为0.830,特异度为0.888,准确度为0.869;关联性检验显著(χ~2=138.706,P=0.000),优势性检验不显著(χ~2=0.432,P=0.511)。结论 STA可增加人群缺血性脑卒中的发病风险,对缺血性脑卒中的预测效能较高。

Route choice models based on altering OD

The condition and physical sense of actual dynamic user optimum are explained by analyzing a simple road network route choice. To match the practical application requirements, assignment network and simulation network are classified account for varying flowing loading. Instantaneous dynamic user optimum model should be applied to the former and actual dynamic user optimum model the latter respectively. The two model’s feasibility is studied as well. Considering the application in ATMS, the model is mainly used to analyze the altering OD problem. Moreover, it adds the method of route adapting into the object function selection to appraise elastic trip strategy and set up real means of route inducement.

Hydrothermal alteration of the surface volcanic rocks at the Acoculco geothermal field,Mexico:a multi-parametric approach

The studies on hydrothermal alteration-induced eff ects in surface and subsurface rocks provide useful information in the characterization and exploitation of a geothermal reservoir.Generally,these studies are based on traditional,and reliable methods like petrography(primary and secondary minerals,and grade of alteration),and geochemistry(mobility of elements,changes in mass and concentration of elements,and fluid inclusions).Recently,apart from these established methods,some methods based on the geochemical(Chemical Index of Alteration,CIA;Weathering Index of Parkar,WIP;Loss on Ignition,LOI;and Sulfur,S)and rock magnetic properties(magnetic susceptibility,χlf;and percentage frequency-dependent susceptibility,χfd%)are also being applied in the identification of whether a rock is an altered or a fresh one.The Acoculco Geothermal Field(AGF),Mexico,is characterized by high temperature and very low permeability,and it is considered a promissory Enhanced Geothermal System.The following changes are observed in the rocks as a result of an increase in hydrothermal alteration:(1)an increase in CIA,LOI,and S values,and a decrease in WIP;(2)an increase in quartz and quartz polymorph minerals(silicification),and clay minerals(argillization);and(3)decrease inχlf values.At AGF,the most altered surface acid rocks are characterized by entirely quartz and its polymorphs,and clay minerals.The present study also indicates the applicability of the binary plots of major elements(felsic vs mafic component)and rock magnetic parameters(χlf vs.χfd%).The rock withχfd%value of 2-10 andχlf value<0.5×10^(-6)m^(3) kg^(-1)indicate the presence of single domain and stable single domain grains,which in turn suggests that it is an altered rock.These methods are simple to apply,rapid,reliable,and have the potential to become eff ective tools for the identifi cation of hydrothermally altered rocks during the initial stage of geothermal exploration.

Genomic alterations in oral multiple primary cancers

Oral squamous cell carcinoma (OSCC) is the predominant type of oral cancer, while some patients may develop oral multiple primary cancers (MPCs) with unclear etiology. This study aimed to investigate the clinicopathological characteristics and genomic alterations of oral MPCs. Clinicopathological data from patients with oral single primary carcinoma (SPC, n=202) and oral MPCs (n=34) were collected and compared. Copy number alteration (CNA) analysis was conducted to identify chromosomal-instability differences among oral MPCs, recurrent OSCC cases, and OSCC patients with lymph node metastasis. Whole-exome sequencing was employed to identify potential unique gene mutations in oral MPCs patients. Additionally, CNA and phylogenetic tree analyses were used to gain preliminary insights into the molecular characteristics of different primary tumors within individual patients. Our findings revealed that, in contrast to oral SPC, females predominated the oral MPCs (70.59%), while smoking and alcohol use were not frequent in MPCs.Moreover, long-term survival outcomes were poorer in oral MPCs. From a CNA perspective, no significant differences were observed between oral MPCs patients and those with recurrence and lymph node metastasis. In addition to commonly mutated genes such as CASP8, TP53 and MUC16, in oral MPCs we also detected relatively rare mutations, such as HS3ST6 and RFPL4A. Furthermore, this study also demonstrated that most MPCs patients exhibited similarities in certain genomic regions within individuals, and distinct differences of the similarity degree were observed between synchronous and metachronous oral MPCs.

Identifying Comprehensive Genomic Alterations and Potential Neoantigens for Cervical Cancer Immunotherapy in a Cohort of Chinese Squamous Cell Carcinoma of the Cervix

Objective Genomic alterations and potential neoantigens for cervical cancer immunotherapy were identified in a cohort of Chinese patients with cervical squamous cell carcinoma(CSCC).Methods Whole-exome sequencing was used to identify genomic alterations and potential neoantigens for CSCC immunotherapy.RNA Sequencing was performed to analyze neoantigen expression.Results Systematic bioinformatics analysis showed that C>T/G>A transitions/transversions were dominant in CSCCs.Missense mutations were the most frequent types of somatic mutation in the coding sequence regions.Mutational signature analysis detected signature 2,signature 6,and signature 7 in CSCC samples.PIK3CA,FBXW7,and BICRA were identified as potential driver genes,with BICRA as a newly reported gene.Genomic variation profiling identified 4,960 potential neoantigens,of which 114 were listed in two neoantigen-related databases.Conclusion The present findings contribute to our understanding of the genomic characteristics of CSCC and provide a foundation for the development of new biotechnology methods for individualized immunotherapy in CSCC.

Application of Remote Sensing and GIS in Mineral Alteration Mapping and Lineament Extraction Case of Oudiane Elkharoub (Requibat Shield, Northern of Mauritania)

The integration of remotely sensed data allowed the successful characterization of the mineral alteration zones of the Oudiane Elkharoub area in the Northeastern part of Reguibat Shield using image transformation techniques. As both chemical and geochemical analyses showed significant Au, Ag, Cu, Pb, Mn, Cr, Ni, Th and Y anomalies, it’s very interesting to apply the remote sensing and GIS in mineral resources mapping. The remote sensing is a direct adjunct to the field, lithologic and structural mapping, and more recently, GIS has played an important role in the study of mineralization areas. The integration of several evidential maps highlighted the plausible areas with high concentrations of chlorite, epidote, kaolinite, calcite, alunite, hematite, illite and sulfur among other key mineral alterations that reflect the intensity of hydrothermal effects and the probable sites of ore bodies. The methodological approach integrates geological information acquired from Aster and Landsat 8 OLI/TIRS (Operational Land Imager/Thermal InfraRed Sensor) images and a multi-criteria GIS analysis. The superimposition of various lineament and hydrothermal alteration maps and the consideration of precious and base metal indicators allowed the zoning of sites likely to contain mineral concentrations. Remote sensing becomes an important tool for locating mineral deposits in its own right, when the primary and secondary processes of mineralization result in the formation of spectral anomalies. Reconnaissance lithological mapping is usually the first step of mineral resource mapping. This is complimented with structural mapping, as mineral deposits usually occur along or adjacent to geologic structures, and alteration mapping, as mineral deposits are commonly associated with hydrothermal alteration of the surrounding rocks. Ground truthing and laboratory studies including XRD analysis were utilized to verify the results.

Bilateral meibomian gland morphological alterations in unilateral herpes simplex keratitis based on artificial intelligence analysis

AIM:To explore whether unilateral herpes simplex keratitis(HSK)can cause morphological changes of bilateral meibomian glands(MGs)based on artificial intelligence(AI)analytical system.METHODS:In the retrospective study,29 patients with unilateral HSK and 29 participants matched in terms of age and sex were included as control group.Meibographic images of the upper eyelid using Keratograph 5M and assessed ocular surface parameters including tear meniscus height and tear break-up time.MG density and vagueness values were automatically analyzed and calculated using an AI analytical system.We compared the differences between the affected and the contralateral unaffected eyes in HSK patients,and the normal control eyes.We employed either the paired t-test or the Wilcoxon signed-rank test to compare significant difference between the affected and unaffected eyes in HSK patients or between the HSK group and control group.RESULTS:The MG density was 0.19±0.09 in the HSKaffected eye and 0.18±0.07 in contralateral unaffected eye,which had no significant difference(P=0.616).The MG density between the affected eye with HSK and the normal control group was statistically significant(P=0.028).There was a significant difference in MG density between the contralateral unaffected eye and the normal control group(P=0.012).However,no significant difference in vagueness value was observed between the eye with HSK and the control group or between HSK eye and contralateral eye.CONCLUSION:The MG density between the HSKaffected eye and the contralateral unaffected eye don’t significantly differ,whereas there is a significant decrease in the HSK group compared to that of the normal participants.Unilateral HSV keratitis may suffer from bilateral changes of MG morphology indicating bilateral dry eye.Therefore,the fellow eye of patients with unilateral HSK should be considered a potential case of MG dysfunction,necessitating early treatment for bilateral dry eye in the clinic.

Clinicopathological alterations in wild mammals from the reservoir system of Trypanosoma cruzi:a scoping review

Trypanosoma cruzi is the etiologic agent of Chagas disease.This flagellated protozoan is transmitted to humans as well as different species of domestic and wild animals via vectors from the Reduviidae family(known as"kissing bugs").Despite the fact that hundreds of species of wild mammals are part of the reservoir system,the morphologi-cal changes and clinical manifestations resulting from the pathogenesis of the infection have been largely neglected.The aim of this review is to systematically compile the available information regarding clinicopathological altera-tions in wild mammals due to natural infection by T.cruzi.Information was obtained from six online bibliographic data search platforms,resulting in the identification of 29 publications that met the inclusion criteria.Mortality was the most common clinical manifestation,cardiac damage was the main finding at necropsy,and lymphoplas-macytic inflammation was the most frequent microscopic injury.Thus,regardless of its role as a reservoir,T.cruzi has the potential to affect the health status of wild mammals,a situation that highlights the need for further research to analyze,measure,and compare its effects at both the individual and population levels.

Multi-scale data joint inversion of minerals and porosity in altered igneous reservoirs—A case study in the South China Sea

There are abundant igneous gas reservoirs in the South China Sea with significant value of research,and lithology classification,mineral analysis and porosity inversion are important links in reservoir evaluation.However,affected by the diverse lithology,complicated mineral and widespread alteration,conventional logging lithology classification and mineral inversion become considerably difficult.At the same time,owing to the limitation of the wireline log response equation,the quantity and accuracy of minerals can hardly meet the exploration requirements of igneous formations.To overcome those issues,this study takes the South China Sea as an example,and combines multi-scale data such as micro rock slices,petrophysical experiments,wireline log and element cutting log to establish a set of joint inversion methods for minerals and porosity of altered igneous rocks.Specifically,we define the lithology and mineral characteristics through core slices and mineral data,and establish an igneous multi-mineral volumetric model.Then we determine element cutting log correction method based on core element data,and combine wireline log and corrected element cutting log to perform the lithology classification and joint inversion of minerals and porosity.However,it is always difficult to determine the elemental eigenvalues of different minerals in inversion.This paper uses multiple linear regression methods to solve this problem.Finally,an integrated inversion technique for altered igneous formations was developed.The results show that the corrected element cutting log are in good agreement with the core element data,and the mineral and porosity results obtained from the joint inversion based on the wireline log and corrected element cutting log are also in good agreement with the core data from X-ray diffraction.The results demonstrate that the inversion technique is applicable and this study provides a new direction for the mineral inversion research of altered igneous formations.

Research on the Application of Electromagnetic Method in the Exploration of Altered Rock-type Gold Deposits in the East Kunlun Metallogenic Belt

Introduction The East Kunlun Orogenic Belt is located in the northeastern part of the Qinghai–Tibet Plateau(Li et al.,2007),stretching from the East Kunlun to the Elashan area in an east–west direction(Guo et al.,2018).It is an important part of the Central Orogenic Belt(Xiong et al.,2023).It is considered one of the important gold mineralization regions in the Tethys tectonic domain(Norbu et al.,2023)and an essential potential base for mineral resources in China.Wulonggou and Gouli gold mines have been discovered successively,earning the reputation of the"Golden Belt of Qinghai Province"(Feng et al.,2004;He et al.,2023).